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The map label for this gene is dnaX [H]

Identifier: 114330605

GI number: 114330605

Start: 597546

End: 599129

Strand: Direct

Name: dnaX [H]

Synonym: Neut_0590

Alternate gene names: 114330605

Gene position: 597546-599129 (Clockwise)

Preceding gene: 114330604

Following gene: 114330606

Centisome position: 22.46

GC content: 47.16

Gene sequence:

>1584_bases
TTGACGGATTCTCAGGCACTTGCCCGCAAATGGCGCCCCAAAGACTTCACGGGGCTGGTTGGACAAGAACACGTTGTAAG
AGCACTGGTCAACTCAATGGAGCAAAACCGGTTGCACCACGCATACTTGTTTACGGGTACGCGCGGGGTTGGCAAGACAA
CGGTAGCCAGAATCTTGGCAAAGGCCCTGAATTGTGAACAGGGAGTTACTGCCACACCTTGCGGCAAGTGTGCGGCTTGC
CTGGCAATTGATCAAGGAAATTTTGTTGATCTGATTGAGCTGGATGCAGCATCCAATACACAAGTGGATGCCATGCGTGA
GCTACTGGATAACGCACAATATGCACCAGTTACGGCACGGTACAAAGTCTATCTGATCGATGAAGTGCATATGCTTTCCA
AGTCAGCATTTAACGCAATGCTCAAAACCTTGGAAGAACCGCCAGAGCATGTCAAATTCATTCTTGCCACCACCGATCCT
CAAAAAATACCTGTTACTGTATTATCTCGTTGTCTGCAGTTCAATTTGAAGCAGATACCTCCTTCTCTGATCGTGACGCG
TCTGTCCGAGATTCTCTCCATGGAGAGAATTGTGGCGGATGCGACTGCCTTGAAGTTGCTGGCAAAAGCTGCGAAAGGAA
GTTTGCGTGATGCTCTGAGCCTGCTAGATCAGGCCATTGCACTCGGTAACGCCACAGTGGATGAAAAAAATACTCGTGTG
ATGCTGGGAGCGCTGGATCAGGATCATTTGTTCGCATTACTGGAAGCACTGGCGGAGCAGGATGGAGCGGCATTGTTAGC
TATTGCTGATCAGCTAGAAGCGGCGAGTGTATCATTTGATTCTGCCTTGCAGGATCTGGCAGCATTGCTACACCGGTTGG
CAATAGTTCAGACCGTTCCACAGATGCTTGATGAAGAACAGCCGGAGAGTGACAGGTTGCTCGCCTTGGTAAAATGTTTC
ACGCCCGAGGATATTCAACTGTTTTATCAGATTGCATTGCACGGGCGTGCTGATCTTGGTCAGGCTCCGGATGAGTACAG
TGGTTTTACCATGACATTAATGCGGATGCTGGCCTTTATGCCTCATTCTCAACAATCCAGTCATCCGGTGCACGCAAGTA
CCAATGCCAATATCACTCGGAAAATTAAATCTGAGCTGCCTGCAGATTCCAGGAAGCAGGAAAAATCAATAGAGAACGAT
TCTCCGAATGACGCCTGGCTTGCGCTGGTAAACCAATTGGAATTGAGTGGGATGACACGGATGCTGGCACAGTACAGTGA
AGCAAAACACTTCTCTGCAAACAGAATAGAATTGTGTGTGGCAGAAATGCACAAACATCTGCTGGAAAAATCCTATCAGG
ACAAGTTGAAATTTCAACTGGAGTCTCATTTTGGGAAACCCGTTGAAGTGATTTTTTCGCTGGGGAGTATTACTGGTGTT
ACTCCAGCTATATTACAGGATCGCGATAAGCTCGCAAAGCAATCCCAGGCAGTTGAGGCGATTAAATCGGATCCTTATGT
TCAGGAACTGATCGAACAATTTGACGCAAAATTGAATATTTATTCCATTAAACCAATTAATTAA

Upstream 100 bases:

>100_bases
GGTTCGGCTCGCCACCTGTCTTTATACAGATTGCAGAGTCTGTTTCTTTGCAGCTTCATAATAAATCCGGGTTGTAATAA
TCTCTTCTCGATAAAAAACC

Downstream 100 bases:

>100_bases
CGGAGATTGTAAATTGATGAAAGCCAATTTGGGCAATCTGATGAAGCAGGCCCAGCAAATGCAGGAAAACATGAAGGCTA
TGCAAGAAAAGCTGGCAACG

Product: DNA polymerase III, subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTDSQALARKWRPKDFTGLVGQEHVVRALVNSMEQNRLHHAYLFTGTRGVGKTTVARILAKALNCEQGVTATPCGKCAAC
LAIDQGNFVDLIELDAASNTQVDAMRELLDNAQYAPVTARYKVYLIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDP
QKIPVTVLSRCLQFNLKQIPPSLIVTRLSEILSMERIVADATALKLLAKAAKGSLRDALSLLDQAIALGNATVDEKNTRV
MLGALDQDHLFALLEALAEQDGAALLAIADQLEAASVSFDSALQDLAALLHRLAIVQTVPQMLDEEQPESDRLLALVKCF
TPEDIQLFYQIALHGRADLGQAPDEYSGFTMTLMRMLAFMPHSQQSSHPVHASTNANITRKIKSELPADSRKQEKSIEND
SPNDAWLALVNQLELSGMTRMLAQYSEAKHFSANRIELCVAEMHKHLLEKSYQDKLKFQLESHFGKPVEVIFSLGSITGV
TPAILQDRDKLAKQSQAVEAIKSDPYVQELIEQFDAKLNIYSIKPIN

Sequences:

>Translated_527_residues
MTDSQALARKWRPKDFTGLVGQEHVVRALVNSMEQNRLHHAYLFTGTRGVGKTTVARILAKALNCEQGVTATPCGKCAAC
LAIDQGNFVDLIELDAASNTQVDAMRELLDNAQYAPVTARYKVYLIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDP
QKIPVTVLSRCLQFNLKQIPPSLIVTRLSEILSMERIVADATALKLLAKAAKGSLRDALSLLDQAIALGNATVDEKNTRV
MLGALDQDHLFALLEALAEQDGAALLAIADQLEAASVSFDSALQDLAALLHRLAIVQTVPQMLDEEQPESDRLLALVKCF
TPEDIQLFYQIALHGRADLGQAPDEYSGFTMTLMRMLAFMPHSQQSSHPVHASTNANITRKIKSELPADSRKQEKSIEND
SPNDAWLALVNQLELSGMTRMLAQYSEAKHFSANRIELCVAEMHKHLLEKSYQDKLKFQLESHFGKPVEVIFSLGSITGV
TPAILQDRDKLAKQSQAVEAIKSDPYVQELIEQFDAKLNIYSIKPIN
>Mature_526_residues
TDSQALARKWRPKDFTGLVGQEHVVRALVNSMEQNRLHHAYLFTGTRGVGKTTVARILAKALNCEQGVTATPCGKCAACL
AIDQGNFVDLIELDAASNTQVDAMRELLDNAQYAPVTARYKVYLIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQ
KIPVTVLSRCLQFNLKQIPPSLIVTRLSEILSMERIVADATALKLLAKAAKGSLRDALSLLDQAIALGNATVDEKNTRVM
LGALDQDHLFALLEALAEQDGAALLAIADQLEAASVSFDSALQDLAALLHRLAIVQTVPQMLDEEQPESDRLLALVKCFT
PEDIQLFYQIALHGRADLGQAPDEYSGFTMTLMRMLAFMPHSQQSSHPVHASTNANITRKIKSELPADSRKQEKSIENDS
PNDAWLALVNQLELSGMTRMLAQYSEAKHFSANRIELCVAEMHKHLLEKSYQDKLKFQLESHFGKPVEVIFSLGSITGVT
PAILQDRDKLAKQSQAVEAIKSDPYVQELIEQFDAKLNIYSIKPIN

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=293, Percent_Identity=23.5494880546075, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI194306571, Length=296, Percent_Identity=23.3108108108108, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI194306567, Length=296, Percent_Identity=23.3108108108108, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI31563534, Length=233, Percent_Identity=27.0386266094421, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786676, Length=358, Percent_Identity=56.145251396648, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1787341, Length=263, Percent_Identity=30.4182509505703, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71986063, Length=302, Percent_Identity=25.1655629139073, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17541988, Length=243, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=259, Percent_Identity=25.4826254826255, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921076, Length=293, Percent_Identity=23.2081911262799, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI18859927, Length=229, Percent_Identity=26.2008733624454, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17647857, Length=231, Percent_Identity=24.6753246753247, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58249; Mature: 58117

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSQALARKWRPKDFTGLVGQEHVVRALVNSMEQNRLHHAYLFTGTRGVGKTTVARILA
CCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHH
KALNCEQGVTATPCGKCAACLAIDQGNFVDLIELDAASNTQVDAMRELLDNAQYAPVTAR
HHHCCCCCCCCCCCHHHHHHEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEE
YKVYLIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQIP
EEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
PSLIVTRLSEILSMERIVADATALKLLAKAAKGSLRDALSLLDQAIALGNATVDEKNTRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
MLGALDQDHLFALLEALAEQDGAALLAIADQLEAASVSFDSALQDLAALLHRLAIVQTVP
EEECCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QMLDEEQPESDRLLALVKCFTPEDIQLFYQIALHGRADLGQAPDEYSGFTMTLMRMLAFM
HHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
PHSQQSSHPVHASTNANITRKIKSELPADSRKQEKSIENDSPNDAWLALVNQLELSGMTR
CCCCCCCCCEECCCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MLAQYSEAKHFSANRIELCVAEMHKHLLEKSYQDKLKFQLESHFGKPVEVIFSLGSITGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
TPAILQDRDKLAKQSQAVEAIKSDPYVQELIEQFDAKLNIYSIKPIN
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCC
>Mature Secondary Structure 
TDSQALARKWRPKDFTGLVGQEHVVRALVNSMEQNRLHHAYLFTGTRGVGKTTVARILA
CCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHH
KALNCEQGVTATPCGKCAACLAIDQGNFVDLIELDAASNTQVDAMRELLDNAQYAPVTAR
HHHCCCCCCCCCCCHHHHHHEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEE
YKVYLIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQIP
EEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCC
PSLIVTRLSEILSMERIVADATALKLLAKAAKGSLRDALSLLDQAIALGNATVDEKNTRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
MLGALDQDHLFALLEALAEQDGAALLAIADQLEAASVSFDSALQDLAALLHRLAIVQTVP
EEECCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QMLDEEQPESDRLLALVKCFTPEDIQLFYQIALHGRADLGQAPDEYSGFTMTLMRMLAFM
HHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
PHSQQSSHPVHASTNANITRKIKSELPADSRKQEKSIENDSPNDAWLALVNQLELSGMTR
CCCCCCCCCEECCCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
MLAQYSEAKHFSANRIELCVAEMHKHLLEKSYQDKLKFQLESHFGKPVEVIFSLGSITGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
TPAILQDRDKLAKQSQAVEAIKSDPYVQELIEQFDAKLNIYSIKPIN
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]