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The map label for this gene is cyoB [H]

Identifier: 114330711

GI number: 114330711

Start: 699629

End: 701740

Strand: Reverse

Name: cyoB [H]

Synonym: Neut_0696

Alternate gene names: 114330711

Gene position: 701740-699629 (Counterclockwise)

Preceding gene: 114330712

Following gene: 114330710

Centisome position: 26.37

GC content: 51.8

Gene sequence:

>2112_bases
ATGAGCTGGTCTACCATTTTCAATCATCCGCTAGGACTTCTCGGTGCGGATTCGTTTCCGTTTCTGGCCATGCTCAGCAG
CGATGATAGCGATATTTTTATTAACGGGCTTCTAGGCAGTTTTGCAGCCGCGCTCGTAATCATCAGCGTGATGGTGGTGG
TGGCATTGCTGACGCGCTACCGCGCCTGGCGCACTTTGTGGTTCGACTGGCTCACCAGCACCGATCACAAGAAGATTGGG
ATCATGTATGTAGTGCTGGCACTGGTGATGTTAACGCGTGCCATCGCCGAAGCAGTTTTGATGCGCGCGCAGGGCGCAGT
CGGATTAGGTGGCGGCTTTCTTTCATCCGACCACTTCGCCCAGCTTTTCAGTACGCACGGCACGATTATGATCTTCTTCA
TGGCGATGCCGTTTCTCACGGGGCTCATCAACTATGTCGTACCGCTACAAATCGGCGCACGCGACGTTGCTTTCCCGATA
CTCAATTCCATCAGCCTGTGGCTAACTGCAGCAGGTGCTGCGTTGGTGATGATTTCACTTGTCGTCGGAGCTTTTTCTAC
CGGTGGCTGGTTTGGTTACCCCCCCTATACCGAAACCTTATACAACCCGGGCATCGGGGTTGATTACTGGATTTGGTCAC
TCACACTGGCTTCTTTGGGCTCCACACTCACCGGCATCAACATTGCCGTCACCATTTACAAAAAACGTGCGCCTGGCATG
AAGCTTTATTACATGCCGCTCTTTACCTGGACCGCGCTATGCACCGCTATCATGATGATTTTTGCCATGCCTCCACTTAC
TGTAGTGACACTACAGCTGGCACTGGATCGCTACCTCGATTTTCATTTCTTCACCAACGGCCTGGGCGGCAATCAGATGA
ATTTCCTCAACATGTTCTGGCTCTTTGGTCACCCTGAAGTTTACATTCTGATTTTGCCTGCCTTCGGTGTCTATTCCGAG
ATCTTCTCGACCTTCTCCGGTAAAGTTCTGTTTGGCTATAAATCGTTAGTGTGGGCAACCATATCGATTGCATTCCTGTC
ATTTTTGGTGTGGCTGCATCACTTCTTCACCATGGGTCAATCGGGCCATATCAACGCGGTGTTCGGGATTGCCTCCATGC
TGATCGGCATTCCTACCGGAGTCAAAATTTATGACTGGATGTGGACCATGCTTCGCGGTCGCATACGCTTCAGTGTACCC
ATGATTTATTCGTTGGCGTTCATCTTTCTGTTCGTGATTGGCGGCATTACCGGCATCATGCTGGCCAATCCCATCCTGGA
TTATCAAGTACACAACACGGTTTTTCTGGTGGCACATTTTCATAATATGGTCGTACCAGGCGTACTGTTTGGCATGCTGG
CGGGTTATACCTTCTGGTTTCCCAAAGCATTCGGGTTTCGCCTGGATGAACGTTGGGGAAGAATTTCCGCATACTGCTGG
ATTTTTGGCTGGATGGGTGCATTCTTCCCGCTGTACATTCTGGGCTTGATGGGGTTGCCACGCCGCAGTGTTGCCTACGA
ACAGGCTAGCTACGTACCACTGGAAATCGTTGCATTTGTAGGTGCTCTACTGGTTGCAGCAGCGCTCATGGCGCTTGTAA
TTCAGCTGTGGGTTTCAATCAAGTATCGTGAAAAAAACCGCGTTTTTGTGGGCGATCCATGGAACGGTCGCAGCCTTGAA
TGGGCTACATCAGCGCCCCCGCCGGAGTACAATTTCCCAGTTGTTCCAAGTATCAACGATCGTGATGCTTTTACCGCCGC
CAAGGAATTTGGCGTCGGCTATCAGGAACCCGATGCATACGTCAATATCGAAATACCGCAGAACAGCGCAATGGGTCCAG
TATTTGGCGGCACTAGCTTCTTGTTAGCATTCGGGCTGGTATGGCAAATCTGGTGGCTCGTAATCCTGACAGGATTGATA
ACGATTGGCACCCTGGTGATGCGCGGCTTTCAGCGTGACACACTTAAAATCATCCCGGCAGAAGCTGTCTGCCGGACGCA
TCAGCACTGGATCCAGGCTGCACGCTTGGCGCTGCCGATCAAGCGCAGCCAAGAGCACACGGCCGCGAACAAAGGGCGTG
CCGCGATTGAAACCGTAGAGGTGCCCACATGA

Upstream 100 bases:

>100_bases
GAAAGCTAATTTCTTCACCGATTTAGTGATATCAGTCATGGATGAGAAACCATTGCCGTCAACCGCGCTGGCGCCCGCGA
TCACTAAGGGTCAATAACCT

Downstream 100 bases:

>100_bases
TCTCAGAGCTTTTCAAGCGCTTGGAGTTTTACCTTGACGCACGCCAGAACAAGGAGATTTTTATCTACCCGGGCCTGAAC
CTCGGGGTCGAACACTCGGA

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MSWSTIFNHPLGLLGADSFPFLAMLSSDDSDIFINGLLGSFAAALVIISVMVVVALLTRYRAWRTLWFDWLTSTDHKKIG
IMYVVLALVMLTRAIAEAVLMRAQGAVGLGGGFLSSDHFAQLFSTHGTIMIFFMAMPFLTGLINYVVPLQIGARDVAFPI
LNSISLWLTAAGAALVMISLVVGAFSTGGWFGYPPYTETLYNPGIGVDYWIWSLTLASLGSTLTGINIAVTIYKKRAPGM
KLYYMPLFTWTALCTAIMMIFAMPPLTVVTLQLALDRYLDFHFFTNGLGGNQMNFLNMFWLFGHPEVYILILPAFGVYSE
IFSTFSGKVLFGYKSLVWATISIAFLSFLVWLHHFFTMGQSGHINAVFGIASMLIGIPTGVKIYDWMWTMLRGRIRFSVP
MIYSLAFIFLFVIGGITGIMLANPILDYQVHNTVFLVAHFHNMVVPGVLFGMLAGYTFWFPKAFGFRLDERWGRISAYCW
IFGWMGAFFPLYILGLMGLPRRSVAYEQASYVPLEIVAFVGALLVAAALMALVIQLWVSIKYREKNRVFVGDPWNGRSLE
WATSAPPPEYNFPVVPSINDRDAFTAAKEFGVGYQEPDAYVNIEIPQNSAMGPVFGGTSFLLAFGLVWQIWWLVILTGLI
TIGTLVMRGFQRDTLKIIPAEAVCRTHQHWIQAARLALPIKRSQEHTAANKGRAAIETVEVPT

Sequences:

>Translated_703_residues
MSWSTIFNHPLGLLGADSFPFLAMLSSDDSDIFINGLLGSFAAALVIISVMVVVALLTRYRAWRTLWFDWLTSTDHKKIG
IMYVVLALVMLTRAIAEAVLMRAQGAVGLGGGFLSSDHFAQLFSTHGTIMIFFMAMPFLTGLINYVVPLQIGARDVAFPI
LNSISLWLTAAGAALVMISLVVGAFSTGGWFGYPPYTETLYNPGIGVDYWIWSLTLASLGSTLTGINIAVTIYKKRAPGM
KLYYMPLFTWTALCTAIMMIFAMPPLTVVTLQLALDRYLDFHFFTNGLGGNQMNFLNMFWLFGHPEVYILILPAFGVYSE
IFSTFSGKVLFGYKSLVWATISIAFLSFLVWLHHFFTMGQSGHINAVFGIASMLIGIPTGVKIYDWMWTMLRGRIRFSVP
MIYSLAFIFLFVIGGITGIMLANPILDYQVHNTVFLVAHFHNMVVPGVLFGMLAGYTFWFPKAFGFRLDERWGRISAYCW
IFGWMGAFFPLYILGLMGLPRRSVAYEQASYVPLEIVAFVGALLVAAALMALVIQLWVSIKYREKNRVFVGDPWNGRSLE
WATSAPPPEYNFPVVPSINDRDAFTAAKEFGVGYQEPDAYVNIEIPQNSAMGPVFGGTSFLLAFGLVWQIWWLVILTGLI
TIGTLVMRGFQRDTLKIIPAEAVCRTHQHWIQAARLALPIKRSQEHTAANKGRAAIETVEVPT
>Mature_702_residues
SWSTIFNHPLGLLGADSFPFLAMLSSDDSDIFINGLLGSFAAALVIISVMVVVALLTRYRAWRTLWFDWLTSTDHKKIGI
MYVVLALVMLTRAIAEAVLMRAQGAVGLGGGFLSSDHFAQLFSTHGTIMIFFMAMPFLTGLINYVVPLQIGARDVAFPIL
NSISLWLTAAGAALVMISLVVGAFSTGGWFGYPPYTETLYNPGIGVDYWIWSLTLASLGSTLTGINIAVTIYKKRAPGMK
LYYMPLFTWTALCTAIMMIFAMPPLTVVTLQLALDRYLDFHFFTNGLGGNQMNFLNMFWLFGHPEVYILILPAFGVYSEI
FSTFSGKVLFGYKSLVWATISIAFLSFLVWLHHFFTMGQSGHINAVFGIASMLIGIPTGVKIYDWMWTMLRGRIRFSVPM
IYSLAFIFLFVIGGITGIMLANPILDYQVHNTVFLVAHFHNMVVPGVLFGMLAGYTFWFPKAFGFRLDERWGRISAYCWI
FGWMGAFFPLYILGLMGLPRRSVAYEQASYVPLEIVAFVGALLVAAALMALVIQLWVSIKYREKNRVFVGDPWNGRSLEW
ATSAPPPEYNFPVVPSINDRDAFTAAKEFGVGYQEPDAYVNIEIPQNSAMGPVFGGTSFLLAFGLVWQIWWLVILTGLIT
IGTLVMRGFQRDTLKIIPAEAVCRTHQHWIQAARLALPIKRSQEHTAANKGRAAIETVEVPT

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=506, Percent_Identity=40.1185770750988, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1786634, Length=638, Percent_Identity=51.8808777429467, Blast_Score=685, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=534, Percent_Identity=35.9550561797753, Blast_Score=319, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=39.3188854489164, Blast_Score=213, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6226523, Length=244, Percent_Identity=33.1967213114754, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 78309; Mature: 78178

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSTIFNHPLGLLGADSFPFLAMLSSDDSDIFINGLLGSFAAALVIISVMVVVALLTRY
CCCCHHHCCCCCCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RAWRTLWFDWLTSTDHKKIGIMYVVLALVMLTRAIAEAVLMRAQGAVGLGGGFLSSDHFA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
QLFSTHGTIMIFFMAMPFLTGLINYVVPLQIGARDVAFPILNSISLWLTAAGAALVMISL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVGAFSTGGWFGYPPYTETLYNPGIGVDYWIWSLTLASLGSTLTGINIAVTIYKKRAPGM
HHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCHHCCCEEEEEEEECCCCCC
KLYYMPLFTWTALCTAIMMIFAMPPLTVVTLQLALDRYLDFHFFTNGLGGNQMNFLNMFW
EEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEE
LFGHPEVYILILPAFGVYSEIFSTFSGKVLFGYKSLVWATISIAFLSFLVWLHHFFTMGQ
EECCCCEEEEEEECHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGHINAVFGIASMLIGIPTGVKIYDWMWTMLRGRIRFSVPMIYSLAFIFLFVIGGITGIM
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHH
LANPILDYQVHNTVFLVAHFHNMVVPGVLFGMLAGYTFWFPKAFGFRLDERWGRISAYCW
HHCCHHCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
IFGWMGAFFPLYILGLMGLPRRSVAYEQASYVPLEIVAFVGALLVAAALMALVIQLWVSI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
KYREKNRVFVGDPWNGRSLEWATSAPPPEYNFPVVPSINDRDAFTAAKEFGVGYQEPDAY
EEECCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCE
VNIEIPQNSAMGPVFGGTSFLLAFGLVWQIWWLVILTGLITIGTLVMRGFQRDTLKIIPA
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECH
EAVCRTHQHWIQAARLALPIKRSQEHTAANKGRAAIETVEVPT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEECCCC
>Mature Secondary Structure 
SWSTIFNHPLGLLGADSFPFLAMLSSDDSDIFINGLLGSFAAALVIISVMVVVALLTRY
CCCHHHCCCCCCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RAWRTLWFDWLTSTDHKKIGIMYVVLALVMLTRAIAEAVLMRAQGAVGLGGGFLSSDHFA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
QLFSTHGTIMIFFMAMPFLTGLINYVVPLQIGARDVAFPILNSISLWLTAAGAALVMISL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVGAFSTGGWFGYPPYTETLYNPGIGVDYWIWSLTLASLGSTLTGINIAVTIYKKRAPGM
HHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCHHCCCEEEEEEEECCCCCC
KLYYMPLFTWTALCTAIMMIFAMPPLTVVTLQLALDRYLDFHFFTNGLGGNQMNFLNMFW
EEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEE
LFGHPEVYILILPAFGVYSEIFSTFSGKVLFGYKSLVWATISIAFLSFLVWLHHFFTMGQ
EECCCCEEEEEEECHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGHINAVFGIASMLIGIPTGVKIYDWMWTMLRGRIRFSVPMIYSLAFIFLFVIGGITGIM
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHH
LANPILDYQVHNTVFLVAHFHNMVVPGVLFGMLAGYTFWFPKAFGFRLDERWGRISAYCW
HHCCHHCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
IFGWMGAFFPLYILGLMGLPRRSVAYEQASYVPLEIVAFVGALLVAAALMALVIQLWVSI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHE
KYREKNRVFVGDPWNGRSLEWATSAPPPEYNFPVVPSINDRDAFTAAKEFGVGYQEPDAY
EEECCCEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCE
VNIEIPQNSAMGPVFGGTSFLLAFGLVWQIWWLVILTGLITIGTLVMRGFQRDTLKIIPA
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECH
EAVCRTHQHWIQAARLALPIKRSQEHTAANKGRAAIETVEVPT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]