Click here to switch to the map view.

The map label for this gene is hrcA

Identifier: 114330782

GI number: 114330782

Start: 785371

End: 786387

Strand: Direct

Name: hrcA

Synonym: Neut_0769

Alternate gene names: 114330782

Gene position: 785371-786387 (Clockwise)

Preceding gene: 114330779

Following gene: 114330783

Centisome position: 29.51

GC content: 45.03

Gene sequence:

>1017_bases
ATGCTTAACGAACGCGCGAAAATTCTGCTTAAAACCTTGGTTGAACGGTATATCCATGAAGGCCAACCTGTTGGTTCGCG
TTCGCTCGCCAAGTTTTCAGGACTGGATCTGAGTCCGGCCACGATTCGTAATGTAATGACTGATCTGGAGGAAATGGGGT
TTGTTTCCAGCCCGCATACATCTGCCGGGCGTATGCCAACCACACTTGGCTACCGTTTTTTTGTTGATACCTTGTTGGTG
GTGCAATCTCTGGATAATGAACAGATTACTCTACTGGAAAACCGGATGCACCCAAATAACCCATCGCATTTGATTAATGT
TACCTCTCGCTTGCTTTCAGATTTGACCCAGTTTGTTGGTGTGGTGGTAACACCCAAGCGAATGGGAGGGGCGGTATTTC
GCCATATTGAATTTGTGCCATTATCTGAAAAACGGATTCTCCTGATTCTGGTAACGCCAGAGGGGGATGTTCAGAACCGG
ATTATTTTTACTGAAACGGTTTATAACCAGTCTGACCTAATTGAGGCTGGGAATTTTCTCAATCAGCACTATGCTGGTTG
TGCGCTGGAAGAAATTCGTTCCGGGTTACAGCACGAATTGACACAGTTGCGCCGGAATATGACAGATCTTATGAATGCGG
CAATAGAAATAGGTAATGCTGCGCTGCAGGAAAGCAGTGAAGCAGTGGTGATTGCCGGAGAACACAAACTGTTTGATGTT
CGTGATTTATCGGAAAATCTGTCTAGTTTGAAACAATTATTCGAGCTGTTTGAGCGAAAATCAAAGTTGTTGCAGTTAAT
GGAATTAAGTCGCCAGGCGTGCGGCGTTAAAATCTTTATTGGTGGTGAGTCTGATGAAACCATGCTGGAAGAGATCAGTG
TGGTAACTGCACCCTATGAAATGGAAGGTAAAATTGTAGGTACTGTGGGGGTGATCGGTCCACGACGTATGGCTTATGAG
CGCATTATCCCTATTGTTGATATAACTGCCCGCCTGCTTTCAAATAATCTGTCGTAA

Upstream 100 bases:

>100_bases
AATGAGTTGAAAAACTGTATTCCACTTATATGTAGCATTTGAAATCCCCGCTTTAGGCTGTCTCTGCTCGTGGCAGGACC
GATTCGTGTAAAATAAATAT

Downstream 100 bases:

>100_bases
TATCCCGCCCTCTATTTTTATGTCACGAATAATATTACCGGAGCCGGCTTATCAACACGGTTCAATTGATAGAGTCGGTG
TTCTGCTGATTAATCTGGGT

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLNERAKILLKTLVERYIHEGQPVGSRSLAKFSGLDLSPATIRNVMTDLEEMGFVSSPHTSAGRMPTTLGYRFFVDTLLV
VQSLDNEQITLLENRMHPNNPSHLINVTSRLLSDLTQFVGVVVTPKRMGGAVFRHIEFVPLSEKRILLILVTPEGDVQNR
IIFTETVYNQSDLIEAGNFLNQHYAGCALEEIRSGLQHELTQLRRNMTDLMNAAIEIGNAALQESSEAVVIAGEHKLFDV
RDLSENLSSLKQLFELFERKSKLLQLMELSRQACGVKIFIGGESDETMLEEISVVTAPYEMEGKIVGTVGVIGPRRMAYE
RIIPIVDITARLLSNNLS

Sequences:

>Translated_338_residues
MLNERAKILLKTLVERYIHEGQPVGSRSLAKFSGLDLSPATIRNVMTDLEEMGFVSSPHTSAGRMPTTLGYRFFVDTLLV
VQSLDNEQITLLENRMHPNNPSHLINVTSRLLSDLTQFVGVVVTPKRMGGAVFRHIEFVPLSEKRILLILVTPEGDVQNR
IIFTETVYNQSDLIEAGNFLNQHYAGCALEEIRSGLQHELTQLRRNMTDLMNAAIEIGNAALQESSEAVVIAGEHKLFDV
RDLSENLSSLKQLFELFERKSKLLQLMELSRQACGVKIFIGGESDETMLEEISVVTAPYEMEGKIVGTVGVIGPRRMAYE
RIIPIVDITARLLSNNLS
>Mature_338_residues
MLNERAKILLKTLVERYIHEGQPVGSRSLAKFSGLDLSPATIRNVMTDLEEMGFVSSPHTSAGRMPTTLGYRFFVDTLLV
VQSLDNEQITLLENRMHPNNPSHLINVTSRLLSDLTQFVGVVVTPKRMGGAVFRHIEFVPLSEKRILLILVTPEGDVQNR
IIFTETVYNQSDLIEAGNFLNQHYAGCALEEIRSGLQHELTQLRRNMTDLMNAAIEIGNAALQESSEAVVIAGEHKLFDV
RDLSENLSSLKQLFELFERKSKLLQLMELSRQACGVKIFIGGESDETMLEEISVVTAPYEMEGKIVGTVGVIGPRRMAYE
RIIPIVDITARLLSNNLS

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_NITEC (Q0AHZ3)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747004.1
- ProteinModelPortal:   Q0AHZ3
- SMR:   Q0AHZ3
- STRING:   Q0AHZ3
- GeneID:   4272993
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0769
- NMPDR:   fig|335283.3.peg.2384
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   NEUT335283:NEUT_0769-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 37765; Mature: 37765

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNERAKILLKTLVERYIHEGQPVGSRSLAKFSGLDLSPATIRNVMTDLEEMGFVSSPHT
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SAGRMPTTLGYRFFVDTLLVVQSLDNEQITLLENRMHPNNPSHLINVTSRLLSDLTQFVG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
VVVTPKRMGGAVFRHIEFVPLSEKRILLILVTPEGDVQNRIIFTETVYNQSDLIEAGNFL
EEECCHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHH
NQHYAGCALEEIRSGLQHELTQLRRNMTDLMNAAIEIGNAALQESSEAVVIAGEHKLFDV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEH
RDLSENLSSLKQLFELFERKSKLLQLMELSRQACGVKIFIGGESDETMLEEISVVTAPYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCEE
MEGKIVGTVGVIGPRRMAYERIIPIVDITARLLSNNLS
ECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLNERAKILLKTLVERYIHEGQPVGSRSLAKFSGLDLSPATIRNVMTDLEEMGFVSSPHT
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SAGRMPTTLGYRFFVDTLLVVQSLDNEQITLLENRMHPNNPSHLINVTSRLLSDLTQFVG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
VVVTPKRMGGAVFRHIEFVPLSEKRILLILVTPEGDVQNRIIFTETVYNQSDLIEAGNFL
EEECCHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHH
NQHYAGCALEEIRSGLQHELTQLRRNMTDLMNAAIEIGNAALQESSEAVVIAGEHKLFDV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEH
RDLSENLSSLKQLFELFERKSKLLQLMELSRQACGVKIFIGGESDETMLEEISVVTAPYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCEE
MEGKIVGTVGVIGPRRMAYERIIPIVDITARLLSNNLS
ECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA