Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 114332291

GI number: 114332291

Start: 2455965

End: 2457872

Strand: Reverse

Name: thrS

Synonym: Neut_2331

Alternate gene names: 114332291

Gene position: 2457872-2455965 (Counterclockwise)

Preceding gene: 114332292

Following gene: 114332290

Centisome position: 92.36

GC content: 43.5

Gene sequence:

>1908_bases
GTGACAGTTGTTCGTTTGCCGGATGGCACAGACAAAGTGTTCGATTATCCCGTGACGGTGCTTGATGTTGCTGAGTCAAT
TGGCCCCGGGCTTGCGCGTGTAGCATTGGCAGGTAAGTTGAATGGGAGGCTAGTAGATTTATCGGAGCCGATAGAGATTG
ATAGTGATCTGGTGCTGATAACAAACAAGGATCCTGAAGGTCTGGAAATCATTCGTCACTCTTGTGCACACTTATTAGCA
CACGCAGTAAAGGAATTATTTCCAAGTGCGCAAGTTACCATCGGGCCGGTTATAGAGGATGGGTTTTATTATGATTTTTC
TTATGAACGGCCTTTTACACCAGAAGATCTGGCAGCCATAGAGAAGAGAATGCAAGAAATCAGCAGGAGAAATCTGAAGA
TAGAGCGCAAGGTGTGGGATCGTTCAAAAGCAATTGGCTTTTTTAAGGATCTAGGCGAGCACTATAAGGCTCAGATAATT
GCATCTATTCCGAATGATGAGCCTGTTTCACTTTATTCTCAGGGTGATTTCACAGATTTATGTCGCGGGCCGCACGTGCC
GTATACATCAAGAATCAAAGTCTTTAAGTTGATGAAAATAGCAGGTGCTTATTGGCGTGGAGACTCAAAAAATGAAATGC
TGCAAAGAATATATGGAACAGCGTGGGTAAGCAGCGAAGAGCAAAATAATTATCTTCGGCGCCTGGAAGAAGCAGAAAAA
CGAGATCATCGTAAACTTGGTAAACAGCTTGATCTGTTCCACATGCAGGAAGAAGCTCCGGGAATGGTGTATTGGCATCC
CAAAGGGTGGGCTATATGGCAGCAAATAGAGCAATATATGCGGCAGGTGCTGGCCAAGAATGGTTACGTCGAGATTCGTA
CTCCTCAGGTTCTGGACATATCGTTATGGGAAAAATCCGGACATTGGGAAAATTTCCGAGAAAATATGTTTATTACGGAA
TCTGAGAGTAGGCATTACGCTATTAAACCCATGAATTGTCCGGGGCATGTTCAGGTATTTAATCACGGGTTAAGGAGCTA
TCGTGATTTGCCGCTTCGACTGGCAGAGTTTGGTTCATGTCATCGAAATGAGGCGTCTGGTGCTTTACATGGGCTTATGC
GCGTTCGTTCATTTACGCAGGATGATGCTCATATTTTTTGCACGGAAGACCAGGTTCTGGAAGAAGTAACTAAATTCATT
GATCTGTTAAATCAGGTGTATATAGATTTTGGATTCCATGAAAACTTGATAAAACTTTCAACCCGCCCAGCCCAGAGAGT
TGGAACCGAAGAACAATGGGACAGAGCTGAGGCCGCCTTGGCTGCAGCTCTAAATCAAAAGGAACTAAACTGGGAGCTGC
AACCGGGTGAAGGGGCTTTCTATGGCCCCAAAATAGAATTTACATTGAAAGATAGCCTTGGACGTAAGTGGCAATGTGGA
ACTTTGCAGCTTGACTTCTCTATGCCAGCGAGATTAGGCGCAGGGTATATCGCAGAAGATAATACGAAAAAGATCCCAGT
AATGCTGCATAGAGCTATTTTAGGATCTATGGAGCGTTTTATCGGAATTCTTATTGAGCATCATGCGGGCGCTTTGCCGG
TATGGCTTTCTCCTGATCAAGTGGTTGTACTTAATATTTCTAGAAATCAAGCTGATTATGTTCAGTCAATCACAAATGAA
CTCAAACAAAATGATATTCGCGTCAGCTCGGACTTGAGAAATGAGAAAATAAGCTATAAAATCAGAGAACATAGCTTGCA
GAAAGTGCCTTATTTAATAGTGGTTGGCGATAAGGAAGTCGAAAATCAGACTGTTACTGTGAGAGGACGATCAAACCATG
ATCATGGGGCGATGTCTCTTGAAGGTTTTGTTACCTTAATTCGGAAAGAGATGGCCGAAAGAGTGTAA

Upstream 100 bases:

>100_bases
GTATTTGCTGATTAAATGGGTAAACCACAAAAATTTATTACCTTGAATTCGCGAATGGCTAGCTTAATATATATATTTGT
TCAAGTGATGAGGTAAATAA

Downstream 100 bases:

>100_bases
TTAAGGGGTTTTTATGGATTTACGGAGGGTACCATAGCTCAAGAAAAGACTGTAAGGGTTAATGATGAAATCACGGCACT
ACAAGTCAGATTGATTGGCG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MTVVRLPDGTDKVFDYPVTVLDVAESIGPGLARVALAGKLNGRLVDLSEPIEIDSDLVLITNKDPEGLEIIRHSCAHLLA
HAVKELFPSAQVTIGPVIEDGFYYDFSYERPFTPEDLAAIEKRMQEISRRNLKIERKVWDRSKAIGFFKDLGEHYKAQII
ASIPNDEPVSLYSQGDFTDLCRGPHVPYTSRIKVFKLMKIAGAYWRGDSKNEMLQRIYGTAWVSSEEQNNYLRRLEEAEK
RDHRKLGKQLDLFHMQEEAPGMVYWHPKGWAIWQQIEQYMRQVLAKNGYVEIRTPQVLDISLWEKSGHWENFRENMFITE
SESRHYAIKPMNCPGHVQVFNHGLRSYRDLPLRLAEFGSCHRNEASGALHGLMRVRSFTQDDAHIFCTEDQVLEEVTKFI
DLLNQVYIDFGFHENLIKLSTRPAQRVGTEEQWDRAEAALAAALNQKELNWELQPGEGAFYGPKIEFTLKDSLGRKWQCG
TLQLDFSMPARLGAGYIAEDNTKKIPVMLHRAILGSMERFIGILIEHHAGALPVWLSPDQVVVLNISRNQADYVQSITNE
LKQNDIRVSSDLRNEKISYKIREHSLQKVPYLIVVGDKEVENQTVTVRGRSNHDHGAMSLEGFVTLIRKEMAERV

Sequences:

>Translated_635_residues
MTVVRLPDGTDKVFDYPVTVLDVAESIGPGLARVALAGKLNGRLVDLSEPIEIDSDLVLITNKDPEGLEIIRHSCAHLLA
HAVKELFPSAQVTIGPVIEDGFYYDFSYERPFTPEDLAAIEKRMQEISRRNLKIERKVWDRSKAIGFFKDLGEHYKAQII
ASIPNDEPVSLYSQGDFTDLCRGPHVPYTSRIKVFKLMKIAGAYWRGDSKNEMLQRIYGTAWVSSEEQNNYLRRLEEAEK
RDHRKLGKQLDLFHMQEEAPGMVYWHPKGWAIWQQIEQYMRQVLAKNGYVEIRTPQVLDISLWEKSGHWENFRENMFITE
SESRHYAIKPMNCPGHVQVFNHGLRSYRDLPLRLAEFGSCHRNEASGALHGLMRVRSFTQDDAHIFCTEDQVLEEVTKFI
DLLNQVYIDFGFHENLIKLSTRPAQRVGTEEQWDRAEAALAAALNQKELNWELQPGEGAFYGPKIEFTLKDSLGRKWQCG
TLQLDFSMPARLGAGYIAEDNTKKIPVMLHRAILGSMERFIGILIEHHAGALPVWLSPDQVVVLNISRNQADYVQSITNE
LKQNDIRVSSDLRNEKISYKIREHSLQKVPYLIVVGDKEVENQTVTVRGRSNHDHGAMSLEGFVTLIRKEMAERV
>Mature_634_residues
TVVRLPDGTDKVFDYPVTVLDVAESIGPGLARVALAGKLNGRLVDLSEPIEIDSDLVLITNKDPEGLEIIRHSCAHLLAH
AVKELFPSAQVTIGPVIEDGFYYDFSYERPFTPEDLAAIEKRMQEISRRNLKIERKVWDRSKAIGFFKDLGEHYKAQIIA
SIPNDEPVSLYSQGDFTDLCRGPHVPYTSRIKVFKLMKIAGAYWRGDSKNEMLQRIYGTAWVSSEEQNNYLRRLEEAEKR
DHRKLGKQLDLFHMQEEAPGMVYWHPKGWAIWQQIEQYMRQVLAKNGYVEIRTPQVLDISLWEKSGHWENFRENMFITES
ESRHYAIKPMNCPGHVQVFNHGLRSYRDLPLRLAEFGSCHRNEASGALHGLMRVRSFTQDDAHIFCTEDQVLEEVTKFID
LLNQVYIDFGFHENLIKLSTRPAQRVGTEEQWDRAEAALAAALNQKELNWELQPGEGAFYGPKIEFTLKDSLGRKWQCGT
LQLDFSMPARLGAGYIAEDNTKKIPVMLHRAILGSMERFIGILIEHHAGALPVWLSPDQVVVLNISRNQADYVQSITNEL
KQNDIRVSSDLRNEKISYKIREHSLQKVPYLIVVGDKEVENQTVTVRGRSNHDHGAMSLEGFVTLIRKEMAERV

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=622, Percent_Identity=39.871382636656, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI38202255, Length=621, Percent_Identity=39.9355877616747, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI20070344, Length=641, Percent_Identity=38.3775351014041, Blast_Score=424, Evalue=1e-118,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=57.4803149606299, Blast_Score=789, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=140, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789048, Length=136, Percent_Identity=31.6176470588235, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984192, Length=638, Percent_Identity=39.0282131661442, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71984184, Length=638, Percent_Identity=39.0282131661442, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322112, Length=627, Percent_Identity=39.2344497607655, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=39.2947103274559, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24583839, Length=629, Percent_Identity=40.3815580286169, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24583842, Length=629, Percent_Identity=40.3815580286169, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI28574141, Length=629, Percent_Identity=40.3815580286169, Blast_Score=495, Evalue=1e-140,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_NITEC (Q0ADN4)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748513.1
- ProteinModelPortal:   Q0ADN4
- SMR:   Q0ADN4
- STRING:   Q0ADN4
- GeneID:   4272755
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2331
- NMPDR:   fig|335283.3.peg.81
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- PhylomeDB:   Q0ADN4
- ProtClustDB:   PRK00413
- BioCyc:   NEUT335283:NEUT_2331-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72785; Mature: 72654

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVRLPDGTDKVFDYPVTVLDVAESIGPGLARVALAGKLNGRLVDLSEPIEIDSDLVLI
CEEEECCCCCCCCEECCHHHHHHHHHHCCCHHHHHHEECCCCEEEECCCCCCCCCCEEEE
TNKDPEGLEIIRHSCAHLLAHAVKELFPSAQVTIGPVIEDGFYYDFSYERPFTPEDLAAI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEECCCCCCCHHHHHHH
EKRMQEISRRNLKIERKVWDRSKAIGFFKDLGEHYKAQIIASIPNDEPVSLYSQGDFTDL
HHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEECCCCHHHH
CRGPHVPYTSRIKVFKLMKIAGAYWRGDSKNEMLQRIYGTAWVSSEEQNNYLRRLEEAEK
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RDHRKLGKQLDLFHMQEEAPGMVYWHPKGWAIWQQIEQYMRQVLAKNGYVEIRTPQVLDI
HHHHHHCCHHCCEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEE
SLWEKSGHWENFRENMFITESESRHYAIKPMNCPGHVQVFNHGLRSYRDLPLRLAEFGSC
EEECCCCCCHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
HRNEASGALHGLMRVRSFTQDDAHIFCTEDQVLEEVTKFIDLLNQVYIDFGFHENLIKLS
CCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
TRPAQRVGTEEQWDRAEAALAAALNQKELNWELQPGEGAFYGPKIEFTLKDSLGRKWQCG
CCCHHHCCCHHHHHHHHHHHHHHHCHHHCCEEEECCCCCEECCEEEEEECCCCCCEEECC
TLQLDFSMPARLGAGYIAEDNTKKIPVMLHRAILGSMERFIGILIEHHAGALPVWLSPDQ
EEEECCCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
VVVLNISRNQADYVQSITNELKQNDIRVSSDLRNEKISYKIREHSLQKVPYLIVVGDKEV
EEEEEECCCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEHHHHHHHCCEEEEECCCCC
ENQTVTVRGRSNHDHGAMSLEGFVTLIRKEMAERV
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVVRLPDGTDKVFDYPVTVLDVAESIGPGLARVALAGKLNGRLVDLSEPIEIDSDLVLI
EEEECCCCCCCCEECCHHHHHHHHHHCCCHHHHHHEECCCCEEEECCCCCCCCCCEEEE
TNKDPEGLEIIRHSCAHLLAHAVKELFPSAQVTIGPVIEDGFYYDFSYERPFTPEDLAAI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEECCCCCCCHHHHHHH
EKRMQEISRRNLKIERKVWDRSKAIGFFKDLGEHYKAQIIASIPNDEPVSLYSQGDFTDL
HHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEECCCCHHHH
CRGPHVPYTSRIKVFKLMKIAGAYWRGDSKNEMLQRIYGTAWVSSEEQNNYLRRLEEAEK
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RDHRKLGKQLDLFHMQEEAPGMVYWHPKGWAIWQQIEQYMRQVLAKNGYVEIRTPQVLDI
HHHHHHCCHHCCEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEE
SLWEKSGHWENFRENMFITESESRHYAIKPMNCPGHVQVFNHGLRSYRDLPLRLAEFGSC
EEECCCCCCHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCC
HRNEASGALHGLMRVRSFTQDDAHIFCTEDQVLEEVTKFIDLLNQVYIDFGFHENLIKLS
CCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
TRPAQRVGTEEQWDRAEAALAAALNQKELNWELQPGEGAFYGPKIEFTLKDSLGRKWQCG
CCCHHHCCCHHHHHHHHHHHHHHHCHHHCCEEEECCCCCEECCEEEEEECCCCCCEEECC
TLQLDFSMPARLGAGYIAEDNTKKIPVMLHRAILGSMERFIGILIEHHAGALPVWLSPDQ
EEEECCCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
VVVLNISRNQADYVQSITNELKQNDIRVSSDLRNEKISYKIREHSLQKVPYLIVVGDKEV
EEEEEECCCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEHHHHHHHCCEEEEECCCCC
ENQTVTVRGRSNHDHGAMSLEGFVTLIRKEMAERV
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA