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The map label for this gene is pth [H]

Identifier: 114330911

GI number: 114330911

Start: 931604

End: 933457

Strand: Direct

Name: pth [H]

Synonym: Neut_0908

Alternate gene names: 114330911

Gene position: 931604-933457 (Clockwise)

Preceding gene: 114330910

Following gene: 114330914

Centisome position: 35.01

GC content: 44.71

Gene sequence:

>1854_bases
ATGAGCTTGAAGGAACGGTACGGGGATGTAAAGTGGAAATATCGAGTCGCGAGCGCCTATTTTAATGCATGGCTGCATTT
GTTAAGGCTGAGGCATACTTCATTTATTGGGATCACAGGTAGCGCAGGTAAAACGACCACCAAGGATCTTTGTTACCTGA
TTCTTTCCGGTTTTTATCCGGTTGCACAGAGTTACAAATCCCTTAATGTGGTTAAGGCAACAGCAGATTTTGTATTGGAA
GTTGAGTCAAAACATCGTTTTAGTATTATCGAGATGTCAGGAAATAGGCCAGGTGCACTGGATCTTCCCTTGTGGCTGGT
TAAACCGGAAATCGCTGTTTTAACCAATATAGAAAAAGATCACTTTAGAGCCTTCAAGGGTGAGAGTGTTGATGGAATCG
CCCGGGAAAAAGCAAAATTGATTGAGGCTCTGTCAGAGAATGGCACTGCAGTTCTCAATATGGATGATCCGCGCGTAAAA
GTAATAGGAGAACGCTGCAAAGCTAAGGTTATCTGGGTGGGAAAAAGTAAGGGGGCAACCCTTCGTTTGCTTAACGCTAC
TTCCAGCTATCCACAACCACTTACACTTACCATCAAATATGAAGGTATTACTCATGAAGTAATAACCGGGTTGCATGGTA
CCTATCTTGCCACATCAGTATTATGTGCGTTGGGTGTGGCCCTAGCAGCGGGAATTAGGCTTGACCAAGCGATTCCACGG
CTGGCTCTGGCTGTTCCTGTGGAGGGTCGCATGCAGCCGGTTGTTATGGGTGATGGCGTGACGTTTATTCGCGATGATAT
GAAAGCGCCTGCCTGGTCATTGCCAATGGTGCTGGATTTTTTGAGTGAAGCAACTGCTGTCAGGAAGATCGCAGTCGTCG
GGTCAATTTCGGATTTTTCGGGTGATCGTTCTGATAAATACAAACAATTTGCCAGACAGGTACTGCAACATGCTGATATG
GTCATTTTTGTTGGGGATAATGCCCATCGTGCTTTACGCGCCAGGAAGGATGAGAATGATTCGGCCCTGCAGGGGTTTTT
GACATTAAAGGAAGCTTCGTCATTCTTGCAGAAGACGCTACGGCCGGGTGATCTGGTTTTGCTGAAAGGATCGAATAAAT
CTGATCACTTGCAGCGTCTGATACTGGATCGCTATAAGCCAATTCAGTGCTGGCAAGAACGTTGTGGACTTGAGCATTTT
TGTGATTGCTGTGTTTATCTTTATCGTGCTGATTCTGTTGCAGACTTGGGTTCAGATATTCGAACAGAGTCTAAAATTCA
ATCAATAGCAGTTGTTTCTAAAGAGGAAGGGGTGGCGATCCCTATAATTGTGGGTCTGGGTAATCCGGGTGCTGAATACA
AGAATACGCCACATAATATAGGGTATTTTGTACTGGATAGCCTTGCAGAAAATCATGGGGCCATATGGCAAGAAACAGAT
GAAGGTCAGATCTGTTCGATTCAACTTGAAAGTAAGCCAGTTAGTCTGTTCAAGGCTACTGCTTACATGAATGAAACTGG
CCCTAAGCTACAACGTTACCTAGCTAAAACAGGCTGTTTGCCTGAGCAGTGTATTATCGTTCATGATGATACAGATATTG
AATTCGGGAAGATTTATATTAAATCAGATGGCGGTGATGCCGGGCATTGGGGTGTCAGATCGTGCCTTGTAGCGTTAGGC
ACAGATCAAGTTAAAAGGCTAAGACTGGGTGTGGGAGTGCCAGGAAAAACCGGAAGCGCCAAAAGGAGAGTGCTAACAAA
TTTTTCCCAGGAAGAGCAGCAACGGTTACAACAAATTGTGGAAGATGCAGTAGTAATACTGGGTAAAACGCTATCTGCTT
TTAATTCCATATAG

Upstream 100 bases:

>100_bases
GCCGGAGTCATTATCGGAATTACCAGCCGCATAGATTTATTCTGAATTAGAAAGTTATTCCTGATTTTAGTAATGAATCG
ATATAAAGGTGCTACTCAGA

Downstream 100 bases:

>100_bases
GAATGTGATATTTGTTCATTGCGCCCACGTCATCGAGAATTGCTATTGTGTTATCAGGTTTGGATGAGAAGTGTCATCTG
CGAATCAGATCAACAACCTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MSLKERYGDVKWKYRVASAYFNAWLHLLRLRHTSFIGITGSAGKTTTKDLCYLILSGFYPVAQSYKSLNVVKATADFVLE
VESKHRFSIIEMSGNRPGALDLPLWLVKPEIAVLTNIEKDHFRAFKGESVDGIAREKAKLIEALSENGTAVLNMDDPRVK
VIGERCKAKVIWVGKSKGATLRLLNATSSYPQPLTLTIKYEGITHEVITGLHGTYLATSVLCALGVALAAGIRLDQAIPR
LALAVPVEGRMQPVVMGDGVTFIRDDMKAPAWSLPMVLDFLSEATAVRKIAVVGSISDFSGDRSDKYKQFARQVLQHADM
VIFVGDNAHRALRARKDENDSALQGFLTLKEASSFLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQERCGLEHF
CDCCVYLYRADSVADLGSDIRTESKIQSIAVVSKEEGVAIPIIVGLGNPGAEYKNTPHNIGYFVLDSLAENHGAIWQETD
EGQICSIQLESKPVSLFKATAYMNETGPKLQRYLAKTGCLPEQCIIVHDDTDIEFGKIYIKSDGGDAGHWGVRSCLVALG
TDQVKRLRLGVGVPGKTGSAKRRVLTNFSQEEQQRLQQIVEDAVVILGKTLSAFNSI

Sequences:

>Translated_617_residues
MSLKERYGDVKWKYRVASAYFNAWLHLLRLRHTSFIGITGSAGKTTTKDLCYLILSGFYPVAQSYKSLNVVKATADFVLE
VESKHRFSIIEMSGNRPGALDLPLWLVKPEIAVLTNIEKDHFRAFKGESVDGIAREKAKLIEALSENGTAVLNMDDPRVK
VIGERCKAKVIWVGKSKGATLRLLNATSSYPQPLTLTIKYEGITHEVITGLHGTYLATSVLCALGVALAAGIRLDQAIPR
LALAVPVEGRMQPVVMGDGVTFIRDDMKAPAWSLPMVLDFLSEATAVRKIAVVGSISDFSGDRSDKYKQFARQVLQHADM
VIFVGDNAHRALRARKDENDSALQGFLTLKEASSFLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQERCGLEHF
CDCCVYLYRADSVADLGSDIRTESKIQSIAVVSKEEGVAIPIIVGLGNPGAEYKNTPHNIGYFVLDSLAENHGAIWQETD
EGQICSIQLESKPVSLFKATAYMNETGPKLQRYLAKTGCLPEQCIIVHDDTDIEFGKIYIKSDGGDAGHWGVRSCLVALG
TDQVKRLRLGVGVPGKTGSAKRRVLTNFSQEEQQRLQQIVEDAVVILGKTLSAFNSI
>Mature_616_residues
SLKERYGDVKWKYRVASAYFNAWLHLLRLRHTSFIGITGSAGKTTTKDLCYLILSGFYPVAQSYKSLNVVKATADFVLEV
ESKHRFSIIEMSGNRPGALDLPLWLVKPEIAVLTNIEKDHFRAFKGESVDGIAREKAKLIEALSENGTAVLNMDDPRVKV
IGERCKAKVIWVGKSKGATLRLLNATSSYPQPLTLTIKYEGITHEVITGLHGTYLATSVLCALGVALAAGIRLDQAIPRL
ALAVPVEGRMQPVVMGDGVTFIRDDMKAPAWSLPMVLDFLSEATAVRKIAVVGSISDFSGDRSDKYKQFARQVLQHADMV
IFVGDNAHRALRARKDENDSALQGFLTLKEASSFLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQERCGLEHFC
DCCVYLYRADSVADLGSDIRTESKIQSIAVVSKEEGVAIPIIVGLGNPGAEYKNTPHNIGYFVLDSLAENHGAIWQETDE
GQICSIQLESKPVSLFKATAYMNETGPKLQRYLAKTGCLPEQCIIVHDDTDIEFGKIYIKSDGGDAGHWGVRSCLVALGT
DQVKRLRLGVGVPGKTGSAKRRVLTNFSQEEQQRLQQIVEDAVVILGKTLSAFNSI

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=171, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI1787455, Length=169, Percent_Identity=31.9526627218935, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786274, Length=320, Percent_Identity=23.75, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 68015; Mature: 67884

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKERYGDVKWKYRVASAYFNAWLHLLRLRHTSFIGITGSAGKTTTKDLCYLILSGFYP
CCCHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCHH
VAQSYKSLNVVKATADFVLEVESKHRFSIIEMSGNRPGALDLPLWLVKPEIAVLTNIEKD
HHHHHHHCEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEECCCEEEEECCCHH
HFRAFKGESVDGIAREKAKLIEALSENGTAVLNMDDPRVKVIGERCKAKVIWVGKSKGAT
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHEECCCCEEEEEEECCCCCE
LRLLNATSSYPQPLTLTIKYEGITHEVITGLHGTYLATSVLCALGVALAAGIRLDQAIPR
EEEEECCCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC
LALAVPVEGRMQPVVMGDGVTFIRDDMKAPAWSLPMVLDFLSEATAVRKIAVVGSISDFS
EEEEECCCCCCCEEEEECCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCHHCC
GDRSDKYKQFARQVLQHADMVIFVGDNAHRALRARKDENDSALQGFLTLKEASSFLQKTL
CCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
RPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQERCGLEHFCDCCVYLYRADSVADLGSDI
CCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHCHHH
RTESKIQSIAVVSKEEGVAIPIIVGLGNPGAEYKNTPHNIGYFVLDSLAENHGAIWQETD
HHHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECC
EGQICSIQLESKPVSLFKATAYMNETGPKLQRYLAKTGCLPEQCIIVHDDTDIEFGKIYI
CCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEE
KSDGGDAGHWGVRSCLVALGTDQVKRLRLGVGVPGKTGSAKRRVLTNFSQEEQQRLQQIV
ECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHH
EDAVVILGKTLSAFNSI
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLKERYGDVKWKYRVASAYFNAWLHLLRLRHTSFIGITGSAGKTTTKDLCYLILSGFYP
CCHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCCHH
VAQSYKSLNVVKATADFVLEVESKHRFSIIEMSGNRPGALDLPLWLVKPEIAVLTNIEKD
HHHHHHHCEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEECCCEEEEECCCHH
HFRAFKGESVDGIAREKAKLIEALSENGTAVLNMDDPRVKVIGERCKAKVIWVGKSKGAT
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHEECCCCEEEEEEECCCCCE
LRLLNATSSYPQPLTLTIKYEGITHEVITGLHGTYLATSVLCALGVALAAGIRLDQAIPR
EEEEECCCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCC
LALAVPVEGRMQPVVMGDGVTFIRDDMKAPAWSLPMVLDFLSEATAVRKIAVVGSISDFS
EEEEECCCCCCCEEEEECCCCEEHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCHHCC
GDRSDKYKQFARQVLQHADMVIFVGDNAHRALRARKDENDSALQGFLTLKEASSFLQKTL
CCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
RPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQERCGLEHFCDCCVYLYRADSVADLGSDI
CCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHCHHH
RTESKIQSIAVVSKEEGVAIPIIVGLGNPGAEYKNTPHNIGYFVLDSLAENHGAIWQETD
HHHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECC
EGQICSIQLESKPVSLFKATAYMNETGPKLQRYLAKTGCLPEQCIIVHDDTDIEFGKIYI
CCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEE
KSDGGDAGHWGVRSCLVALGTDQVKRLRLGVGVPGKTGSAKRRVLTNFSQEEQQRLQQIV
ECCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHH
EDAVVILGKTLSAFNSI
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA