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The map label for this gene is lpxK

Identifier: 114332075

GI number: 114332075

Start: 2233310

End: 2234500

Strand: Direct

Name: lpxK

Synonym: Neut_2110

Alternate gene names: 114332075

Gene position: 2233310-2234500 (Clockwise)

Preceding gene: 114332067

Following gene: 114332076

Centisome position: 83.93

GC content: 46.77

Gene sequence:

>1191_bases
ATGAACTGGTCAGAACTGTATTGGCAACGTATCACTCCGCTACATCTCCTTTTATGGCCAGTCAGCTTGCTATTTGTCCT
GTTTCAGTCTATCCGGCGCCATCTATATCGGCGTGCGATATTAACCTCGGTTCACCTTCCTGTGCCGGTGATTGTTGTTG
ACAGCATCACTGCCACAAGCCCGGTTAAAACACCACTCATCATCCAGATAGTCAATATGCTGAGAGCAAGTGGATTACGG
CCTGGGATCATTGGCCACGGCTACACCGATAACTATCACTCGCCAATGAGCGTGACCATTGATAGTCCTCTGCAGCTCGC
TGGTAAGAAATCACTGTTACTCGCCTATTATTTGCGTGAAACCTGCCCTGTATGGATCGGCCACGATCGGATCGAAGTGG
CAAAAGCGCTGCTGGAAACACATAAGGAATGTAACGTACTGATATGTAATGACGGCCTGCAGGATCTTCGGCTGCAGCGT
GACTTTGAGGTCGTTATTGTTGATACCAGTGTTATCAATTCCGGGAATGGTCTGATCATGCCTGCCGGGCCACTGCGAGA
CAGCTTTGCTCGCTTAAAGCATTCGAATGTCGTCGTGCAGGCAGGCCATCACAGACAAATTCCAGATATCGGGGAAGAAA
TCCGAACGTTTTATATCACACCGCTGAAAGAGCATTTTTTCAACCTGTCACGGCCTGAATTAACGGCCAGTGCAGCAGAG
CTTGCAAACAAACGTATCCATGCGGTTACCTGTGATCCGGATATACAAAATTTTCTGGATAACCTCAAATTTCTGAGATT
GACGGTCACCCCATACATCTTTTCTGAAGATCATCATTTTGTTGCAGAGGATTTTCCGTTTGATGAAGCTGAAATCATTC
TGATACCGGAAGAAGATGCAGTAAAATGCTTTAATCTGCACGACGAGCGCATCTGGGTTTTACAACAGGAATATCGTGTT
GACCTCGGGTTACGCACAATCATACTTAAGAAGCTGAGAGAAAAATTCATGGATCCAAAACTTCTGGACATTTTAGCTTG
TCCACTATGCAAAGGCCCTCTTATCTACAAAAAAGACCGACTGGAGCTAATCTGCAAGGCGGATCGGTTAGCTTACCCCA
TTCGGGACGGCATTCCCGTTATGCTGGAGGACGAAGCAAGAAGACTGCCTGACGAAGAAGAAATCAAGTAG

Upstream 100 bases:

>100_bases
CTGCTGTAAAACTATTTATTTAATATTGAGCCTCTGAATCGGATGGTGTTACAGTTGACGACAAACGATTCTCAAAGCCT
AATCATCCCAACCACACATC

Downstream 100 bases:

>100_bases
ACAGACTTTCCGCGGACGGAACCTACTCCTGCCATTTTCCCGACAACAGAAACTAAACTACCGCTTGCTCAAAGCAGGCT
GGTTGGCGCAGCTTGGATGC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNWSELYWQRITPLHLLLWPVSLLFVLFQSIRRHLYRRAILTSVHLPVPVIVVDSITATSPVKTPLIIQIVNMLRASGLR
PGIIGHGYTDNYHSPMSVTIDSPLQLAGKKSLLLAYYLRETCPVWIGHDRIEVAKALLETHKECNVLICNDGLQDLRLQR
DFEVVIVDTSVINSGNGLIMPAGPLRDSFARLKHSNVVVQAGHHRQIPDIGEEIRTFYITPLKEHFFNLSRPELTASAAE
LANKRIHAVTCDPDIQNFLDNLKFLRLTVTPYIFSEDHHFVAEDFPFDEAEIILIPEEDAVKCFNLHDERIWVLQQEYRV
DLGLRTIILKKLREKFMDPKLLDILACPLCKGPLIYKKDRLELICKADRLAYPIRDGIPVMLEDEARRLPDEEEIK

Sequences:

>Translated_396_residues
MNWSELYWQRITPLHLLLWPVSLLFVLFQSIRRHLYRRAILTSVHLPVPVIVVDSITATSPVKTPLIIQIVNMLRASGLR
PGIIGHGYTDNYHSPMSVTIDSPLQLAGKKSLLLAYYLRETCPVWIGHDRIEVAKALLETHKECNVLICNDGLQDLRLQR
DFEVVIVDTSVINSGNGLIMPAGPLRDSFARLKHSNVVVQAGHHRQIPDIGEEIRTFYITPLKEHFFNLSRPELTASAAE
LANKRIHAVTCDPDIQNFLDNLKFLRLTVTPYIFSEDHHFVAEDFPFDEAEIILIPEEDAVKCFNLHDERIWVLQQEYRV
DLGLRTIILKKLREKFMDPKLLDILACPLCKGPLIYKKDRLELICKADRLAYPIRDGIPVMLEDEARRLPDEEEIK
>Mature_396_residues
MNWSELYWQRITPLHLLLWPVSLLFVLFQSIRRHLYRRAILTSVHLPVPVIVVDSITATSPVKTPLIIQIVNMLRASGLR
PGIIGHGYTDNYHSPMSVTIDSPLQLAGKKSLLLAYYLRETCPVWIGHDRIEVAKALLETHKECNVLICNDGLQDLRLQR
DFEVVIVDTSVINSGNGLIMPAGPLRDSFARLKHSNVVVQAGHHRQIPDIGEEIRTFYITPLKEHFFNLSRPELTASAAE
LANKRIHAVTCDPDIQNFLDNLKFLRLTVTPYIFSEDHHFVAEDFPFDEAEIILIPEEDAVKCFNLHDERIWVLQQEYRV
DLGLRTIILKKLREKFMDPKLLDILACPLCKGPLIYKKDRLELICKADRLAYPIRDGIPVMLEDEARRLPDEEEIK

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the UPF0434 family

Homologues:

Organism=Escherichia coli, GI1787144, Length=314, Percent_Identity=30.2547770700637, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787146, Length=57, Percent_Identity=59.6491228070175, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_NITEC (Q0AEA0)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748297.1
- ProteinModelPortal:   Q0AEA0
- SMR:   Q0AEA0
- STRING:   Q0AEA0
- GeneID:   4273606
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2110
- NMPDR:   fig|335283.3.peg.136
- eggNOG:   COG1663
- HOGENOM:   HBG135383
- OMA:   RLELICK
- PhylomeDB:   Q0AEA0
- ProtClustDB:   CLSK586118
- BioCyc:   NEUT335283:NEUT_2110-MONOMER
- HAMAP:   MF_00409
- HAMAP:   MF_01187
- InterPro:   IPR003758
- InterPro:   IPR005651
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK; PF03966 Trm112p

EC number: =2.7.1.130

Molecular weight: Translated: 45511; Mature: 45511

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWSELYWQRITPLHLLLWPVSLLFVLFQSIRRHLYRRAILTSVHLPVPVIVVDSITATS
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
PVKTPLIIQIVNMLRASGLRPGIIGHGYTDNYHSPMSVTIDSPLQLAGKKSLLLAYYLRE
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCHHHHHHHHHHH
TCPVWIGHDRIEVAKALLETHKECNVLICNDGLQDLRLQRDFEVVIVDTSVINSGNGLIM
CCCEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCCCEEEEEEEEEEECCCEEEE
PAGPLRDSFARLKHSNVVVQAGHHRQIPDIGEEIRTFYITPLKEHFFNLSRPELTASAAE
CCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHEEEECCHHHHHCCCCCCCHHHHHHH
LANKRIHAVTCDPDIQNFLDNLKFLRLTVTPYIFSEDHHFVAEDFPFDEAEIILIPEEDA
HCCCCEEEEECCHHHHHHHHCCEEEEEEECEEEECCCCCEEECCCCCCCCEEEEECCCCC
VKCFNLHDERIWVLQQEYRVDLGLRTIILKKLREKFMDPKLLDILACPLCKGPLIYKKDR
EEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCC
LELICKADRLAYPIRDGIPVMLEDEARRLPDEEEIK
HHEEECHHHHCCCCCCCCCEEECCHHHCCCCHHCCC
>Mature Secondary Structure
MNWSELYWQRITPLHLLLWPVSLLFVLFQSIRRHLYRRAILTSVHLPVPVIVVDSITATS
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
PVKTPLIIQIVNMLRASGLRPGIIGHGYTDNYHSPMSVTIDSPLQLAGKKSLLLAYYLRE
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCHHHHHHHHHHH
TCPVWIGHDRIEVAKALLETHKECNVLICNDGLQDLRLQRDFEVVIVDTSVINSGNGLIM
CCCEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCCCEEEEEEEEEEECCCEEEE
PAGPLRDSFARLKHSNVVVQAGHHRQIPDIGEEIRTFYITPLKEHFFNLSRPELTASAAE
CCCCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHEEEECCHHHHHCCCCCCCHHHHHHH
LANKRIHAVTCDPDIQNFLDNLKFLRLTVTPYIFSEDHHFVAEDFPFDEAEIILIPEEDA
HCCCCEEEEECCHHHHHHHHCCEEEEEEECEEEECCCCCEEECCCCCCCCEEEEECCCCC
VKCFNLHDERIWVLQQEYRVDLGLRTIILKKLREKFMDPKLLDILACPLCKGPLIYKKDR
EEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCC
LELICKADRLAYPIRDGIPVMLEDEARRLPDEEEIK
HHEEECHHHHCCCCCCCCCEEECCHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA