Click here to switch to the map view.

The map label for this gene is pth

Identifier: 114331140

GI number: 114331140

Start: 1181029

End: 1181616

Strand: Direct

Name: pth

Synonym: Neut_1142

Alternate gene names: 114331140

Gene position: 1181029-1181616 (Clockwise)

Preceding gene: 114331139

Following gene: 114331141

Centisome position: 44.38

GC content: 51.87

Gene sequence:

>588_bases
ATGGAACTACCCATAAGGTTGGTGGTCGGCCTTGGCAATCCTGGCGATAAATATACCTCAACCCGCCATAATATCGGTTC
TGATTGGCTGGATCGTTTGGCTGATGCGCAGCGAGTTTCTTTTGCGCTGGATATCCGTTTCAGGGGATTGTGTGCACGCA
TTGTTCAATCCGATACAGATATCTGGTTGCTCAAGCCGCAAACCTACATGAATGCCAGCGGTATGTCGGTGGGGGCCATG
TGTCGTTACTACAAGATAACACCCGAGCAGATACTGGTCGTCCACGATGAGCTGGATTTGCAACCCGGTATTATCAAGCT
GAAATCCGGTGGTGGGACCGGGGGGCACAATGGCCTTAAAAGTATCGTTGCTGATCTTTCCACTCAGGTTTTCTGGCGCT
TGCGGATTGGCGTGGGGCATCCGGGGGACAGAAATCAGGTAGTGGATTATGTGCTACACCTCCCGCGCAGAGAAGAAGCG
GCGCTGATTGATGAGGCAATAGACCACAGCATACAAGTGTGGCCACTAATCGCCCGAGGAAATTTTGCAGCAGCCATGCA
GCAATTGCATACCCGGCAGGAAAACTGA

Upstream 100 bases:

>100_bases
GTCTGATGTACGCCAGAGAATTTCTCTGGCGTAATTCTTGCTATTCTGAAATTCACTTCACTTTTTGTTGAGTCATCTGT
TGTCGGGACTGTACTGAGTT

Downstream 100 bases:

>100_bases
CAAAACAAGCAGCGTACTCTACGCAACATTCAGGAAATTGATGGAAACCGGATTATGAGCTTGAAATGTGGAATCGTCGG
TTTGCCCAATGTCGGCAAAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MELPIRLVVGLGNPGDKYTSTRHNIGSDWLDRLADAQRVSFALDIRFRGLCARIVQSDTDIWLLKPQTYMNASGMSVGAM
CRYYKITPEQILVVHDELDLQPGIIKLKSGGGTGGHNGLKSIVADLSTQVFWRLRIGVGHPGDRNQVVDYVLHLPRREEA
ALIDEAIDHSIQVWPLIARGNFAAAMQQLHTRQEN

Sequences:

>Translated_195_residues
MELPIRLVVGLGNPGDKYTSTRHNIGSDWLDRLADAQRVSFALDIRFRGLCARIVQSDTDIWLLKPQTYMNASGMSVGAM
CRYYKITPEQILVVHDELDLQPGIIKLKSGGGTGGHNGLKSIVADLSTQVFWRLRIGVGHPGDRNQVVDYVLHLPRREEA
ALIDEAIDHSIQVWPLIARGNFAAAMQQLHTRQEN
>Mature_195_residues
MELPIRLVVGLGNPGDKYTSTRHNIGSDWLDRLADAQRVSFALDIRFRGLCARIVQSDTDIWLLKPQTYMNASGMSVGAM
CRYYKITPEQILVVHDELDLQPGIIKLKSGGGTGGHNGLKSIVADLSTQVFWRLRIGVGHPGDRNQVVDYVLHLPRREEA
ALIDEAIDHSIQVWPLIARGNFAAAMQQLHTRQEN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=37.0588235294118, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=46.3157894736842, Blast_Score=157, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_NITEC (Q0AGY5)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747362.1
- ProteinModelPortal:   Q0AGY5
- SMR:   Q0AGY5
- STRING:   Q0AGY5
- GeneID:   4274108
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1142
- NMPDR:   fig|335283.3.peg.975
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- PhylomeDB:   Q0AGY5
- ProtClustDB:   PRK05426
- BioCyc:   NEUT335283:NEUT_1142-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21765; Mature: 21765

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPIRLVVGLGNPGDKYTSTRHNIGSDWLDRLADAQRVSFALDIRFRGLCARIVQSDTD
CCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCCC
IWLLKPQTYMNASGMSVGAMCRYYKITPEQILVVHDELDLQPGIIKLKSGGGTGGHNGLK
EEEECCHHHCCCCCCCHHHEEEEEEECHHHEEEEECCCCCCCCEEEEECCCCCCCHHHHH
SIVADLSTQVFWRLRIGVGHPGDRNQVVDYVLHLPRREEAALIDEAIDHSIQVWPLIARG
HHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECC
NFAAAMQQLHTRQEN
CHHHHHHHHHHCCCC
>Mature Secondary Structure
MELPIRLVVGLGNPGDKYTSTRHNIGSDWLDRLADAQRVSFALDIRFRGLCARIVQSDTD
CCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCCC
IWLLKPQTYMNASGMSVGAMCRYYKITPEQILVVHDELDLQPGIIKLKSGGGTGGHNGLK
EEEECCHHHCCCCCCCHHHEEEEEEECHHHEEEEECCCCCCCCEEEEECCCCCCCHHHHH
SIVADLSTQVFWRLRIGVGHPGDRNQVVDYVLHLPRREEAALIDEAIDHSIQVWPLIARG
HHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEECC
NFAAAMQQLHTRQEN
CHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA