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The map label for this gene is macA [H]

Identifier: 114331334

GI number: 114331334

Start: 1408206

End: 1409360

Strand: Direct

Name: macA [H]

Synonym: Neut_1341

Alternate gene names: 114331334

Gene position: 1408206-1409360 (Clockwise)

Preceding gene: 114331333

Following gene: 114331335

Centisome position: 52.92

GC content: 53.42

Gene sequence:

>1155_bases
ATGCCTGGAACACGTTTACTGCTTCGCATAGCAGGCATTGCGCTACTGATTACCGCAGCAGGGTACATCACTTGGCATTT
AACCAGAAGCCAGCCTCTGGAAGTGGAACTGGCGACCGTTAGTCGCGGTGCCGTTGAAGCCACGGTGGTCAATACGCGCG
CTGGCACGATCAAGGCATGCCGACGAGCCAAATTATCTCCACAAGCAGGTGGCCAGATCATCCGTATGGAAATCAGAGAA
GGAGATCGGATCAAGAAAGATCAGGTGCTACTTGAATTATGGAATACCGATCTGCAAGCACAACATGATCTGGCAAAGCA
GCAATTGGCTACAGCAGAAAGCCGGCGACAGGAATCCTGCATCCTGGCTGACAACGCACAACGTGAATATATCCGCACCC
AACAACTGGTTGAGAAAGGATTTGTTAGCGTACAGCGTGCCGATGATGCAAGCGCTACTGCCAAAGCCAACCGGGCAGCC
TGTGCCGCCACGGGTGCAGAAGTCAGGCGAGCGCGTGCACAGATTGCAGTCAGCCAGGCCAACCTGGATCGAACACAGCT
TATTGCTCCTTTTGCTGGAGTCATTGCTCAGATCACAGGAGAACTGGGCGAATATGTCACCCCTTCCCCGCCGGGAATTC
CCACCCCGCCAGCAGTTGATCTGATTGATGACTCCTGCCTGTATGTCAGTGCGCCGATGGATGAAGTCGATGCACCCAAA
ATCCGGGTGGGACAAGTTGCACGCATCACGCTGGATGCCCTCCCTGGCCAGATTTTTGAGGGGAAAGTACGTCGTATTGC
CCCTTATGTGACTGAAGTCGAGAAACAGGCGCGCACGGTGGATGTGGAAGCCGAATTTGCCAATCCTGATCAGGCTGTTT
TGCTGGTGGGTTATAGCGCAGATATCGAAGCAATTATTGATCATCGTGAAAATGTGCTACGCGTTCCCACCCAGGTGATC
CGTCAGGGCAACAAGGTTTGGGTGCTGGATCAAGATAGCAGGCTTGAGGAGCAAACGCTGAAAACAGGCCTGGCAAACTG
GGCCTATACCGAAGTGCTTGAAGGGTTGTCTGAAGGGGATCAGGTACTGCTGTCCGGCGATAATGGAGAAATCAAAACGG
GCACACAAGTGACCCCCAAACCTCCTCAGCCATGA

Upstream 100 bases:

>100_bases
CGCGGTACGCATGTTCTGGCGTTACTACGTTATCCATACATGGCATAAACGAGCCAAGCGTAAGCGTCACTCCAACAATA
ACCCCTAACCTTTCATCTTC

Downstream 100 bases:

>100_bases
TACAGCTCCAGGGTATCACCCGGATTTTTCATATGGGGGATCAAGCTATCCATGCACTTGACCATATTGATCTGACAATC
GACTCTGGTGAATATGTTTC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MPGTRLLLRIAGIALLITAAGYITWHLTRSQPLEVELATVSRGAVEATVVNTRAGTIKACRRAKLSPQAGGQIIRMEIRE
GDRIKKDQVLLELWNTDLQAQHDLAKQQLATAESRRQESCILADNAQREYIRTQQLVEKGFVSVQRADDASATAKANRAA
CAATGAEVRRARAQIAVSQANLDRTQLIAPFAGVIAQITGELGEYVTPSPPGIPTPPAVDLIDDSCLYVSAPMDEVDAPK
IRVGQVARITLDALPGQIFEGKVRRIAPYVTEVEKQARTVDVEAEFANPDQAVLLVGYSADIEAIIDHRENVLRVPTQVI
RQGNKVWVLDQDSRLEEQTLKTGLANWAYTEVLEGLSEGDQVLLSGDNGEIKTGTQVTPKPPQP

Sequences:

>Translated_384_residues
MPGTRLLLRIAGIALLITAAGYITWHLTRSQPLEVELATVSRGAVEATVVNTRAGTIKACRRAKLSPQAGGQIIRMEIRE
GDRIKKDQVLLELWNTDLQAQHDLAKQQLATAESRRQESCILADNAQREYIRTQQLVEKGFVSVQRADDASATAKANRAA
CAATGAEVRRARAQIAVSQANLDRTQLIAPFAGVIAQITGELGEYVTPSPPGIPTPPAVDLIDDSCLYVSAPMDEVDAPK
IRVGQVARITLDALPGQIFEGKVRRIAPYVTEVEKQARTVDVEAEFANPDQAVLLVGYSADIEAIIDHRENVLRVPTQVI
RQGNKVWVLDQDSRLEEQTLKTGLANWAYTEVLEGLSEGDQVLLSGDNGEIKTGTQVTPKPPQP
>Mature_383_residues
PGTRLLLRIAGIALLITAAGYITWHLTRSQPLEVELATVSRGAVEATVVNTRAGTIKACRRAKLSPQAGGQIIRMEIREG
DRIKKDQVLLELWNTDLQAQHDLAKQQLATAESRRQESCILADNAQREYIRTQQLVEKGFVSVQRADDASATAKANRAAC
AATGAEVRRARAQIAVSQANLDRTQLIAPFAGVIAQITGELGEYVTPSPPGIPTPPAVDLIDDSCLYVSAPMDEVDAPKI
RVGQVARITLDALPGQIFEGKVRRIAPYVTEVEKQARTVDVEAEFANPDQAVLLVGYSADIEAIIDHRENVLRVPTQVIR
QGNKVWVLDQDSRLEEQTLKTGLANWAYTEVLEGLSEGDQVLLSGDNGEIKTGTQVTPKPPQP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=368, Percent_Identity=27.1739130434783, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87081951, Length=270, Percent_Identity=25.1851851851852, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789929, Length=377, Percent_Identity=25.9946949602122, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41773; Mature: 41642

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGTRLLLRIAGIALLITAAGYITWHLTRSQPLEVELATVSRGAVEATVVNTRAGTIKAC
CCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCHHHHH
RRAKLSPQAGGQIIRMEIREGDRIKKDQVLLELWNTDLQAQHDLAKQQLATAESRRQESC
HHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCE
ILADNAQREYIRTQQLVEKGFVSVQRADDASATAKANRAACAATGAEVRRARAQIAVSQA
EEECCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHHHCHHHHHHHHHHHHHHHC
NLDRTQLIAPFAGVIAQITGELGEYVTPSPPGIPTPPAVDLIDDSCLYVSAPMDEVDAPK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCC
IRVGQVARITLDALPGQIFEGKVRRIAPYVTEVEKQARTVDVEAEFANPDQAVLLVGYSA
EEECCEEEEEEECCCCHHHHCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEECC
DIEAIIDHRENVLRVPTQVIRQGNKVWVLDQDSRLEEQTLKTGLANWAYTEVLEGLSEGD
CHHHHHHCCHHHHHCCHHHHHCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCC
QVLLSGDNGEIKTGTQVTPKPPQP
EEEEECCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
PGTRLLLRIAGIALLITAAGYITWHLTRSQPLEVELATVSRGAVEATVVNTRAGTIKAC
CCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCHHHHH
RRAKLSPQAGGQIIRMEIREGDRIKKDQVLLELWNTDLQAQHDLAKQQLATAESRRQESC
HHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCE
ILADNAQREYIRTQQLVEKGFVSVQRADDASATAKANRAACAATGAEVRRARAQIAVSQA
EEECCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHHHCHHHHHHHHHHHHHHHC
NLDRTQLIAPFAGVIAQITGELGEYVTPSPPGIPTPPAVDLIDDSCLYVSAPMDEVDAPK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCC
IRVGQVARITLDALPGQIFEGKVRRIAPYVTEVEKQARTVDVEAEFANPDQAVLLVGYSA
EEECCEEEEEEECCCCHHHHCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEECC
DIEAIIDHRENVLRVPTQVIRQGNKVWVLDQDSRLEEQTLKTGLANWAYTEVLEGLSEGD
CHHHHHHCCHHHHHCCHHHHHCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCC
QVLLSGDNGEIKTGTQVTPKPPQP
EEEEECCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]