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The map label for this gene is lon [H]

Identifier: 114330973

GI number: 114330973

Start: 999685

End: 1002060

Strand: Reverse

Name: lon [H]

Synonym: Neut_0970

Alternate gene names: 114330973

Gene position: 1002060-999685 (Counterclockwise)

Preceding gene: 114330974

Following gene: 114330972

Centisome position: 37.66

GC content: 51.22

Gene sequence:

>2376_bases
ATGGAACAATCCGCTGTAACCCCGTTTGAGCTGCCCGCCGATATCATCGCCCTGATACCGATGCGGAATGTCGTACTGTT
TCCGCATGTCGTTATGCCTGTCACGGTTGGTCGGGCGCGATCGATTGCATCCATTCAGTATGTCCTGCAATCAAAAACAC
CGATCGGCATTGTGCTACAGAAAGATCCTGCAATTGAAGAACCTGGACTGGATGTACTTTACCCGGTAGGCACCCTCGCT
AATGTCGTGCGCCACATCACATCCGAAGATGGCACGCATCATGCAATTTGTCTGGGCATTGAGCGCTTCCGGATCAAAGA
ACTGGTTGAAGGTTACCCCTTCATTGCCGCACGGATACAACGCATCCCGGAAACCATACCAGATACCACGCAAGTAGAAG
CACTCACGTTGCAATTGCGTGAGCGTGCCATGGAAATTTTGTCACTGTTACCTGGTGTACCGGCTGAACTGGCGCATGCA
CTGCAGGCAACCCGCTCACCGTCTGATCTGGCAGATATTACTGCCAGTCTGCTCGATACTGAAGTAGCTGAAAAGCAGGC
GCTGCTGGAAACAATTGATATTGAAGAACGTTTGCATAAAGTGCTGCAAATTCTGGCGCGGCGTATTGAGGTGCTGCGGC
TCTCACAAGAAATAGGCGAGCGTACCAAGGAGCAAATGGAAGATCGCGAACGCAAGTTTTTGTTGCGCGAGCAACTGAAA
GCAATCCAGAAAGAACTCGGCGAAGAGGGTGAAAATGAACAGGAAGTCGCCAAACTGGATGAAGCCATTACTGCTGCCGG
CATGCCGGAAGATATCGAACAGCAAACCCGCAAAGAATTGCAGCGATTACAGCGGATGCCTGCTGCTTCCAGCGAATTTT
CCATGCTGCATACCTACCTTGAATGGATAACAGAATTGCCCTGGAAGTTGCCGGAGGAAACACCGATAAACCTTGATGCT
GCGCGCTCAATTCTTGAAGCTGACCATTTTGGATTGGAACGAATCAAACAGCGCATCATCGAATTTCTCGCTGTGCAAAA
ATTGAAACCACAAGGCCGCGCACCGATTCTCTGTTTCGTCGGTCCGCCTGGTGTCGGAAAAACTTCGCTCGGACAAAGCA
TTGCCCGCGCGTTACAACGTCCATTTGTCCGGGTATCGCTGGGTGGTATACATGATGAAGCGGAAATGCGTGGTCACCGC
CGCACCTACGTTGGTGCCATGCCGGGCAATATTGTGCAGAATCTACGCAAGGCTGGTGCACGCAACTGCGTGATGATGCT
GGATGAAATTGACAAAATGACCGCCAGCGCACATGGAGATCCCTCAGCAGCATTACTGGAAATCCTTGATCCGGAACAAA
ATGCAACATTCCGTGATAACTATCTGGGTGTCCCGTTCGATTTAAGCCGAGTGGTTTTCATCGCCACTGCCAATGTTATT
GACCAAGTCTCACCGCCGGTCCGCGACCGTATGGAAATCATTGATCTACCTGGTTATACACCGGAAGAAAAACTGCAAAT
CGCACAACGTTATCTGGTGCAACGACAAAGCGAAGCCAACGGCTTGCAATTGGATCAATGCATATTGTTACCTGAAGCCT
TGCAAAGCATTATTGCCAATTACACCCGTGAAGCGGGCGTACGCCAGTTCGAACGTGAAATCGGCCGGATCATGCGCCAC
GCTGCCCTGAAAATCGCGCAAGGTGAGCAGCAACAGGTACGAATTGATGCGAACAATCTGATGGATATCCTGGGCCCTGA
AAAATATGAACATGAACTGGCACTTCGCACCAGTTTGTCGGGGGTGGCAACTGGCTTAGCCTGGACACCGGCCGGTGGAG
ATATCCTGTTTATAGAGGCTACGCGCGTTAGTGGCAGTGGCCGCCTGATCCTAACCGGGCAGCTTGGCGACGTGATGAAA
GAAAGTGCACAGGCCGCTCTCACGCTGGTTAAGGCACGTGCGAGTGATTTGAATATTGCGGCTTCAATGTTTGACGGAAT
CGATGTGCATTTGCATGTGCCTGCCGGTGCCATTCCTAAAGATGGACCAAGTGCCGGGGTAGCAATGTTTACCGCACTAG
CTTCGTTATTCACCAATCAACTGGTAAGGCACGATGTTGCAATGACGGGTGAAATCAGCCTGCGAGGCCTGGTCTTGCCG
GTTGGCGGTATCAAGGAAAAAATACTGGCAGCACAACGCGCCGGTATTCAAACCGTGCTGCTGCCTGCCCGGAACCGGAA
GGATCTGCATGATGTTCCCGAAGCAATACGCACAACCATGCAGTTTGTTTTTCTGGAAACGGCTGATGATGCTATTCGGG
CAGCCTTGGATGTTTCTATTAACGCATCTGACAACAACGATCAGGAATCGTCCTGA

Upstream 100 bases:

>100_bases
ACAGGGCAGGTTTACGGCTTACTTCTCGCACGCTCTCTTGAAATTCCACTGAATCGCTCAATATTGAGACCAGTTAACAA
TTCCTGAGAGGAAACACCAC

Downstream 100 bases:

>100_bases
AGACAAGAAGCCGCTGCCACCTACTTTTCTTGTAGCAGCGGCAATTTGTCGCATAGCCATTAAGTGTCATCCGAGTTATA
GTTAAATTATCAGGCAGCTT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 791; Mature: 791

Protein sequence:

>791_residues
MEQSAVTPFELPADIIALIPMRNVVLFPHVVMPVTVGRARSIASIQYVLQSKTPIGIVLQKDPAIEEPGLDVLYPVGTLA
NVVRHITSEDGTHHAICLGIERFRIKELVEGYPFIAARIQRIPETIPDTTQVEALTLQLRERAMEILSLLPGVPAELAHA
LQATRSPSDLADITASLLDTEVAEKQALLETIDIEERLHKVLQILARRIEVLRLSQEIGERTKEQMEDRERKFLLREQLK
AIQKELGEEGENEQEVAKLDEAITAAGMPEDIEQQTRKELQRLQRMPAASSEFSMLHTYLEWITELPWKLPEETPINLDA
ARSILEADHFGLERIKQRIIEFLAVQKLKPQGRAPILCFVGPPGVGKTSLGQSIARALQRPFVRVSLGGIHDEAEMRGHR
RTYVGAMPGNIVQNLRKAGARNCVMMLDEIDKMTASAHGDPSAALLEILDPEQNATFRDNYLGVPFDLSRVVFIATANVI
DQVSPPVRDRMEIIDLPGYTPEEKLQIAQRYLVQRQSEANGLQLDQCILLPEALQSIIANYTREAGVRQFEREIGRIMRH
AALKIAQGEQQQVRIDANNLMDILGPEKYEHELALRTSLSGVATGLAWTPAGGDILFIEATRVSGSGRLILTGQLGDVMK
ESAQAALTLVKARASDLNIAASMFDGIDVHLHVPAGAIPKDGPSAGVAMFTALASLFTNQLVRHDVAMTGEISLRGLVLP
VGGIKEKILAAQRAGIQTVLLPARNRKDLHDVPEAIRTTMQFVFLETADDAIRAALDVSINASDNNDQESS

Sequences:

>Translated_791_residues
MEQSAVTPFELPADIIALIPMRNVVLFPHVVMPVTVGRARSIASIQYVLQSKTPIGIVLQKDPAIEEPGLDVLYPVGTLA
NVVRHITSEDGTHHAICLGIERFRIKELVEGYPFIAARIQRIPETIPDTTQVEALTLQLRERAMEILSLLPGVPAELAHA
LQATRSPSDLADITASLLDTEVAEKQALLETIDIEERLHKVLQILARRIEVLRLSQEIGERTKEQMEDRERKFLLREQLK
AIQKELGEEGENEQEVAKLDEAITAAGMPEDIEQQTRKELQRLQRMPAASSEFSMLHTYLEWITELPWKLPEETPINLDA
ARSILEADHFGLERIKQRIIEFLAVQKLKPQGRAPILCFVGPPGVGKTSLGQSIARALQRPFVRVSLGGIHDEAEMRGHR
RTYVGAMPGNIVQNLRKAGARNCVMMLDEIDKMTASAHGDPSAALLEILDPEQNATFRDNYLGVPFDLSRVVFIATANVI
DQVSPPVRDRMEIIDLPGYTPEEKLQIAQRYLVQRQSEANGLQLDQCILLPEALQSIIANYTREAGVRQFEREIGRIMRH
AALKIAQGEQQQVRIDANNLMDILGPEKYEHELALRTSLSGVATGLAWTPAGGDILFIEATRVSGSGRLILTGQLGDVMK
ESAQAALTLVKARASDLNIAASMFDGIDVHLHVPAGAIPKDGPSAGVAMFTALASLFTNQLVRHDVAMTGEISLRGLVLP
VGGIKEKILAAQRAGIQTVLLPARNRKDLHDVPEAIRTTMQFVFLETADDAIRAALDVSINASDNNDQESS
>Mature_791_residues
MEQSAVTPFELPADIIALIPMRNVVLFPHVVMPVTVGRARSIASIQYVLQSKTPIGIVLQKDPAIEEPGLDVLYPVGTLA
NVVRHITSEDGTHHAICLGIERFRIKELVEGYPFIAARIQRIPETIPDTTQVEALTLQLRERAMEILSLLPGVPAELAHA
LQATRSPSDLADITASLLDTEVAEKQALLETIDIEERLHKVLQILARRIEVLRLSQEIGERTKEQMEDRERKFLLREQLK
AIQKELGEEGENEQEVAKLDEAITAAGMPEDIEQQTRKELQRLQRMPAASSEFSMLHTYLEWITELPWKLPEETPINLDA
ARSILEADHFGLERIKQRIIEFLAVQKLKPQGRAPILCFVGPPGVGKTSLGQSIARALQRPFVRVSLGGIHDEAEMRGHR
RTYVGAMPGNIVQNLRKAGARNCVMMLDEIDKMTASAHGDPSAALLEILDPEQNATFRDNYLGVPFDLSRVVFIATANVI
DQVSPPVRDRMEIIDLPGYTPEEKLQIAQRYLVQRQSEANGLQLDQCILLPEALQSIIANYTREAGVRQFEREIGRIMRH
AALKIAQGEQQQVRIDANNLMDILGPEKYEHELALRTSLSGVATGLAWTPAGGDILFIEATRVSGSGRLILTGQLGDVMK
ESAQAALTLVKARASDLNIAASMFDGIDVHLHVPAGAIPKDGPSAGVAMFTALASLFTNQLVRHDVAMTGEISLRGLVLP
VGGIKEKILAAQRAGIQTVLLPARNRKDLHDVPEAIRTTMQFVFLETADDAIRAALDVSINASDNNDQESS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=843, Percent_Identity=40.0948991696323, Blast_Score=595, Evalue=1e-170,
Organism=Homo sapiens, GI21396489, Length=652, Percent_Identity=43.0981595092025, Blast_Score=539, Evalue=1e-153,
Organism=Escherichia coli, GI1786643, Length=742, Percent_Identity=44.4743935309973, Blast_Score=656, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=650, Percent_Identity=40.9230769230769, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=42.9097605893186, Blast_Score=459, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319449, Length=402, Percent_Identity=41.7910447761194, Blast_Score=352, Evalue=1e-97,
Organism=Drosophila melanogaster, GI221513036, Length=694, Percent_Identity=42.507204610951, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24666867, Length=694, Percent_Identity=42.507204610951, Blast_Score=548, Evalue=1e-156,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87254; Mature: 87254

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQSAVTPFELPADIIALIPMRNVVLFPHVVMPVTVGRARSIASIQYVLQSKTPIGIVLQ
CCCCCCCCCCCCHHHHHHHHHCCHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEE
KDPAIEEPGLDVLYPVGTLANVVRHITSEDGTHHAICLGIERFRIKELVEGYPFIAARIQ
CCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHH
RIPETIPDTTQVEALTLQLRERAMEILSLLPGVPAELAHALQATRSPSDLADITASLLDT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
EVAEKQALLETIDIEERLHKVLQILARRIEVLRLSQEIGERTKEQMEDRERKFLLREQLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQKELGEEGENEQEVAKLDEAITAAGMPEDIEQQTRKELQRLQRMPAASSEFSMLHTYL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EWITELPWKLPEETPINLDAARSILEADHFGLERIKQRIIEFLAVQKLKPQGRAPILCFV
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
GPPGVGKTSLGQSIARALQRPFVRVSLGGIHDEAEMRGHRRTYVGAMPGNIVQNLRKAGA
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHHCCC
RNCVMMLDEIDKMTASAHGDPSAALLEILDPEQNATFRDNYLGVPFDLSRVVFIATANVI
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEHHHHHHHH
DQVSPPVRDRMEIIDLPGYTPEEKLQIAQRYLVQRQSEANGLQLDQCILLPEALQSIIAN
HHCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
YTREAGVRQFEREIGRIMRHAALKIAQGEQQQVRIDANNLMDILGPEKYEHELALRTSLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCHHHHHHHHHHHHH
GVATGLAWTPAGGDILFIEATRVSGSGRLILTGQLGDVMKESAQAALTLVKARASDLNIA
HHHHCCEECCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHH
ASMFDGIDVHLHVPAGAIPKDGPSAGVAMFTALASLFTNQLVRHDVAMTGEISLRGLVLP
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEEEEE
VGGIKEKILAAQRAGIQTVLLPARNRKDLHDVPEAIRTTMQFVFLETADDAIRAALDVSI
CCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEECHHHHHHHHHEEEE
NASDNNDQESS
ECCCCCCCCCC
>Mature Secondary Structure
MEQSAVTPFELPADIIALIPMRNVVLFPHVVMPVTVGRARSIASIQYVLQSKTPIGIVLQ
CCCCCCCCCCCCHHHHHHHHHCCHHHCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEE
KDPAIEEPGLDVLYPVGTLANVVRHITSEDGTHHAICLGIERFRIKELVEGYPFIAARIQ
CCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHH
RIPETIPDTTQVEALTLQLRERAMEILSLLPGVPAELAHALQATRSPSDLADITASLLDT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
EVAEKQALLETIDIEERLHKVLQILARRIEVLRLSQEIGERTKEQMEDRERKFLLREQLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQKELGEEGENEQEVAKLDEAITAAGMPEDIEQQTRKELQRLQRMPAASSEFSMLHTYL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EWITELPWKLPEETPINLDAARSILEADHFGLERIKQRIIEFLAVQKLKPQGRAPILCFV
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
GPPGVGKTSLGQSIARALQRPFVRVSLGGIHDEAEMRGHRRTYVGAMPGNIVQNLRKAGA
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHHCCC
RNCVMMLDEIDKMTASAHGDPSAALLEILDPEQNATFRDNYLGVPFDLSRVVFIATANVI
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEHHHHHHHH
DQVSPPVRDRMEIIDLPGYTPEEKLQIAQRYLVQRQSEANGLQLDQCILLPEALQSIIAN
HHCCCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
YTREAGVRQFEREIGRIMRHAALKIAQGEQQQVRIDANNLMDILGPEKYEHELALRTSLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCHHHHHHHHHHHHH
GVATGLAWTPAGGDILFIEATRVSGSGRLILTGQLGDVMKESAQAALTLVKARASDLNIA
HHHHCCEECCCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHH
ASMFDGIDVHLHVPAGAIPKDGPSAGVAMFTALASLFTNQLVRHDVAMTGEISLRGLVLP
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEEEEE
VGGIKEKILAAQRAGIQTVLLPARNRKDLHDVPEAIRTTMQFVFLETADDAIRAALDVSI
CCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEECHHHHHHHHHEEEE
NASDNNDQESS
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA