Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 114330760

GI number: 114330760

Start: 767568

End: 768881

Strand: Direct

Name: atoC [H]

Synonym: Neut_0747

Alternate gene names: 114330760

Gene position: 767568-768881 (Clockwise)

Preceding gene: 114330759

Following gene: 114330761

Centisome position: 28.84

GC content: 50.46

Gene sequence:

>1314_bases
ATGCAAAATTTGCCTGTACTGATTGTAGAAGATGATCCGGATTTGCTGGAAGCGTTGTGTGCAACCCTCAAATTGAAGGG
TTACACCAGTCTTGCCGCCAGCGGAGGTGAGCGCGCTCTTGACCTATTACGCAGCCATCCAGTAGGGCTGGTTATCAGTG
ATGTACAAATGCGTCCGATGGATGGCCATACACTGTTGCAAAATATCAGGCGAAGTCATCCGTGGATTCCAGTTGTGCTA
ATGACCGCTTATGGTGAGGTAGACAAGGCCGTAGCTGCAATGCGTGCTGGAGCGAGGGATTATCTGCCTAAGCCATTTGA
TCCGCACAGCCTGTTGGCGTATGTCGAACGTTACTTGCTGACGATCAGCAATGAGGATGAACCGGAAATTGTGGCGGAAG
ATCCCCGTACCTTGACATTGTTGTCATTGGCAAAGAAAGTAGCCGTGACTGATGCGACCGTAATGCTGATGGGGGAAAGT
GGCAGTGGCAAGGAGGTGTTGGCCCGGTTTGTGCATCGTCATTCGTCGCGTGTATCTCAACCTTTTGTCGCAATCAATTG
TGCTGCCATTCCCGAAAATCTGCTGGAAGCAACCCTGTTCGGTTATGAAAAAGGAGCGTTTACTGGCGCATTTCAGGGGC
AGGCAGGAAAGTTTGAGCAGGCCAATGGTGGCACTTTGCTGCTGGATGAAATTTCGGAAATGCCACTTAGCCTTCAGGTA
AAACTATTGCGTGTATTGCAAGAGCGTGAAGTGGAGCGGGTGGGCAGCAATAAAGCTATCAAGCTCGATATTCGTCTGAT
TGCCACTTCCAACCGGGATATGCAGGCGTATGTGCGGGCAAGCCAATTTCGTGAGGATTTGTACTACCGGCTGAATGTTT
TTCCACTAGAGATTCCTCCGTTGCGTGAACGCGTGCAGGATATTGTGCCATTGGCGCAGTATATTCTGGATAAATCCACC
CAACCTGGCTGTACGTTGACAAAATCAGCCATGCTGTCTCTGGAACGGTACACCTGGCCGGGAAATGTTCGTGAGCTGGA
GAATGTGATGCAACGTGCCATGATTCTAGCGACAGGGCCAATTGAGCCTGCGCATCTGAACTTACCGGAGTCGCCGATGA
ACAAGTCTTCCCAGGAGAATGTGCAGGGAGCAGCTGAATCCTCCCTGTGTGACATCAAATCACTTGAGCGAGATCATATT
CTGCAAACATTGGCGGCTGTGAACGGTTCACGCAAACTGGCTGTACAAAAACTTGGTATTTCCGAGCGGACACTGCGTTA
CAAGCTGCAGCAATACCGGCTTGCCGAATGCTGA

Upstream 100 bases:

>100_bases
CCGGTTTACGATCTGCCTGCCAAGAGCAGCAAAGGCACGAACCAATAAATTTGTCCCGGCAGGTGAAATGGCAACAACTA
AAAATGAGGACAGATAAAAG

Downstream 100 bases:

>100_bases
TCAATTTTACAAAAGCGGAGAACAAATATGAATATTGCATCAGGGATGAATCAGATGCTGGCGCAGCTCAAGGCAACCTC
GGATCTGGCAGCGGGCGGCA

Product: two component, sigma54 specific, transcriptional regulator, Fis family protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MQNLPVLIVEDDPDLLEALCATLKLKGYTSLAASGGERALDLLRSHPVGLVISDVQMRPMDGHTLLQNIRRSHPWIPVVL
MTAYGEVDKAVAAMRAGARDYLPKPFDPHSLLAYVERYLLTISNEDEPEIVAEDPRTLTLLSLAKKVAVTDATVMLMGES
GSGKEVLARFVHRHSSRVSQPFVAINCAAIPENLLEATLFGYEKGAFTGAFQGQAGKFEQANGGTLLLDEISEMPLSLQV
KLLRVLQEREVERVGSNKAIKLDIRLIATSNRDMQAYVRASQFREDLYYRLNVFPLEIPPLRERVQDIVPLAQYILDKST
QPGCTLTKSAMLSLERYTWPGNVRELENVMQRAMILATGPIEPAHLNLPESPMNKSSQENVQGAAESSLCDIKSLERDHI
LQTLAAVNGSRKLAVQKLGISERTLRYKLQQYRLAEC

Sequences:

>Translated_437_residues
MQNLPVLIVEDDPDLLEALCATLKLKGYTSLAASGGERALDLLRSHPVGLVISDVQMRPMDGHTLLQNIRRSHPWIPVVL
MTAYGEVDKAVAAMRAGARDYLPKPFDPHSLLAYVERYLLTISNEDEPEIVAEDPRTLTLLSLAKKVAVTDATVMLMGES
GSGKEVLARFVHRHSSRVSQPFVAINCAAIPENLLEATLFGYEKGAFTGAFQGQAGKFEQANGGTLLLDEISEMPLSLQV
KLLRVLQEREVERVGSNKAIKLDIRLIATSNRDMQAYVRASQFREDLYYRLNVFPLEIPPLRERVQDIVPLAQYILDKST
QPGCTLTKSAMLSLERYTWPGNVRELENVMQRAMILATGPIEPAHLNLPESPMNKSSQENVQGAAESSLCDIKSLERDHI
LQTLAAVNGSRKLAVQKLGISERTLRYKLQQYRLAEC
>Mature_437_residues
MQNLPVLIVEDDPDLLEALCATLKLKGYTSLAASGGERALDLLRSHPVGLVISDVQMRPMDGHTLLQNIRRSHPWIPVVL
MTAYGEVDKAVAAMRAGARDYLPKPFDPHSLLAYVERYLLTISNEDEPEIVAEDPRTLTLLSLAKKVAVTDATVMLMGES
GSGKEVLARFVHRHSSRVSQPFVAINCAAIPENLLEATLFGYEKGAFTGAFQGQAGKFEQANGGTLLLDEISEMPLSLQV
KLLRVLQEREVERVGSNKAIKLDIRLIATSNRDMQAYVRASQFREDLYYRLNVFPLEIPPLRERVQDIVPLAQYILDKST
QPGCTLTKSAMLSLERYTWPGNVRELENVMQRAMILATGPIEPAHLNLPESPMNKSSQENVQGAAESSLCDIKSLERDHI
LQTLAAVNGSRKLAVQKLGISERTLRYKLQQYRLAEC

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=43.3333333333333, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=41.5730337078652, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=36.5591397849462, Blast_Score=294, Evalue=6e-81,
Organism=Escherichia coli, GI1788905, Length=364, Percent_Identity=43.6813186813187, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI87082117, Length=325, Percent_Identity=44, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=42.2712933753943, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789233, Length=329, Percent_Identity=41.3373860182371, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082152, Length=270, Percent_Identity=42.2222222222222, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1786524, Length=301, Percent_Identity=41.1960132890365, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1787583, Length=314, Percent_Identity=37.8980891719745, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=42.2413793103448, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789828, Length=287, Percent_Identity=34.1463414634146, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081858, Length=304, Percent_Identity=28.9473684210526, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788394, Length=119, Percent_Identity=35.2941176470588, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=29.8387096774194, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082012, Length=112, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790552, Length=128, Percent_Identity=31.25, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48571; Mature: 48571

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLPVLIVEDDPDLLEALCATLKLKGYTSLAASGGERALDLLRSHPVGLVISDVQMRPM
CCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHCCCCEEEEECCEECCC
DGHTLLQNIRRSHPWIPVVLMTAYGEVDKAVAAMRAGARDYLPKPFDPHSLLAYVERYLL
CHHHHHHHHHHHCCCEEEEEEEHHCHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHE
TISNEDEPEIVAEDPRTLTLLSLAKKVAVTDATVMLMGESGSGKEVLARFVHRHSSRVSQ
EECCCCCCCEEECCCCEEHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCC
PFVAINCAAIPENLLEATLFGYEKGAFTGAFQGQAGKFEQANGGTLLLDEISEMPLSLQV
CEEEEEEHHCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCEEEEEHHHCCCHHHHH
KLLRVLQEREVERVGSNKAIKLDIRLIATSNRDMQAYVRASQFREDLYYRLNVFPLEIPP
HHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEECCCH
LRERVQDIVPLAQYILDKSTQPGCTLTKSAMLSLERYTWPGNVRELENVMQRAMILATGP
HHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCC
IEPAHLNLPESPMNKSSQENVQGAAESSLCDIKSLERDHILQTLAAVNGSRKLAVQKLGI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCC
SERTLRYKLQQYRLAEC
CHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNLPVLIVEDDPDLLEALCATLKLKGYTSLAASGGERALDLLRSHPVGLVISDVQMRPM
CCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHCCCCEEEEECCEECCC
DGHTLLQNIRRSHPWIPVVLMTAYGEVDKAVAAMRAGARDYLPKPFDPHSLLAYVERYLL
CHHHHHHHHHHHCCCEEEEEEEHHCHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHE
TISNEDEPEIVAEDPRTLTLLSLAKKVAVTDATVMLMGESGSGKEVLARFVHRHSSRVSQ
EECCCCCCCEEECCCCEEHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHCCC
PFVAINCAAIPENLLEATLFGYEKGAFTGAFQGQAGKFEQANGGTLLLDEISEMPLSLQV
CEEEEEEHHCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCEEEEEHHHCCCHHHHH
KLLRVLQEREVERVGSNKAIKLDIRLIATSNRDMQAYVRASQFREDLYYRLNVFPLEIPP
HHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEECCCH
LRERVQDIVPLAQYILDKSTQPGCTLTKSAMLSLERYTWPGNVRELENVMQRAMILATGP
HHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCC
IEPAHLNLPESPMNKSSQENVQGAAESSLCDIKSLERDHILQTLAAVNGSRKLAVQKLGI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCC
SERTLRYKLQQYRLAEC
CHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]