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The map label for this gene is ctaB

Identifier: 114332346

GI number: 114332346

Start: 2503392

End: 2504288

Strand: Reverse

Name: ctaB

Synonym: Neut_2389

Alternate gene names: 114332346

Gene position: 2504288-2503392 (Counterclockwise)

Preceding gene: 114332347

Following gene: 114332343

Centisome position: 94.11

GC content: 45.26

Gene sequence:

>897_bases
ATGTCAACAAATCCATTAGTCTGGCAACAGGCGACTGTGCGTATTCAGCAGTTTTACCGACTTACTAAACCACGAGTAGT
TTCTCTAATCGTTTTCACTGCTGTGATTGGTATGTTTTTATCGGTCCCTGGTGCGGTGCCCCTAGACAAGTTGCTCCTGG
GTACGATTGGAATATCACTTGTTGCCGGCGCAGCCGCCGCGCTTAATTGCCTGGTTGAGTATAAGTTTGATGCAATCATG
GCTCGAACAAAGGGACGACCCTTACCCCAGGGAAAAGTAAGTGTTCCTGAAACGCTGTTCTTTCTGGTAATGGTTGGCGG
GCTTGGGCTCTTCATTCTCCACCAATGGATAAACCCTTTGACCATGTGGCTAACTCTCGGCACATTTGTAGGGTATGCAA
TTATATACACTGTAATACTCAAACCACTCACACCACAAAATATCGTCATTGGGGGTGCGTCTGGCGCTATGCCACCTGTA
TTGGGGTGGGCAGCAATTACAGGGGAAATCTCAGCTGATGCCTTGTTATTGTTCCTCATTATTTTTGCCTGGACACCTCC
ACATTTCTGGGCACTGGCGCTTTACCGTAAGTCAGATTATGCAAAAATTGGGATGCCAATGCTCCCGGTAACACACGGTG
AGGAGTTTACTCGCCTGCATGTACTACTTTATACAATCATTCTTTGTATCGCTACAGTTTTGCCCTATCTCACTCAGATG
AGTGGCTTGATTTATCTCGTAAGTGTGCTGATTCTTGATGCAATATTTCTTTATTACGCTATCAGGATCTACTTGCACTA
CACTGACCAAATTGCCAGGGAGGCTTTCCGCTACTCTATAATTTATCTGGCGTTACTGTTTACTGCGCTATTGGTGGATC
ACTATTTTTATTTCTGA

Upstream 100 bases:

>100_bases
CGAGTATTAGCTGAAGATTCCCAGATAGCATATTAGCGAAAGAAAGCAAACAGGTGCCATAACATCTGTAACTATGAATT
AGTTTCATAAGGAGTGAGTG

Downstream 100 bases:

>100_bases
TACCAGAAAAAAACGAATTCTCTAAAAAAAACAGCCCGATAAGGATGTAATTTTTATCGGGCTGTTTTTTTTGTTTATCT
GGCTGAAAAACATTCAGGGA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSTNPLVWQQATVRIQQFYRLTKPRVVSLIVFTAVIGMFLSVPGAVPLDKLLLGTIGISLVAGAAAALNCLVEYKFDAIM
ARTKGRPLPQGKVSVPETLFFLVMVGGLGLFILHQWINPLTMWLTLGTFVGYAIIYTVILKPLTPQNIVIGGASGAMPPV
LGWAAITGEISADALLLFLIIFAWTPPHFWALALYRKSDYAKIGMPMLPVTHGEEFTRLHVLLYTIILCIATVLPYLTQM
SGLIYLVSVLILDAIFLYYAIRIYLHYTDQIAREAFRYSIIYLALLFTALLVDHYFYF

Sequences:

>Translated_298_residues
MSTNPLVWQQATVRIQQFYRLTKPRVVSLIVFTAVIGMFLSVPGAVPLDKLLLGTIGISLVAGAAAALNCLVEYKFDAIM
ARTKGRPLPQGKVSVPETLFFLVMVGGLGLFILHQWINPLTMWLTLGTFVGYAIIYTVILKPLTPQNIVIGGASGAMPPV
LGWAAITGEISADALLLFLIIFAWTPPHFWALALYRKSDYAKIGMPMLPVTHGEEFTRLHVLLYTIILCIATVLPYLTQM
SGLIYLVSVLILDAIFLYYAIRIYLHYTDQIAREAFRYSIIYLALLFTALLVDHYFYF
>Mature_297_residues
STNPLVWQQATVRIQQFYRLTKPRVVSLIVFTAVIGMFLSVPGAVPLDKLLLGTIGISLVAGAAAALNCLVEYKFDAIMA
RTKGRPLPQGKVSVPETLFFLVMVGGLGLFILHQWINPLTMWLTLGTFVGYAIIYTVILKPLTPQNIVIGGASGAMPPVL
GWAAITGEISADALLLFLIIFAWTPPHFWALALYRKSDYAKIGMPMLPVTHGEEFTRLHVLLYTIILCIATVLPYLTQMS
GLIYLVSVLILDAIFLYYAIRIYLHYTDQIAREAFRYSIIYLALLFTALLVDHYFYF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=257, Percent_Identity=33.0739299610895, Blast_Score=118, Evalue=5e-27,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=32.258064516129, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71998235, Length=297, Percent_Identity=28.956228956229, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325085, Length=273, Percent_Identity=27.4725274725275, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921064, Length=285, Percent_Identity=30.8771929824561, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_NITEC (Q0ADH9)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748568.1
- STRING:   Q0ADH9
- GeneID:   4272521
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2389
- NMPDR:   fig|335283.3.peg.679
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- PhylomeDB:   Q0ADH9
- ProtClustDB:   PRK04375
- BioCyc:   NEUT335283:NEUT_2389-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33241; Mature: 33110

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x15467610)-; HASH(0x16ba6ee4)-; HASH(0x1612d194)-; HASH(0x16c83104)-; HASH(0x156acb34)-; HASH(0x16bfc8a8)-; HASH(0x15fb3c64)-; HASH(0x15bfd684)-; HASH(0x16149600)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
STNPLVWQQATVRIQQFYRLTKPRVVSLIVFTAVIGMFLSVPGAVPLDKLLLGTIGISL
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VAGAAAALNCLVEYKFDAIMARTKGRPLPQGKVSVPETLFFLVMVGGLGLFILHQWINPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TMWLTLGTFVGYAIIYTVILKPLTPQNIVIGGASGAMPPVLGWAAITGEISADALLLFLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHH
IFAWTPPHFWALALYRKSDYAKIGMPMLPVTHGEEFTRLHVLLYTIILCIATVLPYLTQM
HHHCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLIYLVSVLILDAIFLYYAIRIYLHYTDQIAREAFRYSIIYLALLFTALLVDHYFYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA