Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 114331080

GI number: 114331080

Start: 1120702

End: 1122801

Strand: Reverse

Name: uvrB [H]

Synonym: Neut_1082

Alternate gene names: 114331080

Gene position: 1122801-1120702 (Counterclockwise)

Preceding gene: 114331082

Following gene: 114331079

Centisome position: 42.19

GC content: 48.81

Gene sequence:

>2100_bases
GTGATTATTACCTTTCCGGACAGTCCTTACAAGCTCAATCAGGCATTTCAGCCTGCGGGTGATCAACCGGATGCCATCCG
CAAGTTGGTGGATGGAATAGAATCAGGCTTGTCATTCCAGACGTTGTTAGGCGTAACCGGATCCGGAAAAACGTTCACCA
TCGCCAATATGATTGCGCAACTCGGGCGCCCGGCCATCATCATGGCCCCGAACAAGACGCTGGCCGCGCAGCTCTATGCT
GAAATGCGTGAATTCTTTCCAGAAAATGCAGTTGAGTATTTTGTCTCCTACTATGATTATTACCAGCCTGAAGCCTATGT
TCCCTCCCGCGATCTGTTCATCGAAAAGGATTCCAGTATTAACGAACATATCGAACAGATGCGCCTCTCTGCTACAAAAT
CCCTACTGGAACGGGAAGACACCATCATTGTAGCAAGCGTATCCTGCATTTACGGCATTGGTGATCCCGTTGATTATCAC
GGTATGATTCTACATGTGCGTGAGCATGAAAAAATCACGCAACGCGACATCATCCAGCGGTTGGCAGACATGCAATACCA
GCGTAACGAATTCGAGTTTGCGCGTGGCACCTTTCGTGTACGTGGCGACGTGCTGGATATCTTCCCGGCAGAGAACTCTG
AAACCGCACTACGCATTTCCCTGTTTGATGATGAGGTGGAAAGCATAGCGCTGTTTGATCCGCTCACCGGACATACCCGG
CAGAAAGTTTCGCGCTATACGGTTTACCCTTCCAGTCATTACGTCACTCCGCGCAGCACCACCCTGCGCGCAATCGAAAC
CATCAAAACCGAACTTGCCGAACGACTCAATCATCTTCACGAAAATCATAAGCTGGTGGAAGCTCAGCGCCTGGAACAAC
GTACCCGTTTCGATCTGGAAATGTTAAATGAATTGGGTTTCTGCAAAGGAATTGAGAACTACTCGCGCCATTTGTCAGGT
CGCTTACCCGGGGATCCACCGCCAACACTCATTGATTACCTGCCGGGTAACGCATTGATGATTATTGATGAGAGCCATGT
TACCGTGCCTCAAGTTGGCGGAATGTACAAAGGTGATCGTTCAAGAAAGGAAAACCTGGTGGCTTACGGATTTCGCCTGC
CTTCCGCATTGGACAACCGGCCGCTCAGGTTTGAGGAATTTGAAAAACTGATGCCTCAAACTATTTTCGTTTCCGCCACA
CCGGCAGATTATGAAATACAGCACAGCGGCCAGATTGTTGAACAGGTTGTACGACCAACCGGGCTGGTGGATCCGGTAAT
CATCATCCGTCCGGTAGCCACCCAGGTGGACGACCTGATGTCTGAAGTCTCAATGCGTACCAAACAAGGCGAGCGAACAT
TGATCACCACCCTGACCAAGCGCATGGCGGAAGATCTGACCGATTATTTTTCTGATCACGGCATCCGGGTACGTTATCTA
CATTCCGATATTGATACCGTTGAGCGAGTTGAAATTATTCGTGATCTGCGCCTGGGAAAATTTGACGTCCTGGTCGGAAT
CAATCTGTTACGGGAGGGACTGGATATTCCAGAAGCTTCACTGGTTGGCATACTGGATGCCGATAAAGAAGGTTTCCTGC
GTTCAGAACGCTCATTGATCCAGACCATGGGACGCGCCGCCCGACATATCAATGGAACCGTCATTCTTTATGCTGACAGG
ATTACCAATTCGATGCGGCGCGCCATTGATGAAACTGAACGGCGACGTAACAAACAGAAGCTGTTCAATCAGCAGAACGA
TATTACGCCACGCGGTGTCAGCAAGCGGATCAAGGATTTGATTGATGGTGTTTACGACAGCAAAGATGCGGCAGAACATC
AGAAAGTCGCACAAATCCAGGCACACTACGCTGCCATGGATGAAACACAACTTGCAAAAGAAATTCAACGGTTGGAAAAA
GCCATGCTGACGGCCGCAAAAAGCATGGAATTTGAACAGGCAGCCCAGTATCGTGATGAAATAAAAAATCTTAAAAACAA
GCTGTTTATCGGTATGATTGATCCCACTGAAATTGGGGACATACTGCAGCCAGCGATTAAAAAATCCGGAAAAAAATCCG
GGAAGCGTCTCCAAATCTGA

Upstream 100 bases:

>100_bases
GAACGCGTTGCGAGAGTTTCACGAGACAGCTCCTGATGTATGTGATTTGCGCATGTTAGAATCAAAAAATAATTAAATTT
CGAGTACAGCGATCAAACTT

Downstream 100 bases:

>100_bases
TTGATTCCCTCTCCTGTAGGTTTTGCATAGATCGTTCATCCATGTCAAAATAAAAAGGAACGCTCGGCTGGAAACAGGGT
TTTCCGGCAATCTCATTTCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MIITFPDSPYKLNQAFQPAGDQPDAIRKLVDGIESGLSFQTLLGVTGSGKTFTIANMIAQLGRPAIIMAPNKTLAAQLYA
EMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINEHIEQMRLSATKSLLEREDTIIVASVSCIYGIGDPVDYH
GMILHVREHEKITQRDIIQRLADMQYQRNEFEFARGTFRVRGDVLDIFPAENSETALRISLFDDEVESIALFDPLTGHTR
QKVSRYTVYPSSHYVTPRSTTLRAIETIKTELAERLNHLHENHKLVEAQRLEQRTRFDLEMLNELGFCKGIENYSRHLSG
RLPGDPPPTLIDYLPGNALMIIDESHVTVPQVGGMYKGDRSRKENLVAYGFRLPSALDNRPLRFEEFEKLMPQTIFVSAT
PADYEIQHSGQIVEQVVRPTGLVDPVIIIRPVATQVDDLMSEVSMRTKQGERTLITTLTKRMAEDLTDYFSDHGIRVRYL
HSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEASLVGILDADKEGFLRSERSLIQTMGRAARHINGTVILYADR
ITNSMRRAIDETERRRNKQKLFNQQNDITPRGVSKRIKDLIDGVYDSKDAAEHQKVAQIQAHYAAMDETQLAKEIQRLEK
AMLTAAKSMEFEQAAQYRDEIKNLKNKLFIGMIDPTEIGDILQPAIKKSGKKSGKRLQI

Sequences:

>Translated_699_residues
MIITFPDSPYKLNQAFQPAGDQPDAIRKLVDGIESGLSFQTLLGVTGSGKTFTIANMIAQLGRPAIIMAPNKTLAAQLYA
EMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINEHIEQMRLSATKSLLEREDTIIVASVSCIYGIGDPVDYH
GMILHVREHEKITQRDIIQRLADMQYQRNEFEFARGTFRVRGDVLDIFPAENSETALRISLFDDEVESIALFDPLTGHTR
QKVSRYTVYPSSHYVTPRSTTLRAIETIKTELAERLNHLHENHKLVEAQRLEQRTRFDLEMLNELGFCKGIENYSRHLSG
RLPGDPPPTLIDYLPGNALMIIDESHVTVPQVGGMYKGDRSRKENLVAYGFRLPSALDNRPLRFEEFEKLMPQTIFVSAT
PADYEIQHSGQIVEQVVRPTGLVDPVIIIRPVATQVDDLMSEVSMRTKQGERTLITTLTKRMAEDLTDYFSDHGIRVRYL
HSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEASLVGILDADKEGFLRSERSLIQTMGRAARHINGTVILYADR
ITNSMRRAIDETERRRNKQKLFNQQNDITPRGVSKRIKDLIDGVYDSKDAAEHQKVAQIQAHYAAMDETQLAKEIQRLEK
AMLTAAKSMEFEQAAQYRDEIKNLKNKLFIGMIDPTEIGDILQPAIKKSGKKSGKRLQI
>Mature_699_residues
MIITFPDSPYKLNQAFQPAGDQPDAIRKLVDGIESGLSFQTLLGVTGSGKTFTIANMIAQLGRPAIIMAPNKTLAAQLYA
EMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSINEHIEQMRLSATKSLLEREDTIIVASVSCIYGIGDPVDYH
GMILHVREHEKITQRDIIQRLADMQYQRNEFEFARGTFRVRGDVLDIFPAENSETALRISLFDDEVESIALFDPLTGHTR
QKVSRYTVYPSSHYVTPRSTTLRAIETIKTELAERLNHLHENHKLVEAQRLEQRTRFDLEMLNELGFCKGIENYSRHLSG
RLPGDPPPTLIDYLPGNALMIIDESHVTVPQVGGMYKGDRSRKENLVAYGFRLPSALDNRPLRFEEFEKLMPQTIFVSAT
PADYEIQHSGQIVEQVVRPTGLVDPVIIIRPVATQVDDLMSEVSMRTKQGERTLITTLTKRMAEDLTDYFSDHGIRVRYL
HSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEASLVGILDADKEGFLRSERSLIQTMGRAARHINGTVILYADR
ITNSMRRAIDETERRRNKQKLFNQQNDITPRGVSKRIKDLIDGVYDSKDAAEHQKVAQIQAHYAAMDETQLAKEIQRLEK
AMLTAAKSMEFEQAAQYRDEIKNLKNKLFIGMIDPTEIGDILQPAIKKSGKKSGKRLQI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=669, Percent_Identity=65.1718983557548, Blast_Score=894, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=21.4983713355049, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79628; Mature: 79628

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITFPDSPYKLNQAFQPAGDQPDAIRKLVDGIESGLSFQTLLGVTGSGKTFTIANMIAQ
CEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHEECCCCCEEEHHHHHHH
LGRPAIIMAPNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSI
HCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
NEHIEQMRLSATKSLLEREDTIIVASVSCIYGIGDPVDYHGMILHVREHEKITQRDIIQR
HHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
LADMQYQRNEFEFARGTFRVRGDVLDIFPAENSETALRISLFDDEVESIALFDPLTGHTR
HHHHHHHCCHHHHHCCEEEEECCEEEEECCCCCCCEEEEEEECCCHHHEEEECCCCCHHH
QKVSRYTVYPSSHYVTPRSTTLRAIETIKTELAERLNHLHENHKLVEAQRLEQRTRFDLE
HHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MLNELGFCKGIENYSRHLSGRLPGDPPPTLIDYLPGNALMIIDESHVTVPQVGGMYKGDR
HHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
SRKENLVAYGFRLPSALDNRPLRFEEFEKLMPQTIFVSATPADYEIQHSGQIVEQVVRPT
CHHCCEEEEEEECCHHHCCCCCCHHHHHHHCCCEEEEEECCCCCEECCCHHHHHHHHCCC
GLVDPVIIIRPVATQVDDLMSEVSMRTKQGERTLITTLTKRMAEDLTDYFSDHGIRVRYL
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
HSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEASLVGILDADKEGFLRSERSLI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHH
QTMGRAARHINGTVILYADRITNSMRRAIDETERRRNKQKLFNQQNDITPRGVSKRIKDL
HHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IDGVYDSKDAAEHQKVAQIQAHYAAMDETQLAKEIQRLEKAMLTAAKSMEFEQAAQYRDE
HHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IKNLKNKLFIGMIDPTEIGDILQPAIKKSGKKSGKRLQI
HHHHHHCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIITFPDSPYKLNQAFQPAGDQPDAIRKLVDGIESGLSFQTLLGVTGSGKTFTIANMIAQ
CEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHEECCCCCEEEHHHHHHH
LGRPAIIMAPNKTLAAQLYAEMREFFPENAVEYFVSYYDYYQPEAYVPSRDLFIEKDSSI
HCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCH
NEHIEQMRLSATKSLLEREDTIIVASVSCIYGIGDPVDYHGMILHVREHEKITQRDIIQR
HHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
LADMQYQRNEFEFARGTFRVRGDVLDIFPAENSETALRISLFDDEVESIALFDPLTGHTR
HHHHHHHCCHHHHHCCEEEEECCEEEEECCCCCCCEEEEEEECCCHHHEEEECCCCCHHH
QKVSRYTVYPSSHYVTPRSTTLRAIETIKTELAERLNHLHENHKLVEAQRLEQRTRFDLE
HHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MLNELGFCKGIENYSRHLSGRLPGDPPPTLIDYLPGNALMIIDESHVTVPQVGGMYKGDR
HHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCC
SRKENLVAYGFRLPSALDNRPLRFEEFEKLMPQTIFVSATPADYEIQHSGQIVEQVVRPT
CHHCCEEEEEEECCHHHCCCCCCHHHHHHHCCCEEEEEECCCCCEECCCHHHHHHHHCCC
GLVDPVIIIRPVATQVDDLMSEVSMRTKQGERTLITTLTKRMAEDLTDYFSDHGIRVRYL
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
HSDIDTVERVEIIRDLRLGKFDVLVGINLLREGLDIPEASLVGILDADKEGFLRSERSLI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHH
QTMGRAARHINGTVILYADRITNSMRRAIDETERRRNKQKLFNQQNDITPRGVSKRIKDL
HHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
IDGVYDSKDAAEHQKVAQIQAHYAAMDETQLAKEIQRLEKAMLTAAKSMEFEQAAQYRDE
HHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IKNLKNKLFIGMIDPTEIGDILQPAIKKSGKKSGKRLQI
HHHHHHCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]