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The map label for this gene is typA [H]

Identifier: 114332461

GI number: 114332461

Start: 2642077

End: 2643891

Strand: Reverse

Name: typA [H]

Synonym: Neut_2514

Alternate gene names: 114332461

Gene position: 2643891-2642077 (Counterclockwise)

Preceding gene: 114332469

Following gene: 114332460

Centisome position: 99.35

GC content: 51.57

Gene sequence:

>1815_bases
ATGACACGCCTGCTCCGTAATATCGCCATTATCGCCCATGTGGACCATGGCAAGACCACGATGGTGGATAAGCTGCTGCA
TCAGGCCGGCACCTTTGCTGCTCACCAGACCATTGCTGAACGGGTGATGGATTCTGATGATATTGAGCGCGAACGCGGAA
TCACGATTTTTTCCAAAAATTGTGCAATCGATTATGCCGGCGTACATATCAATATTGTGGATACCCCGGGCCACGCCGAT
TTTGGCGGAGAAGTCGAGCGTGTGCTGTCAATGGTGGATGGTGTGTTGTTGCTGGTGGATGCGGTTGAGGGCCCTATGCC
GCAAACCCGTTTCGTCACTCGCAAGGCGCTGGCAGCCGGTTTGTGCCCGATTGTGGTGATTAACAAGATAGACCGTCCCG
GTGCCCGGCCGGATTGGGTGGTGAACCAGACATTCGATTTGTTCGATAAATTGAATGCTACCGAAGAACAACTGGATTTC
CCGGTGATCTACGCTTCCGGACTCAACGGTTATGCCACATCGGATCCCAAACAGCCTGGCAGCGATATGCGTCCGCTGTT
TGATCTGATACTCAAGCATGTACCCGCACCGACAGGAGATCCTGATCAGCCGCTGCAACTGCAAATCAGTGCGCTTGATT
ATTCCAGTTTTGTTGGGCGTCTTGGTATTGGCAGAATCAGCCGGGGTCGTCTGAAATCGGGGCAGGAAGTGATGGTAATG
ACGGGTGGACAAACACCGAAAAAAGCGCGTGTCAACCAGATATCTGCTTTTAGCGGACTGGATCGGGTTCAGTTGAGTGA
AGCAGCTGCGGGCGAAATTGTGTTGATCAGCGGGATTGATGAGCTCAGTATTGGCACGACGCTGGCGGATACTGATCGCC
CGGAAGCTTTGCCGATGCCAAAGGTTGATGAACCAACGCTTTCAATGAATTTTCAGGTCAATACTTCACCTTTTGCCGGC
AAGGAGGGTAAATTTATTACCAGCCGCCAGTTGCGCGAGCGCCTTGAAAAAGAATTGCTGACCAATGTTGCATTGAAGCT
GGAAGAAACCGGCGAAACCGATTCATTTCTTGTTTCTGGGCGTGGTGAGCTGCATTTGACAATTCTGCTTGAAAACATGC
GTCGGGAAGGTTATGAGCTGGCGGTGTCTCGCCCCAAGGTGGTTATCCGGGAAATTGATGGCGTTAAGTGCGAACCGTTC
GAGATATTGACGATTGATATTGATGAAACCCACCAGGGAGCGGTGATGGAGACATTGGGAACACGCCGTGGTGATCTGCT
GGATATGATAAGTGACGGGCGTGGCCGGGTCAGGCTGGATTATCGTATTCCTGCACGCGGCCTGATTGGATTCCAATCCG
AATTTATGACACTGACGCGCGGCACTGGCATCATAAGCCATATCTTCGATGAATATGCACCGATGCGGCCGGATATTGCT
TCACGTAAAAATGGTGTGCTGATCTCGGCAGAATATGGTGAGGTAGTGGCTTACGCGCTCTGGAAGCTACAGGAGCGTGG
CCGCATGTTTGTCAGCCCCGGTGAGCCGGTTTATGAAGGGATGGTGATTGGCATACATACCCGTGAGAATGATCTCGTCG
TTAACCCGATCAAAGGTAAACAACTGACTAATATCCGGGCATCCGGCCATGATGAGGCGGTTGTGCTGACACCCCCGATT
CAGTTGACATTGGAATCAGCAGTTGAATTCATTACGGATGATGAGTTGGTTGAAATTACTCCAAAAAGTATCCGTATCCG
TAAACGTTTCCTGCTGGAACACGAGCGTAAACGGGCGGGCCGCTCCGTTGCCTGA

Upstream 100 bases:

>100_bases
GTAAATAGATAATACCCCGGTCAGTCTGATAGTTCGAACACTGTTATAATCAACAGTTTATCCGGGATTGCCCGGGCCGA
TTTCCGAGGAACTTTCAATT

Downstream 100 bases:

>100_bases
TGTTTCCTGGCAGCAGATATAAAAAATTGGTTCTATGGTATATCGCTGACCCCATGTGCTCATGGTGCTGGGGGTTTGCG
CCGGTTATCGAGCAAATTAG

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MTRLLRNIAIIAHVDHGKTTMVDKLLHQAGTFAAHQTIAERVMDSDDIERERGITIFSKNCAIDYAGVHINIVDTPGHAD
FGGEVERVLSMVDGVLLLVDAVEGPMPQTRFVTRKALAAGLCPIVVINKIDRPGARPDWVVNQTFDLFDKLNATEEQLDF
PVIYASGLNGYATSDPKQPGSDMRPLFDLILKHVPAPTGDPDQPLQLQISALDYSSFVGRLGIGRISRGRLKSGQEVMVM
TGGQTPKKARVNQISAFSGLDRVQLSEAAAGEIVLISGIDELSIGTTLADTDRPEALPMPKVDEPTLSMNFQVNTSPFAG
KEGKFITSRQLRERLEKELLTNVALKLEETGETDSFLVSGRGELHLTILLENMRREGYELAVSRPKVVIREIDGVKCEPF
EILTIDIDETHQGAVMETLGTRRGDLLDMISDGRGRVRLDYRIPARGLIGFQSEFMTLTRGTGIISHIFDEYAPMRPDIA
SRKNGVLISAEYGEVVAYALWKLQERGRMFVSPGEPVYEGMVIGIHTRENDLVVNPIKGKQLTNIRASGHDEAVVLTPPI
QLTLESAVEFITDDELVEITPKSIRIRKRFLLEHERKRAGRSVA

Sequences:

>Translated_604_residues
MTRLLRNIAIIAHVDHGKTTMVDKLLHQAGTFAAHQTIAERVMDSDDIERERGITIFSKNCAIDYAGVHINIVDTPGHAD
FGGEVERVLSMVDGVLLLVDAVEGPMPQTRFVTRKALAAGLCPIVVINKIDRPGARPDWVVNQTFDLFDKLNATEEQLDF
PVIYASGLNGYATSDPKQPGSDMRPLFDLILKHVPAPTGDPDQPLQLQISALDYSSFVGRLGIGRISRGRLKSGQEVMVM
TGGQTPKKARVNQISAFSGLDRVQLSEAAAGEIVLISGIDELSIGTTLADTDRPEALPMPKVDEPTLSMNFQVNTSPFAG
KEGKFITSRQLRERLEKELLTNVALKLEETGETDSFLVSGRGELHLTILLENMRREGYELAVSRPKVVIREIDGVKCEPF
EILTIDIDETHQGAVMETLGTRRGDLLDMISDGRGRVRLDYRIPARGLIGFQSEFMTLTRGTGIISHIFDEYAPMRPDIA
SRKNGVLISAEYGEVVAYALWKLQERGRMFVSPGEPVYEGMVIGIHTRENDLVVNPIKGKQLTNIRASGHDEAVVLTPPI
QLTLESAVEFITDDELVEITPKSIRIRKRFLLEHERKRAGRSVA
>Mature_603_residues
TRLLRNIAIIAHVDHGKTTMVDKLLHQAGTFAAHQTIAERVMDSDDIERERGITIFSKNCAIDYAGVHINIVDTPGHADF
GGEVERVLSMVDGVLLLVDAVEGPMPQTRFVTRKALAAGLCPIVVINKIDRPGARPDWVVNQTFDLFDKLNATEEQLDFP
VIYASGLNGYATSDPKQPGSDMRPLFDLILKHVPAPTGDPDQPLQLQISALDYSSFVGRLGIGRISRGRLKSGQEVMVMT
GGQTPKKARVNQISAFSGLDRVQLSEAAAGEIVLISGIDELSIGTTLADTDRPEALPMPKVDEPTLSMNFQVNTSPFAGK
EGKFITSRQLRERLEKELLTNVALKLEETGETDSFLVSGRGELHLTILLENMRREGYELAVSRPKVVIREIDGVKCEPFE
ILTIDIDETHQGAVMETLGTRRGDLLDMISDGRGRVRLDYRIPARGLIGFQSEFMTLTRGTGIISHIFDEYAPMRPDIAS
RKNGVLISAEYGEVVAYALWKLQERGRMFVSPGEPVYEGMVIGIHTRENDLVVNPIKGKQLTNIRASGHDEAVVLTPPIQ
LTLESAVEFITDDELVEITPKSIRIRKRFLLEHERKRAGRSVA

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=504, Percent_Identity=26.5873015873016, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI94966754, Length=135, Percent_Identity=44.4444444444444, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI18390331, Length=222, Percent_Identity=34.6846846846847, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=39.5833333333333, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI25306287, Length=168, Percent_Identity=36.9047619047619, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI19923640, Length=168, Percent_Identity=36.9047619047619, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI25306283, Length=168, Percent_Identity=36.9047619047619, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI34147630, Length=242, Percent_Identity=31.404958677686, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=42.7272727272727, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=42.7272727272727, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=42.7272727272727, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI217272892, Length=143, Percent_Identity=39.8601398601399, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI217272894, Length=143, Percent_Identity=39.8601398601399, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI94966752, Length=131, Percent_Identity=32.0610687022901, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=62.8524046434494, Blast_Score=781, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=546, Percent_Identity=28.7545787545788, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789738, Length=150, Percent_Identity=40.6666666666667, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789737, Length=290, Percent_Identity=29.3103448275862, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790412, Length=290, Percent_Identity=29.3103448275862, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790835, Length=133, Percent_Identity=33.0827067669173, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=290, Percent_Identity=33.448275862069, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17533571, Length=171, Percent_Identity=39.1812865497076, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17556745, Length=133, Percent_Identity=45.8646616541353, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=41.40625, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=41.40625, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=158, Percent_Identity=36.0759493670886, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17552882, Length=181, Percent_Identity=33.7016574585635, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=284, Percent_Identity=28.5211267605634, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32566303, Length=255, Percent_Identity=27.0588235294118, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=507, Percent_Identity=27.6134122287968, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324761, Length=289, Percent_Identity=31.4878892733564, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=40.9722222222222, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=40.9722222222222, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=175, Percent_Identity=40, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=148, Percent_Identity=38.5135135135135, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=143, Percent_Identity=37.7622377622378, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78706572, Length=513, Percent_Identity=26.3157894736842, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24582462, Length=171, Percent_Identity=37.4269005847953, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24585709, Length=150, Percent_Identity=38, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585711, Length=150, Percent_Identity=38, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585713, Length=150, Percent_Identity=38, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28574573, Length=137, Percent_Identity=40.1459854014599, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221458488, Length=166, Percent_Identity=39.7590361445783, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281363316, Length=318, Percent_Identity=27.0440251572327, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17864358, Length=318, Percent_Identity=27.0440251572327, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357743, Length=137, Percent_Identity=38.6861313868613, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921738, Length=285, Percent_Identity=28.4210526315789, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137380, Length=324, Percent_Identity=26.5432098765432, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66745; Mature: 66613

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLLRNIAIIAHVDHGKTTMVDKLLHQAGTFAAHQTIAERVMDSDDIERERGITIFSKN
CCHHHCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCEEEECC
CAIDYAGVHINIVDTPGHADFGGEVERVLSMVDGVLLLVDAVEGPMPQTRFVTRKALAAG
CEEEEECEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEHHCCCCCCHHHHHHHHHHHC
LCPIVVINKIDRPGARPDWVVNQTFDLFDKLNATEEQLDFPVIYASGLNGYATSDPKQPG
CCCEEEEECCCCCCCCCCEEECCHHHHHHHCCCCHHHCCCCEEEECCCCCCCCCCCCCCC
SDMRPLFDLILKHVPAPTGDPDQPLQLQISALDYSSFVGRLGIGRISRGRLKSGQEVMVM
CCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCCCCCEEEEE
TGGQTPKKARVNQISAFSGLDRVQLSEAAAGEIVLISGIDELSIGTTLADTDRPEALPMP
ECCCCCCHHHHHHHHHHCCCCHHEEHHCCCCCEEEEECCCCCCCCCEECCCCCCCCCCCC
KVDEPTLSMNFQVNTSPFAGKEGKFITSRQLRERLEKELLTNVALKLEETGETDSFLVSG
CCCCCCEEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEC
RGELHLTILLENMRREGYELAVSRPKVVIREIDGVKCEPFEILTIDIDETHQGAVMETLG
CCCEEEEEEEEHHHCCCEEEEECCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHC
TRRGDLLDMISDGRGRVRLDYRIPARGLIGFQSEFMTLTRGTGIISHIFDEYAPMRPDIA
CCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHHHHCCCCCCCC
SRKNGVLISAEYGEVVAYALWKLQERGRMFVSPGEPVYEGMVIGIHTRENDLVVNPIKGK
CCCCCEEEEECCHHHHHHHHHHHHHCCCEEECCCCCHHCCEEEEEEECCCCEEEECCCCC
QLTNIRASGHDEAVVLTPPIQLTLESAVEFITDDELVEITPKSIRIRKRFLLEHERKRAG
EEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCC
RSVA
CCCC
>Mature Secondary Structure 
TRLLRNIAIIAHVDHGKTTMVDKLLHQAGTFAAHQTIAERVMDSDDIERERGITIFSKN
CHHHCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCCEEEECC
CAIDYAGVHINIVDTPGHADFGGEVERVLSMVDGVLLLVDAVEGPMPQTRFVTRKALAAG
CEEEEECEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEHHCCCCCCHHHHHHHHHHHC
LCPIVVINKIDRPGARPDWVVNQTFDLFDKLNATEEQLDFPVIYASGLNGYATSDPKQPG
CCCEEEEECCCCCCCCCCEEECCHHHHHHHCCCCHHHCCCCEEEECCCCCCCCCCCCCCC
SDMRPLFDLILKHVPAPTGDPDQPLQLQISALDYSSFVGRLGIGRISRGRLKSGQEVMVM
CCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCCCCCCCEEEEE
TGGQTPKKARVNQISAFSGLDRVQLSEAAAGEIVLISGIDELSIGTTLADTDRPEALPMP
ECCCCCCHHHHHHHHHHCCCCHHEEHHCCCCCEEEEECCCCCCCCCEECCCCCCCCCCCC
KVDEPTLSMNFQVNTSPFAGKEGKFITSRQLRERLEKELLTNVALKLEETGETDSFLVSG
CCCCCCEEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEC
RGELHLTILLENMRREGYELAVSRPKVVIREIDGVKCEPFEILTIDIDETHQGAVMETLG
CCCEEEEEEEEHHHCCCEEEEECCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHC
TRRGDLLDMISDGRGRVRLDYRIPARGLIGFQSEFMTLTRGTGIISHIFDEYAPMRPDIA
CCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHHHHCCCCCCCC
SRKNGVLISAEYGEVVAYALWKLQERGRMFVSPGEPVYEGMVIGIHTRENDLVVNPIKGK
CCCCCEEEEECCHHHHHHHHHHHHHCCCEEECCCCCHHCCEEEEEEECCCCEEEECCCCC
QLTNIRASGHDEAVVLTPPIQLTLESAVEFITDDELVEITPKSIRIRKRFLLEHERKRAG
EEEEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCC
RSVA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]