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The map label for this gene is macA [H]

Identifier: 114330978

GI number: 114330978

Start: 1005583

End: 1006542

Strand: Direct

Name: macA [H]

Synonym: Neut_0975

Alternate gene names: 114330978

Gene position: 1005583-1006542 (Clockwise)

Preceding gene: 114330977

Following gene: 114330980

Centisome position: 37.79

GC content: 52.4

Gene sequence:

>960_bases
ATGAAAATTGGACATACCTTGCCTATATTGGCAATTGGTGGATTTCTGTTCGCGTCCTATACGATCGTCAGCAGTAACCA
GTCGCTCCCAGTGGCCCTTGCTGCAGCAGAGCCAGCTGCCTCGCCTTACGAATCATTTATTGCAGGAGCGGGTATCATCG
AGGCGAAAAGCCGGAATATTTCTGTTGGTACCGCTCTGTCTGGGCTGGTTACTCGAGTTGCTGTCGAAGTGGGAGATAAA
GTTAAAGTAGGCACTCCGCTCTTTTACCTGGATGATCGCGAAGCGCGTGCGGAACTCGCCATCAGAAATTCTGATCTTGC
CAGGGCCAGAGCTGGTCTTATGGAAGCCAGAGCCATGCTCGAGGACAGCAAATCGTTAAGTGATCTGATTGAATCCCTTG
CCGATCAGCGCGCCGTCAGCAGCGAAGAAATGCTCAGGCGGCACAACACCTTGCGTATTAGCAAAGCTCGGCTGAGCAGT
GCGGAAACCGCTGTACGGCAGGCGGAGGCCTTGCTGGCCAGCACACAGACTACGCTTGATCTGCTGGTTGTCCGGGCACC
AGTGAGCGGCGAAATCCTGCAAGTCAATATTCGCCCGGGTGAATTTGCACAGGTGGGTTTCCTGACCACGCCGTTGATGC
TGTTGGGTAATCTTGATCAGTTGCATGTGCGGGTGGATATTGACGAAAATGATGCCTGGCGATTCGACCGACATAGCAAG
GCCATGGCTTATCTGCGGGGAAACCGGAACTTTAGCGTTGAACTAACGCCAGCTTATGTGGAGCCCTACGTTATCCCCAA
ACAGTCCCTTACCGGCGACAGTACCGAACAGGTCGATACACGGGTATTACAGGCGCTTTATAGCTTCGATCGAGAACAAT
TGCCTGTTTATGTAGGGCAACAGATGGATGTATTTATTGAAGTGCGGGACCATGCAGACAATGGTAGTCCCGCTATCTGA

Upstream 100 bases:

>100_bases
AACAATGAGACATATCAAATGGATAGGCGAGGTAGTGAGTATCGCGTAATGCCGCGGTTCACCTGGAAAATAATTTTTAG
AGGTACCCTAAAAAATCATC

Downstream 100 bases:

>100_bases
TTTCCAGCATTATCCTTTGTGCATATTTCCAATAACTCCAATATTTGCATCATGCTCAAAATATGAAGACCCCATTTCTT
CTTGCGATAAGCGTAAATCA

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKIGHTLPILAIGGFLFASYTIVSSNQSLPVALAAAEPAASPYESFIAGAGIIEAKSRNISVGTALSGLVTRVAVEVGDK
VKVGTPLFYLDDREARAELAIRNSDLARARAGLMEARAMLEDSKSLSDLIESLADQRAVSSEEMLRRHNTLRISKARLSS
AETAVRQAEALLASTQTTLDLLVVRAPVSGEILQVNIRPGEFAQVGFLTTPLMLLGNLDQLHVRVDIDENDAWRFDRHSK
AMAYLRGNRNFSVELTPAYVEPYVIPKQSLTGDSTEQVDTRVLQALYSFDREQLPVYVGQQMDVFIEVRDHADNGSPAI

Sequences:

>Translated_319_residues
MKIGHTLPILAIGGFLFASYTIVSSNQSLPVALAAAEPAASPYESFIAGAGIIEAKSRNISVGTALSGLVTRVAVEVGDK
VKVGTPLFYLDDREARAELAIRNSDLARARAGLMEARAMLEDSKSLSDLIESLADQRAVSSEEMLRRHNTLRISKARLSS
AETAVRQAEALLASTQTTLDLLVVRAPVSGEILQVNIRPGEFAQVGFLTTPLMLLGNLDQLHVRVDIDENDAWRFDRHSK
AMAYLRGNRNFSVELTPAYVEPYVIPKQSLTGDSTEQVDTRVLQALYSFDREQLPVYVGQQMDVFIEVRDHADNGSPAI
>Mature_319_residues
MKIGHTLPILAIGGFLFASYTIVSSNQSLPVALAAAEPAASPYESFIAGAGIIEAKSRNISVGTALSGLVTRVAVEVGDK
VKVGTPLFYLDDREARAELAIRNSDLARARAGLMEARAMLEDSKSLSDLIESLADQRAVSSEEMLRRHNTLRISKARLSS
AETAVRQAEALLASTQTTLDLLVVRAPVSGEILQVNIRPGEFAQVGFLTTPLMLLGNLDQLHVRVDIDENDAWRFDRHSK
AMAYLRGNRNFSVELTPAYVEPYVIPKQSLTGDSTEQVDTRVLQALYSFDREQLPVYVGQQMDVFIEVRDHADNGSPAI

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=191, Percent_Identity=23.0366492146597, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 34811; Mature: 34811

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGHTLPILAIGGFLFASYTIVSSNQSLPVALAAAEPAASPYESFIAGAGIIEAKSRNI
CCCCCCCHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCEEEECCCCE
SVGTALSGLVTRVAVEVGDKVKVGTPLFYLDDREARAELAIRNSDLARARAGLMEARAML
EHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHEEEEECCCHHHHHHHHHHHHHHHH
EDSKSLSDLIESLADQRAVSSEEMLRRHNTLRISKARLSSAETAVRQAEALLASTQTTLD
HCCHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHEEE
LLVVRAPVSGEILQVNIRPGEFAQVGFLTTPLMLLGNLDQLHVRVDIDENDAWRFDRHSK
EEEEECCCCCCEEEEEECCCCCEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHH
AMAYLRGNRNFSVELTPAYVEPYVIPKQSLTGDSTEQVDTRVLQALYSFDREQLPVYVGQ
EEEEEECCCEEEEEEECCEECCEEECCCCCCCCCHHHHHHHHHHHHHHCCHHCCCEEECC
QMDVFIEVRDHADNGSPAI
CEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MKIGHTLPILAIGGFLFASYTIVSSNQSLPVALAAAEPAASPYESFIAGAGIIEAKSRNI
CCCCCCCHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCEEEECCCCE
SVGTALSGLVTRVAVEVGDKVKVGTPLFYLDDREARAELAIRNSDLARARAGLMEARAML
EHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHEEEEECCCHHHHHHHHHHHHHHHH
EDSKSLSDLIESLADQRAVSSEEMLRRHNTLRISKARLSSAETAVRQAEALLASTQTTLD
HCCHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHEEE
LLVVRAPVSGEILQVNIRPGEFAQVGFLTTPLMLLGNLDQLHVRVDIDENDAWRFDRHSK
EEEEECCCCCCEEEEEECCCCCEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHH
AMAYLRGNRNFSVELTPAYVEPYVIPKQSLTGDSTEQVDTRVLQALYSFDREQLPVYVGQ
EEEEEECCCEEEEEEECCEECCEEECCCCCCCCCHHHHHHHHHHHHHHCCHHCCCEEECC
QMDVFIEVRDHADNGSPAI
CEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]