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The map label for this gene is fabF [H]

Identifier: 114330486

GI number: 114330486

Start: 481943

End: 483184

Strand: Reverse

Name: fabF [H]

Synonym: Neut_0466

Alternate gene names: 114330486

Gene position: 483184-481943 (Counterclockwise)

Preceding gene: 114330487

Following gene: 114330485

Centisome position: 18.16

GC content: 49.36

Gene sequence:

>1242_bases
TTGTCCAAGCGTAAAATAGCCATTACCGGGTTAGGCATTGTCTCACCTATCGGCAATACGGTTCCCGAAGCATGGGGAAA
CGTAATTGCCGGGAAATCCGGTATTACACAAATCACACATTTTGATACATCAGATTTTTCCTCAAAAATTGCTGGGGAGG
TCAAAGAATTCGAGATAACAGAGTATCTCTCTGCCAAGGAAGCACGCCGTATGGATATTTTTATCCAGTACGGGATGGCA
GCGGCTATTCAAGCTGTCAAGGATGCCGGAATCAGTGATGTAACTCGATTCGATGCTGAGCGTATCGGTGTTAATATCGG
CTCCGGAATCGGTGGCCTGCCCATGATTGAAAATACCAACGCAGCCTATCATGCGGGTGGCCCCCGAAAAATCTCTCCCT
TCTTTATCCCCAGCACCATTATCAACATGGTGGCCGGTAATTTATCCATCATGTTTGGGTATAAAGGGCCCAATCTTGCC
ATTGTTACTGCCTGCACCACCGCTACACACTGCATTGGCAGCTCTGCCAGAATGATTGAGCACGGTGACGCGGATATTAT
GATCTGTGGTGGTGCAGAATCATGCATAACTCCGCTGGCTGTTGGGGGATTTGCCTCCGCCCGCGCCCTGTCATCAAACA
ATGACGATCCGGCGACAGCAAGCCGGCCATGGGATCTCAAAAGAGACGGATTTGTCTTGGGAGAAGGTGCAGGCATCCTG
GTTCTGGAAGAGATGGAACACGCCAAAAAACGTGGCGCAAAGATTTATGCGGAGCTGGCCGGATTCGGCATGAGTGCGGA
TGCTTATCATATGACAGCCCCCTGTGAAGATGGTGAAGGTGCCGCTCGCTGCATGAAGAACGCATTATCTGACGCGCAGT
TGAATCTGGAAGATATCCACTATATCAATGCACACGGAACATCAACGCCTTTGGGCGACATTGCAGAAACAGTTGCAGTC
AAACGTTGCTTTGGAGCACACGCCGGAAGCCTGGCAATCAGTTCCACTAAATCGATGACCGGGCATTTGCTGGGTGCGGC
AGGAGGTGTGGAAGCAATTTTCTCTACTCTGGCCATTTTCCATCAGATTGCTCCACCCACCATTAATCTTGATGAGCCTG
ATCCCGAATGTGATCTGGATTATGTACCCAACACTGCCAGAGAAATGAAAATTGACACCGCGCTGTCAAACTCATTCGGA
TTTGGTGGAACTAACGGTACATTAGTCTTTCGAAAAACCTGA

Upstream 100 bases:

>100_bases
CAAGCCGAAAAAATCAATACAGTTCAAGAGGCTATTGATTTCGTAGCTGCTAATACAACTCAGTAAGAATAATTTTTTTC
AATGATTCAGCGGAGTCGTT

Downstream 100 bases:

>100_bases
ATATCATTTCCCGTGTTTCTGGGATGTGGTATTTGGGAATAATCGAAATACATATGAGAATAACTGATTATGCTTTCCGG
GGAAATATCTGGCATGATCA

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSKRKIAITGLGIVSPIGNTVPEAWGNVIAGKSGITQITHFDTSDFSSKIAGEVKEFEITEYLSAKEARRMDIFIQYGMA
AAIQAVKDAGISDVTRFDAERIGVNIGSGIGGLPMIENTNAAYHAGGPRKISPFFIPSTIINMVAGNLSIMFGYKGPNLA
IVTACTTATHCIGSSARMIEHGDADIMICGGAESCITPLAVGGFASARALSSNNDDPATASRPWDLKRDGFVLGEGAGIL
VLEEMEHAKKRGAKIYAELAGFGMSADAYHMTAPCEDGEGAARCMKNALSDAQLNLEDIHYINAHGTSTPLGDIAETVAV
KRCFGAHAGSLAISSTKSMTGHLLGAAGGVEAIFSTLAIFHQIAPPTINLDEPDPECDLDYVPNTAREMKIDTALSNSFG
FGGTNGTLVFRKT

Sequences:

>Translated_413_residues
MSKRKIAITGLGIVSPIGNTVPEAWGNVIAGKSGITQITHFDTSDFSSKIAGEVKEFEITEYLSAKEARRMDIFIQYGMA
AAIQAVKDAGISDVTRFDAERIGVNIGSGIGGLPMIENTNAAYHAGGPRKISPFFIPSTIINMVAGNLSIMFGYKGPNLA
IVTACTTATHCIGSSARMIEHGDADIMICGGAESCITPLAVGGFASARALSSNNDDPATASRPWDLKRDGFVLGEGAGIL
VLEEMEHAKKRGAKIYAELAGFGMSADAYHMTAPCEDGEGAARCMKNALSDAQLNLEDIHYINAHGTSTPLGDIAETVAV
KRCFGAHAGSLAISSTKSMTGHLLGAAGGVEAIFSTLAIFHQIAPPTINLDEPDPECDLDYVPNTAREMKIDTALSNSFG
FGGTNGTLVFRKT
>Mature_412_residues
SKRKIAITGLGIVSPIGNTVPEAWGNVIAGKSGITQITHFDTSDFSSKIAGEVKEFEITEYLSAKEARRMDIFIQYGMAA
AIQAVKDAGISDVTRFDAERIGVNIGSGIGGLPMIENTNAAYHAGGPRKISPFFIPSTIINMVAGNLSIMFGYKGPNLAI
VTACTTATHCIGSSARMIEHGDADIMICGGAESCITPLAVGGFASARALSSNNDDPATASRPWDLKRDGFVLGEGAGILV
LEEMEHAKKRGAKIYAELAGFGMSADAYHMTAPCEDGEGAARCMKNALSDAQLNLEDIHYINAHGTSTPLGDIAETVAVK
RCFGAHAGSLAISSTKSMTGHLLGAAGGVEAIFSTLAIFHQIAPPTINLDEPDPECDLDYVPNTAREMKIDTALSNSFGF
GGTNGTLVFRKT

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=414, Percent_Identity=49.0338164251208, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=61.3793103448276, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI41872631, Length=431, Percent_Identity=24.3619489559165, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=61.501210653753, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=41.6464891041162, Blast_Score=272, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=35.9036144578313, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=41.1764705882353, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI212642053, Length=363, Percent_Identity=25.8953168044077, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=25.3623188405797, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=37.8923766816144, Blast_Score=283, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=412, Percent_Identity=40.7766990291262, Blast_Score=330, Evalue=7e-91,
Organism=Drosophila melanogaster, GI221330659, Length=407, Percent_Identity=23.3415233415233, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19920632, Length=407, Percent_Identity=23.3415233415233, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581345, Length=361, Percent_Identity=24.6537396121884, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43314; Mature: 43182

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRKIAITGLGIVSPIGNTVPEAWGNVIAGKSGITQITHFDTSDFSSKIAGEVKEFEIT
CCCCEEEEEECCHHHHCCCHHHHHHHCEECCCCCCCEEEECCCHHHHHHHHCCHHHHHHH
EYLSAKEARRMDIFIQYGMAAAIQAVKDAGISDVTRFDAERIGVNIGSGIGGLPMIENTN
HHHHHHHHHHEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCCCEEECCC
AAYHAGGPRKISPFFIPSTIINMVAGNLSIMFGYKGPNLAIVTACTTATHCIGSSARMIE
CEEECCCCCCCCCEECHHHHHHHHCCCEEEEEEECCCCEEEEEEEHHHHHHHCCCCCEEE
HGDADIMICGGAESCITPLAVGGFASARALSSNNDDPATASRPWDLKRDGFVLGEGAGIL
CCCCCEEEECCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLEEMEHAKKRGAKIYAELAGFGMSADAYHMTAPCEDGEGAARCMKNALSDAQLNLEDIH
EEHHHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHEE
YINAHGTSTPLGDIAETVAVKRCFGAHAGSLAISSTKSMTGHLLGAAGGVEAIFSTLAIF
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHEECCCCHHHHHHHHHHH
HQIAPPTINLDEPDPECDLDYVPNTAREMKIDTALSNSFGFGGTNGTLVFRKT
HHCCCCCCCCCCCCCCCCCCCCCCCHHHEEEHHHHCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SKRKIAITGLGIVSPIGNTVPEAWGNVIAGKSGITQITHFDTSDFSSKIAGEVKEFEIT
CCCEEEEEECCHHHHCCCHHHHHHHCEECCCCCCCEEEECCCHHHHHHHHCCHHHHHHH
EYLSAKEARRMDIFIQYGMAAAIQAVKDAGISDVTRFDAERIGVNIGSGIGGLPMIENTN
HHHHHHHHHHEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCCCEEECCC
AAYHAGGPRKISPFFIPSTIINMVAGNLSIMFGYKGPNLAIVTACTTATHCIGSSARMIE
CEEECCCCCCCCCEECHHHHHHHHCCCEEEEEEECCCCEEEEEEEHHHHHHHCCCCCEEE
HGDADIMICGGAESCITPLAVGGFASARALSSNNDDPATASRPWDLKRDGFVLGEGAGIL
CCCCCEEEECCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLEEMEHAKKRGAKIYAELAGFGMSADAYHMTAPCEDGEGAARCMKNALSDAQLNLEDIH
EEHHHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCHHHEE
YINAHGTSTPLGDIAETVAVKRCFGAHAGSLAISSTKSMTGHLLGAAGGVEAIFSTLAIF
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHEECCCCHHHHHHHHHHH
HQIAPPTINLDEPDPECDLDYVPNTAREMKIDTALSNSFGFGGTNGTLVFRKT
HHCCCCCCCCCCCCCCCCCCCCCCCHHHEEEHHHHCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]