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The map label for this gene is hppA [H]

Identifier: 114330799

GI number: 114330799

Start: 802695

End: 804752

Strand: Reverse

Name: hppA [H]

Synonym: Neut_0786

Alternate gene names: 114330799

Gene position: 804752-802695 (Counterclockwise)

Preceding gene: 114330800

Following gene: 114330795

Centisome position: 30.24

GC content: 51.55

Gene sequence:

>2058_bases
ATGGCAAACGGTTTAACGATTGCAATCTGCAGCGCGATACTTGCCCTGATTTTTAGTGGCCTGTGGATTCGGCGTATCTA
CGCACAACCCGCGGGCAATGCGCACATGCAGGAAATTGCAGCCGCCATACAGGAAGGTGCGTCGGCTTACCTCAAGCGAC
AATATCTAACCATTGGTATGGTAGGTATGGTTTTATTCCTAATTATCGGCTTGACACTTTCCTGGGATACAGCCTTTGGT
TTTGCGCTGGGAGCTATACTTTCCGGCCTGGCCGGTTTCATGGGCATGAATGTCTCGGTTCAGTCCAACGTTCGGACAGC
TGAAGCCGCACGCAGCGGATTGAGCGAAGCGTTGGCCATCGCCTTCCGTGGCGGTGCTGTAACCGGGATGCTGGTTGTGG
GGCTCGGCTTGCTTGGTGTAGCCGGTTATACAGCGTTGCTGGTCAATGGCGCAGATGTAAGTAGCAATATCAGCAACCTC
ATCCACCCACTGATTGGTTTTGCTTTTGGTGGCTCACTCATTTCAATTTTCGCACGGCTGGGTGGTGGTATTTTCACGAA
AGGCGCGGATGTTGGCGCTGATCTGGTCGGTAAAGTCGAAGCCGGAATCCCTGAAGATGATCCGCGCAACCCGGCAGTGA
TTGCAGACAACGTAGGCGACAATGTAGGTGACTGTGCCGGGATGGCAGCTGATCTTTTTGAAACCTATGCAGTCACAATC
ATTGCAACAATGTTGCTGGGTGCTTTATTGTTCCAGACCGAAACTGGCAATGCAGTAGTCTACCCACTCGCACTGGGTGC
AGTATCCATCGTTGCTTCAATTATCGGTTGCTATTTTGTCAAGATGCGTGAAGGCGGCAAGATCATGAACGCCCTGTATC
GCGGACTGGCAGTTGCCGGTGGAATTGCTTTCTTCGCTTATTTGCCGATAACCGTATGGTTTATGGGGGGAGCAACCTTG
TCACTGGGCGGTGTCGAAGTCGGAGGCGGCGAGTTGATCATGCGTCTGTTTGCCAGTACAGCCGTTGGCCTGGCTCTAAC
CGGTCTATTAGTTATCATCACCGAATACTACACTTCTACCGAATATCCACCAGTACAGCATATCGCCAATGCTTCCACCA
CCGGGCACGCTACCAATATCATCGCCGGGCTCGGCGTGGGCATGCGTGCTACTGCAGCTCCTGTGCTAGCAATCTGTGCA
AGTATCATCATTGCCTATTCACTCGCCGGTCTTTATGGAATTGCGATCGCTGCAACCGCCATGTTATCCATGACCGGGAT
CATCGTAGCACTGGATGCCTATGGTCCGATTACTGACAACGCTGGCGGTATTGCTGAAATGTCGGGTATGCCCGAATCCG
TCCGTGCCATTACCGACCCGCTGGATGCGGTAGGCAACACCACCAAGGCTGTTACCAAAGGCTACGCGATTGGCTCGGCC
GGCCTGGCTGCACTGGTGCTGTTCGCCGATTATACTCACGGACTAGAACATGCTGACAAACTGCTTACCTTTGATTTATC
TAATCACCTGGTGATTATTGGGTTATTTATTGGCGGCATGGTCCCTTTCTTGTTTGGTGCAATGTCGATGGAAGCGGTTG
GTCGTGCAGCAAGCTCCGTTGTGATTGAAGTACGTCGCCAATTCAAAGAAATCCCGGGAATCATGGATGGTACGAGTAAA
CCTGATTACTCCCGTGCGGTCGATATGCTGACCAAGGCAGCGATTCGGGAAATGATCATTCCATCCTTGCTGCCTGTACT
GATACCAGTGCTGGTCGGAGTTTTCCTCGGCCCGCAGGCTTTGGGAGGTGTATTGATGGGCTCAATCATTACGGGCTTGT
TCCTTGCTATCTCCATGACTGCTGGTGGCGGAGCATGGGATAATGCAAAGAAATATATCGAAGACGGAAATTATGGTGGC
AAAGGCAGTGATGCCCACAAAGCTGCTGTAACGGGTGATACGGTTGGTGATCCTTACAAGGATACTGCGGGCCCGGCTAT
TAACCCACTCATCAAAATTATCAATATCGTAGCACTACTGATTATTCCGCTGCTATAA

Upstream 100 bases:

>100_bases
ATGCTCAAGCTGTTCACGATTTTGATTGTAGATTGATGCGGGGCTATCAGGCCTGGCTCCGTACATATTTAGGATGGTCT
GATTTTAACTGGAGTTCTTT

Downstream 100 bases:

>100_bases
TTAGAAGTTAGGCTCCACTGCCAAAAAGCCCACCAAATCTGGTGGGCTTTTTCGTACATCCTGCAAAAAGATCCATTCAA
AGATAAAACGCTCTATTTAT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MANGLTIAICSAILALIFSGLWIRRIYAQPAGNAHMQEIAAAIQEGASAYLKRQYLTIGMVGMVLFLIIGLTLSWDTAFG
FALGAILSGLAGFMGMNVSVQSNVRTAEAARSGLSEALAIAFRGGAVTGMLVVGLGLLGVAGYTALLVNGADVSSNISNL
IHPLIGFAFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTI
IATMLLGALLFQTETGNAVVYPLALGAVSIVASIIGCYFVKMREGGKIMNALYRGLAVAGGIAFFAYLPITVWFMGGATL
SLGGVEVGGGELIMRLFASTAVGLALTGLLVIITEYYTSTEYPPVQHIANASTTGHATNIIAGLGVGMRATAAPVLAICA
SIIIAYSLAGLYGIAIAATAMLSMTGIIVALDAYGPITDNAGGIAEMSGMPESVRAITDPLDAVGNTTKAVTKGYAIGSA
GLAALVLFADYTHGLEHADKLLTFDLSNHLVIIGLFIGGMVPFLFGAMSMEAVGRAASSVVIEVRRQFKEIPGIMDGTSK
PDYSRAVDMLTKAAIREMIIPSLLPVLIPVLVGVFLGPQALGGVLMGSIITGLFLAISMTAGGGAWDNAKKYIEDGNYGG
KGSDAHKAAVTGDTVGDPYKDTAGPAINPLIKIINIVALLIIPLL

Sequences:

>Translated_685_residues
MANGLTIAICSAILALIFSGLWIRRIYAQPAGNAHMQEIAAAIQEGASAYLKRQYLTIGMVGMVLFLIIGLTLSWDTAFG
FALGAILSGLAGFMGMNVSVQSNVRTAEAARSGLSEALAIAFRGGAVTGMLVVGLGLLGVAGYTALLVNGADVSSNISNL
IHPLIGFAFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTI
IATMLLGALLFQTETGNAVVYPLALGAVSIVASIIGCYFVKMREGGKIMNALYRGLAVAGGIAFFAYLPITVWFMGGATL
SLGGVEVGGGELIMRLFASTAVGLALTGLLVIITEYYTSTEYPPVQHIANASTTGHATNIIAGLGVGMRATAAPVLAICA
SIIIAYSLAGLYGIAIAATAMLSMTGIIVALDAYGPITDNAGGIAEMSGMPESVRAITDPLDAVGNTTKAVTKGYAIGSA
GLAALVLFADYTHGLEHADKLLTFDLSNHLVIIGLFIGGMVPFLFGAMSMEAVGRAASSVVIEVRRQFKEIPGIMDGTSK
PDYSRAVDMLTKAAIREMIIPSLLPVLIPVLVGVFLGPQALGGVLMGSIITGLFLAISMTAGGGAWDNAKKYIEDGNYGG
KGSDAHKAAVTGDTVGDPYKDTAGPAINPLIKIINIVALLIIPLL
>Mature_684_residues
ANGLTIAICSAILALIFSGLWIRRIYAQPAGNAHMQEIAAAIQEGASAYLKRQYLTIGMVGMVLFLIIGLTLSWDTAFGF
ALGAILSGLAGFMGMNVSVQSNVRTAEAARSGLSEALAIAFRGGAVTGMLVVGLGLLGVAGYTALLVNGADVSSNISNLI
HPLIGFAFGGSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTII
ATMLLGALLFQTETGNAVVYPLALGAVSIVASIIGCYFVKMREGGKIMNALYRGLAVAGGIAFFAYLPITVWFMGGATLS
LGGVEVGGGELIMRLFASTAVGLALTGLLVIITEYYTSTEYPPVQHIANASTTGHATNIIAGLGVGMRATAAPVLAICAS
IIIAYSLAGLYGIAIAATAMLSMTGIIVALDAYGPITDNAGGIAEMSGMPESVRAITDPLDAVGNTTKAVTKGYAIGSAG
LAALVLFADYTHGLEHADKLLTFDLSNHLVIIGLFIGGMVPFLFGAMSMEAVGRAASSVVIEVRRQFKEIPGIMDGTSKP
DYSRAVDMLTKAAIREMIIPSLLPVLIPVLVGVFLGPQALGGVLMGSIITGLFLAISMTAGGGAWDNAKKYIEDGNYGGK
GSDAHKAAVTGDTVGDPYKDTAGPAINPLIKIINIVALLIIPLL

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 70151; Mature: 70020

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGLTIAICSAILALIFSGLWIRRIYAQPAGNAHMQEIAAAIQEGASAYLKRQYLTIGM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGMVLFLIIGLTLSWDTAFGFALGAILSGLAGFMGMNVSVQSNVRTAEAARSGLSEALAI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
AFRGGAVTGMLVVGLGLLGVAGYTALLVNGADVSSNISNLIHPLIGFAFGGSLISIFARL
HHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTI
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IATMLLGALLFQTETGNAVVYPLALGAVSIVASIIGCYFVKMREGGKIMNALYRGLAVAG
HHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GIAFFAYLPITVWFMGGATLSLGGVEVGGGELIMRLFASTAVGLALTGLLVIITEYYTST
HHHHHHHHHHHHHHHCCCEEEECCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EYPPVQHIANASTTGHATNIIAGLGVGMRATAAPVLAICASIIIAYSLAGLYGIAIAATA
CCCHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLSMTGIIVALDAYGPITDNAGGIAEMSGMPESVRAITDPLDAVGNTTKAVTKGYAIGSA
HHHHHHHHEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCHH
GLAALVLFADYTHGLEHADKLLTFDLSNHLVIIGLFIGGMVPFLFGAMSMEAVGRAASSV
HHHHHHHHHHHHHHHHHHHHHEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEVRRQFKEIPGIMDGTSKPDYSRAVDMLTKAAIREMIIPSLLPVLIPVLVGVFLGPQA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
LGGVLMGSIITGLFLAISMTAGGGAWDNAKKYIEDGNYGGKGSDAHKAAVTGDTVGDPYK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCC
DTAGPAINPLIKIINIVALLIIPLL
CCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANGLTIAICSAILALIFSGLWIRRIYAQPAGNAHMQEIAAAIQEGASAYLKRQYLTIGM
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGMVLFLIIGLTLSWDTAFGFALGAILSGLAGFMGMNVSVQSNVRTAEAARSGLSEALAI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
AFRGGAVTGMLVVGLGLLGVAGYTALLVNGADVSSNISNLIHPLIGFAFGGSLISIFARL
HHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTI
CCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
IATMLLGALLFQTETGNAVVYPLALGAVSIVASIIGCYFVKMREGGKIMNALYRGLAVAG
HHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GIAFFAYLPITVWFMGGATLSLGGVEVGGGELIMRLFASTAVGLALTGLLVIITEYYTST
HHHHHHHHHHHHHHHCCCEEEECCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EYPPVQHIANASTTGHATNIIAGLGVGMRATAAPVLAICASIIIAYSLAGLYGIAIAATA
CCCHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLSMTGIIVALDAYGPITDNAGGIAEMSGMPESVRAITDPLDAVGNTTKAVTKGYAIGSA
HHHHHHHHEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCHH
GLAALVLFADYTHGLEHADKLLTFDLSNHLVIIGLFIGGMVPFLFGAMSMEAVGRAASSV
HHHHHHHHHHHHHHHHHHHHHEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIEVRRQFKEIPGIMDGTSKPDYSRAVDMLTKAAIREMIIPSLLPVLIPVLVGVFLGPQA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
LGGVLMGSIITGLFLAISMTAGGGAWDNAKKYIEDGNYGGKGSDAHKAAVTGDTVGDPYK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCC
DTAGPAINPLIKIINIVALLIIPLL
CCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]