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The map label for this gene is guaB [H]

Identifier: 114332210

GI number: 114332210

Start: 2374761

End: 2376224

Strand: Direct

Name: guaB [H]

Synonym: Neut_2250

Alternate gene names: 114332210

Gene position: 2374761-2376224 (Clockwise)

Preceding gene: 114332209

Following gene: 114332211

Centisome position: 89.24

GC content: 50.55

Gene sequence:

>1464_bases
ATGCGACTCATACAAAAAGCACTCACCTTCGACGATATATTACTGCTTCCCGCTCATTCCGAAGTCTTGCCCAGGGATGT
TGACCTCACCACACAGCTAACCCGTTCTCTCCGGATCAGGATTCCGATTGTTTCAGCCGCGATGGATACAGTTACCGAAG
CACGACTTGCTATTGCTATCGCCCAAGAGGGCGGGATCGGCATTATCCACAAAAATATGCCGATCAGCGCCCAAGCAGCG
CAGGTTGCACAAGTAAAACGCTTCGAAAGCGGCATTGTCACTGATCCGATTGTCGTCTCTCCAGACATGACCGTCAGAAG
CGTTCTGGAACTGATTCGGCAACACAACATATCCGGCTTGCCCGTAGTAAAGGGCAAAAAGGTTGTAGGCATTGTTACCA
ACCGCGATCTGCGGTTTGAAACCAACCTTGATCAGCCGGTCAAAAATATCATGACCCCGAAGAAGCGTCTGGTTACTGTC
CGAGAAGGCATCTCACAGGAAGAAGCACTGGCCTTACTGCATAAACACAGGCTTGAGAAAGCACTGATTGTCGATGAAAA
CTTCGAATTGCGCGGGATGATTACCGTCAAGGACATCACCAGAACAACCGAACATCCCTATGCCAGCAAGGATGAACGGG
AACGTTTATACGTGGGTGCTGCAATCGGGGTGGGGGAAGGCAGTGACGAACGTGCCGCCGCTTTGGTGGAAGCTGGTGCA
GATGTAATTGTCGTGGACACAGCACATGGGCATTCGCAGGGCGTATTGGAACGCGTGTACTGGGTCAGGAGAAATTTTCC
TGAAATTCAGGTAATCGCTGGTAATGTTGCCACGGCTGCAGGAGCCAAAGCATTGGTAGATCATGGTGTTGATGCCGTAA
AGGTTGGAATCGGTCCAGGTTCAATCTGTACCACCCGGGTCATTGCTGGTGTTGGTGTCCCGCAAATTTCAGCAATTGAT
AATGTTGCTACTGCACTGCAGGGTACAGGTGTACCAGTTATCGCAGATGGAGGTATTCGTTATTCCGGTGATATTGCCAA
GGCCATTGCTGCAGGGGCAAGCGCAGTCATGCTGGGAGGTCTACTGGCTGGAACAGAGGAATCCCCAGGTGAAGTCGAGC
TACTCAAGGGTAGAGCCTATAAAAGTTATCGCGGCATGGGCTCATTATCTGCCATGCAACAAGGATCAAGCGATCGCTAT
TTTCAGGAAACCGAGCGCCATGAAGCAGAAAAACTGGTACCCGAGGGCGTGGAAGGTCGCGTTCCTTACAAAGGCTCTCT
CGCCAATGTCATCCATCAACTGACAGGAGGTGTCCGTTCCAGCATGGGTTATCTGGGATGCCATACCATCAGTGAAATGC
ATGAAAAAGCTGAGTTTATCGAAATCACGTCTGCCGGAATCCGGGAATCTCATGTGCATGACGTTCAGATCACCAAAGAA
GCCCCCAATTATCACGTTGAATAA

Upstream 100 bases:

>100_bases
CCCTTGCCAGGATTCGCTCCGGCTGGAAGAAACACATGAAGTCAAGACAGACAATACAGCTGGTTCCGATATAATATCGG
TTTTGTGAAGGATCGGCAGC

Downstream 100 bases:

>100_bases
CCCTTTACTGATATGCATTCAGCAATTCTTATCCTGGATTTTGGCTCGCAGTACGCTCGTTTAATCGCACGGCGCATCCG
GGAAACCAGTGTTTACTGTG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRLIQKALTFDDILLLPAHSEVLPRDVDLTTQLTRSLRIRIPIVSAAMDTVTEARLAIAIAQEGGIGIIHKNMPISAQAA
QVAQVKRFESGIVTDPIVVSPDMTVRSVLELIRQHNISGLPVVKGKKVVGIVTNRDLRFETNLDQPVKNIMTPKKRLVTV
REGISQEEALALLHKHRLEKALIVDENFELRGMITVKDITRTTEHPYASKDERERLYVGAAIGVGEGSDERAAALVEAGA
DVIVVDTAHGHSQGVLERVYWVRRNFPEIQVIAGNVATAAGAKALVDHGVDAVKVGIGPGSICTTRVIAGVGVPQISAID
NVATALQGTGVPVIADGGIRYSGDIAKAIAAGASAVMLGGLLAGTEESPGEVELLKGRAYKSYRGMGSLSAMQQGSSDRY
FQETERHEAEKLVPEGVEGRVPYKGSLANVIHQLTGGVRSSMGYLGCHTISEMHEKAEFIEITSAGIRESHVHDVQITKE
APNYHVE

Sequences:

>Translated_487_residues
MRLIQKALTFDDILLLPAHSEVLPRDVDLTTQLTRSLRIRIPIVSAAMDTVTEARLAIAIAQEGGIGIIHKNMPISAQAA
QVAQVKRFESGIVTDPIVVSPDMTVRSVLELIRQHNISGLPVVKGKKVVGIVTNRDLRFETNLDQPVKNIMTPKKRLVTV
REGISQEEALALLHKHRLEKALIVDENFELRGMITVKDITRTTEHPYASKDERERLYVGAAIGVGEGSDERAAALVEAGA
DVIVVDTAHGHSQGVLERVYWVRRNFPEIQVIAGNVATAAGAKALVDHGVDAVKVGIGPGSICTTRVIAGVGVPQISAID
NVATALQGTGVPVIADGGIRYSGDIAKAIAAGASAVMLGGLLAGTEESPGEVELLKGRAYKSYRGMGSLSAMQQGSSDRY
FQETERHEAEKLVPEGVEGRVPYKGSLANVIHQLTGGVRSSMGYLGCHTISEMHEKAEFIEITSAGIRESHVHDVQITKE
APNYHVE
>Mature_487_residues
MRLIQKALTFDDILLLPAHSEVLPRDVDLTTQLTRSLRIRIPIVSAAMDTVTEARLAIAIAQEGGIGIIHKNMPISAQAA
QVAQVKRFESGIVTDPIVVSPDMTVRSVLELIRQHNISGLPVVKGKKVVGIVTNRDLRFETNLDQPVKNIMTPKKRLVTV
REGISQEEALALLHKHRLEKALIVDENFELRGMITVKDITRTTEHPYASKDERERLYVGAAIGVGEGSDERAAALVEAGA
DVIVVDTAHGHSQGVLERVYWVRRNFPEIQVIAGNVATAAGAKALVDHGVDAVKVGIGPGSICTTRVIAGVGVPQISAID
NVATALQGTGVPVIADGGIRYSGDIAKAIAAGASAVMLGGLLAGTEESPGEVELLKGRAYKSYRGMGSLSAMQQGSSDRY
FQETERHEAEKLVPEGVEGRVPYKGSLANVIHQLTGGVRSSMGYLGCHTISEMHEKAEFIEITSAGIRESHVHDVQITKE
APNYHVE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=452, Percent_Identity=42.2566371681416, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI34328928, Length=452, Percent_Identity=42.2566371681416, Blast_Score=351, Evalue=9e-97,
Organism=Homo sapiens, GI34328930, Length=452, Percent_Identity=42.2566371681416, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI156616279, Length=452, Percent_Identity=42.2566371681416, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.8713692946058, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI217035152, Length=448, Percent_Identity=42.1875, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI217035148, Length=452, Percent_Identity=41.5929203539823, Blast_Score=341, Evalue=9e-94,
Organism=Homo sapiens, GI217035150, Length=452, Percent_Identity=39.6017699115044, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI156104880, Length=263, Percent_Identity=38.7832699619772, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI50541956, Length=249, Percent_Identity=39.7590361445783, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI50541954, Length=249, Percent_Identity=39.7590361445783, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI50541952, Length=249, Percent_Identity=39.7590361445783, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI50541948, Length=249, Percent_Identity=39.7590361445783, Blast_Score=168, Evalue=9e-42,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=63.2443531827515, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1786293, Length=349, Percent_Identity=30.945558739255, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=481, Percent_Identity=38.045738045738, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=39.9527186761229, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=242, Percent_Identity=38.0165289256198, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=40.495867768595, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=38.3196721311475, Blast_Score=329, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.6694214876033, Blast_Score=319, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=36.8421052631579, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=42.5, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641071, Length=486, Percent_Identity=42.3868312757202, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24641073, Length=486, Percent_Identity=42.3868312757202, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=42.5675675675676, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52307; Mature: 52307

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQKALTFDDILLLPAHSEVLPRDVDLTTQLTRSLRIRIPIVSAAMDTVTEARLAIAI
CCHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHCEEEEEEEHHHHHHHHHHCEEEEEE
AQEGGIGIIHKNMPISAQAAQVAQVKRFESGIVTDPIVVSPDMTVRSVLELIRQHNISGL
ECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
PVVKGKKVVGIVTNRDLRFETNLDQPVKNIMTPKKRLVTVREGISQEEALALLHKHRLEK
CEECCCEEEEEEECCCEEEECCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
ALIVDENFELRGMITVKDITRTTEHPYASKDERERLYVGAAIGVGEGSDERAAALVEAGA
EEEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCC
DVIVVDTAHGHSQGVLERVYWVRRNFPEIQVIAGNVATAAGAKALVDHGVDAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHCHHHHHHCCCCEEEEECCCC
SICTTRVIAGVGVPQISAIDNVATALQGTGVPVIADGGIRYSGDIAKAIAAGASAVMLGG
CHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHHHHHH
LLAGTEESPGEVELLKGRAYKSYRGMGSLSAMQQGSSDRYFQETERHEAEKLVPEGVEGR
HHCCCCCCCCCEEEEECCCHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
VPYKGSLANVIHQLTGGVRSSMGYLGCHTISEMHEKAEFIEITSAGIRESHVHDVQITKE
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEEEC
APNYHVE
CCCCCCC
>Mature Secondary Structure
MRLIQKALTFDDILLLPAHSEVLPRDVDLTTQLTRSLRIRIPIVSAAMDTVTEARLAIAI
CCHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHCEEEEEEEHHHHHHHHHHCEEEEEE
AQEGGIGIIHKNMPISAQAAQVAQVKRFESGIVTDPIVVSPDMTVRSVLELIRQHNISGL
ECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
PVVKGKKVVGIVTNRDLRFETNLDQPVKNIMTPKKRLVTVREGISQEEALALLHKHRLEK
CEECCCEEEEEEECCCEEEECCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
ALIVDENFELRGMITVKDITRTTEHPYASKDERERLYVGAAIGVGEGSDERAAALVEAGA
EEEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCC
DVIVVDTAHGHSQGVLERVYWVRRNFPEIQVIAGNVATAAGAKALVDHGVDAVKVGIGPG
CEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHCHHHHHHCCCCEEEEECCCC
SICTTRVIAGVGVPQISAIDNVATALQGTGVPVIADGGIRYSGDIAKAIAAGASAVMLGG
CHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHHHHHH
LLAGTEESPGEVELLKGRAYKSYRGMGSLSAMQQGSSDRYFQETERHEAEKLVPEGVEGR
HHCCCCCCCCCEEEEECCCHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
VPYKGSLANVIHQLTGGVRSSMGYLGCHTISEMHEKAEFIEITSAGIRESHVHDVQITKE
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEEEEC
APNYHVE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA