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The map label for this gene is sdhA [H]

Identifier: 114332436

GI number: 114332436

Start: 2613599

End: 2615362

Strand: Direct

Name: sdhA [H]

Synonym: Neut_2486

Alternate gene names: 114332436

Gene position: 2613599-2615362 (Clockwise)

Preceding gene: 114332435

Following gene: 114332437

Centisome position: 98.22

GC content: 51.13

Gene sequence:

>1764_bases
GTGAAAGTTAAACAAAGGAAATTTGATGTGGTCATTGTCGGCGCGGGCGGAGCAGGTATGCGTGCCGCATTGCAGTTGTC
CGAGGCTGGATTCAAGGTTGCGGTTTTATCCAAGGTTTTCCCGACCCGGTCACATACCGTGGCAGCACAAGGGGGGATTG
CTGCAGCATTGGGCAATATAACTGAAGATGACTGGCGGTGGCACATGTATGATACCGTCAAGGGTTCGGATTATCTCGGC
GACCAGGATGCGATTGAATTTATGTGTCGCCACGCTTCCGAAGTTGTATATGAGCTGGAACATTTCGGAATGCCATTTGA
CAGATTGGCGAATGGTAAAATTTATCAACGCCCGTTTGGCGGGCAATCCCTACACTTTGGTGAAGAGCAGGCCAGCCGTT
CCTGTGCAGTTGCTGATCGTACCGGCCATGCCATGCTGCATACTCTGTATCAGCGTAATGTCAGCTCCAACACCCAGTTT
TTCGTGGAATGGTTGGGGCTGGATTTGATCCGCGATCATGAAGGCGAAGTGCTGGGAATCACGGCACTGGAAATGGAAAC
TGGTGAAGTCATGATCTTGCAGGCTCGTGCAACGCTACTGGCCACGGGAGGAGCTTGTCGCATTTTTGAGGCCAGTACCA
ATGCGCTCATTAATACGGGCGATGGCTTGGGAATGGCTGCGCGAGCAGGTATTCCACTGGAAGACATGGAATTCTGGCAG
TTTCACCCAACAGGCGTGTATGGTGCAGGCATGCTGATCAGTGAGGCAGTGCGCGGAGAAGGTGGCTATCTGCTGAATGC
TGAGGGTGAACGTTTTATGGAGCGTTATGCACCCCATGCCAAGGATCTGGCCAGCCGGGATGTTGTATCGCGTGCGCTGG
TTACGGAGATTATGCAAGGCAGAGGGTGCGGCCCGGACGGTGATCACTTGCTGTTAAAGCTGGATCATCTAGGTGCAGAA
ACCATCCAATCCAAACTTCCCGGCATCCGGGAAATCTCGCTCAGATTTGCGCATATCGATCCTATTGAGGCACCCATTCC
GGTTGTCCCGACTGCGCACTACATGATGGGGGGTATTCCCACTAATTATCATGGCCAGGTGGTCGCTCCCTATAAAACCA
GTCCGGAAGAAGCCGTGCCGGGGCTTTATGCGGTCGGCGAATGCGCCTGTGTGTCAGTACATGGTGCAAACCGGCTGGGT
ACGAATTCGCTGCTGGATATTGTCGTGTTTGGACGTGCTGCCGGTAATCAAATTATTGAAGATCTGACCAAAAATAGTCA
TCACAAATCATTGCCACAGGATGTAGCAGAACAAACACTGACAAGGCTTTCACGTCTGGAAACCCAGAAGAATGGAGAAA
GTGTTGCTGCAACGAATGCGGCACTGCGTAAAACCATGCAGACGCATTGTGGTGTCTTCCGCTTTTCTGACGTATTGAAA
GAGGGTGTGGAAAAAATTAACGAAATCGCCGAACGGGTTAAGTACACTGAAATTCAGGACAAAAGCAGGGTGTTCAATAC
CGCCAGAGTGGAAGCGCTTGAGTTGGATAACTTGATTGAAGTAGCTGTAGCTACCATGATTTCAGCGGAAGCACGCCATG
AAAGTCGGGGAGCGCATGCTCGTGATGATTTTCCCGAGCGGGATGACCAGAAATGGCTCAAGCACTCTCTGTTTTTCAGC
AAGGATAAACACCTGGATTATAAACCGGTACGACTAAAGCCGCTGACCGTTGAATCTTTCCCGCCCAAAGCGAGAACCTA
TTGA

Upstream 100 bases:

>100_bases
TATGTTCACCCGATGTTTATTCGTCTGACACTGCAAGTCATGTGTATCGTGGCATTATTGGGCTATCTGATATGGTTCTT
GGATATTTTGTGGGGCTGAC

Downstream 100 bases:

>100_bases
ACAACCATCCTCTGAAAAGCAACCTTGGCTTATTTATCAACAGAACCTATTTCTTTATAAAAAATACCAACATTCAAATG
AAATCAACGGAAAGCATATT

Product: succinate dehydrogenase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MKVKQRKFDVVIVGAGGAGMRAALQLSEAGFKVAVLSKVFPTRSHTVAAQGGIAAALGNITEDDWRWHMYDTVKGSDYLG
DQDAIEFMCRHASEVVYELEHFGMPFDRLANGKIYQRPFGGQSLHFGEEQASRSCAVADRTGHAMLHTLYQRNVSSNTQF
FVEWLGLDLIRDHEGEVLGITALEMETGEVMILQARATLLATGGACRIFEASTNALINTGDGLGMAARAGIPLEDMEFWQ
FHPTGVYGAGMLISEAVRGEGGYLLNAEGERFMERYAPHAKDLASRDVVSRALVTEIMQGRGCGPDGDHLLLKLDHLGAE
TIQSKLPGIREISLRFAHIDPIEAPIPVVPTAHYMMGGIPTNYHGQVVAPYKTSPEEAVPGLYAVGECACVSVHGANRLG
TNSLLDIVVFGRAAGNQIIEDLTKNSHHKSLPQDVAEQTLTRLSRLETQKNGESVAATNAALRKTMQTHCGVFRFSDVLK
EGVEKINEIAERVKYTEIQDKSRVFNTARVEALELDNLIEVAVATMISAEARHESRGAHARDDFPERDDQKWLKHSLFFS
KDKHLDYKPVRLKPLTVESFPPKARTY

Sequences:

>Translated_587_residues
MKVKQRKFDVVIVGAGGAGMRAALQLSEAGFKVAVLSKVFPTRSHTVAAQGGIAAALGNITEDDWRWHMYDTVKGSDYLG
DQDAIEFMCRHASEVVYELEHFGMPFDRLANGKIYQRPFGGQSLHFGEEQASRSCAVADRTGHAMLHTLYQRNVSSNTQF
FVEWLGLDLIRDHEGEVLGITALEMETGEVMILQARATLLATGGACRIFEASTNALINTGDGLGMAARAGIPLEDMEFWQ
FHPTGVYGAGMLISEAVRGEGGYLLNAEGERFMERYAPHAKDLASRDVVSRALVTEIMQGRGCGPDGDHLLLKLDHLGAE
TIQSKLPGIREISLRFAHIDPIEAPIPVVPTAHYMMGGIPTNYHGQVVAPYKTSPEEAVPGLYAVGECACVSVHGANRLG
TNSLLDIVVFGRAAGNQIIEDLTKNSHHKSLPQDVAEQTLTRLSRLETQKNGESVAATNAALRKTMQTHCGVFRFSDVLK
EGVEKINEIAERVKYTEIQDKSRVFNTARVEALELDNLIEVAVATMISAEARHESRGAHARDDFPERDDQKWLKHSLFFS
KDKHLDYKPVRLKPLTVESFPPKARTY
>Mature_587_residues
MKVKQRKFDVVIVGAGGAGMRAALQLSEAGFKVAVLSKVFPTRSHTVAAQGGIAAALGNITEDDWRWHMYDTVKGSDYLG
DQDAIEFMCRHASEVVYELEHFGMPFDRLANGKIYQRPFGGQSLHFGEEQASRSCAVADRTGHAMLHTLYQRNVSSNTQF
FVEWLGLDLIRDHEGEVLGITALEMETGEVMILQARATLLATGGACRIFEASTNALINTGDGLGMAARAGIPLEDMEFWQ
FHPTGVYGAGMLISEAVRGEGGYLLNAEGERFMERYAPHAKDLASRDVVSRALVTEIMQGRGCGPDGDHLLLKLDHLGAE
TIQSKLPGIREISLRFAHIDPIEAPIPVVPTAHYMMGGIPTNYHGQVVAPYKTSPEEAVPGLYAVGECACVSVHGANRLG
TNSLLDIVVFGRAAGNQIIEDLTKNSHHKSLPQDVAEQTLTRLSRLETQKNGESVAATNAALRKTMQTHCGVFRFSDVLK
EGVEKINEIAERVKYTEIQDKSRVFNTARVEALELDNLIEVAVATMISAEARHESRGAHARDDFPERDDQKWLKHSLFFS
KDKHLDYKPVRLKPLTVESFPPKARTY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=51.1073253833049, Blast_Score=590, Evalue=1e-168,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=59.5238095238095, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=39.8260869565217, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=32.9749103942652, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=587, Percent_Identity=51.9591141396934, Blast_Score=613, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17505833, Length=588, Percent_Identity=52.0408163265306, Blast_Score=594, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI71986328, Length=485, Percent_Identity=24.7422680412371, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=52.7824620573356, Blast_Score=609, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6322701, Length=590, Percent_Identity=51.6949152542373, Blast_Score=608, Evalue=1e-175,
Organism=Drosophila melanogaster, GI17137288, Length=604, Percent_Identity=52.4834437086093, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24655642, Length=604, Percent_Identity=52.4834437086093, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24655647, Length=604, Percent_Identity=52.4834437086093, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24663005, Length=607, Percent_Identity=47.2817133443163, Blast_Score=550, Evalue=1e-156,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64611; Mature: 64611

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKQRKFDVVIVGAGGAGMRAALQLSEAGFKVAVLSKVFPTRSHTVAAQGGIAAALGNI
CCCCCEECCEEEEECCCCCHHHHHHHHCCCCEEEEHHHHCCCCCCEEEECCCHHHHHCCC
TEDDWRWHMYDTVKGSDYLGDQDAIEFMCRHASEVVYELEHFGMPFDRLANGKIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCCC
GQSLHFGEEQASRSCAVADRTGHAMLHTLYQRNVSSNTQFFVEWLGLDLIRDHEGEVLGI
CCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCEEEE
TALEMETGEVMILQARATLLATGGACRIFEASTNALINTGDGLGMAARAGIPLEDMEFWQ
EEEEECCCCEEEEEECEEEEECCCCEEEEECCCCCEEECCCCCCCHHHCCCCCCCCHHEE
FHPTGVYGAGMLISEAVRGEGGYLLNAEGERFMERYAPHAKDLASRDVVSRALVTEIMQG
ECCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGCGPDGDHLLLKLDHLGAETIQSKLPGIREISLRFAHIDPIEAPIPVVPTAHYMMGGIP
CCCCCCCCEEEEEEECCCHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHCCCC
TNYHGQVVAPYKTSPEEAVPGLYAVGECACVSVHGANRLGTNSLLDIVVFGRAAGNQIIE
CCCCCEEEECCCCCHHHHCCCCEECCCEEEEEECCCCCCCCHHHEEEEEECCHHHHHHHH
DLTKNSHHKSLPQDVAEQTLTRLSRLETQKNGESVAATNAALRKTMQTHCGVFRFSDVLK
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
EGVEKINEIAERVKYTEIQDKSRVFNTARVEALELDNLIEVAVATMISAEARHESRGAHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RDDFPERDDQKWLKHSLFFSKDKHLDYKPVRLKPLTVESFPPKARTY
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MKVKQRKFDVVIVGAGGAGMRAALQLSEAGFKVAVLSKVFPTRSHTVAAQGGIAAALGNI
CCCCCEECCEEEEECCCCCHHHHHHHHCCCCEEEEHHHHCCCCCCEEEECCCHHHHHCCC
TEDDWRWHMYDTVKGSDYLGDQDAIEFMCRHASEVVYELEHFGMPFDRLANGKIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCCC
GQSLHFGEEQASRSCAVADRTGHAMLHTLYQRNVSSNTQFFVEWLGLDLIRDHEGEVLGI
CCCCCCCHHHHCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCEEEE
TALEMETGEVMILQARATLLATGGACRIFEASTNALINTGDGLGMAARAGIPLEDMEFWQ
EEEEECCCCEEEEEECEEEEECCCCEEEEECCCCCEEECCCCCCCHHHCCCCCCCCHHEE
FHPTGVYGAGMLISEAVRGEGGYLLNAEGERFMERYAPHAKDLASRDVVSRALVTEIMQG
ECCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGCGPDGDHLLLKLDHLGAETIQSKLPGIREISLRFAHIDPIEAPIPVVPTAHYMMGGIP
CCCCCCCCEEEEEEECCCHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHCCCC
TNYHGQVVAPYKTSPEEAVPGLYAVGECACVSVHGANRLGTNSLLDIVVFGRAAGNQIIE
CCCCCEEEECCCCCHHHHCCCCEECCCEEEEEECCCCCCCCHHHEEEEEECCHHHHHHHH
DLTKNSHHKSLPQDVAEQTLTRLSRLETQKNGESVAATNAALRKTMQTHCGVFRFSDVLK
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHH
EGVEKINEIAERVKYTEIQDKSRVFNTARVEALELDNLIEVAVATMISAEARHESRGAHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RDDFPERDDQKWLKHSLFFSKDKHLDYKPVRLKPLTVESFPPKARTY
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]