Click here to switch to the map view.

The map label for this gene is lolC [H]

Identifier: 114332442

GI number: 114332442

Start: 2621621

End: 2622868

Strand: Reverse

Name: lolC [H]

Synonym: Neut_2492

Alternate gene names: 114332442

Gene position: 2622868-2621621 (Counterclockwise)

Preceding gene: 114332443

Following gene: 114332441

Centisome position: 98.56

GC content: 48.88

Gene sequence:

>1248_bases
GTGGCCAGCTATGAATTCCTGATCGGCTTACGCTACACACGCGCCAAGCGCCGCAATCATTTTATTTCCTTTATTTCACT
GATCTCATTACTAGGGATGACACTGGGTATGACGGCACTGATCACCGTCATGTCGGTCATGAATGGCTTCCATAAGGAAG
TGCGTGCCCGAATTCTTGGCGTTGCATCACATGCCCAGATTAGTAGCTATGAAGGGAGCCTGTACGATTGGGAAAAAATT
GAGGAAATCGTCACTCGGAATCCGCAGATTGTCGCGGCTGCGCCTTACATTGATGCACAGGGCATGCTTTCCCACGACAA
TATGGTGCACGGGGTAATGGTACGAGGTATTTTGCCGGATGATGAAAACAAAGTTGCTGATTTTGGCGACAAAATGATCA
TGGGCAAACTGGATCAGCTGGTACCAGGAGGGTTCGGTATCGTTATTGGCCGGGAGCTGGCACGCAATCTGAATGTTTTT
CCAGGTGACAAAATCGTGCTGATCTCGCCCCAAGGGCAAATCACACCAGCCGGGATACTCCCACGCCTGAAACAGTTCAC
TGTCATAGGTATTTTTGAAGTCGGACACTTTGAATACGATTCCGGGCTGGCATTGATCCATCTATCAGATGCACAAAAGC
TTTACCGCATGGCACCTAATCAGGTTTCCGGCATCCGGCTCAAACTGCACGATATGTTTGACGCACCACAAGTCATCCGG
GATCTGGCCGAGATATTACCCCCCGATCTCTATTTCACCGACTGGACACAACAACACGCCAACTATTTCCGGGCGATCCA
GATTGAAAAACGTATGCTATCGCTGATTCTTGCGTTAATCATCGCAGTGGCAGCATTCAATATTGTTTCCACGCTGGTGA
TGGCGGTAACTGATAAACAATCGGATATCGCAATCTTGCGTACACTGGGAGCAAGCTCTGGCAGCATCATGAAAATATTC
ATCATCCAGGGTGCACTGATCGGTATTCTGGGAACTTTGCTGGGATTACTGGGGGGGGTGTTACTGGCCTATAATGTGGG
GGACGTTGTTGCATTCATCGAACATATGTCCAACACTCAGTTTTTATCGCAGGAAGTCTATTACATCAGCAAGATTCCTT
CTGATCCACAATTGGCCGATATTGCAACCGTTGCGGTTGTTTCCCTGATTTTGACCCTGCTGGCCACGCTCTATCCCAGC
TACCGGGCATCAAAAGTCAATCCGGCCGAGGCATTGCGCTATGAGTAA

Upstream 100 bases:

>100_bases
TATGCATCAGACATATCTGCCGGGTCAATGACACAAATCTGCTTGAAAGATATGTCATACTCCTTCTTTACTTTACTCTG
TTTCGGAGGAGTGTTTTTTC

Downstream 100 bases:

>100_bases
AATTATCATTGCCTGTCGCAACTTGTATAAAAGTTACTATCAGGGTGATCTTGAAGTACCTGTGCTGCACGGTATCAATC
TACAAGTAAATGAAGGTGAA

Product: lipoprotein releasing system, transmembrane protein, LolC/E family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MASYEFLIGLRYTRAKRRNHFISFISLISLLGMTLGMTALITVMSVMNGFHKEVRARILGVASHAQISSYEGSLYDWEKI
EEIVTRNPQIVAAAPYIDAQGMLSHDNMVHGVMVRGILPDDENKVADFGDKMIMGKLDQLVPGGFGIVIGRELARNLNVF
PGDKIVLISPQGQITPAGILPRLKQFTVIGIFEVGHFEYDSGLALIHLSDAQKLYRMAPNQVSGIRLKLHDMFDAPQVIR
DLAEILPPDLYFTDWTQQHANYFRAIQIEKRMLSLILALIIAVAAFNIVSTLVMAVTDKQSDIAILRTLGASSGSIMKIF
IIQGALIGILGTLLGLLGGVLLAYNVGDVVAFIEHMSNTQFLSQEVYYISKIPSDPQLADIATVAVVSLILTLLATLYPS
YRASKVNPAEALRYE

Sequences:

>Translated_415_residues
MASYEFLIGLRYTRAKRRNHFISFISLISLLGMTLGMTALITVMSVMNGFHKEVRARILGVASHAQISSYEGSLYDWEKI
EEIVTRNPQIVAAAPYIDAQGMLSHDNMVHGVMVRGILPDDENKVADFGDKMIMGKLDQLVPGGFGIVIGRELARNLNVF
PGDKIVLISPQGQITPAGILPRLKQFTVIGIFEVGHFEYDSGLALIHLSDAQKLYRMAPNQVSGIRLKLHDMFDAPQVIR
DLAEILPPDLYFTDWTQQHANYFRAIQIEKRMLSLILALIIAVAAFNIVSTLVMAVTDKQSDIAILRTLGASSGSIMKIF
IIQGALIGILGTLLGLLGGVLLAYNVGDVVAFIEHMSNTQFLSQEVYYISKIPSDPQLADIATVAVVSLILTLLATLYPS
YRASKVNPAEALRYE
>Mature_414_residues
ASYEFLIGLRYTRAKRRNHFISFISLISLLGMTLGMTALITVMSVMNGFHKEVRARILGVASHAQISSYEGSLYDWEKIE
EIVTRNPQIVAAAPYIDAQGMLSHDNMVHGVMVRGILPDDENKVADFGDKMIMGKLDQLVPGGFGIVIGRELARNLNVFP
GDKIVLISPQGQITPAGILPRLKQFTVIGIFEVGHFEYDSGLALIHLSDAQKLYRMAPNQVSGIRLKLHDMFDAPQVIRD
LAEILPPDLYFTDWTQQHANYFRAIQIEKRMLSLILALIIAVAAFNIVSTLVMAVTDKQSDIAILRTLGASSGSIMKIFI
IQGALIGILGTLLGLLGGVLLAYNVGDVVAFIEHMSNTQFLSQEVYYISKIPSDPQLADIATVAVVSLILTLLATLYPSY
RASKVNPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=408, Percent_Identity=36.5196078431373, Blast_Score=244, Evalue=5e-66,
Organism=Escherichia coli, GI1787360, Length=413, Percent_Identity=35.5932203389831, Blast_Score=213, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45706; Mature: 45575

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASYEFLIGLRYTRAKRRNHFISFISLISLLGMTLGMTALITVMSVMNGFHKEVRARILG
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASHAQISSYEGSLYDWEKIEEIVTRNPQIVAAAPYIDAQGMLSHDNMVHGVMVRGILPD
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEHHEEEECCCC
DENKVADFGDKMIMGKLDQLVPGGFGIVIGRELARNLNVFPGDKIVLISPQGQITPAGIL
CCCCHHHHCCHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCCEEEEECCCCCCCCHHHH
PRLKQFTVIGIFEVGHFEYDSGLALIHLSDAQKLYRMAPNQVSGIRLKLHDMFDAPQVIR
HHHHHEEEEEEEEECCEEECCCEEEEEECCHHHHHHCCCCCCCCEEEEEHHHCCCHHHHH
DLAEILPPDLYFTDWTQQHANYFRAIQIEKRMLSLILALIIAVAAFNIVSTLVMAVTDKQ
HHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDIAILRTLGASSGSIMKIFIIQGALIGILGTLLGLLGGVLLAYNVGDVVAFIEHMSNTQ
CCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLSQEVYYISKIPSDPQLADIATVAVVSLILTLLATLYPSYRASKVNPAEALRYE
HHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure 
ASYEFLIGLRYTRAKRRNHFISFISLISLLGMTLGMTALITVMSVMNGFHKEVRARILG
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VASHAQISSYEGSLYDWEKIEEIVTRNPQIVAAAPYIDAQGMLSHDNMVHGVMVRGILPD
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEHHEEEECCCC
DENKVADFGDKMIMGKLDQLVPGGFGIVIGRELARNLNVFPGDKIVLISPQGQITPAGIL
CCCCHHHHCCHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCCEEEEECCCCCCCCHHHH
PRLKQFTVIGIFEVGHFEYDSGLALIHLSDAQKLYRMAPNQVSGIRLKLHDMFDAPQVIR
HHHHHEEEEEEEEECCEEECCCEEEEEECCHHHHHHCCCCCCCCEEEEEHHHCCCHHHHH
DLAEILPPDLYFTDWTQQHANYFRAIQIEKRMLSLILALIIAVAAFNIVSTLVMAVTDKQ
HHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDIAILRTLGASSGSIMKIFIIQGALIGILGTLLGLLGGVLLAYNVGDVVAFIEHMSNTQ
CCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FLSQEVYYISKIPSDPQLADIATVAVVSLILTLLATLYPSYRASKVNPAEALRYE
HHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]