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The map label for this gene is ribD [H]

Identifier: 114331089

GI number: 114331089

Start: 1130595

End: 1131698

Strand: Direct

Name: ribD [H]

Synonym: Neut_1091

Alternate gene names: 114331089

Gene position: 1130595-1131698 (Clockwise)

Preceding gene: 114331087

Following gene: 114331090

Centisome position: 42.49

GC content: 46.29

Gene sequence:

>1104_bases
ATGATAAAACAAGTGTTTACTGCTTCAGATTATATGCACATGTCGCATGCCTTACAGTTGGCAGAAAGAGGGTTGTTTAC
CACAAGCCCGAATCCGCGTGTAGGGTGTGTGATTGTAAATGATGGCAAGGTAGTCGGAACTGGATGGCATGAGCGGGTGG
GGGAATCGCATGCAGAAATCAATGCGTTGCGGGAAGCGGGGGATTTGGCCAGAGGTGCTACAGTTTACGTAACACTGGAA
CCTTGCAGTCATCATGGTCGTACACCGCCATGCGTTGAAGCTTTGATTTGCGCTGAGGTATGCAGAGTGATTATGGCAAT
GGATGACCCTAATCCTCATGTAAACGGTCAAGGAAAGGAGAAGCTGCAGAAAGCCGGAGTTGAAGTGCAAACAGGCTTGT
TGGAGGATGAAGCACAGCAACTGAATATTGGATTTATTACCCGGATGCACCATAGCCGACCGTGGATACGAACTAAGATA
GCGGCCAGCCTGGATGGCAGGATTGCATTGAAAAATGGGAAAAGCCAGTGGATTACAGGCGAGCCAGCTCGACAGGATGG
CCATAGGTGGCGTGCCCGTTCATGTGCAATATTAACGGGAGTCAATTCAGTAAAGGTGGATGATCCACTGTTGACAGTAC
GATATATCGAGACTTCGAGGCAACCCATACGTATCGTTCTGGATTCGAATCTGGAAATTCCTCTACAGGCAAAACTGCTG
GAAAATGCTGATACAACCTGGATTTTTACGGTGCAGGCTGACAGGGGAAAAATACATCTTCTGGAGGATGCGGGTGCTCA
TGTCGTTGTTCTGCCTGATCTGGCAGGTAAAGTTGATCTTAAAGCAATGATAACGAAACTGGCCGAATTGGGTATCAATG
AGCTGCTGGTTGAAGCAGGTCCAGTGTTGAACGGGGCGTTGGTAGCAGCCGAATTGATAGATGAGATTATTTTTTATTTT
GCCCCTAACCTGTTGGGTAATTCGGCGCAAGCAATGCTGGTACTACCCGAAATTACAGATTTATCAGAGAAATATAATTT
ACAGATAACTGATATTCGGAAAATCGGAATAGATATCCGTCTGGTAGCAAGATTTATCAAATAA

Upstream 100 bases:

>100_bases
TTAGATCTGGCGATTGATTTTTTGAGTTGTTGAAAGGAGGGATAGATCGTACTGATAAATTAAGGTGATCGTGCATTATC
GATTTATCTTTCTTAAAGGG

Downstream 100 bases:

>100_bases
GAAAGGATACAGAAATTGCGTGGTAATAAAGAAAGAAGGGGTTTTGTCGTTGGAAAAATATCGATGGTACCGTTATCTGA
ATTTTATCCGGCTGAAAACT

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MIKQVFTASDYMHMSHALQLAERGLFTTSPNPRVGCVIVNDGKVVGTGWHERVGESHAEINALREAGDLARGATVYVTLE
PCSHHGRTPPCVEALICAEVCRVIMAMDDPNPHVNGQGKEKLQKAGVEVQTGLLEDEAQQLNIGFITRMHHSRPWIRTKI
AASLDGRIALKNGKSQWITGEPARQDGHRWRARSCAILTGVNSVKVDDPLLTVRYIETSRQPIRIVLDSNLEIPLQAKLL
ENADTTWIFTVQADRGKIHLLEDAGAHVVVLPDLAGKVDLKAMITKLAELGINELLVEAGPVLNGALVAAELIDEIIFYF
APNLLGNSAQAMLVLPEITDLSEKYNLQITDIRKIGIDIRLVARFIK

Sequences:

>Translated_367_residues
MIKQVFTASDYMHMSHALQLAERGLFTTSPNPRVGCVIVNDGKVVGTGWHERVGESHAEINALREAGDLARGATVYVTLE
PCSHHGRTPPCVEALICAEVCRVIMAMDDPNPHVNGQGKEKLQKAGVEVQTGLLEDEAQQLNIGFITRMHHSRPWIRTKI
AASLDGRIALKNGKSQWITGEPARQDGHRWRARSCAILTGVNSVKVDDPLLTVRYIETSRQPIRIVLDSNLEIPLQAKLL
ENADTTWIFTVQADRGKIHLLEDAGAHVVVLPDLAGKVDLKAMITKLAELGINELLVEAGPVLNGALVAAELIDEIIFYF
APNLLGNSAQAMLVLPEITDLSEKYNLQITDIRKIGIDIRLVARFIK
>Mature_367_residues
MIKQVFTASDYMHMSHALQLAERGLFTTSPNPRVGCVIVNDGKVVGTGWHERVGESHAEINALREAGDLARGATVYVTLE
PCSHHGRTPPCVEALICAEVCRVIMAMDDPNPHVNGQGKEKLQKAGVEVQTGLLEDEAQQLNIGFITRMHHSRPWIRTKI
AASLDGRIALKNGKSQWITGEPARQDGHRWRARSCAILTGVNSVKVDDPLLTVRYIETSRQPIRIVLDSNLEIPLQAKLL
ENADTTWIFTVQADRGKIHLLEDAGAHVVVLPDLAGKVDLKAMITKLAELGINELLVEAGPVLNGALVAAELIDEIIFYF
APNLLGNSAQAMLVLPEITDLSEKYNLQITDIRKIGIDIRLVARFIK

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=364, Percent_Identity=47.2527472527472, Blast_Score=337, Evalue=6e-94,
Organism=Escherichia coli, GI145693172, Length=165, Percent_Identity=33.9393939393939, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40349; Mature: 40349

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQVFTASDYMHMSHALQLAERGLFTTSPNPRVGCVIVNDGKVVGTGWHERVGESHAEI
CCCCEECCHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEECCEEEECCHHHHHCCHHHHH
NALREAGDLARGATVYVTLEPCSHHGRTPPCVEALICAEVCRVIMAMDDPNPHVNGQGKE
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHH
KLQKAGVEVQTGLLEDEAQQLNIGFITRMHHSRPWIRTKIAASLDGRIALKNGKSQWITG
HHHHCCCEEEECCCCCHHHHCCEEEEEEECCCCCCHHEEHHHCCCCEEEEECCCCCCCCC
EPARQDGHRWRARSCAILTGVNSVKVDDPLLTVRYIETSRQPIRIVLDSNLEIPLQAKLL
CCCCCCCCHHHHCCEEEEECCCCEEECCCEEEEEEEECCCCCEEEEEECCCCCCCHHHHH
ENADTTWIFTVQADRGKIHLLEDAGAHVVVLPDLAGKVDLKAMITKLAELGINELLVEAG
CCCCCEEEEEEEECCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHCC
PVLNGALVAAELIDEIIFYFAPNLLGNSAQAMLVLPEITDLSEKYNLQITDIRKIGIDIR
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHCCEEEEEHHHHCCHHH
LVARFIK
HHHHHHC
>Mature Secondary Structure
MIKQVFTASDYMHMSHALQLAERGLFTTSPNPRVGCVIVNDGKVVGTGWHERVGESHAEI
CCCCEECCHHHHHHHHHHHHHHCCCEECCCCCEEEEEEEECCEEEECCHHHHHCCHHHHH
NALREAGDLARGATVYVTLEPCSHHGRTPPCVEALICAEVCRVIMAMDDPNPHVNGQGKE
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCHH
KLQKAGVEVQTGLLEDEAQQLNIGFITRMHHSRPWIRTKIAASLDGRIALKNGKSQWITG
HHHHCCCEEEECCCCCHHHHCCEEEEEEECCCCCCHHEEHHHCCCCEEEEECCCCCCCCC
EPARQDGHRWRARSCAILTGVNSVKVDDPLLTVRYIETSRQPIRIVLDSNLEIPLQAKLL
CCCCCCCCHHHHCCEEEEECCCCEEECCCEEEEEEEECCCCCEEEEEECCCCCCCHHHHH
ENADTTWIFTVQADRGKIHLLEDAGAHVVVLPDLAGKVDLKAMITKLAELGINELLVEAG
CCCCCEEEEEEEECCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHCC
PVLNGALVAAELIDEIIFYFAPNLLGNSAQAMLVLPEITDLSEKYNLQITDIRKIGIDIR
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHCCEEEEEHHHHCCHHH
LVARFIK
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]