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The map label for this gene is trxA [H]

Identifier: 114332429

GI number: 114332429

Start: 2606450

End: 2606776

Strand: Direct

Name: trxA [H]

Synonym: Neut_2478

Alternate gene names: 114332429

Gene position: 2606450-2606776 (Clockwise)

Preceding gene: 114332427

Following gene: 114332430

Centisome position: 97.95

GC content: 41.59

Gene sequence:

>327_bases
ATGAGCCAACACATCCATTATGTTACAGATGCAACTTTTGAGGCAGAGGTATTGCAATGTCCCCTCCCGGTACTTGTCGA
TTATTGGGCTGAATGGTGTGGACCATGCAGAATGATTGCACCCATTCTGGATGAAATTGCAAATGAATATAATGGTCGCC
TTAAAGTAGCTAAACTTAATATTGATGAAAATCAATCAACTCCACAGAAATACGGTATTCGTGGAATTCCGACCTTGATG
CTGTTCAAGAACGGGAATATTGAGGCCACAAAGGTTGGGGCCTTATCAAAATCGCAGTTGATAGCGTTTGTTGATGACCA
TCTGTAA

Upstream 100 bases:

>100_bases
TAGGACACTATCATTTGAATTCAGTTAATTGGTCAGTTGCAACAGACTGCAACTGCCGTCAGCGTTCACTTTGATCCAGC
AAACTTTAAAAGAGGATTTC

Downstream 100 bases:

>100_bases
AACCAGATTTTAAGTACTGATACAGGCCGAGTGAGTTACGTGCAATTTTACATTCGGCTGACTCTATTTCATTAGAGCTT
GAGCGGTCTTTACAAATCGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSQHIHYVTDATFEAEVLQCPLPVLVDYWAEWCGPCRMIAPILDEIANEYNGRLKVAKLNIDENQSTPQKYGIRGIPTLM
LFKNGNIEATKVGALSKSQLIAFVDDHL

Sequences:

>Translated_108_residues
MSQHIHYVTDATFEAEVLQCPLPVLVDYWAEWCGPCRMIAPILDEIANEYNGRLKVAKLNIDENQSTPQKYGIRGIPTLM
LFKNGNIEATKVGALSKSQLIAFVDDHL
>Mature_107_residues
SQHIHYVTDATFEAEVLQCPLPVLVDYWAEWCGPCRMIAPILDEIANEYNGRLKVAKLNIDENQSTPQKYGIRGIPTLML
FKNGNIEATKVGALSKSQLIAFVDDHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=33.695652173913, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=29.2929292929293, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=65.7407407407407, Blast_Score=154, Evalue=1e-39,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=38.8349514563107, Blast_Score=92, Evalue=8e-21,
Organism=Escherichia coli, GI87081747, Length=64, Percent_Identity=42.1875, Blast_Score=65, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=40.625, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=45.0704225352113, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=102, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=63, Percent_Identity=39.6825396825397, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=107, Percent_Identity=34.5794392523364, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=61, Percent_Identity=40.9836065573771, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=40.4494382022472, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=69, Percent_Identity=42.0289855072464, Blast_Score=67, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=43.8356164383562, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=35.2941176470588, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=40.5405405405405, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17648013, Length=62, Percent_Identity=38.7096774193548, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24583090, Length=62, Percent_Identity=38.7096774193548, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12132; Mature: 12001

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHIHYVTDATFEAEVLQCPLPVLVDYWAEWCGPCRMIAPILDEIANEYNGRLKVAKLN
CCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEE
IDENQSTPQKYGIRGIPTLMLFKNGNIEATKVGALSKSQLIAFVDDHL
CCCCCCCHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEECCCC
>Mature Secondary Structure 
SQHIHYVTDATFEAEVLQCPLPVLVDYWAEWCGPCRMIAPILDEIANEYNGRLKVAKLN
CCCEEEEECCCCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEE
IDENQSTPQKYGIRGIPTLMLFKNGNIEATKVGALSKSQLIAFVDDHL
CCCCCCCHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]