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The map label for this gene is lptD

Identifier: 114331214

GI number: 114331214

Start: 1272424

End: 1274601

Strand: Direct

Name: lptD

Synonym: Neut_1216

Alternate gene names: 114331214

Gene position: 1272424-1274601 (Clockwise)

Preceding gene: 114331211

Following gene: 114331215

Centisome position: 47.82

GC content: 46.83

Gene sequence:

>2178_bases
ATGAGTCTTCTGTCAAAATTACATTTAATACTGTACATCTGCTTGTTGCTGCTGCCGCTTCGATTCGTGAATGCGGAGCA
ATTATCCGGATCAGGCGAATCTCAACCGGTTCATATTGAAGCAGATCGGATCGATGGGCATTATCAGCAGGAAATTGAGG
CAACCGGCAATGTGCGGATGCGTCGTGGTGATCAGACATTATCAGCCGATCACGTTAAATATTATCAGGATACAGAAGAT
GTGGAGGTGAAAGGTAATGCGCTGCTTGAGCGCCCTGACGATACGCTATGGGGTACCTTCCTGCAGATGAATCTACAGAC
CGATATTGGCGAGTTGCGTGATCCTCGCTACGCTCTCAAGGGTGGAAATGGGCGGGGCAGCGGGAGCCTGCTGCTACTAG
AAGGAGAAAATCAGTACAGAATCAAGAAAGCGCGTTATACCACTTGTCCGGAAGATAATCATGACTGGTACATTTTGGCG
GATGATCTGGAAATAGATAATGAAAAAAAAGTAGGAACTGCACGCCATGCTTCAATCCGGTTCAAGGATGTGCCGATTCT
TTACCTACCGTGGATGAACTTTTCCTTCAGCAAGGAACGAAAAACCGGCTTTCTGTCGCCTATTATGGGTAACACAAGTA
GAAGCGGAGTCGAAGTATCAGTTCCTTTTTACTGGAATATTGCACCCAATTATGATGCCACGATTACGCCGCGCCTCATG
AGCAGGCGTGGTGTCATGCTGGATAACGAGTTTCGCTACATCGGACAGGGACTCGGTGGTCGTTTACAGTTTGATTATTT
GCCGAATGATCTGGTAACCGATACAACGCGCTATGGCTTACAGTTTAATCACTCCCAATTTCTTGGATCTGGGTGGTTTG
GGGCGTTGAACTACAACCGGGTATCTGATCACAATTATTTCCGGGATCTGGGTAACAATATTCTGTTTACTTCTCAAGTC
AACCTGCTGCAACAGGCAACGGCAAGTTATTTCAGTGAACTGGGCCGCAATGGCATGCTCACATTCAGTACACTTATGCA
ACAATTTCAGACAGTTCAGGACCCCAGGGCGCCTATTATTTCACCCTTCAAAATCCTGCCACGATTCACACTGAACGCAG
TGAAAAGTAATGTCTATGGTCTGGATTTCGACCTTGCCAGCAGTTTTACGCACTTTTCTCACCCGACATTACCGCATGGT
TTACGTTTTACAGCATTCCCCAGTGTTGCTTTGCCACTAGAAAACTCCTTTGGTTTCATTCGGCCACGGGTGGGGCTGCA
CTACACAAAATATGATTTGAATACACCAGCCTTTCCAGGCACAAATGATAAGCATCCTGACCGATCTGTGCCGATATTCA
GCCTGGATAGCGGCGTGGTACTGGAGCGTGATATGACATTAGGGGGTGGGAATTTTATTCAAACCCTGGAGCCACGCGTT
TTTTATACCTATATTCCATACAGAGAACAGCGGCTGTTACCCAACTTTGATTCGGCAGAAATGGACTTTAGTTTTGCCCA
GCTGTTCATGGAAAAAAGGTTTAGTGGTGAAGATCGAATCAATGATGCCAATGAAATTACGCTGGCAATGAGTTCACGCC
TGATTCATTCAGCGACCGGTAATGAACGCCTGCGCTTTTCTGTAGGGCAAAGAATTCGTTTCAGCGATCGCCGGGTCTTG
CTAACCTCACCCCAGGTCACAAGGGCAGGATCCGATTTTATTGCAGAACTTTCCGGTAGTCTTGCACAGCATGTCAAGAC
TGACGCAGGGATACAGCTTAACCAGAATAACCTGCTGATAGAAAAAATTCGTACCGGCATCAGCTATAACCCGGCCCCAG
GTCAGGTTATAAACGCTGGCTATCGTTTTACCAGGGATGTTCTGGAACAGGTTGACTTGTCTACTCAGTGGCCTTTCCTG
AAAAGATGGCAGGGCTTTGCCGCTATCAATTATTCTTTGAAAAATGACAAGCTGCTTGCCGGCCTGCTAGGTCTTGAATA
TAACGCCTGCTGCTGGTCACTGCGCCTGGTAGCCAGCCGCTTTACGACGGCAACACAAAAAACCTCAACCAATATTTTCG
TTCAACTGGAATTGAACGATTTAATGAGAATCGGTACCAATCCGATACGTGTGCTGCAACAGAGTATTCCAGGTTACGTA
AGGACAGACTTGCAATGA

Upstream 100 bases:

>100_bases
ACCAGACCTTTGTTCCGATTATCCACCCGGGATAATTACCGGATAATGGTGCCTTTATTAAAAGACATCCAGAAAAAATC
CATTTAAGTCCTGGTCCTGA

Downstream 100 bases:

>100_bases
TCCGATTAAGCCAGTTTATACAGTCAAAGTTTGGAAAGTTCGCATTGATCGGAGCTTTTACCACTATGTGGGTGGTAAAT
ATTTCTGCACAAAATTTCCA

Product: organic solvent tolerance protein

Products: NA

Alternate protein names: Organic solvent tolerance protein

Number of amino acids: Translated: 725; Mature: 724

Protein sequence:

>725_residues
MSLLSKLHLILYICLLLLPLRFVNAEQLSGSGESQPVHIEADRIDGHYQQEIEATGNVRMRRGDQTLSADHVKYYQDTED
VEVKGNALLERPDDTLWGTFLQMNLQTDIGELRDPRYALKGGNGRGSGSLLLLEGENQYRIKKARYTTCPEDNHDWYILA
DDLEIDNEKKVGTARHASIRFKDVPILYLPWMNFSFSKERKTGFLSPIMGNTSRSGVEVSVPFYWNIAPNYDATITPRLM
SRRGVMLDNEFRYIGQGLGGRLQFDYLPNDLVTDTTRYGLQFNHSQFLGSGWFGALNYNRVSDHNYFRDLGNNILFTSQV
NLLQQATASYFSELGRNGMLTFSTLMQQFQTVQDPRAPIISPFKILPRFTLNAVKSNVYGLDFDLASSFTHFSHPTLPHG
LRFTAFPSVALPLENSFGFIRPRVGLHYTKYDLNTPAFPGTNDKHPDRSVPIFSLDSGVVLERDMTLGGGNFIQTLEPRV
FYTYIPYREQRLLPNFDSAEMDFSFAQLFMEKRFSGEDRINDANEITLAMSSRLIHSATGNERLRFSVGQRIRFSDRRVL
LTSPQVTRAGSDFIAELSGSLAQHVKTDAGIQLNQNNLLIEKIRTGISYNPAPGQVINAGYRFTRDVLEQVDLSTQWPFL
KRWQGFAAINYSLKNDKLLAGLLGLEYNACCWSLRLVASRFTTATQKTSTNIFVQLELNDLMRIGTNPIRVLQQSIPGYV
RTDLQ

Sequences:

>Translated_725_residues
MSLLSKLHLILYICLLLLPLRFVNAEQLSGSGESQPVHIEADRIDGHYQQEIEATGNVRMRRGDQTLSADHVKYYQDTED
VEVKGNALLERPDDTLWGTFLQMNLQTDIGELRDPRYALKGGNGRGSGSLLLLEGENQYRIKKARYTTCPEDNHDWYILA
DDLEIDNEKKVGTARHASIRFKDVPILYLPWMNFSFSKERKTGFLSPIMGNTSRSGVEVSVPFYWNIAPNYDATITPRLM
SRRGVMLDNEFRYIGQGLGGRLQFDYLPNDLVTDTTRYGLQFNHSQFLGSGWFGALNYNRVSDHNYFRDLGNNILFTSQV
NLLQQATASYFSELGRNGMLTFSTLMQQFQTVQDPRAPIISPFKILPRFTLNAVKSNVYGLDFDLASSFTHFSHPTLPHG
LRFTAFPSVALPLENSFGFIRPRVGLHYTKYDLNTPAFPGTNDKHPDRSVPIFSLDSGVVLERDMTLGGGNFIQTLEPRV
FYTYIPYREQRLLPNFDSAEMDFSFAQLFMEKRFSGEDRINDANEITLAMSSRLIHSATGNERLRFSVGQRIRFSDRRVL
LTSPQVTRAGSDFIAELSGSLAQHVKTDAGIQLNQNNLLIEKIRTGISYNPAPGQVINAGYRFTRDVLEQVDLSTQWPFL
KRWQGFAAINYSLKNDKLLAGLLGLEYNACCWSLRLVASRFTTATQKTSTNIFVQLELNDLMRIGTNPIRVLQQSIPGYV
RTDLQ
>Mature_724_residues
SLLSKLHLILYICLLLLPLRFVNAEQLSGSGESQPVHIEADRIDGHYQQEIEATGNVRMRRGDQTLSADHVKYYQDTEDV
EVKGNALLERPDDTLWGTFLQMNLQTDIGELRDPRYALKGGNGRGSGSLLLLEGENQYRIKKARYTTCPEDNHDWYILAD
DLEIDNEKKVGTARHASIRFKDVPILYLPWMNFSFSKERKTGFLSPIMGNTSRSGVEVSVPFYWNIAPNYDATITPRLMS
RRGVMLDNEFRYIGQGLGGRLQFDYLPNDLVTDTTRYGLQFNHSQFLGSGWFGALNYNRVSDHNYFRDLGNNILFTSQVN
LLQQATASYFSELGRNGMLTFSTLMQQFQTVQDPRAPIISPFKILPRFTLNAVKSNVYGLDFDLASSFTHFSHPTLPHGL
RFTAFPSVALPLENSFGFIRPRVGLHYTKYDLNTPAFPGTNDKHPDRSVPIFSLDSGVVLERDMTLGGGNFIQTLEPRVF
YTYIPYREQRLLPNFDSAEMDFSFAQLFMEKRFSGEDRINDANEITLAMSSRLIHSATGNERLRFSVGQRIRFSDRRVLL
TSPQVTRAGSDFIAELSGSLAQHVKTDAGIQLNQNNLLIEKIRTGISYNPAPGQVINAGYRFTRDVLEQVDLSTQWPFLK
RWQGFAAINYSLKNDKLLAGLLGLEYNACCWSLRLVASRFTTATQKTSTNIFVQLELNDLMRIGTNPIRVLQQSIPGYVR
TDLQ

Specific function: Involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis

COG id: COG1452

COG function: function code M; Organic solvent tolerance protein OstA

Gene ontology:

Cell location: Cell outer membrane

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lptD family

Homologues:

Organism=Escherichia coli, GI1786239, Length=715, Percent_Identity=28.5314685314685, Blast_Score=291, Evalue=1e-79,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): LPTD_NITEC (Q0AGR1)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747436.1
- ProteinModelPortal:   Q0AGR1
- SMR:   Q0AGR1
- STRING:   Q0AGR1
- GeneID:   4272176
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1216
- NMPDR:   fig|335283.3.peg.1123
- eggNOG:   COG1452
- HOGENOM:   HBG701380
- OMA:   TPYYWNI
- PhylomeDB:   Q0AGR1
- ProtClustDB:   CLSK585519
- BioCyc:   NEUT335283:NEUT_1216-MONOMER
- HAMAP:   MF_01411
- InterPro:   IPR020889
- InterPro:   IPR005653
- InterPro:   IPR007543

Pfam domain/function: PF03968 OstA; PF04453 OstA_C

EC number: NA

Molecular weight: Translated: 82358; Mature: 82227

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLSKLHLILYICLLLLPLRFVNAEQLSGSGESQPVHIEADRIDGHYQQEIEATGNVRM
CCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEECCCCCHHHHHHHCCCCEEE
RRGDQTLSADHVKYYQDTEDVEVKGNALLERPDDTLWGTFLQMNLQTDIGELRDPRYALK
ECCCCCCCCCCCEEECCCCCEEECCCEEEECCCCCCEEEEEEEEECCCHHHHCCCCEEEE
GGNGRGSGSLLLLEGENQYRIKKARYTTCPEDNHDWYILADDLEIDNEKKVGTARHASIR
CCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEECEEE
FKDVPILYLPWMNFSFSKERKTGFLSPIMGNTSRSGVEVSVPFYWNIAPNYDATITPRLM
EECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCEECHHHH
SRRGVMLDNEFRYIGQGLGGRLQFDYLPNDLVTDTTRYGLQFNHSQFLGSGWFGALNYNR
HCCCCEECCCHHHHHCCCCCEEEEEECCCCHHCCCHHHCEEECCHHHCCCCCEEEEECCC
VSDHNYFRDLGNNILFTSQVNLLQQATASYFSELGRNGMLTFSTLMQQFQTVQDPRAPII
CCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCC
SPFKILPRFTLNAVKSNVYGLDFDLASSFTHFSHPTLPHGLRFTAFPSVALPLENSFGFI
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCEE
RPRVGLHYTKYDLNTPAFPGTNDKHPDRSVPIFSLDSGVVLERDMTLGGGNFIQTLEPRV
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEEEECEECCCCCEEEECCCEE
FYTYIPYREQRLLPNFDSAEMDFSFAQLFMEKRFSGEDRINDANEITLAMSSRLIHSATG
EEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHCCCCC
NERLRFSVGQRIRFSDRRVLLTSPQVTRAGSDFIAELSGSLAQHVKTDAGIQLNQNNLLI
CCEEEEECCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCEEH
EKIRTGISYNPAPGQVINAGYRFTRDVLEQVDLSTQWPFLKRWQGFAAINYSLKNDKLLA
HHHHCCCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEECCCCCEEE
GLLGLEYNACCWSLRLVASRFTTATQKTSTNIFVQLELNDLMRIGTNPIRVLQQSIPGYV
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCHHHHHHHHCCCCE
RTDLQ
ECCCC
>Mature Secondary Structure 
SLLSKLHLILYICLLLLPLRFVNAEQLSGSGESQPVHIEADRIDGHYQQEIEATGNVRM
CHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEECCCCCHHHHHHHCCCCEEE
RRGDQTLSADHVKYYQDTEDVEVKGNALLERPDDTLWGTFLQMNLQTDIGELRDPRYALK
ECCCCCCCCCCCEEECCCCCEEECCCEEEECCCCCCEEEEEEEEECCCHHHHCCCCEEEE
GGNGRGSGSLLLLEGENQYRIKKARYTTCPEDNHDWYILADDLEIDNEKKVGTARHASIR
CCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCEEECEEE
FKDVPILYLPWMNFSFSKERKTGFLSPIMGNTSRSGVEVSVPFYWNIAPNYDATITPRLM
EECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCEECHHHH
SRRGVMLDNEFRYIGQGLGGRLQFDYLPNDLVTDTTRYGLQFNHSQFLGSGWFGALNYNR
HCCCCEECCCHHHHHCCCCCEEEEEECCCCHHCCCHHHCEEECCHHHCCCCCEEEEECCC
VSDHNYFRDLGNNILFTSQVNLLQQATASYFSELGRNGMLTFSTLMQQFQTVQDPRAPII
CCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCC
SPFKILPRFTLNAVKSNVYGLDFDLASSFTHFSHPTLPHGLRFTAFPSVALPLENSFGFI
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCEE
RPRVGLHYTKYDLNTPAFPGTNDKHPDRSVPIFSLDSGVVLERDMTLGGGNFIQTLEPRV
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCEEEEECEECCCCCEEEECCCEE
FYTYIPYREQRLLPNFDSAEMDFSFAQLFMEKRFSGEDRINDANEITLAMSSRLIHSATG
EEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHCCCCC
NERLRFSVGQRIRFSDRRVLLTSPQVTRAGSDFIAELSGSLAQHVKTDAGIQLNQNNLLI
CCEEEEECCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCEEH
EKIRTGISYNPAPGQVINAGYRFTRDVLEQVDLSTQWPFLKRWQGFAAINYSLKNDKLLA
HHHHCCCCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEECCCCCEEE
GLLGLEYNACCWSLRLVASRFTTATQKTSTNIFVQLELNDLMRIGTNPIRVLQQSIPGYV
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCHHHHHHHHCCCCE
RTDLQ
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA