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The map label for this gene is bioF [H]

Identifier: 114330481

GI number: 114330481

Start: 475071

End: 476258

Strand: Direct

Name: bioF [H]

Synonym: Neut_0461

Alternate gene names: 114330481

Gene position: 475071-476258 (Clockwise)

Preceding gene: 114330480

Following gene: 114330482

Centisome position: 17.85

GC content: 48.06

Gene sequence:

>1188_bases
ATGAATCTGCTGGAAAAACTTGATGCAGCTGCAGCAGCAAGGAAAGCACAATTACCCGAGGGGCTCGCTGCTTTTGGTAT
CCCCATAGATGAATCCTACTCTGCGACGGAAGCCAGAATCGGGGAGCGTCGAGTATTAATGCTGGGTACGAACAACTATC
TTGGGCTCAGCTTTTCTTCTGAATGCAGAGAGGCTGCTCATAAGGCTATTGATCGGGAAGGTACTGGTACCACCGGTTCA
CGTATGGCCAATGGTAATTATTACGGGCATCGGGCGCTGGAACGCGAGTTGGCAGAGTTTTATCACTGCCGCGAATGTAT
TGTTTTTACAACAGGCTATCAAGCTAATCTGGGAACTATTTCTGGGTTGGCGGGGGTTGGTGATGTTGTGCTGATTGATG
GGGATGCACATGCCAGTATCTATGATGGATGTATTCTAAGTGGAGCGGATGTTATCCGTTTTCGCCATAATGATGTAGTC
GATCTTGAGAAACGCCTTCGCAGGCTGGGTGATCGCAGCCGTAATACACTGATCGTTATTGAGGGTATTTACAGCATGCT
GGGTGATCAGGCTCCTCTGGCTGAGATCGTGAAATTGAAAAATGTCTACCAGAGCACTCTGCTACTTGATGAGGCGCATT
CACTCGGTGTTCTTGGAGAAACCGGGCAGGGGTTGGTAGAAAAAGCCAGGATGATTGACGAAGTTGATTTTATAACTGGA
ACTTTTAGTAAAAGTCTGTGTGGTATCGGCGGCTTTTGCGTCAGTAATCATCCCCAGCTTAATCAGCTTCGGTATATAAG
CCATCCGTACATATTTACAGCTTCCCCTTCCCCAGCAACAATTGCTTCCACACGTGCTGCTTTGAAGTTGTTGCGTGATG
GGTATTCATTACGTGAACAGCTATGGAGGAATGCTCACCAGCTTTATTCCTGCCTTAAAGAAACTGGGTATTGTCTGGGC
CCAGAGCCCGGACCTATAGTAGCCGTTTTACTTGACAGCCCTAAACAGGCGCTGACCCTGTGGAACGGATTGATGGCGCA
CGATATCTATGTAAATTTGGTGTTGCCTCCTGCTGCTCCGGAAGGAAAATCATTGGTACGTTGCAGCATTAATGCGGCGC
ATACTGCTGAACAAATTGGCCGGGTTTGTGAGACCTTCTCTAAACTGTATCCAGCTGTGACGCAGTGA

Upstream 100 bases:

>100_bases
AAGATCAGTTCGATATCTCAGTTCCGTTGAATGCACTTGTGGATGTCCTGACGGTTCAGGATCTTGCCAATCTGATTTAT
AAAATTAAATCATCATCATA

Downstream 100 bases:

>100_bases
GTGGATGCGATTACTAAATTTAGATCCTGTAATGACAAGAATTCTTGGTTAATGATTGATAGGATTGTACCGGACTGGCC
TTCTCCCGCAAATGTTCGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNLLEKLDAAAAARKAQLPEGLAAFGIPIDESYSATEARIGERRVLMLGTNNYLGLSFSSECREAAHKAIDREGTGTTGS
RMANGNYYGHRALERELAEFYHCRECIVFTTGYQANLGTISGLAGVGDVVLIDGDAHASIYDGCILSGADVIRFRHNDVV
DLEKRLRRLGDRSRNTLIVIEGIYSMLGDQAPLAEIVKLKNVYQSTLLLDEAHSLGVLGETGQGLVEKARMIDEVDFITG
TFSKSLCGIGGFCVSNHPQLNQLRYISHPYIFTASPSPATIASTRAALKLLRDGYSLREQLWRNAHQLYSCLKETGYCLG
PEPGPIVAVLLDSPKQALTLWNGLMAHDIYVNLVLPPAAPEGKSLVRCSINAAHTAEQIGRVCETFSKLYPAVTQ

Sequences:

>Translated_395_residues
MNLLEKLDAAAAARKAQLPEGLAAFGIPIDESYSATEARIGERRVLMLGTNNYLGLSFSSECREAAHKAIDREGTGTTGS
RMANGNYYGHRALERELAEFYHCRECIVFTTGYQANLGTISGLAGVGDVVLIDGDAHASIYDGCILSGADVIRFRHNDVV
DLEKRLRRLGDRSRNTLIVIEGIYSMLGDQAPLAEIVKLKNVYQSTLLLDEAHSLGVLGETGQGLVEKARMIDEVDFITG
TFSKSLCGIGGFCVSNHPQLNQLRYISHPYIFTASPSPATIASTRAALKLLRDGYSLREQLWRNAHQLYSCLKETGYCLG
PEPGPIVAVLLDSPKQALTLWNGLMAHDIYVNLVLPPAAPEGKSLVRCSINAAHTAEQIGRVCETFSKLYPAVTQ
>Mature_395_residues
MNLLEKLDAAAAARKAQLPEGLAAFGIPIDESYSATEARIGERRVLMLGTNNYLGLSFSSECREAAHKAIDREGTGTTGS
RMANGNYYGHRALERELAEFYHCRECIVFTTGYQANLGTISGLAGVGDVVLIDGDAHASIYDGCILSGADVIRFRHNDVV
DLEKRLRRLGDRSRNTLIVIEGIYSMLGDQAPLAEIVKLKNVYQSTLLLDEAHSLGVLGETGQGLVEKARMIDEVDFITG
TFSKSLCGIGGFCVSNHPQLNQLRYISHPYIFTASPSPATIASTRAALKLLRDGYSLREQLWRNAHQLYSCLKETGYCLG
PEPGPIVAVLLDSPKQALTLWNGLMAHDIYVNLVLPPAAPEGKSLVRCSINAAHTAEQIGRVCETFSKLYPAVTQ

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=346, Percent_Identity=32.9479768786127, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=32.9479768786127, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4758668, Length=350, Percent_Identity=34.8571428571429, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=31.5934065934066, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI83977444, Length=371, Percent_Identity=28.0323450134771, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI83977442, Length=371, Percent_Identity=28.0323450134771, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI83977440, Length=371, Percent_Identity=28.0323450134771, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4502025, Length=365, Percent_Identity=27.9452054794521, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI40316939, Length=365, Percent_Identity=27.9452054794521, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI5454084, Length=374, Percent_Identity=28.8770053475936, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1790046, Length=347, Percent_Identity=33.4293948126801, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=29.1066282420749, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71994529, Length=351, Percent_Identity=34.7578347578348, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=379, Percent_Identity=31.3984168865435, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=32.8729281767956, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=32.8729281767956, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71982617, Length=265, Percent_Identity=27.9245283018868, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=262, Percent_Identity=28.2442748091603, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320438, Length=377, Percent_Identity=29.4429708222812, Blast_Score=143, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=351, Percent_Identity=30.1994301994302, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=299, Percent_Identity=29.7658862876254, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24662918, Length=346, Percent_Identity=32.0809248554913, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17137420, Length=357, Percent_Identity=28.5714285714286, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI17136286, Length=366, Percent_Identity=30.6010928961749, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24653280, Length=320, Percent_Identity=30.9375, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653276, Length=320, Percent_Identity=30.9375, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653278, Length=320, Percent_Identity=30.9375, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42990; Mature: 42990

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLEKLDAAAAARKAQLPEGLAAFGIPIDESYSATEARIGERRVLMLGTNNYLGLSFSS
CCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCEEECCCCH
ECREAAHKAIDREGTGTTGSRMANGNYYGHRALERELAEFYHCRECIVFTTGYQANLGTI
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHH
SGLAGVGDVVLIDGDAHASIYDGCILSGADVIRFRHNDVVDLEKRLRRLGDRSRNTLIVI
HHHCCCCCEEEECCCCCCHHHCCEEECCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEE
EGIYSMLGDQAPLAEIVKLKNVYQSTLLLDEAHSLGVLGETGQGLVEKARMIDEVDFITG
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
TFSKSLCGIGGFCVSNHPQLNQLRYISHPYIFTASPSPATIASTRAALKLLRDGYSLREQ
HHHHHHHCCCCEECCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHH
LWRNAHQLYSCLKETGYCLGPEPGPIVAVLLDSPKQALTLWNGLMAHDIYVNLVLPPAAP
HHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCHHHHHHHHHHHEEEEEEEEEECCCCC
EGKSLVRCSINAAHTAEQIGRVCETFSKLYPAVTQ
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNLLEKLDAAAAARKAQLPEGLAAFGIPIDESYSATEARIGERRVLMLGTNNYLGLSFSS
CCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHCCCCEEEEEECCCEEECCCCH
ECREAAHKAIDREGTGTTGSRMANGNYYGHRALERELAEFYHCRECIVFTTGYQANLGTI
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHH
SGLAGVGDVVLIDGDAHASIYDGCILSGADVIRFRHNDVVDLEKRLRRLGDRSRNTLIVI
HHHCCCCCEEEECCCCCCHHHCCEEECCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEE
EGIYSMLGDQAPLAEIVKLKNVYQSTLLLDEAHSLGVLGETGQGLVEKARMIDEVDFITG
EHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
TFSKSLCGIGGFCVSNHPQLNQLRYISHPYIFTASPSPATIASTRAALKLLRDGYSLREQ
HHHHHHHCCCCEECCCCCCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHH
LWRNAHQLYSCLKETGYCLGPEPGPIVAVLLDSPKQALTLWNGLMAHDIYVNLVLPPAAP
HHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCHHHHHHHHHHHEEEEEEEEEECCCCC
EGKSLVRCSINAAHTAEQIGRVCETFSKLYPAVTQ
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]