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The map label for this gene is nuoM [H]

Identifier: 114330937

GI number: 114330937

Start: 960429

End: 961910

Strand: Direct

Name: nuoM [H]

Synonym: Neut_0934

Alternate gene names: 114330937

Gene position: 960429-961910 (Clockwise)

Preceding gene: 114330936

Following gene: 114330938

Centisome position: 36.09

GC content: 43.25

Gene sequence:

>1482_bases
ATGTTATTTGGATTTCCGCTGTTAAGTCTAATTATCTGGTTACCAATTGTTTCTGGTTTAATCGTATTTTTGATGAGTGA
CCGGAATACTCAAGCGGTACGCTGGGTTGCTCTGGCTGGATCTGTGGCCGGTTTCCTCGTAACACTTCCGCTTTATAGTG
GATTTGATACATCCATGGGTTCGATGCAGTTTATCGAGCGGAATGTATGGTTTGAACGCCTCAATGTCTATTATTATTTG
GGGGTTGATGGCATATCAATGCCATTAATTTTATTGAACAGTTTTACGACCCCGCTGGTCGTGATTGCCGGATGGGAGGT
GATTCGTGAAAAGGTTTCCCAATATATGGGAGCTTTTTTGATCATGTCCGGTGTTCTCAATGGGGTGTTCGCGTCACTGG
ATGCCATATTGTTCTATTCTTTCTGGGAAGCATCACTGGTTCCAATGTTTATCATTATTGGAGTCTGGGGAGGGCCTAAC
CGGATTTATGCAGCTCTAAAGTTTTTTCTTTATACATTTCTGGGATCTCTATTGATGCTGGTGGCGCTGATTTATTTATA
TCAGGCTTCTGGTGGTAGCTTCTCAATTCTCGATTATCATCATCTTCCTATACCGATGGCCGCACAAATCCTTATTTTTA
TAGGATTTATGGTCGCCTTCGCGGTTAAGGTGCCGATGTGGCCAGTGCATACTTGGTTGCCGGATGCGCACGTTGAAGCA
CCTACAGGTGGTTCGGTAGTACTGGCAGCTATCCTGCTTAAACTGGGTGGATACGGTTTTCTCAGATTTTCTTTACCAAT
TACGCCAGATGCGAGTCATGAGTTGTCATGGATATTGATCGCTTTATCGCTGATTGCCATTGTATATATTGGCATCGTTG
CGTTAATGCAGCGTGATATGAAGAAGCTGATTGCCTATTCTTCAGTTTCTCATATGGGATTTGTTACGTTGGGCTTTTTC
CTGTTCAATCCTATTGGAATAGAAGGAGCCATGGTGCAGATGATTTCGCATGGATTCATTTCTGGCGCTTTGTTTCTATG
TGTTGGTGTTTTATATGATCGCTTGCATACTAGGATGATCGCAGATTATGGTGGGGTAGTTAATAAAATGCCAGTTTTTG
CTGCTCTTTTTATGTTGTTTGCAATGGCTAACTCCGGGCTTCCAGGCACCAGTGGTTTCGTAGGTGAATTTATGGTGATT
ATGGGGTCCATGGAAGTAAATTTCTGGTATGCATTTTTTGCTGCGCTGACATTGATTTTGGGGGCGTCTTACAGTCTGTG
GCTATATAAAAAAGTTGTGTTTGGTGCCGTGGCAAATCCCAATGTCGAGGGAATGAAAGATATTTCCGCACGTGAATTTT
TGGTTTTGGCTATCCTGGCGGTTGCAGTTCTAGCTCTGGGTATTTATCCGCTGCCACTTACCGAAGTTATGCATGTTACG
GTTGATAATCTGCTGGAGCATGTTGCACGTACCAAGCTTTAA

Upstream 100 bases:

>100_bases
TTTCCTTTTTAGGCTTCAGGGAATTGAAAACGGACTGAACTTCTTTCTGTTCTCTGGGATAACTAATACGCATTGAAATG
CGATTTAAGACGAAAAAAAC

Downstream 100 bases:

>100_bases
GATATTTAGCTAAATTTTTGGATAATAAAAATACTTTCCTGATCGGAAATTAAGGATTTTTCATGGATTTTTTGTTACCT
GACTTCACACCAGCTTACCC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MLFGFPLLSLIIWLPIVSGLIVFLMSDRNTQAVRWVALAGSVAGFLVTLPLYSGFDTSMGSMQFIERNVWFERLNVYYYL
GVDGISMPLILLNSFTTPLVVIAGWEVIREKVSQYMGAFLIMSGVLNGVFASLDAILFYSFWEASLVPMFIIIGVWGGPN
RIYAALKFFLYTFLGSLLMLVALIYLYQASGGSFSILDYHHLPIPMAAQILIFIGFMVAFAVKVPMWPVHTWLPDAHVEA
PTGGSVVLAAILLKLGGYGFLRFSLPITPDASHELSWILIALSLIAIVYIGIVALMQRDMKKLIAYSSVSHMGFVTLGFF
LFNPIGIEGAMVQMISHGFISGALFLCVGVLYDRLHTRMIADYGGVVNKMPVFAALFMLFAMANSGLPGTSGFVGEFMVI
MGSMEVNFWYAFFAALTLILGASYSLWLYKKVVFGAVANPNVEGMKDISAREFLVLAILAVAVLALGIYPLPLTEVMHVT
VDNLLEHVARTKL

Sequences:

>Translated_493_residues
MLFGFPLLSLIIWLPIVSGLIVFLMSDRNTQAVRWVALAGSVAGFLVTLPLYSGFDTSMGSMQFIERNVWFERLNVYYYL
GVDGISMPLILLNSFTTPLVVIAGWEVIREKVSQYMGAFLIMSGVLNGVFASLDAILFYSFWEASLVPMFIIIGVWGGPN
RIYAALKFFLYTFLGSLLMLVALIYLYQASGGSFSILDYHHLPIPMAAQILIFIGFMVAFAVKVPMWPVHTWLPDAHVEA
PTGGSVVLAAILLKLGGYGFLRFSLPITPDASHELSWILIALSLIAIVYIGIVALMQRDMKKLIAYSSVSHMGFVTLGFF
LFNPIGIEGAMVQMISHGFISGALFLCVGVLYDRLHTRMIADYGGVVNKMPVFAALFMLFAMANSGLPGTSGFVGEFMVI
MGSMEVNFWYAFFAALTLILGASYSLWLYKKVVFGAVANPNVEGMKDISAREFLVLAILAVAVLALGIYPLPLTEVMHVT
VDNLLEHVARTKL
>Mature_493_residues
MLFGFPLLSLIIWLPIVSGLIVFLMSDRNTQAVRWVALAGSVAGFLVTLPLYSGFDTSMGSMQFIERNVWFERLNVYYYL
GVDGISMPLILLNSFTTPLVVIAGWEVIREKVSQYMGAFLIMSGVLNGVFASLDAILFYSFWEASLVPMFIIIGVWGGPN
RIYAALKFFLYTFLGSLLMLVALIYLYQASGGSFSILDYHHLPIPMAAQILIFIGFMVAFAVKVPMWPVHTWLPDAHVEA
PTGGSVVLAAILLKLGGYGFLRFSLPITPDASHELSWILIALSLIAIVYIGIVALMQRDMKKLIAYSSVSHMGFVTLGFF
LFNPIGIEGAMVQMISHGFISGALFLCVGVLYDRLHTRMIADYGGVVNKMPVFAALFMLFAMANSGLPGTSGFVGEFMVI
MGSMEVNFWYAFFAALTLILGASYSLWLYKKVVFGAVANPNVEGMKDISAREFLVLAILAVAVLALGIYPLPLTEVMHVT
VDNLLEHVARTKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=366, Percent_Identity=34.1530054644809, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI251831117, Length=226, Percent_Identity=23.8938053097345, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788613, Length=502, Percent_Identity=37.2509960159363, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1788827, Length=266, Percent_Identity=28.1954887218045, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788831, Length=290, Percent_Identity=28.2758620689655, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788829, Length=327, Percent_Identity=26.2996941896024, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI145693160, Length=455, Percent_Identity=24.8351648351648, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788614, Length=421, Percent_Identity=24.9406175771971, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=263, Percent_Identity=25.8555133079848, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54237; Mature: 54237

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]