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The map label for this gene is lysS [H]

Identifier: 114330878

GI number: 114330878

Start: 892152

End: 893750

Strand: Direct

Name: lysS [H]

Synonym: Neut_0872

Alternate gene names: 114330878

Gene position: 892152-893750 (Clockwise)

Preceding gene: 114330875

Following gene: 114330879

Centisome position: 33.53

GC content: 46.4

Gene sequence:

>1599_bases
ATGCGGCAGCGGCTCCAGGATGTCCGTGCCGCTTGGTACGATACAGAGAGATTTTATACCAATAAAAATTACATAAAATT
TGGAATAGATATGACCCAGGAAGATACATCCGGTATTTCCCAGGATGAAAACAGCCTTATTGCAGAGCGTTATTCTAAAT
TGACTGCATTGCGCCAGATCGGCAATGCTTTTCCGAATGATTATCGTCGGGATAGCCTGGCTCGTGACCTGCATGAAAAG
TATGATAATGACTCAAGAGAAGAACTGGAAAGTGGGCAGGTTAAAGTAAAAGTTGCAGGACGCATGTTGTTTAAGCGTGT
AATGGGAAAGGCAAGCTTTGCAACGATCCAGGATATGAGCGGGCGGATACAGCTCTATATCTCCAATGATCATACCGGAG
AATCCGCTCACGAAGCATTCAGGCATTATGATCTGGGGGATATTCTCGGCGCGGAAGGTATTTTGTTCAAAACCAGGACG
GATGAATTGTCATTACGGGTTACCCGACTTCGTCTTCTGACTAAATCCTTGCGCCCGCTACCGGAGAAATTTCATGGCCT
TATCGATCAGGAACAGAAATACCGGCGACGTTACCTTGATCTGATTACAAATGAAGAAACACGCAAGGTATTCCTGGTTC
GCTCAAAAATTATTCAGGCAGTACGTGAATTTCTGGTTAACCGGGGCTATCTTGAAGTTGAAACGCCGATGATGCACTCT
ATTCCAGGAGGGGCTACTGCTCGACCTTTTATTACGCATCATAATGCATTGGATATGTCACTGTATCTGCGTATCGCACC
GGAACTTTACCTGAAGCGGTTGGTAGTGGGTGGTATGGAAAAAGTTTTTGAGATTAACCGTAATTTCAGGAATGAAGGTA
TATCCACTCGCCATAATCCGGAATTCACCATGCTGGAGTTTTATGAGGCTTATCAAGATCATCATTACCTGATGGATCTG
ACGGAATCCATGCTGCGTGAAGTTGCGCTGAAGGTGTTAGGAACCACTCGCATTGTCTATCAGCAGCGCGAAATGGATCT
TGCCCGGCCTTTTGCCCGGTTGACTGTCATGCAGGCCATCCTAAAATACCACCCTGAAAATTCCGAAGCACAACTTAACA
ACAGGGATGATTTGATCAAAATTTTGCAGGCAAAGGGAATCGGATTCAATCCGGACAGTGGAATCGGCGGACTGCAATTG
GCCTTGTTTGATGAAACAACCGAACATTTGCTGTTTGAACCCGTATTTATCGTTGATTATCCGGCCGAGGTATCGCCTTT
GGCACGCCGCAATGATCAAAATCCGGAGATTACGGATCGTTTTGAGCTTTATATTGCCGGGCGGGAAATTGCGAACGGCT
TTTCCGAGCTAAATGATCCTGAAGATCAGGCCAGTCGTTTCCTTGAACAGGCCAGGGCTAAAGAGGCAGGTGATATGGAA
GCGATGCACTATGACGCTGACTATATCCAGGCACTGGAATACGGATTGCCGCCAACGGCAGGTGAGGGAATCGGTATCGA
TCGGCTAGTAATGTTGCTGACAGATTCTCCAAGCATCCGCGATGTTATTCTGTTTCCGCAGTTACGCAAGGAAGACTAG

Upstream 100 bases:

>100_bases
GTGCGATGCCGTGTAACTGTAAGTTTCCTGCCAGATGGTTTTTCGTGAGCCCGTTAGAATGGAGCAGGTAAAGTAACTAT
ATAATACACGTTGATTACGC

Downstream 100 bases:

>100_bases
ACGACAGGTACTGATCCCGTGGTGCGGCTCGGGATTCTTCCTCAAGCACGGGGTGTGATTGCCGATATTACTTTGTTTGT
GCCGAGTCATGGAGTTCAAC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MRQRLQDVRAAWYDTERFYTNKNYIKFGIDMTQEDTSGISQDENSLIAERYSKLTALRQIGNAFPNDYRRDSLARDLHEK
YDNDSREELESGQVKVKVAGRMLFKRVMGKASFATIQDMSGRIQLYISNDHTGESAHEAFRHYDLGDILGAEGILFKTRT
DELSLRVTRLRLLTKSLRPLPEKFHGLIDQEQKYRRRYLDLITNEETRKVFLVRSKIIQAVREFLVNRGYLEVETPMMHS
IPGGATARPFITHHNALDMSLYLRIAPELYLKRLVVGGMEKVFEINRNFRNEGISTRHNPEFTMLEFYEAYQDHHYLMDL
TESMLREVALKVLGTTRIVYQQREMDLARPFARLTVMQAILKYHPENSEAQLNNRDDLIKILQAKGIGFNPDSGIGGLQL
ALFDETTEHLLFEPVFIVDYPAEVSPLARRNDQNPEITDRFELYIAGREIANGFSELNDPEDQASRFLEQARAKEAGDME
AMHYDADYIQALEYGLPPTAGEGIGIDRLVMLLTDSPSIRDVILFPQLRKED

Sequences:

>Translated_532_residues
MRQRLQDVRAAWYDTERFYTNKNYIKFGIDMTQEDTSGISQDENSLIAERYSKLTALRQIGNAFPNDYRRDSLARDLHEK
YDNDSREELESGQVKVKVAGRMLFKRVMGKASFATIQDMSGRIQLYISNDHTGESAHEAFRHYDLGDILGAEGILFKTRT
DELSLRVTRLRLLTKSLRPLPEKFHGLIDQEQKYRRRYLDLITNEETRKVFLVRSKIIQAVREFLVNRGYLEVETPMMHS
IPGGATARPFITHHNALDMSLYLRIAPELYLKRLVVGGMEKVFEINRNFRNEGISTRHNPEFTMLEFYEAYQDHHYLMDL
TESMLREVALKVLGTTRIVYQQREMDLARPFARLTVMQAILKYHPENSEAQLNNRDDLIKILQAKGIGFNPDSGIGGLQL
ALFDETTEHLLFEPVFIVDYPAEVSPLARRNDQNPEITDRFELYIAGREIANGFSELNDPEDQASRFLEQARAKEAGDME
AMHYDADYIQALEYGLPPTAGEGIGIDRLVMLLTDSPSIRDVILFPQLRKED
>Mature_532_residues
MRQRLQDVRAAWYDTERFYTNKNYIKFGIDMTQEDTSGISQDENSLIAERYSKLTALRQIGNAFPNDYRRDSLARDLHEK
YDNDSREELESGQVKVKVAGRMLFKRVMGKASFATIQDMSGRIQLYISNDHTGESAHEAFRHYDLGDILGAEGILFKTRT
DELSLRVTRLRLLTKSLRPLPEKFHGLIDQEQKYRRRYLDLITNEETRKVFLVRSKIIQAVREFLVNRGYLEVETPMMHS
IPGGATARPFITHHNALDMSLYLRIAPELYLKRLVVGGMEKVFEINRNFRNEGISTRHNPEFTMLEFYEAYQDHHYLMDL
TESMLREVALKVLGTTRIVYQQREMDLARPFARLTVMQAILKYHPENSEAQLNNRDDLIKILQAKGIGFNPDSGIGGLQL
ALFDETTEHLLFEPVFIVDYPAEVSPLARRNDQNPEITDRFELYIAGREIANGFSELNDPEDQASRFLEQARAKEAGDME
AMHYDADYIQALEYGLPPTAGEGIGIDRLVMLLTDSPSIRDVILFPQLRKED

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=523, Percent_Identity=41.1089866156788, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI194272210, Length=523, Percent_Identity=41.1089866156788, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI45439306, Length=470, Percent_Identity=24.0425531914894, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40789249, Length=322, Percent_Identity=22.360248447205, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790571, Length=504, Percent_Identity=60.9126984126984, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=489, Percent_Identity=61.3496932515337, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI87082379, Length=327, Percent_Identity=32.4159021406728, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788173, Length=250, Percent_Identity=23.6, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535925, Length=503, Percent_Identity=41.1530815109344, Blast_Score=346, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17535927, Length=503, Percent_Identity=41.1530815109344, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI71994340, Length=503, Percent_Identity=41.1530815109344, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17551876, Length=350, Percent_Identity=25.4285714285714, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI32566633, Length=243, Percent_Identity=26.7489711934156, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=457, Percent_Identity=43.3260393873085, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324256, Length=441, Percent_Identity=34.0136054421769, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6323011, Length=356, Percent_Identity=26.685393258427, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640851, Length=486, Percent_Identity=40.3292181069959, Blast_Score=355, Evalue=6e-98,
Organism=Drosophila melanogaster, GI24640849, Length=486, Percent_Identity=40.3292181069959, Blast_Score=355, Evalue=6e-98,
Organism=Drosophila melanogaster, GI17136276, Length=476, Percent_Identity=23.3193277310924, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24584738, Length=367, Percent_Identity=25.3405994550409, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 61508; Mature: 61508

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQRLQDVRAAWYDTERFYTNKNYIKFGIDMTQEDTSGISQDENSLIAERYSKLTALRQI
CCHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GNAFPNDYRRDSLARDLHEKYDNDSREELESGQVKVKVAGRMLFKRVMGKASFATIQDMS
HHCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHCCCHHHHHHCCC
GRIQLYISNDHTGESAHEAFRHYDLGDILGAEGILFKTRTDELSLRVTRLRLLTKSLRPL
CEEEEEECCCCCCHHHHHHHHHCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
PEKFHGLIDQEQKYRRRYLDLITNEETRKVFLVRSKIIQAVREFLVNRGYLEVETPMMHS
CHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHC
IPGGATARPFITHHNALDMSLYLRIAPELYLKRLVVGGMEKVFEINRNFRNEGISTRHNP
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EFTMLEFYEAYQDHHYLMDLTESMLREVALKVLGTTRIVYQQREMDLARPFARLTVMQAI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKYHPENSEAQLNNRDDLIKILQAKGIGFNPDSGIGGLQLALFDETTEHLLFEPVFIVDY
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHCCEEEEEC
PAEVSPLARRNDQNPEITDRFELYIAGREIANGFSELNDPEDQASRFLEQARAKEAGDME
CCCCCHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCH
AMHYDADYIQALEYGLPPTAGEGIGIDRLVMLLTDSPSIRDVILFPQLRKED
HHHCCHHHHHHHHHCCCCCCCCCCCHHHEEEEEECCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MRQRLQDVRAAWYDTERFYTNKNYIKFGIDMTQEDTSGISQDENSLIAERYSKLTALRQI
CCHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GNAFPNDYRRDSLARDLHEKYDNDSREELESGQVKVKVAGRMLFKRVMGKASFATIQDMS
HHCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHCCCHHHHHHCCC
GRIQLYISNDHTGESAHEAFRHYDLGDILGAEGILFKTRTDELSLRVTRLRLLTKSLRPL
CEEEEEECCCCCCHHHHHHHHHCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
PEKFHGLIDQEQKYRRRYLDLITNEETRKVFLVRSKIIQAVREFLVNRGYLEVETPMMHS
CHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHC
IPGGATARPFITHHNALDMSLYLRIAPELYLKRLVVGGMEKVFEINRNFRNEGISTRHNP
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EFTMLEFYEAYQDHHYLMDLTESMLREVALKVLGTTRIVYQQREMDLARPFARLTVMQAI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKYHPENSEAQLNNRDDLIKILQAKGIGFNPDSGIGGLQLALFDETTEHLLFEPVFIVDY
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHCCEEEEEC
PAEVSPLARRNDQNPEITDRFELYIAGREIANGFSELNDPEDQASRFLEQARAKEAGDME
CCCCCHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCH
AMHYDADYIQALEYGLPPTAGEGIGIDRLVMLLTDSPSIRDVILFPQLRKED
HHHCCHHHHHHHHHCCCCCCCCCCCHHHEEEEEECCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]