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The map label for this gene is norD [H]

Identifier: 114330826

GI number: 114330826

Start: 832375

End: 834735

Strand: Direct

Name: norD [H]

Synonym: Neut_0816

Alternate gene names: 114330826

Gene position: 832375-834735 (Clockwise)

Preceding gene: 114330825

Following gene: 114330827

Centisome position: 31.28

GC content: 57.22

Gene sequence:

>2361_bases
ATGGCTATTCACCTTGAAGAATTCCAGAGTTTGCTCGACGAGCTACCCGGCAGTGCGCAGGAACTGCTGCGCGCGTCTTG
GAACGAGGCGGCGCGCGCACTCACGCCGCGTGGCTTAGATAACTACCTCAAAGGAGCGGTCGCGTTGCATCACCTCGGCC
GCGGGGAGGACCTTGTGGTCGGTTTCATCCAATCCATGCCCGAGTTGGCGCGCGGAGTGGGTGAGGAAGTACTGCCTGAC
CTAGTCAACTTCCTTCTTGGCATGGCATCCAAGACCTCGGGCCATGTGCTTGCGCTGATCGTCGGCACTGCGCCATTAGC
GGCACAGCGCTTGAGCGATGCCGGCCTATTCGTCAGTTATCTGAAGGTGCTCGAGATCATGCTGGCCCAGGCGCCTCGCG
GCCTGCGACCGATGCTGGAAAACTTGGACCGTCTGCTTACCCAGCTCACTCTGGGCGGCTTGCGGCGCTGGGTGCAGTGG
GGTGCACAGGCGTATCGCAGCGATTTAGACGGTCAGGTAGCGTACTTTTCTCTGCAAAGCGCCGACGCGCTGGCTGTGCT
GCAGCAGGAGCGCAAGGGCACGCTGTTCGTCGACATTCAGCGTCGTTTGAACATCTATCAGCGCGCAATGTGGGGACGTG
ATTTTTTCCTGCGCCCTACTTCCGGCGATTACGAAAGCCGTGAAGAGTTGAAGCCCTACATTGAGCATTACGTCATTCAT
ATTGCCGATGCCTACGACAATTACAAGCCACTGGGCCCCGATACGCCGCCCGAGCAATGCGTGCCGGCACTAGAGATCTA
CCGCGCCGCAGTTAACCATTGTGCTGCGCATCTGGTGTTCACTCAACAGCCGCTGTCCATGCAGATGTTGCATCCAGCGC
AAATGGCGGTGATTGAGGTATTCGAAGATGCGCGGGTCGAGGAGCTGTCAATCCGGCAGTTTCCGAACATGCGCGAAGCT
TGGCTGATGCTGCATCCGGTGTTCGATTACTCTCGTGAGCCGCAGAGCATCGGCGAATTGCTCGACCGCCTGGGCCGCGC
CCTGCTTGAAGAGCAGAGCCACGATCCTCATCCGTGGGTGCGTGAGGCCGTGGTGGCGTTTCGCGCACAGACCGATCTTT
CGACCAATCAGACAAGCTGGAACCTCGGCATAGACTTGTCGCACAAGCTGTTCGAGTTGCCGCTACCCGAGTTCAACAAC
CGTACCGACCACCGCTTGAGCGCGATCTACCGAGACGACAACCGAGCGGTATGGCAGCTCGAAGAGTACGACGAGGCACA
GGCACTGGAGGCTACTTGGCAGACGCGGCAGCAGGTACGCAAAAAAGTCAACCTGATGGAAATGGTCAACGAGGTGGATA
ACGAGTTTGCCGGTGATGACGCGCAGGAAGTCTGGGAACTGCCGACCGAATATCTGTTCGATGACGGCGTCAGCATCAAC
GAACTCGAAGGTCGACCACCGATTTCCGAGCCTTTCCATTATCCCGAGTGGGACTATAAGATTCAGCTCGAACGCCCGAA
CTGGGTCACCGTGCTCGAACACCATCCACCCGTGGGCGAACTCGCAATTATCGAGAACATCATCATCGAAAATAAGCCAG
TGATCTCACGGCTGAAATTCCTGATCGAATCGATGGTGCCACAAGGCATGCAGCGCATCAGGCACGTAGAGGACGGCGAC
GATCTCGATATCAACGCCGCAGTGCGCGCGATGATCGACATCCGCATGGGCCAACCACCGGACCCGCGCATCATGATGCG
GTACAAGCGCACGCTGCGCGAGCTTGCAGTGATGGTACTGCTGGATATGTCCGAATCGTCCAACGACAAGGTGCGCGGAC
ACGACTACACGATAATGGATCTCACCCGCGCAGCCACAGTGTTATTCGCCGACGCGCTCGATCGCATCGGCGACCCATTT
GCGATCCATGGCTTTTGCTCCGATGGACGGCACGACGTGCATTATCATCGTTTCAAAGATTTCGACCAGCCGTATGGTGA
CATCGCCAAGGCTCGCTTAGCCGGCATGAAGGGCCATTTTTCTACACGCATGGGCGCAGCGCTGCGTCACGCTGGATATT
ATCTGGCGCAGCAGCCCAAATCCAAGCGGGTAATTTTTGTCATCACCGACGGCGAACCGGCCGACAACGACGTGCACGAC
CCGCAATATCTGCGCTATGATACTAAACATGCAGTCGAAGAACTCGCGCGTAAGGGCATTACGGTGTATGCGTTATCCCT
CGATCCGCATGCTGACCAATATGTGTCGCGTATTTTTGGAGCTAAGAACTTCACCGTCATTGACGAAGTCGAGCGCCTGC
CGGAGAAATTGCCGATGCTCTACATGAGCCTCACACGTTAA

Upstream 100 bases:

>100_bases
GTCGCCCTGGTGCGACCGATCACCGACGACCCTGACATGCGCGATGCGCTTGATGCGGCTGTAACCACCTACTTCTGATG
GGCGACATGGGTCTCGCATT

Downstream 100 bases:

>100_bases
GGGCGCCATGCAATGAAAATAAGCTTGCGTACCTTCGTATTTCTCGACGCACTGCAACCGCAGCTCGCATCTTATCTCGC
CACCTCGTCGCAAGGCTTTC

Product: von Willebrand factor, type A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 785

Protein sequence:

>786_residues
MAIHLEEFQSLLDELPGSAQELLRASWNEAARALTPRGLDNYLKGAVALHHLGRGEDLVVGFIQSMPELARGVGEEVLPD
LVNFLLGMASKTSGHVLALIVGTAPLAAQRLSDAGLFVSYLKVLEIMLAQAPRGLRPMLENLDRLLTQLTLGGLRRWVQW
GAQAYRSDLDGQVAYFSLQSADALAVLQQERKGTLFVDIQRRLNIYQRAMWGRDFFLRPTSGDYESREELKPYIEHYVIH
IADAYDNYKPLGPDTPPEQCVPALEIYRAAVNHCAAHLVFTQQPLSMQMLHPAQMAVIEVFEDARVEELSIRQFPNMREA
WLMLHPVFDYSREPQSIGELLDRLGRALLEEQSHDPHPWVREAVVAFRAQTDLSTNQTSWNLGIDLSHKLFELPLPEFNN
RTDHRLSAIYRDDNRAVWQLEEYDEAQALEATWQTRQQVRKKVNLMEMVNEVDNEFAGDDAQEVWELPTEYLFDDGVSIN
ELEGRPPISEPFHYPEWDYKIQLERPNWVTVLEHHPPVGELAIIENIIIENKPVISRLKFLIESMVPQGMQRIRHVEDGD
DLDINAAVRAMIDIRMGQPPDPRIMMRYKRTLRELAVMVLLDMSESSNDKVRGHDYTIMDLTRAATVLFADALDRIGDPF
AIHGFCSDGRHDVHYHRFKDFDQPYGDIAKARLAGMKGHFSTRMGAALRHAGYYLAQQPKSKRVIFVITDGEPADNDVHD
PQYLRYDTKHAVEELARKGITVYALSLDPHADQYVSRIFGAKNFTVIDEVERLPEKLPMLYMSLTR

Sequences:

>Translated_786_residues
MAIHLEEFQSLLDELPGSAQELLRASWNEAARALTPRGLDNYLKGAVALHHLGRGEDLVVGFIQSMPELARGVGEEVLPD
LVNFLLGMASKTSGHVLALIVGTAPLAAQRLSDAGLFVSYLKVLEIMLAQAPRGLRPMLENLDRLLTQLTLGGLRRWVQW
GAQAYRSDLDGQVAYFSLQSADALAVLQQERKGTLFVDIQRRLNIYQRAMWGRDFFLRPTSGDYESREELKPYIEHYVIH
IADAYDNYKPLGPDTPPEQCVPALEIYRAAVNHCAAHLVFTQQPLSMQMLHPAQMAVIEVFEDARVEELSIRQFPNMREA
WLMLHPVFDYSREPQSIGELLDRLGRALLEEQSHDPHPWVREAVVAFRAQTDLSTNQTSWNLGIDLSHKLFELPLPEFNN
RTDHRLSAIYRDDNRAVWQLEEYDEAQALEATWQTRQQVRKKVNLMEMVNEVDNEFAGDDAQEVWELPTEYLFDDGVSIN
ELEGRPPISEPFHYPEWDYKIQLERPNWVTVLEHHPPVGELAIIENIIIENKPVISRLKFLIESMVPQGMQRIRHVEDGD
DLDINAAVRAMIDIRMGQPPDPRIMMRYKRTLRELAVMVLLDMSESSNDKVRGHDYTIMDLTRAATVLFADALDRIGDPF
AIHGFCSDGRHDVHYHRFKDFDQPYGDIAKARLAGMKGHFSTRMGAALRHAGYYLAQQPKSKRVIFVITDGEPADNDVHD
PQYLRYDTKHAVEELARKGITVYALSLDPHADQYVSRIFGAKNFTVIDEVERLPEKLPMLYMSLTR
>Mature_785_residues
AIHLEEFQSLLDELPGSAQELLRASWNEAARALTPRGLDNYLKGAVALHHLGRGEDLVVGFIQSMPELARGVGEEVLPDL
VNFLLGMASKTSGHVLALIVGTAPLAAQRLSDAGLFVSYLKVLEIMLAQAPRGLRPMLENLDRLLTQLTLGGLRRWVQWG
AQAYRSDLDGQVAYFSLQSADALAVLQQERKGTLFVDIQRRLNIYQRAMWGRDFFLRPTSGDYESREELKPYIEHYVIHI
ADAYDNYKPLGPDTPPEQCVPALEIYRAAVNHCAAHLVFTQQPLSMQMLHPAQMAVIEVFEDARVEELSIRQFPNMREAW
LMLHPVFDYSREPQSIGELLDRLGRALLEEQSHDPHPWVREAVVAFRAQTDLSTNQTSWNLGIDLSHKLFELPLPEFNNR
TDHRLSAIYRDDNRAVWQLEEYDEAQALEATWQTRQQVRKKVNLMEMVNEVDNEFAGDDAQEVWELPTEYLFDDGVSINE
LEGRPPISEPFHYPEWDYKIQLERPNWVTVLEHHPPVGELAIIENIIIENKPVISRLKFLIESMVPQGMQRIRHVEDGDD
LDINAAVRAMIDIRMGQPPDPRIMMRYKRTLRELAVMVLLDMSESSNDKVRGHDYTIMDLTRAATVLFADALDRIGDPFA
IHGFCSDGRHDVHYHRFKDFDQPYGDIAKARLAGMKGHFSTRMGAALRHAGYYLAQQPKSKRVIFVITDGEPADNDVHDP
QYLRYDTKHAVEELARKGITVYALSLDPHADQYVSRIFGAKNFTVIDEVERLPEKLPMLYMSLTR

Specific function: Part of the operon norEFCBQD encoding nitric oxide reductase. Essential virulence factor, probably involved in the detoxification of nitric oxide (NO) produced in the macrophages during the innate response against infection [H]

COG id: COG4548

COG function: function code P; Nitric oxide reductase activation protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002035 [H]

Pfam domain/function: PF00092 VWA [H]

EC number: NA

Molecular weight: Translated: 89855; Mature: 89723

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHLEEFQSLLDELPGSAQELLRASWNEAARALTPRGLDNYLKGAVALHHLGRGEDLVV
CEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHH
GFIQSMPELARGVGEEVLPDLVNFLLGMASKTSGHVLALIVGTAPLAAQRLSDAGLFVSY
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LKVLEIMLAQAPRGLRPMLENLDRLLTQLTLGGLRRWVQWGAQAYRSDLDGQVAYFSLQS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
ADALAVLQQERKGTLFVDIQRRLNIYQRAMWGRDFFLRPTSGDYESREELKPYIEHYVIH
CHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
IADAYDNYKPLGPDTPPEQCVPALEIYRAAVNHCAAHLVFTQQPLSMQMLHPAQMAVIEV
EEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCHHHHHHHHH
FEDARVEELSIRQFPNMREAWLMLHPVFDYSREPQSIGELLDRLGRALLEEQSHDPHPWV
HHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
REAVVAFRAQTDLSTNQTSWNLGIDLSHKLFELPLPEFNNRTDHRLSAIYRDDNRAVWQL
HHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCCCCCCCCCCHHHHHEEECCCCEEEEE
EEYDEAQALEATWQTRQQVRKKVNLMEMVNEVDNEFAGDDAQEVWELPTEYLFDDGVSIN
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCCCC
ELEGRPPISEPFHYPEWDYKIQLERPNWVTVLEHHPPVGELAIIENIIIENKPVISRLKF
CCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHH
LIESMVPQGMQRIRHVEDGDDLDINAAVRAMIDIRMGQPPDPRIMMRYKRTLRELAVMVL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LDMSESSNDKVRGHDYTIMDLTRAATVLFADALDRIGDPFAIHGFCSDGRHDVHYHRFKD
HCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHC
FDQPYGDIAKARLAGMKGHFSTRMGAALRHAGYYLAQQPKSKRVIFVITDGEPADNDVHD
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
PQYLRYDTKHAVEELARKGITVYALSLDPHADQYVSRIFGAKNFTVIDEVERLPEKLPML
CHHHHCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YMSLTR
HHHHCC
>Mature Secondary Structure 
AIHLEEFQSLLDELPGSAQELLRASWNEAARALTPRGLDNYLKGAVALHHLGRGEDLVV
EEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHH
GFIQSMPELARGVGEEVLPDLVNFLLGMASKTSGHVLALIVGTAPLAAQRLSDAGLFVSY
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LKVLEIMLAQAPRGLRPMLENLDRLLTQLTLGGLRRWVQWGAQAYRSDLDGQVAYFSLQS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
ADALAVLQQERKGTLFVDIQRRLNIYQRAMWGRDFFLRPTSGDYESREELKPYIEHYVIH
CHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
IADAYDNYKPLGPDTPPEQCVPALEIYRAAVNHCAAHLVFTQQPLSMQMLHPAQMAVIEV
EEHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCHHHHHHHHH
FEDARVEELSIRQFPNMREAWLMLHPVFDYSREPQSIGELLDRLGRALLEEQSHDPHPWV
HHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
REAVVAFRAQTDLSTNQTSWNLGIDLSHKLFELPLPEFNNRTDHRLSAIYRDDNRAVWQL
HHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCCCCCCCCCCHHHHHEEECCCCEEEEE
EEYDEAQALEATWQTRQQVRKKVNLMEMVNEVDNEFAGDDAQEVWELPTEYLFDDGVSIN
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCCCC
ELEGRPPISEPFHYPEWDYKIQLERPNWVTVLEHHPPVGELAIIENIIIENKPVISRLKF
CCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHH
LIESMVPQGMQRIRHVEDGDDLDINAAVRAMIDIRMGQPPDPRIMMRYKRTLRELAVMVL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LDMSESSNDKVRGHDYTIMDLTRAATVLFADALDRIGDPFAIHGFCSDGRHDVHYHRFKD
HCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHC
FDQPYGDIAKARLAGMKGHFSTRMGAALRHAGYYLAQQPKSKRVIFVITDGEPADNDVHD
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
PQYLRYDTKHAVEELARKGITVYALSLDPHADQYVSRIFGAKNFTVIDEVERLPEKLPML
CHHHHCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YMSLTR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA