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The map label for this gene is argH

Identifier: 114331264

GI number: 114331264

Start: 1330762

End: 1332147

Strand: Direct

Name: argH

Synonym: Neut_1269

Alternate gene names: 114331264

Gene position: 1330762-1332147 (Clockwise)

Preceding gene: 114331262

Following gene: 114331265

Centisome position: 50.01

GC content: 52.6

Gene sequence:

>1386_bases
GTGGAAAAAGATAAAAAGACCTGGTCAGGTCGTTTCAGTGAACCTGTTGCACTACTGGTACAACGCTATACCGCATCAGT
CGGATTCGATTATCGACTGGCCGAGTACGATATTCAGGGATCGTTTGCGCATGCACGTATGCTGGCAGCCACAAATATCA
TCCCGCAAACTGATCTGGAAGCTATTGAAAAAGGGCTGACGCAGATCTGGGAAGAAATCAAAAATGGCCAGTTTGAGTGG
CAGCTTGAGCAGGAAGATGTACATCTGAACATTGAACGGCGTTTGACGGCGCTGACAGGGGATGCCGGAAAAAGACTGCA
TACCGCCCGCTCACGCAATGACCAGGTGGCCACCGATATTCGGCTCTACCTGCGCGCTGCCATAGATGAGATTATCGACC
TCATCTATGGCCTGCAATATGTATTACTGGATCTGGCGGAACAGCACGCTGCCACCATCATGCCTGGCTTTACCCATTTG
CAGGTGGCGCAACCAGTTTCATTCGGGCATCATCTGCTCGCCTACTATGAAATGCTGCTGCGCGATGGACAACGTCTGCA
GGATTGCAGAAAACGTGTCAATCAGCTACCGCTGGGAGCTGCCGCGCTGGCGGGCACCAGTTATCCGATCGATCGCGAAC
AGGTGGCACGCGAACTGGGGTTTGATGATATCTGTCATAACTCATTGGATGCTGTATCTGATCGTGATTTTGCGATTGAA
TTCTGTGCCAGTGCCGCGCTTATCATGATGCACCTCTCCCGCCTGTCAGAAGAGCTGATCCTATGGATGAGTCCGGCATT
TGGCTTCATCCGCATTGCAGACCGGTTCTGCACAGGTTCATCCATCATGCCACAAAAGAAAAATCCTGATGTGCCTGAGC
TGGTGCGTGGAAAAACCGGCCGCATCAACGGCCATCTGGTTGCACTGTTAACACTGATGAAATCACAGCCTCTGGCCTAT
AACAAGGACAACCAGGAAGACAAAGAGCCCTTGTTTGATACTGTGGATACCTTGAAAGATACGCTGACTATCTACGCCGA
CATGCTGGCCGGGCTGCAAGTTAATCCACAAGCCATGCGCCAGGCGGCATTGCGCGGCTACGCCACGGCGACTGATCTGG
CTGATTATCTGGTCAAAAAAGGAACTCCCTTTCGTGATGCGCACGAAACAGTTGCCCAGGCAGTCCGTTTCGCAGAAAAC
AAAAGATGTGACCTGGGTGAGCTCTCGCTTGCGGATCTGCAGCAATTCTCCGCAATTATCGAACAGGACGTATTTGAGGT
GCTGACACTGGAAGGTTCGCTGCAAAGCCGAAATCACCCCGGCGGCACCGCACCGGAGCAGGTACGCGCGGCTATCTGCC
GGGCACGTTCTCAATTGCCGGACTGA

Upstream 100 bases:

>100_bases
ATGCATATGTGTTGTGAAATCTGCCAGTCTTGTACAGATTCTTTCCGGGTTACGGGTAAAATGCAGGCTTTCAACCAACA
AACAGTAAGTAGATATTCCC

Downstream 100 bases:

>100_bases
AGTAGAAATGAAGCAGCAATGAAACGGAATATACAACAAGCTACTTCCCTTCCATGGACAGCCATTGCTGCGCAAATCTC
ACAGCTTACCCGGCAGGCGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MEKDKKTWSGRFSEPVALLVQRYTASVGFDYRLAEYDIQGSFAHARMLAATNIIPQTDLEAIEKGLTQIWEEIKNGQFEW
QLEQEDVHLNIERRLTALTGDAGKRLHTARSRNDQVATDIRLYLRAAIDEIIDLIYGLQYVLLDLAEQHAATIMPGFTHL
QVAQPVSFGHHLLAYYEMLLRDGQRLQDCRKRVNQLPLGAAALAGTSYPIDREQVARELGFDDICHNSLDAVSDRDFAIE
FCASAALIMMHLSRLSEELILWMSPAFGFIRIADRFCTGSSIMPQKKNPDVPELVRGKTGRINGHLVALLTLMKSQPLAY
NKDNQEDKEPLFDTVDTLKDTLTIYADMLAGLQVNPQAMRQAALRGYATATDLADYLVKKGTPFRDAHETVAQAVRFAEN
KRCDLGELSLADLQQFSAIIEQDVFEVLTLEGSLQSRNHPGGTAPEQVRAAICRARSQLPD

Sequences:

>Translated_461_residues
MEKDKKTWSGRFSEPVALLVQRYTASVGFDYRLAEYDIQGSFAHARMLAATNIIPQTDLEAIEKGLTQIWEEIKNGQFEW
QLEQEDVHLNIERRLTALTGDAGKRLHTARSRNDQVATDIRLYLRAAIDEIIDLIYGLQYVLLDLAEQHAATIMPGFTHL
QVAQPVSFGHHLLAYYEMLLRDGQRLQDCRKRVNQLPLGAAALAGTSYPIDREQVARELGFDDICHNSLDAVSDRDFAIE
FCASAALIMMHLSRLSEELILWMSPAFGFIRIADRFCTGSSIMPQKKNPDVPELVRGKTGRINGHLVALLTLMKSQPLAY
NKDNQEDKEPLFDTVDTLKDTLTIYADMLAGLQVNPQAMRQAALRGYATATDLADYLVKKGTPFRDAHETVAQAVRFAEN
KRCDLGELSLADLQQFSAIIEQDVFEVLTLEGSLQSRNHPGGTAPEQVRAAICRARSQLPD
>Mature_461_residues
MEKDKKTWSGRFSEPVALLVQRYTASVGFDYRLAEYDIQGSFAHARMLAATNIIPQTDLEAIEKGLTQIWEEIKNGQFEW
QLEQEDVHLNIERRLTALTGDAGKRLHTARSRNDQVATDIRLYLRAAIDEIIDLIYGLQYVLLDLAEQHAATIMPGFTHL
QVAQPVSFGHHLLAYYEMLLRDGQRLQDCRKRVNQLPLGAAALAGTSYPIDREQVARELGFDDICHNSLDAVSDRDFAIE
FCASAALIMMHLSRLSEELILWMSPAFGFIRIADRFCTGSSIMPQKKNPDVPELVRGKTGRINGHLVALLTLMKSQPLAY
NKDNQEDKEPLFDTVDTLKDTLTIYADMLAGLQVNPQAMRQAALRGYATATDLADYLVKKGTPFRDAHETVAQAVRFAEN
KRCDLGELSLADLQQFSAIIEQDVFEVLTLEGSLQSRNHPGGTAPEQVRAAICRARSQLPD

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=42.7312775330396, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=42.7312775330396, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=40.7488986784141, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=39.8678414096916, Blast_Score=327, Evalue=1e-89,
Organism=Escherichia coli, GI1790398, Length=453, Percent_Identity=46.3576158940397, Blast_Score=409, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=42.1397379912664, Blast_Score=354, Evalue=2e-98,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=41.5349887133183, Blast_Score=337, Evalue=9e-93,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=41.5349887133183, Blast_Score=337, Evalue=9e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_NITEC (Q0AGL1)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747486.1
- ProteinModelPortal:   Q0AGL1
- SMR:   Q0AGL1
- STRING:   Q0AGL1
- GeneID:   4271871
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1269
- NMPDR:   fig|335283.3.peg.910
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q0AGL1
- ProtClustDB:   PRK00855
- BioCyc:   NEUT335283:NEUT_1269-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51704; Mature: 51704

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKDKKTWSGRFSEPVALLVQRYTASVGFDYRLAEYDIQGSFAHARMLAATNIIPQTDLE
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHH
AIEKGLTQIWEEIKNGQFEWQLEQEDVHLNIERRLTALTGDAGKRLHTARSRNDQVATDI
HHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
RLYLRAAIDEIIDLIYGLQYVLLDLAEQHAATIMPGFTHLQVAQPVSFGHHLLAYYEMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHH
RDGQRLQDCRKRVNQLPLGAAALAGTSYPIDREQVARELGFDDICHNSLDAVSDRDFAIE
HCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHCCCHHHHCCHHHHCCCCHHHHH
FCASAALIMMHLSRLSEELILWMSPAFGFIRIADRFCTGSSIMPQKKNPDVPELVRGKTG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
RINGHLVALLTLMKSQPLAYNKDNQEDKEPLFDTVDTLKDTLTIYADMLAGLQVNPQAMR
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QAALRGYATATDLADYLVKKGTPFRDAHETVAQAVRFAENKRCDLGELSLADLQQFSAII
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EQDVFEVLTLEGSLQSRNHPGGTAPEQVRAAICRARSQLPD
HHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKDKKTWSGRFSEPVALLVQRYTASVGFDYRLAEYDIQGSFAHARMLAATNIIPQTDLE
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHH
AIEKGLTQIWEEIKNGQFEWQLEQEDVHLNIERRLTALTGDAGKRLHTARSRNDQVATDI
HHHHHHHHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
RLYLRAAIDEIIDLIYGLQYVLLDLAEQHAATIMPGFTHLQVAQPVSFGHHLLAYYEMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHH
RDGQRLQDCRKRVNQLPLGAAALAGTSYPIDREQVARELGFDDICHNSLDAVSDRDFAIE
HCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHCCCHHHHCCHHHHCCCCHHHHH
FCASAALIMMHLSRLSEELILWMSPAFGFIRIADRFCTGSSIMPQKKNPDVPELVRGKTG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
RINGHLVALLTLMKSQPLAYNKDNQEDKEPLFDTVDTLKDTLTIYADMLAGLQVNPQAMR
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QAALRGYATATDLADYLVKKGTPFRDAHETVAQAVRFAENKRCDLGELSLADLQQFSAII
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EQDVFEVLTLEGSLQSRNHPGGTAPEQVRAAICRARSQLPD
HHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA