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The map label for this gene is gph2 [H]

Identifier: 114332453

GI number: 114332453

Start: 2634988

End: 2635638

Strand: Reverse

Name: gph2 [H]

Synonym: Neut_2506

Alternate gene names: 114332453

Gene position: 2635638-2634988 (Counterclockwise)

Preceding gene: 114332454

Following gene: 114332452

Centisome position: 99.04

GC content: 49.46

Gene sequence:

>651_bases
ATGATCAGAAAAGCTGTCCTGTTCGATTTCGACGGCACCATTGCGGACACAGCACCGGATCTTGGCCGCGCACTCAACAG
GCAGCGTATTGCGCATGATCAGCCGCCTCTGTCGATCGAACTGATCCGTACCGTTGCGTCTGCTGGCGCACGTGGGTTGT
TGAATCTTGGTTTTGGTTTGAAACCGGATGATCCCGGTTACCAGGTCATGCGGGAGGAGTTTCTCTCCTTTTATACCGAA
CAGCTTTGCCAGGATACTCGCCTGTTTCCAGGTATCCCTGAATTACTGGAACAACTGGATGATCAGGCCATCCCATGGGG
AATCGTCACTAATAAGCCGGCAAGATTCACTCGGCCGCTCATACACCTGCTTGGATTACATCACCGTGCAGCCTGTATTA
TCAGTGGAGATGATACTACCTACACCAAGCCTCATCCGGAACCATTGCTTACTGCTTGTCGTCAGATAAACGTAGCTCCT
GATCATTGTATTTATCTGGGAGATGATATTCGTGATGTGCAAGCCAGCCTTGCTGCTGGAATAAAACCGATTGTAGCGCT
TTATGGTTATCTCGGTACCGGTGATCCACCGGCAACATGGGGAGCATTTGAACTAATTAACCACCCAGGTGATCTATTAC
GGTATATTTAA

Upstream 100 bases:

>100_bases
AATCCAATCACAAAAATCTATGCTCTGGAAGCTGATACCAGTGTCAACTACATCATGACATTCCAAGCCTGATTTAATAC
AAGCACATCAAATATTCCTG

Downstream 100 bases:

>100_bases
TCTGTTACAATTTTCCGGTTGAACTTTCTGAGCCACACCAGCTCTTATACATTAAGAATTCATGTTCGGGGGCGATCCGG
TTTCGACGTGGGTTGCAAAG

Product: phosphoglycolate phosphatase

Products: NA

Alternate protein names: PGP 2; PGPase2 [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MIRKAVLFDFDGTIADTAPDLGRALNRQRIAHDQPPLSIELIRTVASAGARGLLNLGFGLKPDDPGYQVMREEFLSFYTE
QLCQDTRLFPGIPELLEQLDDQAIPWGIVTNKPARFTRPLIHLLGLHHRAACIISGDDTTYTKPHPEPLLTACRQINVAP
DHCIYLGDDIRDVQASLAAGIKPIVALYGYLGTGDPPATWGAFELINHPGDLLRYI

Sequences:

>Translated_216_residues
MIRKAVLFDFDGTIADTAPDLGRALNRQRIAHDQPPLSIELIRTVASAGARGLLNLGFGLKPDDPGYQVMREEFLSFYTE
QLCQDTRLFPGIPELLEQLDDQAIPWGIVTNKPARFTRPLIHLLGLHHRAACIISGDDTTYTKPHPEPLLTACRQINVAP
DHCIYLGDDIRDVQASLAAGIKPIVALYGYLGTGDPPATWGAFELINHPGDLLRYI
>Mature_216_residues
MIRKAVLFDFDGTIADTAPDLGRALNRQRIAHDQPPLSIELIRTVASAGARGLLNLGFGLKPDDPGYQVMREEFLSFYTE
QLCQDTRLFPGIPELLEQLDDQAIPWGIVTNKPARFTRPLIHLLGLHHRAACIISGDDTTYTKPHPEPLLTACRQINVAP
DHCIYLGDDIRDVQASLAAGIKPIVALYGYLGTGDPPATWGAFELINHPGDLLRYI

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1789787, Length=207, Percent_Identity=30.9178743961353, Blast_Score=107, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 23847; Mature: 23847

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKAVLFDFDGTIADTAPDLGRALNRQRIAHDQPPLSIELIRTVASAGARGLLNLGFGL
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHCCCCC
KPDDPGYQVMREEFLSFYTEQLCQDTRLFPGIPELLEQLDDQAIPWGIVTNKPARFTRPL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEECCCCHHHHHHH
IHLLGLHHRAACIISGDDTTYTKPHPEPLLTACRQINVAPDHCIYLGDDIRDVQASLAAG
HHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHC
IKPIVALYGYLGTGDPPATWGAFELINHPGDLLRYI
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MIRKAVLFDFDGTIADTAPDLGRALNRQRIAHDQPPLSIELIRTVASAGARGLLNLGFGL
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHCCCCC
KPDDPGYQVMREEFLSFYTEQLCQDTRLFPGIPELLEQLDDQAIPWGIVTNKPARFTRPL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEECCCCHHHHHHH
IHLLGLHHRAACIISGDDTTYTKPHPEPLLTACRQINVAPDHCIYLGDDIRDVQASLAAG
HHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHC
IKPIVALYGYLGTGDPPATWGAFELINHPGDLLRYI
HHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]