| Definition | Nitrosomonas eutropha C91, complete genome. |
|---|---|
| Accession | NC_008344 |
| Length | 2,661,057 |
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The map label for this gene is hdhA [H]
Identifier: 114331070
GI number: 114331070
Start: 1105098
End: 1105874
Strand: Reverse
Name: hdhA [H]
Synonym: Neut_1072
Alternate gene names: 114331070
Gene position: 1105874-1105098 (Counterclockwise)
Preceding gene: 114331071
Following gene: 114331069
Centisome position: 41.56
GC content: 59.97
Gene sequence:
>777_bases ATGCAACCGACACCACTGTTCGATTTGAGCGGCAAAGTCGCCATCGTGACCGGCGGCGGCAACGGCATCGGCAAAGCCTG CGCGCGGATGCTGGCCGATTACGGAGCCGCCGTCGTCATCGCCGACTTGAAAACCGAAGACGCCCAAAAAGCCGCCGATG AAATTACTTCCAATGGCGGCCAGGCGTTGGCTATCGAATGCAACGTGCTGCGCGACGAAGATTTGGTGCGTTTAGTGGAG CGAACGGTTTCCGAGTGCGGCGGTATTCACATCTTGGTCAACAACGCCGGAGGCGGCGGCGCGGGGCGAGAAAGCCCCGA CCAAATCAGCGTCGAGCAGTTCGCCAAAGTGTTTCAACTGAACCTTTTCAGCGCGTGGCGACTGGCGCAACTGTGCGCGC CGCACATGAAGCAGGCCGGTTACGGCTCGATTATCACCATGTCGTCCATGAGTTCGATCAACAAAAGTCCGGCGATTAGC GCCTACGCTTCATCCAAAGCCGCCATCAATCACATGACGGCCAACCTTGCCTTCGACTACGGCGCGGATGAAATTCGCGT CAATGCCGTTGGGCCGGGCGCGGTCAGGACTGGGGCTTTGGCTTCAGTTCTCACGCCCGAAATCGAGGAGCGAATGCTGG CGCACACGCCACTCAAGCGATTGGGCGAACCCGAAGACATCGCCGGAGCCGTGCTTTATTTTGCCGCTCCGGTCTCGCGG TGGGTGAGCGGTCAGGTGCTGTTCGTCAACGGCGGCGGCGTGCAAACCCTGGATTGA
Upstream 100 bases:
>100_bases TTCGCTTCGCATCCCATCGCCGCCAACAGCGCCAACGACGCGACTTCGCTGCCCGCCTACGAAGCCGTCGCGCGCCATTT GATGAAAGGAAAATAACCTT
Downstream 100 bases:
>100_bases ACGCGCGTTGTGGGTCGTGCATAAATCAGGCAATGGCATTGGTATGTGCGGACGTGACTCGAAAGATCACGTTTGGACCA GAACAGCTATAACAGGTATT
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: 7-alpha-HSDH [H]
Number of amino acids: Translated: 258; Mature: 258
Protein sequence:
>258_residues MQPTPLFDLSGKVAIVTGGGNGIGKACARMLADYGAAVVIADLKTEDAQKAADEITSNGGQALAIECNVLRDEDLVRLVE RTVSECGGIHILVNNAGGGGAGRESPDQISVEQFAKVFQLNLFSAWRLAQLCAPHMKQAGYGSIITMSSMSSINKSPAIS AYASSKAAINHMTANLAFDYGADEIRVNAVGPGAVRTGALASVLTPEIEERMLAHTPLKRLGEPEDIAGAVLYFAAPVSR WVSGQVLFVNGGGVQTLD
Sequences:
>Translated_258_residues MQPTPLFDLSGKVAIVTGGGNGIGKACARMLADYGAAVVIADLKTEDAQKAADEITSNGGQALAIECNVLRDEDLVRLVE RTVSECGGIHILVNNAGGGGAGRESPDQISVEQFAKVFQLNLFSAWRLAQLCAPHMKQAGYGSIITMSSMSSINKSPAIS AYASSKAAINHMTANLAFDYGADEIRVNAVGPGAVRTGALASVLTPEIEERMLAHTPLKRLGEPEDIAGAVLYFAAPVSR WVSGQVLFVNGGGVQTLD >Mature_258_residues MQPTPLFDLSGKVAIVTGGGNGIGKACARMLADYGAAVVIADLKTEDAQKAADEITSNGGQALAIECNVLRDEDLVRLVE RTVSECGGIHILVNNAGGGGAGRESPDQISVEQFAKVFQLNLFSAWRLAQLCAPHMKQAGYGSIITMSSMSSINKSPAIS AYASSKAAINHMTANLAFDYGADEIRVNAVGPGAVRTGALASVLTPEIEERMLAHTPLKRLGEPEDIAGAVLYFAAPVSR WVSGQVLFVNGGGVQTLD
Specific function: 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=33.8775510204082, Blast_Score=128, Evalue=5e-30, Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=31.2252964426877, Blast_Score=119, Evalue=3e-27, Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=33.0645161290323, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=32.034632034632, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=30.078125, Blast_Score=99, Evalue=5e-21, Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=34.375, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=29.0322580645161, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=30.1652892561983, Blast_Score=95, Evalue=7e-20, Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=30.0813008130081, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=32.967032967033, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI4503301, Length=260, Percent_Identity=31.1538461538462, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI4504505, Length=260, Percent_Identity=28.8461538461538, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI31542939, Length=218, Percent_Identity=33.4862385321101, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI226371731, Length=227, Percent_Identity=26.431718061674, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4557649, Length=204, Percent_Identity=28.4313725490196, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=26.7716535433071, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI142976729, Length=230, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI109715829, Length=233, Percent_Identity=27.4678111587983, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI210032110, Length=198, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI7706318, Length=221, Percent_Identity=26.2443438914027, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI40807363, Length=243, Percent_Identity=22.6337448559671, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI7705855, Length=208, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI40254986, Length=217, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-11, Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=48.4, Blast_Score=233, Evalue=1e-62, Organism=Escherichia coli, GI1790717, Length=249, Percent_Identity=30.9236947791165, Blast_Score=126, Evalue=1e-30, Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=32.1428571428571, Blast_Score=113, Evalue=2e-26, Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=30.6451612903226, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=35.0806451612903, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=31.1740890688259, Blast_Score=107, Evalue=6e-25, Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=30.4347826086957, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=29.3877551020408, Blast_Score=91, Evalue=8e-20, Organism=Escherichia coli, GI1786812, Length=255, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=7e-18, Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=27.7551020408163, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=27.6264591439689, Blast_Score=76, Evalue=3e-15, Organism=Escherichia coli, GI1787526, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI1786701, Length=198, Percent_Identity=30.3030303030303, Blast_Score=61, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=33.5907335907336, Blast_Score=130, Evalue=9e-31, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=35.9183673469388, Blast_Score=123, Evalue=8e-29, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=34.2307692307692, Blast_Score=118, Evalue=3e-27, Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=32.6923076923077, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=32.5670498084291, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=28.4584980237154, Blast_Score=110, Evalue=6e-25, Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=33.0769230769231, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17559104, Length=256, Percent_Identity=31.640625, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=32.089552238806, Blast_Score=107, Evalue=7e-24, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=32.6996197718631, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=31.1787072243346, Blast_Score=105, Evalue=3e-23, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=31.7829457364341, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=32.3886639676113, Blast_Score=104, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=30.5343511450382, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=31.2267657992565, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=30, Blast_Score=101, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=31.0606060606061, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17562990, Length=272, Percent_Identity=30.1470588235294, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=30.241935483871, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=29.9242424242424, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=29.8804780876494, Blast_Score=92, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=26.7441860465116, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=29.3172690763052, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=28.6259541984733, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17561272, Length=257, Percent_Identity=30.7392996108949, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17538182, Length=259, Percent_Identity=29.7297297297297, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=29.3650793650794, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=28.6852589641434, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17508651, Length=251, Percent_Identity=27.4900398406374, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17508895, Length=167, Percent_Identity=28.7425149700599, Blast_Score=74, Evalue=8e-14, Organism=Caenorhabditis elegans, GI17568967, Length=196, Percent_Identity=30.6122448979592, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17564282, Length=206, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI193203117, Length=216, Percent_Identity=25, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193203115, Length=214, Percent_Identity=25.2336448598131, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=31.8725099601594, Blast_Score=100, Evalue=2e-22, Organism=Saccharomyces cerevisiae, GI6322861, Length=237, Percent_Identity=29.535864978903, Blast_Score=84, Evalue=2e-17, Organism=Saccharomyces cerevisiae, GI6322227, Length=244, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=4e-15, Organism=Saccharomyces cerevisiae, GI6323882, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6322226, Length=188, Percent_Identity=30.3191489361702, Blast_Score=65, Evalue=1e-11, Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=32.6612903225806, Blast_Score=123, Evalue=1e-28, Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=31.8548387096774, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=7e-25, Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=29.3650793650794, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=29.8804780876494, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=31.0483870967742, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24644337, Length=252, Percent_Identity=31.3492063492063, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24640492, Length=201, Percent_Identity=28.3582089552239, Blast_Score=94, Evalue=7e-20, Organism=Drosophila melanogaster, GI281364892, Length=196, Percent_Identity=29.0816326530612, Blast_Score=88, Evalue=6e-18, Organism=Drosophila melanogaster, GI24649181, Length=205, Percent_Identity=31.7073170731707, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=28.125, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI18859837, Length=216, Percent_Identity=30.0925925925926, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI161076933, Length=199, Percent_Identity=30.1507537688442, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI24584748, Length=199, Percent_Identity=30.1507537688442, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI21357673, Length=211, Percent_Identity=29.8578199052133, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=29.2929292929293, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=29.2929292929293, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24663911, Length=232, Percent_Identity=26.2931034482759, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24640442, Length=237, Percent_Identity=30.379746835443, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=8e-12, Organism=Drosophila melanogaster, GI24580925, Length=208, Percent_Identity=25, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI24641232, Length=238, Percent_Identity=26.0504201680672, Blast_Score=64, Evalue=9e-11, Organism=Drosophila melanogaster, GI161076371, Length=260, Percent_Identity=28.0769230769231, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.159 [H]
Molecular weight: Translated: 26902; Mature: 26902
Theoretical pI: Translated: 5.07; Mature: 5.07
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQPTPLFDLSGKVAIVTGGGNGIGKACARMLADYGAAVVIADLKTEDAQKAADEITSNGG CCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCC QALAIECNVLRDEDLVRLVERTVSECGGIHILVNNAGGGGAGRESPDQISVEQFAKVFQL CEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH NLFSAWRLAQLCAPHMKQAGYGSIITMSSMSSINKSPAISAYASSKAAINHMTANLAFDY HHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCEEHHHCCHHHHHHHEEEEEEEC GADEIRVNAVGPGAVRTGALASVLTPEIEERMLAHTPLKRLGEPEDIAGAVLYFAAPVSR CCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHH WVSGQVLFVNGGGVQTLD HHCCEEEEEECCCCCCCC >Mature Secondary Structure MQPTPLFDLSGKVAIVTGGGNGIGKACARMLADYGAAVVIADLKTEDAQKAADEITSNGG CCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCC QALAIECNVLRDEDLVRLVERTVSECGGIHILVNNAGGGGAGRESPDQISVEQFAKVFQL CEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH NLFSAWRLAQLCAPHMKQAGYGSIITMSSMSSINKSPAISAYASSKAAINHMTANLAFDY HHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCEEHHHCCHHHHHHHEEEEEEEC GADEIRVNAVGPGAVRTGALASVLTPEIEERMLAHTPLKRLGEPEDIAGAVLYFAAPVSR CCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHH WVSGQVLFVNGGGVQTLD HHCCEEEEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]