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The map label for this gene is pth [H]

Identifier: 114330910

GI number: 114330910

Start: 929645

End: 931537

Strand: Direct

Name: pth [H]

Synonym: Neut_0907

Alternate gene names: 114330910

Gene position: 929645-931537 (Clockwise)

Preceding gene: 114330908

Following gene: 114330911

Centisome position: 34.94

GC content: 43.58

Gene sequence:

>1893_bases
ATGCTTCACCGACTGAGAGCAAGGGTGAAAGAGTTTTATGCCATGTTTTCCTGGCGTAAACGTTTGTTGCTGGCGTTTAC
ACAGGCAAAGCTACACCGGTTAAGTCTTACTCAGACACAGTTTATTGGTATAACGGGCAGTGCGGGTAAAACAACTACCA
AAGAGCTATGCAATCTGATTCTTTCCGGTTCATACTCTGTCATGACTACCCCCCAATCATTGAACACACCCATCATCGTA
GCAGAAACGATGCTAGCAACAGAGAAAAAACATAAGTTCTGTATTATGGAGTTAGGTGCTTTCAAACCTGGCGCTCTTGA
TCTTCCTTTAAGGTTGTTTAGACCAAAAATTGGTGTACTGACTAACATAGAAAAAGATCATTACAGAGCTTTTAAGGGGC
AAGGGGTGGATGGTATTGCTGTTGAAAAAGCAAAATTGATTGAAGCTTTATCAAAGAATGGCACTGCGATTCTCAATATG
GATGATCCGCGCGTAAAAGCAATAGGAGAACGCTGCAAAGCCAGGGTTATCTGGGTGGGGAAAAATCCAGAATCAACCAT
CAGGTTGTGTAAAGTGACATCACGCTGGCCCGAGCCCCTTAAATTGACAGTCACATATCAGGGTAAGTTGTATGAGGTCC
CAACCCACTTATATGGGACACAGCTTGCATTATCCATACTTTCAGCACTTGGGGTAGCAATTGCTGCAGGTTTATCAATT
GAAGAAGCAATTAATAAGCTGGTAGAAGCTGTTCCGACAGCAGGACGTATGCAGATTGTTACAGGTGAAGATGACGTAAC
ATTTATTCGCGATGATATGAAAGCACCTTATTGGTCGCTCCTGGCCCCTTTTAAATTCCTGAAAGAGGCTGATGCATTGA
GAAAAATTGCAGTAGTAGGCTCCATATCCGATTTTTCTGGTGATAGCACGATGATCTATAAAAGATGCGCTAGAGAATTG
AGAGAATATGCAGATATGGTCATTTTTGTTGGGGATAATGCCCATCGTGCTTTACGCGCCAGGAAGGACGAAAATGATTC
CACCCTGCAGGGGTTTTTGACATTAAAGGAAGCTTCGTCGTTCTTGCAGAAGACGCTACGGCCGGGTGATCTGGTTTTGC
TGAAAGGATCGAATAAATCCGATCACTTGCAGCGTCTTATACTAGATCGTTACAAGCCAATTCAGTGCTGGCAAGAACGT
TGTGGACTTGAGCATTTTTGTAATCATTGCTCTCAGCTATATCGAGGTGATTCAACAAATGAACAAACCGGTAATCTGGT
TGATAAAGTAGAAATACCCGTCTCCATACCGGTGAAAGAGACTGGGCGGATGGCGCCAGTCATTGTTGGGCTGGGTAATC
CTGGCAAGGAGTTTGAGAACACTTTGCATAATATTGGTTATAGTGTACTTGACAAACTTGCAGTGGATTATGGCGGGATC
TGGCAGAATGAAGAGGAAGGGCAGACAGCTTGGATTATATTGAATGGTGTTTCAGTTGTTCTGTTTAAATCAGATGCCTA
TATGAATAAAACTGGGCTAAGGCTGAAACATTACCTCGCAAGAACCGGGCGCTTACCTGAACATTGTTTGCTTATTTATG
ACGATATGGATATTGAATTTGGGACGATAAAATTCAAACCAGATGGAGGAGATGGCGGGCATCTCGGGCTGCGTTCCTGC
TTAAAATCGTTAAGGATATATACACTTCCACGATTAAGGTGTGGAGTCCGTTCTCCGGGTAATACTGCAAAAGCGAAAGA
ACAGGTGCTTGCTAAATTCAACAAGAAAGAACTGGAACAGCTGCCACAAATTCTGGATCAGGCGGTAGACATGGTGATCA
AAACAATACCGCAACTGCAGCCGGAGTCATTATCGGAATTACCAGCCGCATAG

Upstream 100 bases:

>100_bases
TTTGTATCAACTTTCTGATGAAATTTGCCATGACCAATAAATCCTAATGCTGTTGCACGCTAGAAATATACATGTCTATT
AAATAAATAAGGTAATCAAA

Downstream 100 bases:

>100_bases
ATTTATTCTGAATTAGAAAGTTATTCCTGATTTTAGTAATGAATCGATATAAAGGTGCTACTCAGAATGAGCTTGAAGGA
ACGGTACGGGGATGTAAAGT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MLHRLRARVKEFYAMFSWRKRLLLAFTQAKLHRLSLTQTQFIGITGSAGKTTTKELCNLILSGSYSVMTTPQSLNTPIIV
AETMLATEKKHKFCIMELGAFKPGALDLPLRLFRPKIGVLTNIEKDHYRAFKGQGVDGIAVEKAKLIEALSKNGTAILNM
DDPRVKAIGERCKARVIWVGKNPESTIRLCKVTSRWPEPLKLTVTYQGKLYEVPTHLYGTQLALSILSALGVAIAAGLSI
EEAINKLVEAVPTAGRMQIVTGEDDVTFIRDDMKAPYWSLLAPFKFLKEADALRKIAVVGSISDFSGDSTMIYKRCAREL
REYADMVIFVGDNAHRALRARKDENDSTLQGFLTLKEASSFLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQER
CGLEHFCNHCSQLYRGDSTNEQTGNLVDKVEIPVSIPVKETGRMAPVIVGLGNPGKEFENTLHNIGYSVLDKLAVDYGGI
WQNEEEGQTAWIILNGVSVVLFKSDAYMNKTGLRLKHYLARTGRLPEHCLLIYDDMDIEFGTIKFKPDGGDGGHLGLRSC
LKSLRIYTLPRLRCGVRSPGNTAKAKEQVLAKFNKKELEQLPQILDQAVDMVIKTIPQLQPESLSELPAA

Sequences:

>Translated_630_residues
MLHRLRARVKEFYAMFSWRKRLLLAFTQAKLHRLSLTQTQFIGITGSAGKTTTKELCNLILSGSYSVMTTPQSLNTPIIV
AETMLATEKKHKFCIMELGAFKPGALDLPLRLFRPKIGVLTNIEKDHYRAFKGQGVDGIAVEKAKLIEALSKNGTAILNM
DDPRVKAIGERCKARVIWVGKNPESTIRLCKVTSRWPEPLKLTVTYQGKLYEVPTHLYGTQLALSILSALGVAIAAGLSI
EEAINKLVEAVPTAGRMQIVTGEDDVTFIRDDMKAPYWSLLAPFKFLKEADALRKIAVVGSISDFSGDSTMIYKRCAREL
REYADMVIFVGDNAHRALRARKDENDSTLQGFLTLKEASSFLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQER
CGLEHFCNHCSQLYRGDSTNEQTGNLVDKVEIPVSIPVKETGRMAPVIVGLGNPGKEFENTLHNIGYSVLDKLAVDYGGI
WQNEEEGQTAWIILNGVSVVLFKSDAYMNKTGLRLKHYLARTGRLPEHCLLIYDDMDIEFGTIKFKPDGGDGGHLGLRSC
LKSLRIYTLPRLRCGVRSPGNTAKAKEQVLAKFNKKELEQLPQILDQAVDMVIKTIPQLQPESLSELPAA
>Mature_630_residues
MLHRLRARVKEFYAMFSWRKRLLLAFTQAKLHRLSLTQTQFIGITGSAGKTTTKELCNLILSGSYSVMTTPQSLNTPIIV
AETMLATEKKHKFCIMELGAFKPGALDLPLRLFRPKIGVLTNIEKDHYRAFKGQGVDGIAVEKAKLIEALSKNGTAILNM
DDPRVKAIGERCKARVIWVGKNPESTIRLCKVTSRWPEPLKLTVTYQGKLYEVPTHLYGTQLALSILSALGVAIAAGLSI
EEAINKLVEAVPTAGRMQIVTGEDDVTFIRDDMKAPYWSLLAPFKFLKEADALRKIAVVGSISDFSGDSTMIYKRCAREL
REYADMVIFVGDNAHRALRARKDENDSTLQGFLTLKEASSFLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQER
CGLEHFCNHCSQLYRGDSTNEQTGNLVDKVEIPVSIPVKETGRMAPVIVGLGNPGKEFENTLHNIGYSVLDKLAVDYGGI
WQNEEEGQTAWIILNGVSVVLFKSDAYMNKTGLRLKHYLARTGRLPEHCLLIYDDMDIEFGTIKFKPDGGDGGHLGLRSC
LKSLRIYTLPRLRCGVRSPGNTAKAKEQVLAKFNKKELEQLPQILDQAVDMVIKTIPQLQPESLSELPAA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0770

COG function: function code M; UDP-N-acetylmuramyl pentapeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=174, Percent_Identity=31.6091954022989, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1786274, Length=309, Percent_Identity=25.8899676375405, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 70318; Mature: 70318

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHRLRARVKEFYAMFSWRKRLLLAFTQAKLHRLSLTQTQFIGITGSAGKTTTKELCNLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHH
LSGSYSVMTTPQSLNTPIIVAETMLATEKKHKFCIMELGAFKPGALDLPLRLFRPKIGVL
HCCCEEEEECCCCCCCCEEEEHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCHH
TNIEKDHYRAFKGQGVDGIAVEKAKLIEALSKNGTAILNMDDPRVKAIGERCKARVIWVG
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCEEEEEEC
KNPESTIRLCKVTSRWPEPLKLTVTYQGKLYEVPTHLYGTQLALSILSALGVAIAAGLSI
CCCCHHHHEEEHHCCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
EEAINKLVEAVPTAGRMQIVTGEDDVTFIRDDMKAPYWSLLAPFKFLKEADALRKIAVVG
HHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEE
SISDFSGDSTMIYKRCARELREYADMVIFVGDNAHRALRARKDENDSTLQGFLTLKEASS
CCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
FLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQERCGLEHFCNHCSQLYRGDSTN
HHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCC
EQTGNLVDKVEIPVSIPVKETGRMAPVIVGLGNPGKEFENTLHNIGYSVLDKLAVDYGGI
CCCCCCCEEEECCEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
WQNEEEGQTAWIILNGVSVVLFKSDAYMNKTGLRLKHYLARTGRLPEHCLLIYDDMDIEF
CCCCCCCCEEEEEEECEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEE
GTIKFKPDGGDGGHLGLRSCLKSLRIYTLPRLRCGVRSPGNTAKAKEQVLAKFNKKELEQ
EEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCHHHHHH
LPQILDQAVDMVIKTIPQLQPESLSELPAA
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCC
>Mature Secondary Structure
MLHRLRARVKEFYAMFSWRKRLLLAFTQAKLHRLSLTQTQFIGITGSAGKTTTKELCNLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHH
LSGSYSVMTTPQSLNTPIIVAETMLATEKKHKFCIMELGAFKPGALDLPLRLFRPKIGVL
HCCCEEEEECCCCCCCCEEEEHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCHH
TNIEKDHYRAFKGQGVDGIAVEKAKLIEALSKNGTAILNMDDPRVKAIGERCKARVIWVG
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCEEEEEEC
KNPESTIRLCKVTSRWPEPLKLTVTYQGKLYEVPTHLYGTQLALSILSALGVAIAAGLSI
CCCCHHHHEEEHHCCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
EEAINKLVEAVPTAGRMQIVTGEDDVTFIRDDMKAPYWSLLAPFKFLKEADALRKIAVVG
HHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEE
SISDFSGDSTMIYKRCARELREYADMVIFVGDNAHRALRARKDENDSTLQGFLTLKEASS
CCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
FLQKTLRPGDLVLLKGSNKSDHLQRLILDRYKPIQCWQERCGLEHFCNHCSQLYRGDSTN
HHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCC
EQTGNLVDKVEIPVSIPVKETGRMAPVIVGLGNPGKEFENTLHNIGYSVLDKLAVDYGGI
CCCCCCCEEEECCEECCCCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
WQNEEEGQTAWIILNGVSVVLFKSDAYMNKTGLRLKHYLARTGRLPEHCLLIYDDMDIEF
CCCCCCCCEEEEEEECEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEE
GTIKFKPDGGDGGHLGLRSCLKSLRIYTLPRLRCGVRSPGNTAKAKEQVLAKFNKKELEQ
EEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCHHHHHH
LPQILDQAVDMVIKTIPQLQPESLSELPAA
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA