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The map label for this gene is pgl [H]

Identifier: 114330450

GI number: 114330450

Start: 445124

End: 445810

Strand: Reverse

Name: pgl [H]

Synonym: Neut_0430

Alternate gene names: 114330450

Gene position: 445810-445124 (Counterclockwise)

Preceding gene: 114330451

Following gene: 114330449

Centisome position: 16.75

GC content: 50.66

Gene sequence:

>687_bases
ATGGCCACTAACCACTTGATCGAACGTCACGTTTTCAATGATCTTCCCTCGTTATCTGAAGCATTGGCAGAATCAGTTGC
CGTCACATTACGTAATGCAATCACACAGCACGGCCAAGCCAGTCTGGTGGTACCTGGTGGAAGAACACCCACTGTTTACC
TTCCTCGGCTGGCACAAATAAACCTCCCCTGGCAACACGTCTTTGTAACGCTAAGCGATGAACGCTGGGTAGAACCAACC
AGCGAGCAATCCAACGAACGGCTAGTGCGTGAGCATTTCCTGCAACACATGCAGCAACAGCCTCATTTTATCTCCCTCAA
AACCAAACACGCTCACCCTGATGAGGCAATTGCTGACCTCGATATGCGCCTGGCCGGGTTACCCTTGCCATTCAGTCTGA
TCATCCTTGGCCTGGGGGCAGACGGCCATATTGCCTCTCTGTTTCCTGGCATGACGCTAGATATGAATTCAGCTAATCTG
TGCCAGGCTGCTACACCTCCTGCTGCACCTTCCCCGCGTATCAGCCTGAGCTTGCAGGCACTTATCAACAGTAGCCGCAT
CATACTGGTCATTACAGGGAAAGAAAAAAGACAACTGGTTGATCAGCTCATTGCATCCCCTGATCCAGCCATACCGTTTG
TACAGCTAATGCAATCCAGACCGGTAGAATTGTTCGAAACGGATTAG

Upstream 100 bases:

>100_bases
ATTATGAAAGTGCCCAGCAGAACGGCGTTATATTTCTTGGTCGCGTCCGCCCAGGCGATGACAATCCTTTTCCTAAATCA
GTTGAAATTATTCCTGACCT

Downstream 100 bases:

>100_bases
TTAGACACCGAATTTCATCATGCGCGAAATTTGGCTTACAGTCGTATTGCTCTCTATCAGCAACGTCTTCATGACATTTG
CCTGGTATGCGCATCTAAAG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MATNHLIERHVFNDLPSLSEALAESVAVTLRNAITQHGQASLVVPGGRTPTVYLPRLAQINLPWQHVFVTLSDERWVEPT
SEQSNERLVREHFLQHMQQQPHFISLKTKHAHPDEAIADLDMRLAGLPLPFSLIILGLGADGHIASLFPGMTLDMNSANL
CQAATPPAAPSPRISLSLQALINSSRIILVITGKEKRQLVDQLIASPDPAIPFVQLMQSRPVELFETD

Sequences:

>Translated_228_residues
MATNHLIERHVFNDLPSLSEALAESVAVTLRNAITQHGQASLVVPGGRTPTVYLPRLAQINLPWQHVFVTLSDERWVEPT
SEQSNERLVREHFLQHMQQQPHFISLKTKHAHPDEAIADLDMRLAGLPLPFSLIILGLGADGHIASLFPGMTLDMNSANL
CQAATPPAAPSPRISLSLQALINSSRIILVITGKEKRQLVDQLIASPDPAIPFVQLMQSRPVELFETD
>Mature_227_residues
ATNHLIERHVFNDLPSLSEALAESVAVTLRNAITQHGQASLVVPGGRTPTVYLPRLAQINLPWQHVFVTLSDERWVEPTS
EQSNERLVREHFLQHMQQQPHFISLKTKHAHPDEAIADLDMRLAGLPLPFSLIILGLGADGHIASLFPGMTLDMNSANLC
QAATPPAAPSPRISLSLQALINSSRIILVITGKEKRQLVDQLIASPDPAIPFVQLMQSRPVELFETD

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=194, Percent_Identity=29.8969072164948, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533058, Length=196, Percent_Identity=29.0816326530612, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533060, Length=196, Percent_Identity=29.0816326530612, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641119, Length=209, Percent_Identity=27.7511961722488, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900 [H]

Pfam domain/function: NA

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25140; Mature: 25009

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNHLIERHVFNDLPSLSEALAESVAVTLRNAITQHGQASLVVPGGRTPTVYLPRLAQI
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCEEEE
NLPWQHVFVTLSDERWVEPTSEQSNERLVREHFLQHMQQQPHFISLKTKHAHPDEAIADL
CCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
DMRLAGLPLPFSLIILGLGADGHIASLFPGMTLDMNSANLCQAATPPAAPSPRISLSLQA
HHHHCCCCCCHHHEEEECCCCCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEHHH
LINSSRIILVITGKEKRQLVDQLIASPDPAIPFVQLMQSRPVELFETD
HHCCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEECC
>Mature Secondary Structure 
ATNHLIERHVFNDLPSLSEALAESVAVTLRNAITQHGQASLVVPGGRTPTVYLPRLAQI
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCEEEE
NLPWQHVFVTLSDERWVEPTSEQSNERLVREHFLQHMQQQPHFISLKTKHAHPDEAIADL
CCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
DMRLAGLPLPFSLIILGLGADGHIASLFPGMTLDMNSANLCQAATPPAAPSPRISLSLQA
HHHHCCCCCCHHHEEEECCCCCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEHHH
LINSSRIILVITGKEKRQLVDQLIASPDPAIPFVQLMQSRPVELFETD
HHCCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]