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The map label for this gene is folP-A [H]

Identifier: 114331001

GI number: 114331001

Start: 1029107

End: 1030009

Strand: Direct

Name: folP-A [H]

Synonym: Neut_0999

Alternate gene names: 114331001

Gene position: 1029107-1030009 (Clockwise)

Preceding gene: 114331000

Following gene: 114331002

Centisome position: 38.67

GC content: 47.84

Gene sequence:

>903_bases
ATGGCCTGTACGGGAAATAAAACGTACAGGCCATTTTTTCTTATCCAAGTGAATAAACTGCAAAGGATTCTTCAAGAAAA
CCGCCCGCTGATCATGGGGGTGATCAATGTCACGCCCGATTCTTTTTCTGATGGTGGCTGTTTTGATACAACGGAGAAAG
CGATTGAACAAGTGAGTCGCCTGGCTCAGGAAGGTGCAGATATCCTTGATATCGGGGGTGAATCTACCCGTCCTGGGAGT
CGATCTGTTGAATCGGACGAAGAACTGTCACGAATCATGCCCGTCATAGAATTTGCACTGAATATGAATATTCCAGTTTC
GGTTGATACTGCCAAACCGGAAGTGATGCAAGCCGCTATTAATGCCGGGGTTGTTCTTATCAATGATACCAATGCGCTGC
AAGCTCCCGGTGCACTGGAAGTTGTTGCAGACAGCTCTGTTATGGCTTGTCTCATGCACATGCAAGGACGGCCGGAGACA
ATGCAGCTTGATCCGCAGTATTCGGATGTAGTTGCCGAGGTTATGGCTTTTCTGAAACAACATGTTGCATTGGCAGTATC
AGCCGGGATTACGCGTGAGCGAATCATTATTGATCCCGGTTTTGGCTTTGGTAAAACACTGGAGCACAATCTCGCCTTGT
TACACCATCTGAATCAATTCATTGCTATGGATCTACCTGTTATGGCCGGCATTTCACGTAAATCAATGCTGGGAATGATT
ACGGGCAGTCCAGTTGATAATCGTGTGTATGCCAGTGTGGCAGCCGCTCTTCTGGCAGTGGGACAAGGTGCCAGGATTGT
ACGGGTACATGATGTCAAGGCAACTCGTGATGCGTTTTCAGTGTTTGCGGCAATGGATCGTATTCATCCGGGTTTTCTGA
TATACCCGTCACCCGGCCAATAG

Upstream 100 bases:

>100_bases
CAAGCGGTGAGGTAAAACAACCCGAAAGTGAGCCTGCAACAACAGAAGAAGCACCTGCTCAAAAAGTAGAAGCCTAGAAA
AATTGTAGTATTCTTAATTA

Downstream 100 bases:

>100_bases
TTGGTTGTACGGTAATCAGTAACAAGGCCCATATAATACAAATATGACGATTGAGTGGCTGGTTGCTGTTGATCTATCAG
ACGCTCGCGTCTGTGGGATG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MACTGNKTYRPFFLIQVNKLQRILQENRPLIMGVINVTPDSFSDGGCFDTTEKAIEQVSRLAQEGADILDIGGESTRPGS
RSVESDEELSRIMPVIEFALNMNIPVSVDTAKPEVMQAAINAGVVLINDTNALQAPGALEVVADSSVMACLMHMQGRPET
MQLDPQYSDVVAEVMAFLKQHVALAVSAGITRERIIIDPGFGFGKTLEHNLALLHHLNQFIAMDLPVMAGISRKSMLGMI
TGSPVDNRVYASVAAALLAVGQGARIVRVHDVKATRDAFSVFAAMDRIHPGFLIYPSPGQ

Sequences:

>Translated_300_residues
MACTGNKTYRPFFLIQVNKLQRILQENRPLIMGVINVTPDSFSDGGCFDTTEKAIEQVSRLAQEGADILDIGGESTRPGS
RSVESDEELSRIMPVIEFALNMNIPVSVDTAKPEVMQAAINAGVVLINDTNALQAPGALEVVADSSVMACLMHMQGRPET
MQLDPQYSDVVAEVMAFLKQHVALAVSAGITRERIIIDPGFGFGKTLEHNLALLHHLNQFIAMDLPVMAGISRKSMLGMI
TGSPVDNRVYASVAAALLAVGQGARIVRVHDVKATRDAFSVFAAMDRIHPGFLIYPSPGQ
>Mature_299_residues
ACTGNKTYRPFFLIQVNKLQRILQENRPLIMGVINVTPDSFSDGGCFDTTEKAIEQVSRLAQEGADILDIGGESTRPGSR
SVESDEELSRIMPVIEFALNMNIPVSVDTAKPEVMQAAINAGVVLINDTNALQAPGALEVVADSSVMACLMHMQGRPETM
QLDPQYSDVVAEVMAFLKQHVALAVSAGITRERIIIDPGFGFGKTLEHNLALLHHLNQFIAMDLPVMAGISRKSMLGMIT
GSPVDNRVYASVAAALLAVGQGARIVRVHDVKATRDAFSVFAAMDRIHPGFLIYPSPGQ

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=46.5648854961832, Blast_Score=251, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6324073, Length=302, Percent_Identity=29.4701986754967, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 32402; Mature: 32271

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACTGNKTYRPFFLIQVNKLQRILQENRPLIMGVINVTPDSFSDGGCFDTTEKAIEQVSR
CCCCCCCCCCCEEEEEHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LAQEGADILDIGGESTRPGSRSVESDEELSRIMPVIEFALNMNIPVSVDTAKPEVMQAAI
HHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
NAGVVLINDTNALQAPGALEVVADSSVMACLMHMQGRPETMQLDPQYSDVVAEVMAFLKQ
HCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHH
HVALAVSAGITRERIIIDPGFGFGKTLEHNLALLHHLNQFIAMDLPVMAGISRKSMLGMI
HHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHEEEEE
TGSPVDNRVYASVAAALLAVGQGARIVRVHDVKATRDAFSVFAAMDRIHPGFLIYPSPGQ
ECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure 
ACTGNKTYRPFFLIQVNKLQRILQENRPLIMGVINVTPDSFSDGGCFDTTEKAIEQVSR
CCCCCCCCCCEEEEEHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LAQEGADILDIGGESTRPGSRSVESDEELSRIMPVIEFALNMNIPVSVDTAKPEVMQAAI
HHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
NAGVVLINDTNALQAPGALEVVADSSVMACLMHMQGRPETMQLDPQYSDVVAEVMAFLKQ
HCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHH
HVALAVSAGITRERIIIDPGFGFGKTLEHNLALLHHLNQFIAMDLPVMAGISRKSMLGMI
HHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHEEEEE
TGSPVDNRVYASVAAALLAVGQGARIVRVHDVKATRDAFSVFAAMDRIHPGFLIYPSPGQ
ECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]