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The map label for this gene is patB [H]

Identifier: 114330844

GI number: 114330844

Start: 853913

End: 855094

Strand: Reverse

Name: patB [H]

Synonym: Neut_0837

Alternate gene names: 114330844

Gene position: 855094-853913 (Counterclockwise)

Preceding gene: 114330845

Following gene: 114330843

Centisome position: 32.13

GC content: 50.93

Gene sequence:

>1182_bases
TTGAGTTACGATTTTGATCGTGAAATCGGCCGGGACGGGACATTCAGCACCAAATATGATGGCCGTGAGATAACGTTCAA
TCGCCCGGATGTCATACCGCTGTGGGTGGCCGATATGGATTTTGCCGCTCCGCCTGCCGTCACCGAAGCGCTGGTCAAGC
GCGCCACTCACCCTGTTTATGGCTACACACAATTTCCTGACAGTCTGTATGAATCACTAATCTATTGGCTGAAATCACGT
CATGGCTGGCAGATAGCACGCGAATGGATCGTTTTCTGTCCGGGTGTAGTACCCTCGCTGAGTGCATCTGTTCTTGCGTT
GAGTAAACCGGGTGAAGCTGTCATAGTTCAGCCGCCGGTGTATTACCCGTTTTTCTCGGTGGTCAAAAGAACCGGCAGAA
AGCTGCTGAACAATGCCTTGCAACAGGCACAGGGGAGCTACGGTATGGATTTTGCTGATCTGGCCCGGCAGGCGGCTTCT
GCGCGCATGCTGTTATTTTGTTCCCCGCATAATCCGGTTGGCCGGGTGTGGAGCAGATCGGAACTGGAAAAGCTGCTGGA
CATTAGCAGGCAATATAACCTGATTGTTGTCTCGGATGAAATCCATGCGGATCTGATTTATCCGGGTAACAAGCATCACA
TATTGGCTGACCTGGCAGATTCATCGGAAGCAATTATCACTGCGGTAGCACCTAGTAAAACGTTCAATATTCCGGGGCTC
AATTTGTCTGCACTGATTATTCCTGATCCGCAACACCGGGCAGCCATTCGCGATCAACTGGAGATAATGCATATCAGTGC
CGCCAATCCGTTCAGCATAGTGGCGTTTGAAGCAGCTTATCGTGCAGGCGGTGAATGGCTGGATGCACTGATGGCCTATC
TGGAATCTTCGCGTGAGATGGTTCAGCACTATCTGGCTGAGTATTTGCCACAAATCCGGCTGATTCCTTCACAGGGAACC
TACCTGTTGTGGCTTGATTGTCGCGAGCTGGGTATGACTGATGATGAACTCAAGCACTTTTTCATATTTGAAGCTGGAAT
CGGGCTAAACGCTGGTATTTCCTATGGCAGGGAAGGCAGCGGCTTCATGCGCATGAATATTGGAGCTCCCCGCCACCGGA
TCAGGCAGGCACTGAATAGCATCCGCAGCGCACTTGAACGTACAAAAAACAACTCCTTTTGA

Upstream 100 bases:

>100_bases
GTTTGCTTGGAGAACCGCAACAGGTACCATTTGTCATTCGTGAAACACGACGTAAATTCCAACATACGTTGTCAGAAGTG
ACTCTCTGGGAGAAACTCAC

Downstream 100 bases:

>100_bases
ATGGTGTGTGGCGATATTATTTGCTTTATCCTGTTTTTACTAACGTAGCAGTACGAGGCAATAATCTTGCAGTGCAGAGA
TAATAGTGCTGGATTGTCAC

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSYDFDREIGRDGTFSTKYDGREITFNRPDVIPLWVADMDFAAPPAVTEALVKRATHPVYGYTQFPDSLYESLIYWLKSR
HGWQIAREWIVFCPGVVPSLSASVLALSKPGEAVIVQPPVYYPFFSVVKRTGRKLLNNALQQAQGSYGMDFADLARQAAS
ARMLLFCSPHNPVGRVWSRSELEKLLDISRQYNLIVVSDEIHADLIYPGNKHHILADLADSSEAIITAVAPSKTFNIPGL
NLSALIIPDPQHRAAIRDQLEIMHISAANPFSIVAFEAAYRAGGEWLDALMAYLESSREMVQHYLAEYLPQIRLIPSQGT
YLLWLDCRELGMTDDELKHFFIFEAGIGLNAGISYGREGSGFMRMNIGAPRHRIRQALNSIRSALERTKNNSF

Sequences:

>Translated_393_residues
MSYDFDREIGRDGTFSTKYDGREITFNRPDVIPLWVADMDFAAPPAVTEALVKRATHPVYGYTQFPDSLYESLIYWLKSR
HGWQIAREWIVFCPGVVPSLSASVLALSKPGEAVIVQPPVYYPFFSVVKRTGRKLLNNALQQAQGSYGMDFADLARQAAS
ARMLLFCSPHNPVGRVWSRSELEKLLDISRQYNLIVVSDEIHADLIYPGNKHHILADLADSSEAIITAVAPSKTFNIPGL
NLSALIIPDPQHRAAIRDQLEIMHISAANPFSIVAFEAAYRAGGEWLDALMAYLESSREMVQHYLAEYLPQIRLIPSQGT
YLLWLDCRELGMTDDELKHFFIFEAGIGLNAGISYGREGSGFMRMNIGAPRHRIRQALNSIRSALERTKNNSF
>Mature_392_residues
SYDFDREIGRDGTFSTKYDGREITFNRPDVIPLWVADMDFAAPPAVTEALVKRATHPVYGYTQFPDSLYESLIYWLKSRH
GWQIAREWIVFCPGVVPSLSASVLALSKPGEAVIVQPPVYYPFFSVVKRTGRKLLNNALQQAQGSYGMDFADLARQAASA
RMLLFCSPHNPVGRVWSRSELEKLLDISRQYNLIVVSDEIHADLIYPGNKHHILADLADSSEAIITAVAPSKTFNIPGLN
LSALIIPDPQHRAAIRDQLEIMHISAANPFSIVAFEAAYRAGGEWLDALMAYLESSREMVQHYLAEYLPQIRLIPSQGTY
LLWLDCRELGMTDDELKHFFIFEAGIGLNAGISYGREGSGFMRMNIGAPRHRIRQALNSIRSALERTKNNSF

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=235, Percent_Identity=28.5106382978723, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI56713256, Length=235, Percent_Identity=28.5106382978723, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI95147551, Length=236, Percent_Identity=24.1525423728814, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI169881279, Length=236, Percent_Identity=24.1525423728814, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787909, Length=391, Percent_Identity=30.690537084399, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786816, Length=317, Percent_Identity=23.6593059936909, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788722, Length=366, Percent_Identity=21.8579234972678, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788627, Length=188, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787710, Length=298, Percent_Identity=23.489932885906, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=165, Percent_Identity=29.0909090909091, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=165, Percent_Identity=29.0909090909091, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17567369, Length=230, Percent_Identity=26.9565217391304, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17567663, Length=318, Percent_Identity=24.8427672955975, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573069, Length=253, Percent_Identity=23.7154150197628, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646114, Length=253, Percent_Identity=23.7154150197628, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573067, Length=253, Percent_Identity=23.7154150197628, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573065, Length=253, Percent_Identity=23.7154150197628, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859735, Length=187, Percent_Identity=24.5989304812834, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44157; Mature: 44026

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDFDREIGRDGTFSTKYDGREITFNRPDVIPLWVADMDFAAPPAVTEALVKRATHPVY
CCCCCCHHCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCC
GYTQFPDSLYESLIYWLKSRHGWQIAREWIVFCPGVVPSLSASVLALSKPGEAVIVQPPV
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCC
YYPFFSVVKRTGRKLLNNALQQAQGSYGMDFADLARQAASARMLLFCSPHNPVGRVWSRS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHCCHH
ELEKLLDISRQYNLIVVSDEIHADLIYPGNKHHILADLADSSEAIITAVAPSKTFNIPGL
HHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEECCCCCEEEEEECCCCEECCCCC
NLSALIIPDPQHRAAIRDQLEIMHISAANPFSIVAFEAAYRAGGEWLDALMAYLESSREM
CEEEEEECCCHHHHHHHHCEEEEEEECCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHH
VQHYLAEYLPQIRLIPSQGTYLLWLDCRELGMTDDELKHFFIFEAGIGLNAGISYGREGS
HHHHHHHHCCCEEEECCCCCEEEEEEHHHCCCCHHHCCEEEEEECCCCCCCCCCCCCCCC
GFMRMNIGAPRHRIRQALNSIRSALERTKNNSF
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SYDFDREIGRDGTFSTKYDGREITFNRPDVIPLWVADMDFAAPPAVTEALVKRATHPVY
CCCCCHHCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCC
GYTQFPDSLYESLIYWLKSRHGWQIAREWIVFCPGVVPSLSASVLALSKPGEAVIVQPPV
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECCCC
YYPFFSVVKRTGRKLLNNALQQAQGSYGMDFADLARQAASARMLLFCSPHNPVGRVWSRS
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHCCHH
ELEKLLDISRQYNLIVVSDEIHADLIYPGNKHHILADLADSSEAIITAVAPSKTFNIPGL
HHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEECCCCCEEEEEECCCCEECCCCC
NLSALIIPDPQHRAAIRDQLEIMHISAANPFSIVAFEAAYRAGGEWLDALMAYLESSREM
CEEEEEECCCHHHHHHHHCEEEEEEECCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHH
VQHYLAEYLPQIRLIPSQGTYLLWLDCRELGMTDDELKHFFIFEAGIGLNAGISYGREGS
HHHHHHHHCCCEEEECCCCCEEEEEEHHHCCCCHHHCCEEEEEECCCCCCCCCCCCCCCC
GFMRMNIGAPRHRIRQALNSIRSALERTKNNSF
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]