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The map label for this gene is prs [H]

Identifier: 114331138

GI number: 114331138

Start: 1179312

End: 1180262

Strand: Direct

Name: prs [H]

Synonym: Neut_1140

Alternate gene names: 114331138

Gene position: 1179312-1180262 (Clockwise)

Preceding gene: 114331137

Following gene: 114331139

Centisome position: 44.32

GC content: 45.01

Gene sequence:

>951_bases
ATGTCCTATGATAGCCTGATGGTTTTTACCGGAACGGCCAATCCTAAGCTGGCGCATGATGTGGTCAAATACCTGAATAT
CAATTTAGGGCGTGCGACCGTAGGGCGCTTCAGTGATGGCGAAGTTATGGTGGAGATACTTGAAAACGTCAGAGGTAACG
ATGTTTTTGTATTGCAATCCACCTGTGCACCAACCAACGACAGTTTGATGGAAATTCTGGTGATTGTTGATGCACTAAAA
CGCGCATCAGCTAGCCGCGTTACTGCAGCGATTCCCTATTTTGGCTATGCGCGACAGGACAGGAGAGCTCGTTCTGCACG
AGTGCCTATTACAGCTAAAGTTGTGGCAAATATGTTGACCAGCGTTGGTGTTGATAGAGTATTGACTATGGATTTGCATT
CTGATCAGATTCAGGGTTTTTTTGATATTCCTGTGGATAATATTTATGGCACTCCTACACTGTTGGGAGACATCTGGAAG
CATGATTATCAGAACCTGATCGTGGTATCTCCTGATGTGGGTGGCGTTGTCAGAGCTCGTCATATGGCCAGGCGTTTGGA
ATGTGATCTGGCTATTATCGACAAGCGACGCCCCAAACCAAATGAATCCAAGGTCATGAACATTATCGGCGACGTCAAAG
AGCGTACCTGTGTAATTATTGACGATATGGTGGATACAGCAAATACATTATGTGAAGCAGCTTCGGCACTTAAACAGGAA
GGTGCGGCTAGCGTGATTGCTTATTCAACCCATGCAGTTTTGTCAGGCAAGGCGGTAGAGCGTGTACAGAATTCTGATCT
GGATAAGCTGGTGGTAACAGATACAATCCCTTTAAGAGAAGATGCCAGCAAATGTAACCGTATACAGCAGTTAAGTGTGG
CTAGTTTGCTGGGTGAATCCATGCTTAGGGTAAGTAATGAAAGTTCACTGAGTTCGTTGTTTATAGAATAA

Upstream 100 bases:

>100_bases
CCCAGCCAAATCTCAGTGAATCTGCCATTATTATGTCAAATGTGGCGCAAGTGGCCGAATCTGTCTGTGTCATCTTTTAA
ACCAGAAGTAAAAGTTACCT

Downstream 100 bases:

>100_bases
GATAATTTTAAGGTCTGTTCACGGATGTGATGGGCTGTTTTCAGGAGAATAGAATGCCAATTGAGATAAGCGCTAACAGT
CGTAATTTACATGGAACCGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSYDSLMVFTGTANPKLAHDVVKYLNINLGRATVGRFSDGEVMVEILENVRGNDVFVLQSTCAPTNDSLMEILVIVDALK
RASASRVTAAIPYFGYARQDRRARSARVPITAKVVANMLTSVGVDRVLTMDLHSDQIQGFFDIPVDNIYGTPTLLGDIWK
HDYQNLIVVSPDVGGVVRARHMARRLECDLAIIDKRRPKPNESKVMNIIGDVKERTCVIIDDMVDTANTLCEAASALKQE
GAASVIAYSTHAVLSGKAVERVQNSDLDKLVVTDTIPLREDASKCNRIQQLSVASLLGESMLRVSNESSLSSLFIE

Sequences:

>Translated_316_residues
MSYDSLMVFTGTANPKLAHDVVKYLNINLGRATVGRFSDGEVMVEILENVRGNDVFVLQSTCAPTNDSLMEILVIVDALK
RASASRVTAAIPYFGYARQDRRARSARVPITAKVVANMLTSVGVDRVLTMDLHSDQIQGFFDIPVDNIYGTPTLLGDIWK
HDYQNLIVVSPDVGGVVRARHMARRLECDLAIIDKRRPKPNESKVMNIIGDVKERTCVIIDDMVDTANTLCEAASALKQE
GAASVIAYSTHAVLSGKAVERVQNSDLDKLVVTDTIPLREDASKCNRIQQLSVASLLGESMLRVSNESSLSSLFIE
>Mature_315_residues
SYDSLMVFTGTANPKLAHDVVKYLNINLGRATVGRFSDGEVMVEILENVRGNDVFVLQSTCAPTNDSLMEILVIVDALKR
ASASRVTAAIPYFGYARQDRRARSARVPITAKVVANMLTSVGVDRVLTMDLHSDQIQGFFDIPVDNIYGTPTLLGDIWKH
DYQNLIVVSPDVGGVVRARHMARRLECDLAIIDKRRPKPNESKVMNIIGDVKERTCVIIDDMVDTANTLCEAASALKQEG
AASVIAYSTHAVLSGKAVERVQNSDLDKLVVTDTIPLREDASKCNRIQQLSVASLLGESMLRVSNESSLSSLFIE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=45.5128205128205, Blast_Score=294, Evalue=9e-80,
Organism=Homo sapiens, GI4506129, Length=312, Percent_Identity=45.5128205128205, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=44.9044585987261, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI28557709, Length=312, Percent_Identity=45.1923076923077, Blast_Score=287, Evalue=7e-78,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=31.8840579710145, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI194018537, Length=331, Percent_Identity=32.6283987915408, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=33.5570469798658, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=33.5570469798658, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=33.5570469798658, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=33.5570469798658, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=60, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=43.5897435897436, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=43.2692307692308, Blast_Score=281, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=43.2692307692308, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=43.2692307692308, Blast_Score=280, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=32.8402366863905, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321776, Length=316, Percent_Identity=44.620253164557, Blast_Score=272, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6320946, Length=317, Percent_Identity=42.9022082018927, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=42.1383647798742, Blast_Score=258, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=41.3265306122449, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=118, Percent_Identity=38.9830508474576, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=46.474358974359, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=43.4131736526946, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24651458, Length=358, Percent_Identity=30.4469273743017, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24651456, Length=358, Percent_Identity=30.4469273743017, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI281362873, Length=358, Percent_Identity=30.4469273743017, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24651454, Length=358, Percent_Identity=30.4469273743017, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24651462, Length=377, Percent_Identity=29.4429708222812, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651464, Length=377, Percent_Identity=29.4429708222812, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI45552010, Length=377, Percent_Identity=29.4429708222812, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34626; Mature: 34495

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDSLMVFTGTANPKLAHDVVKYLNINLGRATVGRFSDGEVMVEILENVRGNDVFVLQS
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEC
TCAPTNDSLMEILVIVDALKRASASRVTAAIPYFGYARQDRRARSARVPITAKVVANMLT
CCCCCCHHHHHHHHHHHHHHHCCCCHHEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
SVGVDRVLTMDLHSDQIQGFFDIPVDNIYGTPTLLGDIWKHDYQNLIVVSPDVGGVVRAR
HCCCCCEEEEECCHHHCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHH
HMARRLECDLAIIDKRRPKPNESKVMNIIGDVKERTCVIIDDMVDTANTLCEAASALKQE
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHC
GAASVIAYSTHAVLSGKAVERVQNSDLDKLVVTDTIPLREDASKCNRIQQLSVASLLGES
CCCEEEEEEHHHHHCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
MLRVSNESSLSSLFIE
HHHHCCCCHHHHHCCC
>Mature Secondary Structure 
SYDSLMVFTGTANPKLAHDVVKYLNINLGRATVGRFSDGEVMVEILENVRGNDVFVLQS
CCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEC
TCAPTNDSLMEILVIVDALKRASASRVTAAIPYFGYARQDRRARSARVPITAKVVANMLT
CCCCCCHHHHHHHHHHHHHHHCCCCHHEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHH
SVGVDRVLTMDLHSDQIQGFFDIPVDNIYGTPTLLGDIWKHDYQNLIVVSPDVGGVVRAR
HCCCCCEEEEECCHHHCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHH
HMARRLECDLAIIDKRRPKPNESKVMNIIGDVKERTCVIIDDMVDTANTLCEAASALKQE
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHC
GAASVIAYSTHAVLSGKAVERVQNSDLDKLVVTDTIPLREDASKCNRIQQLSVASLLGES
CCCEEEEEEHHHHHCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
MLRVSNESSLSSLFIE
HHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]