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The map label for this gene is nuoL [H]

Identifier: 114330936

GI number: 114330936

Start: 958394

End: 960340

Strand: Direct

Name: nuoL [H]

Synonym: Neut_0933

Alternate gene names: 114330936

Gene position: 958394-960340 (Clockwise)

Preceding gene: 114330935

Following gene: 114330937

Centisome position: 36.02

GC content: 44.38

Gene sequence:

>1947_bases
ATGGAAAATCTTTATTTACTAGTACCAGCGGCACCCTTGTTAGGAGCAATCGTTGCCGGGCTGTTTGGGCGACAGATTGG
TCTGATAGGGAGCCATCGTGCGACGATTGCGTTAGTGGCACTGTCATTTATTGCATCTGTTGTAATTTTTATCGATGTAT
TACAAGGAAATCTTTATAACGGTAGTGTCTATACCTGGATGACATCAGGCGAGACTGTAATTGAGATAGGATTTTTGATT
GATACGTTGTCAGCCACGATGATGATGGTAGTAACAGGTGTATCGTTAATGGTACATATTTATACTATCGGCTATATGCA
GGGAGATCCAGGGTATCAGCGATTTTTTAGCTATATATCGCTATTTACGTTTTCGATGCTGATGCTGGTGATGTCAAACA
ATTTCCTGCAATTGTTTTTTGGCTGGGAAGCAGTCGGACTGGTCTCTTATTTGCTAATCGGTTTTTGGTACACTCGCCCG
ACGGCAATTTATGCCAATCTCAAAGCATTTCTGGTTAATCGGATCGCTGATATAGGCTTCCTGCTGGGTATCGCTTTAAT
ACTGGCAAATGTCGGCACTTTGGATTACGAGCTTGTATTTACCCATGCGGAATACCTTGCATCCCGTACTATTGAAATCA
TGCCTGGTGAATCCTGGATGTTGATGACAGTAATATGTTTGCTGCTTTTCATAGGTGCGATGGGTAAATCTGCTCAATTT
CCCCTGCATGTCTGGTTACCGGATTCAATGGAGGGGCCAACACCCATTTCGGCTCTGATTCATGCTGCAACCATGGTAAC
AGCTGGTATCTTCATGGTAGCTCGCATGTCTCCTCTGTTTGAGTTATCTGTTACAGTGCACTCGGTTATTTTTGTGATTG
GTGGAATTACTACCTTGTTTATGGCGCTGGTAGCGGTAGTACAGAATGATATCAAGCGAGTCGTTGCGTATTCAACGCTA
TCCCAGCTCGGATACATGACGGTAGCACTGGGCGCATCTGCTTATTCAGCGGCTATCTTTCATCTTATGACGCATGCCTT
TTTCAAGGCATTGCTGTTTCTGGGTGCAGGGTCCGTCATTATCGCCATGCATCACGAGCAGGATATGCGCAAGATGGGTG
GACTTAAACGATATATGCCGATTACATTTGGCACCATGTTTGTTGCTGCATTGGCCAGTGCAGGAGTGCCAGGTTTTTCA
GGTTTTTTCTCTAAGGATGCGATTATTGAAGGAATTCTCCTCTCGGAAATTCCTGGGGCAGGATTCGCCTATTTCTGCGC
GTTAAGTACAGTATTCGTTACTGCGCTGTATACCTTCCGGCTAATATTCATGACTTTCTATGGCGAACCAGGTATGGATA
GCCATACACGTGATCATTTGCGTGAATCCCCTTGGGTAGTGACGGTACCACTAGTTTTATTGGCAATTCCTACTGTGGCG
GCTGGCTGGCTGATTGATCCAATGCTTTTTGGAGGTTTCTTCACTGAGGCTATTTATATAGATGCGCAGCATGATGTCAT
GGCCAAGATGGGCGAGAGCTATACAGGAATATTCGGCATGATGATACATGCTTTGACTGCCCCTCCGTTCTGGCTGGCGA
TGTCAGGAATTTTTACTGCCTGGTTTTTGTATCGTTATCAAACTGCATTACCCGGTAAAATTAAAAAACTGGCTAATCCG
GTTTATGTTCTGCTTGATCGAAAATATTTTATTGATGAGCTGTACAGCTGGTTATTTGCGGGCGGTTTACGTACGCTAAG
TACCGTGCTGTGGAAATATGTAGATGTGAAAGTCATAGATGGTTTGATGGTTAATGGCACGGCAAGAGCGATGGGTTGGT
TTGCGATGGTGGGACGTCGCTTTCAGTCCGGGTATATCTACCATTATGCATTTAGTATGATTGTGGGTGTATTTGTTCTG
ATGAGTATATGGCTGTTTCCTTTTTAG

Upstream 100 bases:

>100_bases
TACTATCAACGTAGATGATTTGGATAGACTTAAGGGTTGAACGGCAGGCAGTTTTATATCCAGTCAGTTTGTTAAACAGT
ATTGTTAATTGATACCTTAG

Downstream 100 bases:

>100_bases
GCTTCAGGGAATTGAAAACGGACTGAACTTCTTTCTGTTCTCTGGGATAACTAATACGCATTGAAATGCGATTTAAGACG
AAAAAAACATGTTATTTGGA

Product: proton-translocating NADH-quinone oxidoreductase, chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MENLYLLVPAAPLLGAIVAGLFGRQIGLIGSHRATIALVALSFIASVVIFIDVLQGNLYNGSVYTWMTSGETVIEIGFLI
DTLSATMMMVVTGVSLMVHIYTIGYMQGDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRP
TAIYANLKAFLVNRIADIGFLLGIALILANVGTLDYELVFTHAEYLASRTIEIMPGESWMLMTVICLLLFIGAMGKSAQF
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSVTVHSVIFVIGGITTLFMALVAVVQNDIKRVVAYSTL
SQLGYMTVALGASAYSAAIFHLMTHAFFKALLFLGAGSVIIAMHHEQDMRKMGGLKRYMPITFGTMFVAALASAGVPGFS
GFFSKDAIIEGILLSEIPGAGFAYFCALSTVFVTALYTFRLIFMTFYGEPGMDSHTRDHLRESPWVVTVPLVLLAIPTVA
AGWLIDPMLFGGFFTEAIYIDAQHDVMAKMGESYTGIFGMMIHALTAPPFWLAMSGIFTAWFLYRYQTALPGKIKKLANP
VYVLLDRKYFIDELYSWLFAGGLRTLSTVLWKYVDVKVIDGLMVNGTARAMGWFAMVGRRFQSGYIYHYAFSMIVGVFVL
MSIWLFPF

Sequences:

>Translated_648_residues
MENLYLLVPAAPLLGAIVAGLFGRQIGLIGSHRATIALVALSFIASVVIFIDVLQGNLYNGSVYTWMTSGETVIEIGFLI
DTLSATMMMVVTGVSLMVHIYTIGYMQGDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRP
TAIYANLKAFLVNRIADIGFLLGIALILANVGTLDYELVFTHAEYLASRTIEIMPGESWMLMTVICLLLFIGAMGKSAQF
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSVTVHSVIFVIGGITTLFMALVAVVQNDIKRVVAYSTL
SQLGYMTVALGASAYSAAIFHLMTHAFFKALLFLGAGSVIIAMHHEQDMRKMGGLKRYMPITFGTMFVAALASAGVPGFS
GFFSKDAIIEGILLSEIPGAGFAYFCALSTVFVTALYTFRLIFMTFYGEPGMDSHTRDHLRESPWVVTVPLVLLAIPTVA
AGWLIDPMLFGGFFTEAIYIDAQHDVMAKMGESYTGIFGMMIHALTAPPFWLAMSGIFTAWFLYRYQTALPGKIKKLANP
VYVLLDRKYFIDELYSWLFAGGLRTLSTVLWKYVDVKVIDGLMVNGTARAMGWFAMVGRRFQSGYIYHYAFSMIVGVFVL
MSIWLFPF
>Mature_648_residues
MENLYLLVPAAPLLGAIVAGLFGRQIGLIGSHRATIALVALSFIASVVIFIDVLQGNLYNGSVYTWMTSGETVIEIGFLI
DTLSATMMMVVTGVSLMVHIYTIGYMQGDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRP
TAIYANLKAFLVNRIADIGFLLGIALILANVGTLDYELVFTHAEYLASRTIEIMPGESWMLMTVICLLLFIGAMGKSAQF
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSVTVHSVIFVIGGITTLFMALVAVVQNDIKRVVAYSTL
SQLGYMTVALGASAYSAAIFHLMTHAFFKALLFLGAGSVIIAMHHEQDMRKMGGLKRYMPITFGTMFVAALASAGVPGFS
GFFSKDAIIEGILLSEIPGAGFAYFCALSTVFVTALYTFRLIFMTFYGEPGMDSHTRDHLRESPWVVTVPLVLLAIPTVA
AGWLIDPMLFGGFFTEAIYIDAQHDVMAKMGESYTGIFGMMIHALTAPPFWLAMSGIFTAWFLYRYQTALPGKIKKLANP
VYVLLDRKYFIDELYSWLFAGGLRTLSTVLWKYVDVKVIDGLMVNGTARAMGWFAMVGRRFQSGYIYHYAFSMIVGVFVL
MSIWLFPF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=424, Percent_Identity=40.0943396226415, Blast_Score=295, Evalue=8e-80,
Organism=Escherichia coli, GI1788614, Length=438, Percent_Identity=44.7488584474886, Blast_Score=352, Evalue=5e-98,
Organism=Escherichia coli, GI1788829, Length=352, Percent_Identity=34.0909090909091, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788827, Length=442, Percent_Identity=28.2805429864253, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788831, Length=343, Percent_Identity=28.2798833819242, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI2367154, Length=230, Percent_Identity=30.8695652173913, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788613, Length=354, Percent_Identity=28.5310734463277, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI145693160, Length=332, Percent_Identity=25.6024096385542, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71627; Mature: 71627

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLYLLVPAAPLLGAIVAGLFGRQIGLIGSHRATIALVALSFIASVVIFIDVLQGNLYN
CCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GSVYTWMTSGETVIEIGFLIDTLSATMMMVVTGVSLMVHIYTIGYMQGDPGYQRFFSYIS
CEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
LFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIYANLKAFLVNRIADIGF
HHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LLGIALILANVGTLDYELVFTHAEYLASRTIEIMPGESWMLMTVICLLLFIGAMGKSAQF
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSVTVHSVIFVIGGITTLF
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
MALVAVVQNDIKRVVAYSTLSQLGYMTVALGASAYSAAIFHLMTHAFFKALLFLGAGSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IAMHHEQDMRKMGGLKRYMPITFGTMFVAALASAGVPGFSGFFSKDAIIEGILLSEIPGA
EEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCC
GFAYFCALSTVFVTALYTFRLIFMTFYGEPGMDSHTRDHLRESPWVVTVPLVLLAIPTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHH
AGWLIDPMLFGGFFTEAIYIDAQHDVMAKMGESYTGIFGMMIHALTAPPFWLAMSGIFTA
HHHHHHHHHHHHHHHHHEEEECHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
WFLYRYQTALPGKIKKLANPVYVLLDRKYFIDELYSWLFAGGLRTLSTVLWKYVDVKVID
HHHHHHHHCCCHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLMVNGTARAMGWFAMVGRRFQSGYIYHYAFSMIVGVFVLMSIWLFPF
CEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENLYLLVPAAPLLGAIVAGLFGRQIGLIGSHRATIALVALSFIASVVIFIDVLQGNLYN
CCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GSVYTWMTSGETVIEIGFLIDTLSATMMMVVTGVSLMVHIYTIGYMQGDPGYQRFFSYIS
CEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHH
LFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIYANLKAFLVNRIADIGF
HHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LLGIALILANVGTLDYELVFTHAEYLASRTIEIMPGESWMLMTVICLLLFIGAMGKSAQF
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSVTVHSVIFVIGGITTLF
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
MALVAVVQNDIKRVVAYSTLSQLGYMTVALGASAYSAAIFHLMTHAFFKALLFLGAGSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IAMHHEQDMRKMGGLKRYMPITFGTMFVAALASAGVPGFSGFFSKDAIIEGILLSEIPGA
EEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCC
GFAYFCALSTVFVTALYTFRLIFMTFYGEPGMDSHTRDHLRESPWVVTVPLVLLAIPTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHH
AGWLIDPMLFGGFFTEAIYIDAQHDVMAKMGESYTGIFGMMIHALTAPPFWLAMSGIFTA
HHHHHHHHHHHHHHHHHEEEECHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
WFLYRYQTALPGKIKKLANPVYVLLDRKYFIDELYSWLFAGGLRTLSTVLWKYVDVKVID
HHHHHHHHCCCHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLMVNGTARAMGWFAMVGRRFQSGYIYHYAFSMIVGVFVLMSIWLFPF
CEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]