Click here to switch to the map view.

The map label for this gene is guaA

Identifier: 114332211

GI number: 114332211

Start: 2376237

End: 2377796

Strand: Direct

Name: guaA

Synonym: Neut_2251

Alternate gene names: 114332211

Gene position: 2376237-2377796 (Clockwise)

Preceding gene: 114332210

Following gene: 114332212

Centisome position: 89.3

GC content: 50.96

Gene sequence:

>1560_bases
ATGCATTCAGCAATTCTTATCCTGGATTTTGGCTCGCAGTACGCTCGTTTAATCGCACGGCGCATCCGGGAAACCAGTGT
TTACTGTGAACTCCACCCCTTTGATGTCAGCCCGCAATTTATTCGGGAATTTTCTCCTGTTGGCATCATTCTCTCCGGCG
GGCCGGCATCCATCTTTACCAATGACGCGCCGCGTGTGCCTCAAATTGTGTTTGAACTGGGTGTCCCTGTTCTCGGCATA
TGTTATGGAATGCAGGCCATGGCAGCTCAGCTCGGAGGAGAGGTGGAAAATGCGCAAACGCGCGAATTTGGCTATGCAGA
ATTGTTAACAGAACCATGCAGGCTGTTCCAGGACATCAAGGATCGCATCAACTCTGATGGCAAACCCGCTCTTGATGTAT
GGATGAGCCACGGTGACCGGGTTAATAAATTACCGCCTGGGTTCACAGCCATTGCCTTCAATGCAGCCACTCCCTTTGCA
GCCATGGCTGACGAAACACGCAGGTTCTACGGTGTCCAGTTCCATCCTGAAGTCACTCACACCCTTCAGGGAAAAGCTAT
CCTCGATCGTTTCGTTCATGATATCTGTGATGCGGGCTATGACTGGAACATGCCGGATTACGTAGAAGAGGCCATTGGCC
GGATACGCGCGCGCGTCGGCGGCGATAAAGTCATCCTGGGATTGTCTGGGGGGGTAGATTCTTCAGTAGCCGCCGCACTA
ATCCACCGCGCCATCGGTGATCAGCTGGTATGCGTATTCGTAGACAACGGCCTGCTCCGCCTGAATGAAGCCAAGCAAAC
CATGGAAACCTTTAGCCGGAATCTTGCGGTCAACGTCATCTACGTTGATGCTAGCAGACAATTCCTGGAGCAATTGAAAG
GAATCACTGATCCGGAACAGAAACGCCGCACCATCGGCCGCGAATTTGTGGAAATCTTTCAGCAGGAAGCCGCAAAAATT
GAAAACGTCAAATGGCTGGCGCAAGGCACCATTTATCCGGATGTCATTGAATCTGCCGGCAGCCACACAAAGAAATCAGG
ATTAATCAAATCCCACCATAACGTTGGTGGTCTACCAGAAACACTTCGCCTCAAATTGCTGGAACCACTGCGTGAACTGT
TCAAGGATGAAGTACGAGAACTTGGCTTGGCACTGGGACTGCCGCGTGACCTAGTATTTCGTCATCCCTTTCCCGGGCCG
GGACTGGGTGTCCGTATTCTTGGAGAAGTTAAATATGAATACACAGAATTATTGCGCCAGGCTGATGCCATCTTTATTGA
AGAGCTGAGAAACGCTGGATGGTATGAAAAAACCTCCCAGGCATTTGCTGTTTTCCTGCCAATAAAATCAGTTGGCGTTA
TGGGAGATAACCGCAGTTATGAGTATGTCATCGCGCTGCGCGCCGTTCAGACTGAAGATTTCATGACGGCACAATGGGCT
GAACTGCCTTACACCCTGCTGGCCAGAATCTCCAACCGCATCATCAACGAAATTCGTGGCATCAACCGTGTGGTTTACGA
TATCTCAGGCAAACCCCCCGCGACCATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
TATCGAAATCACGTCTGCCGGAATCCGGGAATCTCATGTGCATGACGTTCAGATCACCAAAGAAGCCCCCAATTATCACG
TTGAATAACCCTTTACTGAT

Downstream 100 bases:

>100_bases
TTCCGCGTCTGGCACAGCCAGGCACCTGATGGCATGAAATGCCGCTAAGCCCGCGTAATTGCGGGCTTTTTTTTGTTTGT
GTTTGGCACGATCTGGCAAC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MHSAILILDFGSQYARLIARRIRETSVYCELHPFDVSPQFIREFSPVGIILSGGPASIFTNDAPRVPQIVFELGVPVLGI
CYGMQAMAAQLGGEVENAQTREFGYAELLTEPCRLFQDIKDRINSDGKPALDVWMSHGDRVNKLPPGFTAIAFNAATPFA
AMADETRRFYGVQFHPEVTHTLQGKAILDRFVHDICDAGYDWNMPDYVEEAIGRIRARVGGDKVILGLSGGVDSSVAAAL
IHRAIGDQLVCVFVDNGLLRLNEAKQTMETFSRNLAVNVIYVDASRQFLEQLKGITDPEQKRRTIGREFVEIFQQEAAKI
ENVKWLAQGTIYPDVIESAGSHTKKSGLIKSHHNVGGLPETLRLKLLEPLRELFKDEVRELGLALGLPRDLVFRHPFPGP
GLGVRILGEVKYEYTELLRQADAIFIEELRNAGWYEKTSQAFAVFLPIKSVGVMGDNRSYEYVIALRAVQTEDFMTAQWA
ELPYTLLARISNRIINEIRGINRVVYDISGKPPATIEWE

Sequences:

>Translated_519_residues
MHSAILILDFGSQYARLIARRIRETSVYCELHPFDVSPQFIREFSPVGIILSGGPASIFTNDAPRVPQIVFELGVPVLGI
CYGMQAMAAQLGGEVENAQTREFGYAELLTEPCRLFQDIKDRINSDGKPALDVWMSHGDRVNKLPPGFTAIAFNAATPFA
AMADETRRFYGVQFHPEVTHTLQGKAILDRFVHDICDAGYDWNMPDYVEEAIGRIRARVGGDKVILGLSGGVDSSVAAAL
IHRAIGDQLVCVFVDNGLLRLNEAKQTMETFSRNLAVNVIYVDASRQFLEQLKGITDPEQKRRTIGREFVEIFQQEAAKI
ENVKWLAQGTIYPDVIESAGSHTKKSGLIKSHHNVGGLPETLRLKLLEPLRELFKDEVRELGLALGLPRDLVFRHPFPGP
GLGVRILGEVKYEYTELLRQADAIFIEELRNAGWYEKTSQAFAVFLPIKSVGVMGDNRSYEYVIALRAVQTEDFMTAQWA
ELPYTLLARISNRIINEIRGINRVVYDISGKPPATIEWE
>Mature_519_residues
MHSAILILDFGSQYARLIARRIRETSVYCELHPFDVSPQFIREFSPVGIILSGGPASIFTNDAPRVPQIVFELGVPVLGI
CYGMQAMAAQLGGEVENAQTREFGYAELLTEPCRLFQDIKDRINSDGKPALDVWMSHGDRVNKLPPGFTAIAFNAATPFA
AMADETRRFYGVQFHPEVTHTLQGKAILDRFVHDICDAGYDWNMPDYVEEAIGRIRARVGGDKVILGLSGGVDSSVAAAL
IHRAIGDQLVCVFVDNGLLRLNEAKQTMETFSRNLAVNVIYVDASRQFLEQLKGITDPEQKRRTIGREFVEIFQQEAAKI
ENVKWLAQGTIYPDVIESAGSHTKKSGLIKSHHNVGGLPETLRLKLLEPLRELFKDEVRELGLALGLPRDLVFRHPFPGP
GLGVRILGEVKYEYTELLRQADAIFIEELRNAGWYEKTSQAFAVFLPIKSVGVMGDNRSYEYVIALRAVQTEDFMTAQWA
ELPYTLLARISNRIINEIRGINRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=565, Percent_Identity=37.1681415929204, Blast_Score=311, Evalue=9e-85,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=64.1472868217054, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=573, Percent_Identity=33.8568935427574, Blast_Score=281, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI71992717, Length=573, Percent_Identity=33.8568935427574, Blast_Score=281, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=33.8568935427574, Blast_Score=280, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=529, Percent_Identity=50.8506616257089, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI281365319, Length=565, Percent_Identity=37.3451327433628, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_NITEC (Q0ADW4)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748433.1
- ProteinModelPortal:   Q0ADW4
- SMR:   Q0ADW4
- STRING:   Q0ADW4
- GeneID:   4273979
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2251
- NMPDR:   fig|335283.3.peg.1773
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q0ADW4
- ProtClustDB:   PRK00074
- BioCyc:   NEUT335283:NEUT_2251-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 58050; Mature: 58050

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 81-81 ACT_SITE 175-175 ACT_SITE 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSAILILDFGSQYARLIARRIRETSVYCELHPFDVSPQFIREFSPVGIILSGGPASIFT
CCCEEEEEECCHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHCCCCCEEEEECCCCEEEC
NDAPRVPQIVFELGVPVLGICYGMQAMAAQLGGEVENAQTREFGYAELLTEPCRLFQDIK
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHH
DRINSDGKPALDVWMSHGDRVNKLPPGFTAIAFNAATPFAAMADETRRFYGVQFHPEVTH
HHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEECCCHHH
TLQGKAILDRFVHDICDAGYDWNMPDYVEEAIGRIRARVGGDKVILGLSGGVDSSVAAAL
HHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
IHRAIGDQLVCVFVDNGLLRLNEAKQTMETFSRNLAVNVIYVDASRQFLEQLKGITDPEQ
HHHHHCCCEEEEEECCCCEEEHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCCCHHH
KRRTIGREFVEIFQQEAAKIENVKWLAQGTIYPDVIESAGSHTKKSGLIKSHHNVGGLPE
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCHHCCCHHCCCCCCCCCH
TLRLKLLEPLRELFKDEVRELGLALGLPRDLVFRHPFPGPGLGVRILGEVKYEYTELLRQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCEEEEEHHHHHHHHHHHH
ADAIFIEELRNAGWYEKTSQAFAVFLPIKSVGVMGDNRSYEYVIALRAVQTEDFMTAQWA
HHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHEECCCCCCEEEEEEEEEECCCCHHHHHHH
ELPYTLLARISNRIINEIRGINRVVYDISGKPPATIEWE
HCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MHSAILILDFGSQYARLIARRIRETSVYCELHPFDVSPQFIREFSPVGIILSGGPASIFT
CCCEEEEEECCHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHCCCCCEEEEECCCCEEEC
NDAPRVPQIVFELGVPVLGICYGMQAMAAQLGGEVENAQTREFGYAELLTEPCRLFQDIK
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHH
DRINSDGKPALDVWMSHGDRVNKLPPGFTAIAFNAATPFAAMADETRRFYGVQFHPEVTH
HHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEECCCHHH
TLQGKAILDRFVHDICDAGYDWNMPDYVEEAIGRIRARVGGDKVILGLSGGVDSSVAAAL
HHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
IHRAIGDQLVCVFVDNGLLRLNEAKQTMETFSRNLAVNVIYVDASRQFLEQLKGITDPEQ
HHHHHCCCEEEEEECCCCEEEHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCCCHHH
KRRTIGREFVEIFQQEAAKIENVKWLAQGTIYPDVIESAGSHTKKSGLIKSHHNVGGLPE
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCHHCCCHHCCCCCCCCCH
TLRLKLLEPLRELFKDEVRELGLALGLPRDLVFRHPFPGPGLGVRILGEVKYEYTELLRQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCEEEEEHHHHHHHHHHHH
ADAIFIEELRNAGWYEKTSQAFAVFLPIKSVGVMGDNRSYEYVIALRAVQTEDFMTAQWA
HHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHEECCCCCCEEEEEEEEEECCCCHHHHHHH
ELPYTLLARISNRIINEIRGINRVVYDISGKPPATIEWE
HCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA