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The map label for this gene is regB [H]

Identifier: 114331246

GI number: 114331246

Start: 1306549

End: 1307847

Strand: Direct

Name: regB [H]

Synonym: Neut_1250

Alternate gene names: 114331246

Gene position: 1306549-1307847 (Clockwise)

Preceding gene: 114331245

Following gene: 114331247

Centisome position: 49.1

GC content: 45.19

Gene sequence:

>1299_bases
ATGGGTATTTTCAGTATTCTGAACCAGTCACCTTCTGGCAAAAATCTACAGCGTTTATTCCAGCTCAGGATTATTGCCAT
CGTTTTCCAAATCATTGTTTTTGGGGCTGTCCACAGTCTTATCGAACTTGAACTGCCATGGACAGCAATTATTCTGACTG
TTTTCATGCTTGCGGTTCTAAATTTCTTCACCTGGGTTCGTCTGCGTTATCCTTGGCCAGTAACTTACCCCGAATTTTTC
ACTCAGTTGCTGATTGATGTTGCCGGATTGACTGCATTACTATATTTTAGCGGTGGATCAACCAATCCTTTTATCTCACT
CTATCTGCTTCCGCTTACAATCGCTGCGACTGTGCTGCCATGGCACTATACCTGGGGTATGGCAGTGATCACAATTTCCT
GCTATACTCTCCTGTTATTTAAATACATCCCCTTCCCGCATGATCATCTCGATGATCACAGCCGGCATATGTTTGAATTC
AATTTGCACGTCTCAGGAATGTGGCTGACATTTGTATTGAGCACCTTACTCATTACCTCGTTTGTTGTCAGAATGAATGC
TTCTATTCGTGACCGAGACAAGGAGTTGTCCAGATCGCGTGAACGAGCACTACAAAATGAGCAGATTATTGCCCTGGGCA
CCCTTGCCGCCGGAGCAGCACATGAGCTGAGCACCCCTTTATCAACCATGGCTATTATTACGGGTGAATTACAGCAGGAA
TCTCTCGAAAATACTGAATTTCAGCATAATATTCGCATCCTGCGCGACCAGATTTCTCATTGCAAACAAACGCTGACTCA
TCTGCTGGCAGATGCCGGACAAACCAGAGTAGAAGAAGGCAATGGACAACCTGTCGATCTTTTTTTACAACAGGTAATTG
ATAAATGGCAGCTGATCCGTCCATCTGTCAAATTCACCCATCAATGTGAAGGCACAAAGCCAGCACCGATTATCATGAAT
ACTCGCCTGCTGAGCCAATCTATCCTGAACTTGTTGAACAACGCAGCGGATGCCTCAACCAGACTGGTAACCATCACCAG
TCGCTGGGATGAAAAACAGTTGCACCTCGAAATACTCGATGATGGGACAGGGTTAAACACAGAAGCTGTCGAACATGCAG
GGGAGCCTTTTTTTACCAGTAAGGGGCCAGGACAAGGTTTTGGTATCGGATTATTTCTCGCCAATACTAATATTGAACGC
TTTGGCGGGAATGTACGTTTATTTAATCGACCCGAAGGAGGGGCATGTACTCATGTCACCATTCCGGTTTCGCACAGAAC
AACCAGTACTTCACTATGA

Upstream 100 bases:

>100_bases
TTAATCTACCCGGCAAAAATCGACAATCTGTTATTTAACAGACTAATCCTGATACCTGCCATAGCAAACCAGTAGACTTA
ACAGAGCAAACCAACGGGTC

Downstream 100 bases:

>100_bases
AAGGAGAATGCCCTGTGAATGATTCCATGGATCGCCCAAGCCTGTTAATTGTAGATGATGATGAAGTTTTTTGTGATGTA
CTGGCAAGGGCGATGACAAA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Protein prrB [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MGIFSILNQSPSGKNLQRLFQLRIIAIVFQIIVFGAVHSLIELELPWTAIILTVFMLAVLNFFTWVRLRYPWPVTYPEFF
TQLLIDVAGLTALLYFSGGSTNPFISLYLLPLTIAATVLPWHYTWGMAVITISCYTLLLFKYIPFPHDHLDDHSRHMFEF
NLHVSGMWLTFVLSTLLITSFVVRMNASIRDRDKELSRSRERALQNEQIIALGTLAAGAAHELSTPLSTMAIITGELQQE
SLENTEFQHNIRILRDQISHCKQTLTHLLADAGQTRVEEGNGQPVDLFLQQVIDKWQLIRPSVKFTHQCEGTKPAPIIMN
TRLLSQSILNLLNNAADASTRLVTITSRWDEKQLHLEILDDGTGLNTEAVEHAGEPFFTSKGPGQGFGIGLFLANTNIER
FGGNVRLFNRPEGGACTHVTIPVSHRTTSTSL

Sequences:

>Translated_432_residues
MGIFSILNQSPSGKNLQRLFQLRIIAIVFQIIVFGAVHSLIELELPWTAIILTVFMLAVLNFFTWVRLRYPWPVTYPEFF
TQLLIDVAGLTALLYFSGGSTNPFISLYLLPLTIAATVLPWHYTWGMAVITISCYTLLLFKYIPFPHDHLDDHSRHMFEF
NLHVSGMWLTFVLSTLLITSFVVRMNASIRDRDKELSRSRERALQNEQIIALGTLAAGAAHELSTPLSTMAIITGELQQE
SLENTEFQHNIRILRDQISHCKQTLTHLLADAGQTRVEEGNGQPVDLFLQQVIDKWQLIRPSVKFTHQCEGTKPAPIIMN
TRLLSQSILNLLNNAADASTRLVTITSRWDEKQLHLEILDDGTGLNTEAVEHAGEPFFTSKGPGQGFGIGLFLANTNIER
FGGNVRLFNRPEGGACTHVTIPVSHRTTSTSL
>Mature_431_residues
GIFSILNQSPSGKNLQRLFQLRIIAIVFQIIVFGAVHSLIELELPWTAIILTVFMLAVLNFFTWVRLRYPWPVTYPEFFT
QLLIDVAGLTALLYFSGGSTNPFISLYLLPLTIAATVLPWHYTWGMAVITISCYTLLLFKYIPFPHDHLDDHSRHMFEFN
LHVSGMWLTFVLSTLLITSFVVRMNASIRDRDKELSRSRERALQNEQIIALGTLAAGAAHELSTPLSTMAIITGELQQES
LENTEFQHNIRILRDQISHCKQTLTHLLADAGQTRVEEGNGQPVDLFLQQVIDKWQLIRPSVKFTHQCEGTKPAPIIMNT
RLLSQSILNLLNNAADASTRLVTITSRWDEKQLHLEILDDGTGLNTEAVEHAGEPFFTSKGPGQGFGIGLFLANTNIERF
GGNVRLFNRPEGGACTHVTIPVSHRTTSTSL

Specific function: Member of the two-component regulatory system RegB/RegA. Involved in the positive regulation of photosynthesis gene expression in response to anaerobiosis. Also involved in positive regulation of the cbbI and cbbII Calvin cycle CO2 fixation operons, as we

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=24.4725738396624, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=22.4719101123595, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786912, Length=260, Percent_Identity=25, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48536; Mature: 48405

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIFSILNQSPSGKNLQRLFQLRIIAIVFQIIVFGAVHSLIELELPWTAIILTVFMLAVL
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
NFFTWVRLRYPWPVTYPEFFTQLLIDVAGLTALLYFSGGSTNPFISLYLLPLTIAATVLP
HHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHC
WHYTWGMAVITISCYTLLLFKYIPFPHDHLDDHSRHMFEFNLHVSGMWLTFVLSTLLITS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHH
FVVRMNASIRDRDKELSRSRERALQNEQIIALGTLAAGAAHELSTPLSTMAIITGELQQE
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHCCCHHHHCCCHHHHHHHHHHHHHH
SLENTEFQHNIRILRDQISHCKQTLTHLLADAGQTRVEEGNGQPVDLFLQQVIDKWQLIR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHCC
PSVKFTHQCEGTKPAPIIMNTRLLSQSILNLLNNAADASTRLVTITSRWDEKQLHLEILD
CCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEEE
DGTGLNTEAVEHAGEPFFTSKGPGQGFGIGLFLANTNIERFGGNVRLFNRPEGGACTHVT
CCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCHHHHCCCEEEEECCCCCCEEEEE
IPVSHRTTSTSL
EEECCCCCCCCC
>Mature Secondary Structure 
GIFSILNQSPSGKNLQRLFQLRIIAIVFQIIVFGAVHSLIELELPWTAIILTVFMLAVL
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
NFFTWVRLRYPWPVTYPEFFTQLLIDVAGLTALLYFSGGSTNPFISLYLLPLTIAATVLP
HHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHC
WHYTWGMAVITISCYTLLLFKYIPFPHDHLDDHSRHMFEFNLHVSGMWLTFVLSTLLITS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHH
FVVRMNASIRDRDKELSRSRERALQNEQIIALGTLAAGAAHELSTPLSTMAIITGELQQE
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHCCCHHHHCCCHHHHHHHHHHHHHH
SLENTEFQHNIRILRDQISHCKQTLTHLLADAGQTRVEEGNGQPVDLFLQQVIDKWQLIR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHCC
PSVKFTHQCEGTKPAPIIMNTRLLSQSILNLLNNAADASTRLVTITSRWDEKQLHLEILD
CCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEEEEE
DGTGLNTEAVEHAGEPFFTSKGPGQGFGIGLFLANTNIERFGGNVRLFNRPEGGACTHVT
CCCCCCHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCHHHHCCCEEEEECCCCCCEEEEE
IPVSHRTTSTSL
EEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751278; 10358089 [H]