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The map label for this gene is pyrD

Identifier: 114330661

GI number: 114330661

Start: 656751

End: 657779

Strand: Reverse

Name: pyrD

Synonym: Neut_0646

Alternate gene names: 114330661

Gene position: 657779-656751 (Counterclockwise)

Preceding gene: 114330662

Following gene: 114330660

Centisome position: 24.72

GC content: 52.77

Gene sequence:

>1029_bases
ATGACATACACTCTACTACGTCCGCTGCTGTTTCTGCTTGATGCCGAAACTGCCCATACCCTTACCCTGGATACGCTCGG
ATTACTGCAGAAAACCGGGCTGTTACCTAATCGCACTATCTACTGCACACCGGTTCGCGCTATGGGGCTGGATTTTCCTA
ACCCGGTCGGGCTGGCTGCCGGTCTCGACAAAAACGGCGCGTACATCAGCGCACTGGCCCGGCTGGGGTTCGGTTTTATT
GAAGTGGGAACTGTCACTCCGCGCCCACAACCTGGCAATCCTCGCCCACGGCTGTTTCGCGTCCCGCAGGCTGAAGCAAT
CACCAACCGGATGGGATTTAACAACGTTGGGATAGATAAACTGATAGAAAATGTCCGGCAGGCGGATTATCAAGGCATAT
TAGGCATCAATATCGGTAAAAATGCTGATACGCCCCTGCAAAACGCGATAGATGACTATCTAATCTGTTTACGTAAGGCG
TACCCGTATGCCAGTTATGTCACCGTCAACATCTCCTCACCTAATACGAAACAACTCAGGCAGCTGCAAAATGAAACCGA
GCTGGAACAACTGTTGGGCGCACTCAAGACGGAACAAACCCGACTCAGCGATCAGCATGGCCACTACACCCCGCTGGCCA
TTAAAATCGCACCTGATCTGGAATCTGCTCAAATCGAGGCAATCGCCTCGCTGCTACTGAAACACCGTATGGATGCCGTA
ATTGCAACCAATACCACCATCGCACGTGATGGCCTTGAACACTTGCCGCATGGTGATGAACCAGGCGGATTAAGCGGCGC
ACCATTAACGGAGCGCAGTACTGCCGTCATCCGCCAGCTTGCCATGCATCTCCAGCAGGCTATTCCCATCATCGGGGCGG
GTGGCATCATGTCATCCCTGGATGCACAAGCCAAAATAAAAGCCGGCGCCAGCCTGGTGCAGGTTTATTCCGGATTAATT
TACCGTGGCCCGGCTCTGGTTTCGGAAATCACCTCACTACTTTGCTCTCGTTCAACCTATGCTGGATAA

Upstream 100 bases:

>100_bases
CGAAAATAACCGAAAAATGCGCTATAAAGCCAATTTCCAACCACTACAACTGCTGGTTGACAACCAATGGCAATGTCAGG
AAACCTGCACAACCATCTGA

Downstream 100 bases:

>100_bases
AAGTAAATTGATTGAGCAGATTGATGCCGTGCTGCCGCAAACCCAATGCGGCCAGTGCAGATTTGATGGTTGCCGTCCTT
ATGCTGTAGCGATTGCTGAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTYTLLRPLLFLLDAETAHTLTLDTLGLLQKTGLLPNRTIYCTPVRAMGLDFPNPVGLAAGLDKNGAYISALARLGFGFI
EVGTVTPRPQPGNPRPRLFRVPQAEAITNRMGFNNVGIDKLIENVRQADYQGILGINIGKNADTPLQNAIDDYLICLRKA
YPYASYVTVNISSPNTKQLRQLQNETELEQLLGALKTEQTRLSDQHGHYTPLAIKIAPDLESAQIEAIASLLLKHRMDAV
IATNTTIARDGLEHLPHGDEPGGLSGAPLTERSTAVIRQLAMHLQQAIPIIGAGGIMSSLDAQAKIKAGASLVQVYSGLI
YRGPALVSEITSLLCSRSTYAG

Sequences:

>Translated_342_residues
MTYTLLRPLLFLLDAETAHTLTLDTLGLLQKTGLLPNRTIYCTPVRAMGLDFPNPVGLAAGLDKNGAYISALARLGFGFI
EVGTVTPRPQPGNPRPRLFRVPQAEAITNRMGFNNVGIDKLIENVRQADYQGILGINIGKNADTPLQNAIDDYLICLRKA
YPYASYVTVNISSPNTKQLRQLQNETELEQLLGALKTEQTRLSDQHGHYTPLAIKIAPDLESAQIEAIASLLLKHRMDAV
IATNTTIARDGLEHLPHGDEPGGLSGAPLTERSTAVIRQLAMHLQQAIPIIGAGGIMSSLDAQAKIKAGASLVQVYSGLI
YRGPALVSEITSLLCSRSTYAG
>Mature_341_residues
TYTLLRPLLFLLDAETAHTLTLDTLGLLQKTGLLPNRTIYCTPVRAMGLDFPNPVGLAAGLDKNGAYISALARLGFGFIE
VGTVTPRPQPGNPRPRLFRVPQAEAITNRMGFNNVGIDKLIENVRQADYQGILGINIGKNADTPLQNAIDDYLICLRKAY
PYASYVTVNISSPNTKQLRQLQNETELEQLLGALKTEQTRLSDQHGHYTPLAIKIAPDLESAQIEAIASLLLKHRMDAVI
ATNTTIARDGLEHLPHGDEPGGLSGAPLTERSTAVIRQLAMHLQQAIPIIGAGGIMSSLDAQAKIKAGASLVQVYSGLIY
RGPALVSEITSLLCSRSTYAG

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=335, Percent_Identity=43.2835820895522, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=52.6946107784431, Blast_Score=356, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17509475, Length=337, Percent_Identity=40.3560830860534, Blast_Score=227, Evalue=5e-60,
Organism=Drosophila melanogaster, GI281361352, Length=351, Percent_Identity=39.3162393162393, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI17137316, Length=351, Percent_Identity=39.3162393162393, Blast_Score=241, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_NITEC (Q0AIB4)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746883.1
- ProteinModelPortal:   Q0AIB4
- SMR:   Q0AIB4
- STRING:   Q0AIB4
- GeneID:   4272202
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0646
- NMPDR:   fig|335283.3.peg.1786
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- PhylomeDB:   Q0AIB4
- ProtClustDB:   PRK05286
- BioCyc:   NEUT335283:NEUT_0646-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36898; Mature: 36767

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTLLRPLLFLLDAETAHTLTLDTLGLLQKTGLLPNRTIYCTPVRAMGLDFPNPVGLAA
CCHHHHHHHHHHHCCCCHHEEHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCCCCCCHHC
GLDKNGAYISALARLGFGFIEVGTVTPRPQPGNPRPRLFRVPQAEAITNRMGFNNVGIDK
CCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCHHH
LIENVRQADYQGILGINIGKNADTPLQNAIDDYLICLRKAYPYASYVTVNISSPNTKQLR
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHH
QLQNETELEQLLGALKTEQTRLSDQHGHYTPLAIKIAPDLESAQIEAIASLLLKHRMDAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IATNTTIARDGLEHLPHGDEPGGLSGAPLTERSTAVIRQLAMHLQQAIPIIGAGGIMSSL
EECCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHH
DAQAKIKAGASLVQVYSGLIYRGPALVSEITSLLCSRSTYAG
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TYTLLRPLLFLLDAETAHTLTLDTLGLLQKTGLLPNRTIYCTPVRAMGLDFPNPVGLAA
CHHHHHHHHHHHCCCCHHEEHHHHHHHHHHCCCCCCCEEEECCHHHHCCCCCCCCCHHC
GLDKNGAYISALARLGFGFIEVGTVTPRPQPGNPRPRLFRVPQAEAITNRMGFNNVGIDK
CCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCHHH
LIENVRQADYQGILGINIGKNADTPLQNAIDDYLICLRKAYPYASYVTVNISSPNTKQLR
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHH
QLQNETELEQLLGALKTEQTRLSDQHGHYTPLAIKIAPDLESAQIEAIASLLLKHRMDAV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IATNTTIARDGLEHLPHGDEPGGLSGAPLTERSTAVIRQLAMHLQQAIPIIGAGGIMSSL
EECCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHH
DAQAKIKAGASLVQVYSGLIYRGPALVSEITSLLCSRSTYAG
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA