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The map label for this gene is ilvD

Identifier: 114332199

GI number: 114332199

Start: 2364136

End: 2365809

Strand: Direct

Name: ilvD

Synonym: Neut_2238

Alternate gene names: 114332199

Gene position: 2364136-2365809 (Clockwise)

Preceding gene: 114332194

Following gene: 114332200

Centisome position: 88.84

GC content: 55.02

Gene sequence:

>1674_bases
ATGCCAGACAATCGACGCAGCCAGGCCATCACTAAAGGTGCGAAACGTGCTCCCAATCGCGCCATGTTACGTGCAGTTGG
ATTCGGTGACGGAGATTTCGATAAGCCCATTGTCGGCATTGCCAACGGCTTTTCCACCATCACGCCTTGCAACATGGGGC
TGGATACGCTTGCCAAATGTGCGGAACATGCATTGAAAAATGCCGGTGCCATGCCGCAAATGTTCGGCACGATTACGGTA
TCGGATGGTATCTCCATGGGCACCGAAGGCATGAAATACTCACTGGTATCACGCGAGGTAATCGCTGATTCCATTGAAAC
CTGCGTGCAGGCGGAAAGCATGGATGGCGTCATTGCCATTGGCGGGTGTGACAAAAACATGCCTGGTGCCCTAATCGCGC
TGGCTAGACTGAACGTGCCATCCATTTTTGTCTATGGCGGCACCATCAAGCCCGGTCACTACCAGGGTCGCGATCTGACA
ATCGTCAGTGCGTTTGAAGCGGTTGGGCAACATAGCGCACACAAGATTGATGATCAGGAACTGCTGGAAGTTGAACGCCA
TGCCTGTCCCGGCGCAGGTTCGTGCGGCGGCATGTACACCGCCAACACCATGTCCTCTGCGATTGAGGCGATGGGCATGA
GTCTGCCCCATTCCTCCACTATGGCTGCGGAAGATGAGGAAAAGCGGATCAGCGCCACCCGCTCTGCCGAGGTGCTGGTG
GAAGCAATCAAAAAACAGATTCTGCCGCGCAGCCTGATTACCCGCAAGTCACTCGAAAATGCAGTAACGGTAGTCATGGC
CGTAGGCGGCTCGACCAATGCTGTGCTGCATCTGCTGGCCATCGCCCACGCAGCAGAAGTAGATTTTCATATTGACGATT
TCGAAGCGATTCGTGCCCGTGTGCCGGTGTTGTGTGACCTGAAACCTTCCGGGCGCTACGTCGCCACTGATCTGCACAGA
GCAGGCGGCATTCCACAAGTGATGAAAATGCTGCTCGTGCACGGTCTGCTGCATGGTGACTGTCTGACCATCAGCGGACA
AACTATCGCTGAAGTACTGAAAGATATTCCTGAACAACCGCGCGCGGATCAAAACGTCATCCGCACCTGGGACAACCCGG
TGTATGAACAAGGTCATCTGGCGATCCTGAAGGGTAATCTTTCGCCGGAAGGTGCGGTGGCCAAGATTTCCGGTGTAAAA
AACCCCAATATTACCGGGCCCGCCAGAGTGTTTGAATCCGAAGAAACCTGTATGACTGCCATTCTCGATCGCAAAATCAA
GCCGGGTGATGTTGTCGTTATTCGCTACGAGGGGCCACGCGGCGGTCCCGGCATGCGTGAAATGCTCTCCCCTACTTCGG
CGCTAATCGGTGAAGGATTGGGTGATTCGGTCGGATTGATTACCGATGGCCGTTTTTCCGGCGGCACCTACGGCATGGTC
GTAGGCCATGTAGCACCGGAAGCATACGCCGGGGGAGTGATCGCTCTGGTGGAAGAAGGAGATTCAATCACAATCGATGC
GCATCGCCGCCTGTTACAACTGAATGTTTCAGAAACAGAATTGGAACGCCGCCGGGCTGCCTGGCAGCCGCCTGCGCCGC
GCTACACACGCGGTGTACTGGCAAAATATGCCAAACTGGTATCAACCGCCAGTCGTGGTGCGGTTACTGATTAA

Upstream 100 bases:

>100_bases
TATACGGCAACATCTGCTGACCACAGCAATCACCCCCAGCAATCGTTACCTTGCCTAACTATATTCATCACATCTATCTA
TCTATCTATGAGGGAATAAT

Downstream 100 bases:

>100_bases
TCTCCCTACAAAAAACAATGCCTAACCACCTTGCCGGAGAAACCAGTCCTTACTTGCTGCAGCACGCAGACAATCCTGTG
GACTGATCCATGGGGGAAAG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPDNRRSQAITKGAKRAPNRAMLRAVGFGDGDFDKPIVGIANGFSTITPCNMGLDTLAKCAEHALKNAGAMPQMFGTITV
SDGISMGTEGMKYSLVSREVIADSIETCVQAESMDGVIAIGGCDKNMPGALIALARLNVPSIFVYGGTIKPGHYQGRDLT
IVSAFEAVGQHSAHKIDDQELLEVERHACPGAGSCGGMYTANTMSSAIEAMGMSLPHSSTMAAEDEEKRISATRSAEVLV
EAIKKQILPRSLITRKSLENAVTVVMAVGGSTNAVLHLLAIAHAAEVDFHIDDFEAIRARVPVLCDLKPSGRYVATDLHR
AGGIPQVMKMLLVHGLLHGDCLTISGQTIAEVLKDIPEQPRADQNVIRTWDNPVYEQGHLAILKGNLSPEGAVAKISGVK
NPNITGPARVFESEETCMTAILDRKIKPGDVVVIRYEGPRGGPGMREMLSPTSALIGEGLGDSVGLITDGRFSGGTYGMV
VGHVAPEAYAGGVIALVEEGDSITIDAHRRLLQLNVSETELERRRAAWQPPAPRYTRGVLAKYAKLVSTASRGAVTD

Sequences:

>Translated_557_residues
MPDNRRSQAITKGAKRAPNRAMLRAVGFGDGDFDKPIVGIANGFSTITPCNMGLDTLAKCAEHALKNAGAMPQMFGTITV
SDGISMGTEGMKYSLVSREVIADSIETCVQAESMDGVIAIGGCDKNMPGALIALARLNVPSIFVYGGTIKPGHYQGRDLT
IVSAFEAVGQHSAHKIDDQELLEVERHACPGAGSCGGMYTANTMSSAIEAMGMSLPHSSTMAAEDEEKRISATRSAEVLV
EAIKKQILPRSLITRKSLENAVTVVMAVGGSTNAVLHLLAIAHAAEVDFHIDDFEAIRARVPVLCDLKPSGRYVATDLHR
AGGIPQVMKMLLVHGLLHGDCLTISGQTIAEVLKDIPEQPRADQNVIRTWDNPVYEQGHLAILKGNLSPEGAVAKISGVK
NPNITGPARVFESEETCMTAILDRKIKPGDVVVIRYEGPRGGPGMREMLSPTSALIGEGLGDSVGLITDGRFSGGTYGMV
VGHVAPEAYAGGVIALVEEGDSITIDAHRRLLQLNVSETELERRRAAWQPPAPRYTRGVLAKYAKLVSTASRGAVTD
>Mature_556_residues
PDNRRSQAITKGAKRAPNRAMLRAVGFGDGDFDKPIVGIANGFSTITPCNMGLDTLAKCAEHALKNAGAMPQMFGTITVS
DGISMGTEGMKYSLVSREVIADSIETCVQAESMDGVIAIGGCDKNMPGALIALARLNVPSIFVYGGTIKPGHYQGRDLTI
VSAFEAVGQHSAHKIDDQELLEVERHACPGAGSCGGMYTANTMSSAIEAMGMSLPHSSTMAAEDEEKRISATRSAEVLVE
AIKKQILPRSLITRKSLENAVTVVMAVGGSTNAVLHLLAIAHAAEVDFHIDDFEAIRARVPVLCDLKPSGRYVATDLHRA
GGIPQVMKMLLVHGLLHGDCLTISGQTIAEVLKDIPEQPRADQNVIRTWDNPVYEQGHLAILKGNLSPEGAVAKISGVKN
PNITGPARVFESEETCMTAILDRKIKPGDVVVIRYEGPRGGPGMREMLSPTSALIGEGLGDSVGLITDGRFSGGTYGMVV
GHVAPEAYAGGVIALVEEGDSITIDAHRRLLQLNVSETELERRRAAWQPPAPRYTRGVLAKYAKLVSTASRGAVTD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=40.5891980360065, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1788157, Length=514, Percent_Identity=33.0739299610895, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI2367371, Length=500, Percent_Identity=33.8, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1786464, Length=471, Percent_Identity=34.3949044585987, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=48.932384341637, Blast_Score=535, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_NITEC (Q0ADX6)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748421.1
- STRING:   Q0ADX6
- GeneID:   4274019
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2238
- NMPDR:   fig|335283.3.peg.1761
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- PhylomeDB:   Q0ADX6
- ProtClustDB:   PRK00911
- BioCyc:   NEUT335283:NEUT_2238-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59136; Mature: 59004

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDNRRSQAITKGAKRAPNRAMLRAVGFGDGDFDKPIVGIANGFSTITPCNMGLDTLAKC
CCCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AEHALKNAGAMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETCVQAESMDGVIAI
HHHHHHCCCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEE
GGCDKNMPGALIALARLNVPSIFVYGGTIKPGHYQGRDLTIVSAFEAVGQHSAHKIDDQE
CCCCCCCCCHHEEEECCCCCEEEEECCEECCCCCCCCCEEEEHHHHHHCCCCCCCCCHHH
LLEVERHACPGAGSCGGMYTANTMSSAIEAMGMSLPHSSTMAAEDEEKRISATRSAEVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EAIKKQILPRSLITRKSLENAVTVVMAVGGSTNAVLHLLAIAHAAEVDFHIDDFEAIRAR
HHHHHHHCCHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHCEEECCHHHHHHHC
VPVLCDLKPSGRYVATDLHRAGGIPQVMKMLLVHGLLHGDCLTISGQTIAEVLKDIPEQP
CCEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
RADQNVIRTWDNPVYEQGHLAILKGNLSPEGAVAKISGVKNPNITGPARVFESEETCMTA
CCCCHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHH
ILDRKIKPGDVVVIRYEGPRGGPGMREMLSPTSALIGEGLGDSVGLITDGRFSGGTYGMV
HHHCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHHCCCCCCCCEEECCCCCCCEEEEE
VGHVAPEAYAGGVIALVEEGDSITIDAHRRLLQLNVSETELERRRAAWQPPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEECCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHHHH
AKYAKLVSTASRGAVTD
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PDNRRSQAITKGAKRAPNRAMLRAVGFGDGDFDKPIVGIANGFSTITPCNMGLDTLAKC
CCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
AEHALKNAGAMPQMFGTITVSDGISMGTEGMKYSLVSREVIADSIETCVQAESMDGVIAI
HHHHHHCCCCCCHHHEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEE
GGCDKNMPGALIALARLNVPSIFVYGGTIKPGHYQGRDLTIVSAFEAVGQHSAHKIDDQE
CCCCCCCCCHHEEEECCCCCEEEEECCEECCCCCCCCCEEEEHHHHHHCCCCCCCCCHHH
LLEVERHACPGAGSCGGMYTANTMSSAIEAMGMSLPHSSTMAAEDEEKRISATRSAEVLV
HHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EAIKKQILPRSLITRKSLENAVTVVMAVGGSTNAVLHLLAIAHAAEVDFHIDDFEAIRAR
HHHHHHHCCHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHCEEECCHHHHHHHC
VPVLCDLKPSGRYVATDLHRAGGIPQVMKMLLVHGLLHGDCLTISGQTIAEVLKDIPEQP
CCEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
RADQNVIRTWDNPVYEQGHLAILKGNLSPEGAVAKISGVKNPNITGPARVFESEETCMTA
CCCCHHHHCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHH
ILDRKIKPGDVVVIRYEGPRGGPGMREMLSPTSALIGEGLGDSVGLITDGRFSGGTYGMV
HHHCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHHCCCCCCCCEEECCCCCCCEEEEE
VGHVAPEAYAGGVIALVEEGDSITIDAHRRLLQLNVSETELERRRAAWQPPAPRYTRGVL
EECCCCHHHCCCEEEEEECCCEEEECCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHHHH
AKYAKLVSTASRGAVTD
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA