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The map label for this gene is rmlA1 [H]

Identifier: 114331855

GI number: 114331855

Start: 1994543

End: 1995430

Strand: Reverse

Name: rmlA1 [H]

Synonym: Neut_1880

Alternate gene names: 114331855

Gene position: 1995430-1994543 (Counterclockwise)

Preceding gene: 114331860

Following gene: 114331854

Centisome position: 74.99

GC content: 50.9

Gene sequence:

>888_bases
ATGACAAATAGAAAAGGTATTATTCTTGCTGGCGGTTCCGGTACGCGGCTGCACCCGGCCACGCTTGCGCTGAGCAAACA
ATTATTGCCGGTATTTGATAAACCGATGATCTATTACCCGCTCAGCACCCTGATGCTGGCAGGTATTCGCGACATACTCA
TCATCAGCACGCCGCAGGATACCCCCCGTTTTCAGCAATTGCTGGGCAGTGGTGAGCAATGGGGATTGAATCTGCAATAT
GCGGTACAGCCTGCACCGGATGGTCTCGCACAAGCTTTTCTGATCGGAGAAGCGTTTATTGGCAATCACCCTTCTGCACT
GGTGCTGGGTGACAATATTTTCTACGGCCATGATTTGCAGCAATTACTGGCCAATGCCATGGCGCGCACGGAGGGAGCCA
GTGTGTTTGCTTACCATGTGCTTGATCCTGAGCGCTATGGCGTGGTTGAGTTTGATGCATGCGGGAAGGCGCTGTTACTG
GAAGAAAAACCCAGGCAGCCTAAATCCAACTATGCAGTAACCGGTCTGTATTTCTACGATGACCGGGTTACCAATTTTGC
TAAAACGCTTAAGCCCTCGGCACGTGGAGAGCTGGAAATTACCGACCTGAATCGCCTATATCTGGAACAAGATCAGTTAA
GTGTGGAAATCATGGGCCGGGGTTACGCCTGGCTGGATACAGGAACACATGCAACTCTGCTCGATGCCAGCCAGTTCATC
GCCACTCTGGAAAACCGACAAGGACTTAAAGTGGCCTGCCCGGAGGAAATCGCTTACCGGCAACGATGGATTGATGCGGC
ACAGCTGGAAATGCTGGCCCAGCCACTGGCCAAAAATGGTTATGGCCAGTATCTGCTTAAAATACTTAGGGAAAACGTAT
TTAGATGA

Upstream 100 bases:

>100_bases
GTATAACAGTCCGTATTTTATGGACTAGTTCTATCTGCAAGAATTCACATGTTCCTTGATTCTTCAATTTCATTTTTCTG
CGGATTGCCAGAAAATCATT

Downstream 100 bases:

>100_bases
AAACAAGCTTTGCTTGCGCGGCGGCAGCAGTGATTGCTTAATCTGGTATTTATTCAGATCTGATAAGGTGTTGATATGAA
GGTTCTTGTTACTGGAGGAG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTNRKGIILAGGSGTRLHPATLALSKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGSGEQWGLNLQY
AVQPAPDGLAQAFLIGEAFIGNHPSALVLGDNIFYGHDLQQLLANAMARTEGASVFAYHVLDPERYGVVEFDACGKALLL
EEKPRQPKSNYAVTGLYFYDDRVTNFAKTLKPSARGELEITDLNRLYLEQDQLSVEIMGRGYAWLDTGTHATLLDASQFI
ATLENRQGLKVACPEEIAYRQRWIDAAQLEMLAQPLAKNGYGQYLLKILRENVFR

Sequences:

>Translated_295_residues
MTNRKGIILAGGSGTRLHPATLALSKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGSGEQWGLNLQY
AVQPAPDGLAQAFLIGEAFIGNHPSALVLGDNIFYGHDLQQLLANAMARTEGASVFAYHVLDPERYGVVEFDACGKALLL
EEKPRQPKSNYAVTGLYFYDDRVTNFAKTLKPSARGELEITDLNRLYLEQDQLSVEIMGRGYAWLDTGTHATLLDASQFI
ATLENRQGLKVACPEEIAYRQRWIDAAQLEMLAQPLAKNGYGQYLLKILRENVFR
>Mature_294_residues
TNRKGIILAGGSGTRLHPATLALSKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGSGEQWGLNLQYA
VQPAPDGLAQAFLIGEAFIGNHPSALVLGDNIFYGHDLQQLLANAMARTEGASVFAYHVLDPERYGVVEFDACGKALLLE
EKPRQPKSNYAVTGLYFYDDRVTNFAKTLKPSARGELEITDLNRLYLEQDQLSVEIMGRGYAWLDTGTHATLLDASQFIA
TLENRQGLKVACPEEIAYRQRWIDAAQLEMLAQPLAKNGYGQYLLKILRENVFR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=292, Percent_Identity=74.3150684931507, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=64.6853146853147, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931050, Length=191, Percent_Identity=25.130890052356, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=252, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=23.2931726907631, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=23.2931726907631, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32849; Mature: 32718

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRKGIILAGGSGTRLHPATLALSKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQD
CCCCCEEEEECCCCCEECHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCEEEEEECCCC
TPRFQQLLGSGEQWGLNLQYAVQPAPDGLAQAFLIGEAFIGNHPSALVLGDNIFYGHDLQ
CHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCHH
QLLANAMARTEGASVFAYHVLDPERYGVVEFDACGKALLLEEKPRQPKSNYAVTGLYFYD
HHHHHHHHHCCCCEEEEEEEECCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
DRVTNFAKTLKPSARGELEITDLNRLYLEQDQLSVEIMGRGYAWLDTGTHATLLDASQFI
CHHHHHHHHCCCCCCCCEEEEECHHEEEECCCEEEEEEECCEEEEECCCCEEEHHHHHHH
ATLENRQGLKVACPEEIAYRQRWIDAAQLEMLAQPLAKNGYGQYLLKILRENVFR
HHHHCCCCCEEECHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNRKGIILAGGSGTRLHPATLALSKQLLPVFDKPMIYYPLSTLMLAGIRDILIISTPQD
CCCCEEEEECCCCCEECHHHHHHHHHHHHHHCCCEEEECHHHHHHHCCCEEEEEECCCC
TPRFQQLLGSGEQWGLNLQYAVQPAPDGLAQAFLIGEAFIGNHPSALVLGDNIFYGHDLQ
CHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCHH
QLLANAMARTEGASVFAYHVLDPERYGVVEFDACGKALLLEEKPRQPKSNYAVTGLYFYD
HHHHHHHHHCCCCEEEEEEEECCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
DRVTNFAKTLKPSARGELEITDLNRLYLEQDQLSVEIMGRGYAWLDTGTHATLLDASQFI
CHHHHHHHHCCCCCCCCEEEEECHHEEEECCCEEEEEEECCEEEEECCCCEEEHHHHHHH
ATLENRQGLKVACPEEIAYRQRWIDAAQLEMLAQPLAKNGYGQYLLKILRENVFR
HHHHCCCCCEEECHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]