Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 114330618

GI number: 114330618

Start: 612029

End: 613099

Strand: Direct

Name: hemE

Synonym: Neut_0603

Alternate gene names: 114330618

Gene position: 612029-613099 (Clockwise)

Preceding gene: 114330617

Following gene: 114330635

Centisome position: 23.0

GC content: 50.61

Gene sequence:

>1071_bases
ATGACCAGACTGGAAAATGATACTTTTATTCGCGCACTGCTGCGGCAGCCTGTGGACTATACCCCTGTCTGGATGATGCG
CCAGGCTGGCCGCTATCTGCCAGAGTACAACCAGACGCGGGCGCGTGCGGGTGATTTCCTTGCCCTATGCAAAAATCCCG
CACTTGCAACAGAAGTGACTTTGCAGCCATTGGACAGATTTCCGCTGGATGCAGCCATTTTATTTTCCGATATTCTGACT
ATCCCGGATGCAATGGGGTTGGGATTATATTTTTCGACAGGAGAGGGGCCACGCTTCGAGCGCCCGTTACGTGAAGAACG
AGAAATTCACTCATTGATCGTGCCGGACCCGGGTACACATTTGCGCTATGTCATGGATGCCGTTACAGAAATTCGCAAGG
CGCTGAACAATCGAGTGCCATTAATCGGATTCTCAGGCAGCCCGTTTACGCTGGCATGTTATATGGTGGAGGGTGCAAGC
AGTAATGATTATCGTCAGATCAAAACCATGTTGTATACACGCCCGGATCTGCTGCACCATATTCTGGAGGTAACAGCGCA
AGCGGTGATCGTCTATCTGAACGCCCAGATTGAAGCAGGTGCGCAGGCAGTGATGATTTTCGACAGCTGGGGTGGTGCGC
TATCCCATGCCGCCTATCAGGAGTTTTCCCTGCGTTACATGACCCAGATCATGGAAGGATTAAAACGTGAACATGACAGC
GAACGTATCCCGAATATCCTGTTTACCAAGGGAGGTGGGCTGTGGCTGGAATCCATCATGGCCAGTGGTTGTGATGCCAT
CGGATTGGACTGGACGATTGACATTGGCGAAGCGCGTCGGCGTACGCAAGACAAAGTAGCTTTGCAGGGCAACCTGGATC
CAGCTGTATTGTTTTCCTCACCGGAAGCAATTGCTGCTGAAGTTGGAAAAATACTGGCAAGTTATGGTCATGGGCATGGC
CATGTATTTAACCTCGGGCATGGCATTTCCCAGTTCACTCCGCCAGAAAATGCAAAAACACTGGTTGAAACAGTGCATAT
GCAAAGCGTTCACTATCATCAAGTCAGCTAA

Upstream 100 bases:

>100_bases
ATTGACCACTAGTCGCTGAACGATGATAGAAGTACAGTTATGTACGATTCTTTTCTTACGTTAATTTATAAACCTTTTTG
AGATTTAATCTATATAGACA

Downstream 100 bases:

>100_bases
TTTTTAGTATGAGCAGCGGGTTATCAGAAATTGATAACCCATTTTTGTTGTAATCGTCAATATTCTGCTGGGTTTATAGC
CGGAAAGTTTTCAGATTATT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTRLENDTFIRALLRQPVDYTPVWMMRQAGRYLPEYNQTRARAGDFLALCKNPALATEVTLQPLDRFPLDAAILFSDILT
IPDAMGLGLYFSTGEGPRFERPLREEREIHSLIVPDPGTHLRYVMDAVTEIRKALNNRVPLIGFSGSPFTLACYMVEGAS
SNDYRQIKTMLYTRPDLLHHILEVTAQAVIVYLNAQIEAGAQAVMIFDSWGGALSHAAYQEFSLRYMTQIMEGLKREHDS
ERIPNILFTKGGGLWLESIMASGCDAIGLDWTIDIGEARRRTQDKVALQGNLDPAVLFSSPEAIAAEVGKILASYGHGHG
HVFNLGHGISQFTPPENAKTLVETVHMQSVHYHQVS

Sequences:

>Translated_356_residues
MTRLENDTFIRALLRQPVDYTPVWMMRQAGRYLPEYNQTRARAGDFLALCKNPALATEVTLQPLDRFPLDAAILFSDILT
IPDAMGLGLYFSTGEGPRFERPLREEREIHSLIVPDPGTHLRYVMDAVTEIRKALNNRVPLIGFSGSPFTLACYMVEGAS
SNDYRQIKTMLYTRPDLLHHILEVTAQAVIVYLNAQIEAGAQAVMIFDSWGGALSHAAYQEFSLRYMTQIMEGLKREHDS
ERIPNILFTKGGGLWLESIMASGCDAIGLDWTIDIGEARRRTQDKVALQGNLDPAVLFSSPEAIAAEVGKILASYGHGHG
HVFNLGHGISQFTPPENAKTLVETVHMQSVHYHQVS
>Mature_355_residues
TRLENDTFIRALLRQPVDYTPVWMMRQAGRYLPEYNQTRARAGDFLALCKNPALATEVTLQPLDRFPLDAAILFSDILTI
PDAMGLGLYFSTGEGPRFERPLREEREIHSLIVPDPGTHLRYVMDAVTEIRKALNNRVPLIGFSGSPFTLACYMVEGASS
NDYRQIKTMLYTRPDLLHHILEVTAQAVIVYLNAQIEAGAQAVMIFDSWGGALSHAAYQEFSLRYMTQIMEGLKREHDSE
RIPNILFTKGGGLWLESIMASGCDAIGLDWTIDIGEARRRTQDKVALQGNLDPAVLFSSPEAIAAEVGKILASYGHGHGH
VFNLGHGISQFTPPENAKTLVETVHMQSVHYHQVS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=44.8571428571429, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=63.8418079096045, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=38.7464387464387, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI221330099, Length=346, Percent_Identity=40.1734104046243, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI19921920, Length=346, Percent_Identity=40.1734104046243, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_NITEC (Q0AIF1)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746840.1
- ProteinModelPortal:   Q0AIF1
- SMR:   Q0AIF1
- STRING:   Q0AIF1
- GeneID:   4272686
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0603
- NMPDR:   fig|335283.3.peg.1476
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q0AIF1
- ProtClustDB:   PRK00115
- BioCyc:   NEUT335283:NEUT_0603-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39713; Mature: 39582

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLENDTFIRALLRQPVDYTPVWMMRQAGRYLPEYNQTRARAGDFLALCKNPALATEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCHHHHCCCCCCCEEE
LQPLDRFPLDAAILFSDILTIPDAMGLGLYFSTGEGPRFERPLREEREIHSLIVPDPGTH
HHHHHCCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCHHHHHHHHEEECCCCCHH
LRYVMDAVTEIRKALNNRVPLIGFSGSPFTLACYMVEGASSNDYRQIKTMLYTRPDLLHH
HHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
ILEVTAQAVIVYLNAQIEAGAQAVMIFDSWGGALSHAAYQEFSLRYMTQIMEGLKREHDS
HHHHHHHHEEEEEECEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ERIPNILFTKGGGLWLESIMASGCDAIGLDWTIDIGEARRRTQDKVALQGNLDPAVLFSS
HHCCCEEEECCCCHHHHHHHHCCCCEECCEEEEECHHHHHHHHHCEEEECCCCCEEEECC
PEAIAAEVGKILASYGHGHGHVFNLGHGISQFTPPENAKTLVETVHMQSVHYHQVS
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRLENDTFIRALLRQPVDYTPVWMMRQAGRYLPEYNQTRARAGDFLALCKNPALATEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCHHHHCCCCCCCEEE
LQPLDRFPLDAAILFSDILTIPDAMGLGLYFSTGEGPRFERPLREEREIHSLIVPDPGTH
HHHHHCCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCHHHHHHHHEEECCCCCHH
LRYVMDAVTEIRKALNNRVPLIGFSGSPFTLACYMVEGASSNDYRQIKTMLYTRPDLLHH
HHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCCHHHHHH
ILEVTAQAVIVYLNAQIEAGAQAVMIFDSWGGALSHAAYQEFSLRYMTQIMEGLKREHDS
HHHHHHHHEEEEEECEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ERIPNILFTKGGGLWLESIMASGCDAIGLDWTIDIGEARRRTQDKVALQGNLDPAVLFSS
HHCCCEEEECCCCHHHHHHHHCCCCEECCEEEEECHHHHHHHHHCEEEECCCCCEEEECC
PEAIAAEVGKILASYGHGHGHVFNLGHGISQFTPPENAKTLVETVHMQSVHYHQVS
CHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA