Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 114332113

GI number: 114332113

Start: 2275972

End: 2276784

Strand: Reverse

Name: proC [H]

Synonym: Neut_2148

Alternate gene names: 114332113

Gene position: 2276784-2275972 (Counterclockwise)

Preceding gene: 114332114

Following gene: 114332112

Centisome position: 85.56

GC content: 50.06

Gene sequence:

>813_bases
ATGAATATTGCCTTTATTGGTGGAGGGAATATGGCTGGCGCCATGATCGGCGGTCTGATCCGTCATGGACATACGCCATC
ACAGATCAGTGTTGTAGAGATCGATGCGCAGCAGCAACAGCGACTTGTCAAGGAATATGGCATGACAGTAACTGCATCCA
TAGCTGATGGAATTCGGGGCAGCGAGATCGTTGTTCTGGCTGTAAAGCCACAACAACTACATGCTGCAGTAAGCGAATCA
GCACAACTTTTTCAAGGTAAGCTTGTTATTTCGATTGCAGCAGGTGTCCGTGCAGACGATCTGAGCCAGTGGCTGAACCG
GCATGAGTTTATTATTCGTGCTATGCCTAACACACCGGCTTTAATTGGAAAGGGGGTAACAGGCTTATACGCTCTGCCTC
GTGTGGATACCCGGCAGAAGGAACAAGCAACGAGGATTCTGGCGGGAATCGGAACTATCGTCTGGGTAGATGAAGAAGCT
CAGCTGGATGCTGTAACAGCTTTGTCAGGATGTGGCCCGGCGTATGTCTTCTATTTTCTGGAGGCGATGCAGCAGGCTGG
GGCAGAGCTAGGTTTGACAGCTGATACCGCGAAACAGTTGGCAATGCAAACATTCCTGGGGGCGACATACCTTGCTGTGC
AAAGTGATGACACGCTTGCAACCCTGAGAACACGTGTAACTTCGAAGGGGGGGGTGACCGAACAAGCGTTACTCAGTATG
GAACAGTCCGATATCAGGGGTGCATTTATTCGCGCCATGCATATTGCCAATGATCGTTCCCGGGAAATGGGAGAAATGTT
TAGACATACGTAA

Upstream 100 bases:

>100_bases
ATCAATCTGTTCAAGAAATAAGTATTTTTGTAAATATGCCATCTGCCAGGGTTTGGCTAATCTTATCGGTGCTGTACATT
TAGATAAATCAGGGTTATTC

Downstream 100 bases:

>100_bases
TATTTGAGGTGCTCTTCAGTCTGTATCCAGATAATGGGGTAGAAACAATCATAACTTTCAACGGAAAAAACCATGCCCAA
TCAAATAATAATATTTTTGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNIAFIGGGNMAGAMIGGLIRHGHTPSQISVVEIDAQQQQRLVKEYGMTVTASIADGIRGSEIVVLAVKPQQLHAAVSES
AQLFQGKLVISIAAGVRADDLSQWLNRHEFIIRAMPNTPALIGKGVTGLYALPRVDTRQKEQATRILAGIGTIVWVDEEA
QLDAVTALSGCGPAYVFYFLEAMQQAGAELGLTADTAKQLAMQTFLGATYLAVQSDDTLATLRTRVTSKGGVTEQALLSM
EQSDIRGAFIRAMHIANDRSREMGEMFRHT

Sequences:

>Translated_270_residues
MNIAFIGGGNMAGAMIGGLIRHGHTPSQISVVEIDAQQQQRLVKEYGMTVTASIADGIRGSEIVVLAVKPQQLHAAVSES
AQLFQGKLVISIAAGVRADDLSQWLNRHEFIIRAMPNTPALIGKGVTGLYALPRVDTRQKEQATRILAGIGTIVWVDEEA
QLDAVTALSGCGPAYVFYFLEAMQQAGAELGLTADTAKQLAMQTFLGATYLAVQSDDTLATLRTRVTSKGGVTEQALLSM
EQSDIRGAFIRAMHIANDRSREMGEMFRHT
>Mature_270_residues
MNIAFIGGGNMAGAMIGGLIRHGHTPSQISVVEIDAQQQQRLVKEYGMTVTASIADGIRGSEIVVLAVKPQQLHAAVSES
AQLFQGKLVISIAAGVRADDLSQWLNRHEFIIRAMPNTPALIGKGVTGLYALPRVDTRQKEQATRILAGIGTIVWVDEEA
QLDAVTALSGCGPAYVFYFLEAMQQAGAELGLTADTAKQLAMQTFLGATYLAVQSDDTLATLRTRVTSKGGVTEQALLSM
EQSDIRGAFIRAMHIANDRSREMGEMFRHT

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=262, Percent_Identity=29.0076335877863, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI21361454, Length=280, Percent_Identity=31.4285714285714, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI24797095, Length=277, Percent_Identity=31.4079422382672, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI24797097, Length=277, Percent_Identity=31.4079422382672, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=33.4586466165414, Blast_Score=131, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=282, Percent_Identity=31.9148936170213, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=28.673835125448, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=251, Percent_Identity=29.0836653386454, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=32.6164874551971, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=35.5029585798817, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29028; Mature: 29028

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAFIGGGNMAGAMIGGLIRHGHTPSQISVVEIDAQQQQRLVKEYGMTVTASIADGIRG
CEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHCCEEEEEHHCCCCC
SEIVVLAVKPQQLHAAVSESAQLFQGKLVISIAAGVRADDLSQWLNRHEFIIRAMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHEEEEEECCCCCH
LIGKGVTGLYALPRVDTRQKEQATRILAGIGTIVWVDEEAQLDAVTALSGCGPAYVFYFL
HHCCCCHHHEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCHHHHHHHH
EAMQQAGAELGLTADTAKQLAMQTFLGATYLAVQSDDTLATLRTRVTSKGGVTEQALLSM
HHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHH
EQSDIRGAFIRAMHIANDRSREMGEMFRHT
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MNIAFIGGGNMAGAMIGGLIRHGHTPSQISVVEIDAQQQQRLVKEYGMTVTASIADGIRG
CEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHCCEEEEEHHCCCCC
SEIVVLAVKPQQLHAAVSESAQLFQGKLVISIAAGVRADDLSQWLNRHEFIIRAMPNTPA
CCEEEEEECHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHEEEEEECCCCCH
LIGKGVTGLYALPRVDTRQKEQATRILAGIGTIVWVDEEAQLDAVTALSGCGPAYVFYFL
HHCCCCHHHEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCHHHHHHHH
EAMQQAGAELGLTADTAKQLAMQTFLGATYLAVQSDDTLATLRTRVTSKGGVTEQALLSM
HHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHH
EQSDIRGAFIRAMHIANDRSREMGEMFRHT
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]