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The map label for this gene is msrA [H]

Identifier: 114330440

GI number: 114330440

Start: 431819

End: 433078

Strand: Reverse

Name: msrA [H]

Synonym: Neut_0419

Alternate gene names: 114330440

Gene position: 433078-431819 (Counterclockwise)

Preceding gene: 114330443

Following gene: 114330439

Centisome position: 16.27

GC content: 49.6

Gene sequence:

>1260_bases
GTGACACCCAGCTCTGTAAACTCAAATCAAACTACTGATTCAAAATCAAATTATATTGTTCTGGGCATGGGTTGTTTCTG
GGGTGCCGAGAAGCGCATGGGAGAGCTGCCCGGGGTGGTTGATGTGGAAAGCGGCTATGCAGGTGGTGACCACGCCGGTG
TAGGTTATGAGGATATTCTGAATTTTGAACGCGCGTTGCGTATCGGCAGAGCTGCCGGACGCAATCATGCCGAAGTAGTT
AAAGTGACGTTTGCTCCTGAACAAGTATCATTGGAAAGCGTGCTGGCAAAATTCTGGGAAAGTCATAATCCCACTCAGGG
TGATCGCCAAGGGAATGACATCGGCAGTAATTATCGTAGCGCTATCTACTATCACGATGAGGATCAAAAAACCCTCGCGC
TGGCCACACGTGATACCTACCAGCAAGCGCTGACAGCAGCTGGATATGGCCAGATTACGACTGAAATCCTGCCTCTCAAA
AACTACATCACCGCGGAAGAATACCATCAAAATTATTTGAAGAAAAATCCGGATGGCTACTGTGGCTTGGGCGGCATAGG
TGTGAAATACCCTGCTGCAGATCATACAAAAGATACAACCACAACTTCAGCCGCCCCTTCCGTACAGCCGCTTGACAGCA
AGGATTTAAACTTTGATCGGCAACTGGTGGTGTTTGAATCAGAAAACTGCGAATTTTGCGTACAATTCAAACAGGATATC
CTCGACCACTGGCAGGCAGACGTTCCCATGATCGTGACAATGAATGCCAACCCGCCTACCGATTGGGTACTGGACAAACC
CTTATTTGCGTCTCCCACAATGGTGTTGTTCAGCAAAGGCAAGGAGGTGGCGCGTTATACTGGTTACAACGGAGAAAAGG
AAAAATTCTGGCAATGGCTCGGGTTTCAATTATTGACACCGGAACAACAGAAAATTGCTTTCGAGCAGGGGACCGAGCGC
GCTTTCACCGGCTCCAATCTGGACGAGAAACGTCCGGGCAGGTTTGTTGACCCGATCACTGGTGTCACGCTGTTTCGTAG
CCAGACCAAATTTAACAGCGGAACCGGCTGGCCCAGTTTCTTTGAACCGGCTGAAGGATCTGTCACCTATCACAAAGACA
ACTCCGGCTATATGCAGCGGATTGAAGTGCGCAGTGCCAGCTCTGGCATTCATCTCGGCCATGTATTCAATGACGGCCCT
CCCCCCAGTCATAAACGCTACTGCATCAACGGCAATGTCCTGAAGTTTGTGCCGGATTAA

Upstream 100 bases:

>100_bases
ATATATTTGTTAAAGCACACTAAAAATGAAAACAATTATTGCTGCATTAATTATCTTGATAATAACAATGGTTATAACTG
TCTTTGCAATGGAGAAAATC

Downstream 100 bases:

>100_bases
TCTGCGTAACTTGAAATCAGAAGGCTGAAGTGGGTTAATACCTGTTTAGAACTATTTTTCTCATGGCTGATCATGTCTAC
CACCACTGTTACCTACCTTG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTPSSVNSNQTTDSKSNYIVLGMGCFWGAEKRMGELPGVVDVESGYAGGDHAGVGYEDILNFERALRIGRAAGRNHAEVV
KVTFAPEQVSLESVLAKFWESHNPTQGDRQGNDIGSNYRSAIYYHDEDQKTLALATRDTYQQALTAAGYGQITTEILPLK
NYITAEEYHQNYLKKNPDGYCGLGGIGVKYPAADHTKDTTTTSAAPSVQPLDSKDLNFDRQLVVFESENCEFCVQFKQDI
LDHWQADVPMIVTMNANPPTDWVLDKPLFASPTMVLFSKGKEVARYTGYNGEKEKFWQWLGFQLLTPEQQKIAFEQGTER
AFTGSNLDEKRPGRFVDPITGVTLFRSQTKFNSGTGWPSFFEPAEGSVTYHKDNSGYMQRIEVRSASSGIHLGHVFNDGP
PPSHKRYCINGNVLKFVPD

Sequences:

>Translated_419_residues
MTPSSVNSNQTTDSKSNYIVLGMGCFWGAEKRMGELPGVVDVESGYAGGDHAGVGYEDILNFERALRIGRAAGRNHAEVV
KVTFAPEQVSLESVLAKFWESHNPTQGDRQGNDIGSNYRSAIYYHDEDQKTLALATRDTYQQALTAAGYGQITTEILPLK
NYITAEEYHQNYLKKNPDGYCGLGGIGVKYPAADHTKDTTTTSAAPSVQPLDSKDLNFDRQLVVFESENCEFCVQFKQDI
LDHWQADVPMIVTMNANPPTDWVLDKPLFASPTMVLFSKGKEVARYTGYNGEKEKFWQWLGFQLLTPEQQKIAFEQGTER
AFTGSNLDEKRPGRFVDPITGVTLFRSQTKFNSGTGWPSFFEPAEGSVTYHKDNSGYMQRIEVRSASSGIHLGHVFNDGP
PPSHKRYCINGNVLKFVPD
>Mature_418_residues
TPSSVNSNQTTDSKSNYIVLGMGCFWGAEKRMGELPGVVDVESGYAGGDHAGVGYEDILNFERALRIGRAAGRNHAEVVK
VTFAPEQVSLESVLAKFWESHNPTQGDRQGNDIGSNYRSAIYYHDEDQKTLALATRDTYQQALTAAGYGQITTEILPLKN
YITAEEYHQNYLKKNPDGYCGLGGIGVKYPAADHTKDTTTTSAAPSVQPLDSKDLNFDRQLVVFESENCEFCVQFKQDIL
DHWQADVPMIVTMNANPPTDWVLDKPLFASPTMVLFSKGKEVARYTGYNGEKEKFWQWLGFQLLTPEQQKIAFEQGTERA
FTGSNLDEKRPGRFVDPITGVTLFRSQTKFNSGTGWPSFFEPAEGSVTYHKDNSGYMQRIEVRSASSGIHLGHVFNDGPP
PSHKRYCINGNVLKFVPD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=191, Percent_Identity=44.5026178010471, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI208609995, Length=191, Percent_Identity=44.5026178010471, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI208609993, Length=117, Percent_Identity=53.8461538461538, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI301336164, Length=115, Percent_Identity=46.0869565217391, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI301336162, Length=115, Percent_Identity=46.0869565217391, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI73089054, Length=115, Percent_Identity=46.0869565217391, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=44.3548387096774, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI117606353, Length=131, Percent_Identity=40.4580152671756, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1790665, Length=159, Percent_Identity=40.251572327044, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788077, Length=114, Percent_Identity=49.1228070175439, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI115532676, Length=116, Percent_Identity=41.3793103448276, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17553450, Length=116, Percent_Identity=41.3793103448276, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17533973, Length=152, Percent_Identity=32.2368421052632, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=170, Percent_Identity=34.7058823529412, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319816, Length=122, Percent_Identity=36.0655737704918, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221378664, Length=117, Percent_Identity=44.4444444444444, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI221378662, Length=122, Percent_Identity=42.6229508196721, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45553335, Length=115, Percent_Identity=45.2173913043478, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356369, Length=115, Percent_Identity=45.2173913043478, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645799, Length=117, Percent_Identity=44.4444444444444, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24645804, Length=126, Percent_Identity=42.0634920634921, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645801, Length=126, Percent_Identity=42.0634920634921, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664627, Length=152, Percent_Identity=35.5263157894737, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45553131, Length=150, Percent_Identity=35.3333333333333, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664631, Length=152, Percent_Identity=34.8684210526316, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 46647; Mature: 46516

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSSVNSNQTTDSKSNYIVLGMGCFWGAEKRMGELPGVVDVESGYAGGDHAGVGYEDIL
CCCCCCCCCCCCCCCCCEEEEECCHHCCCHHHHHCCCCEEEECCCCCCCCCCCCCHHHHH
NFERALRIGRAAGRNHAEVVKVTFAPEQVSLESVLAKFWESHNPTQGDRQGNDIGSNYRS
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
AIYYHDEDQKTLALATRDTYQQALTAAGYGQITTEILPLKNYITAEEYHQNYLKKNPDGY
EEEEECCCCCEEEEEEHHHHHHHHHHCCCCCHHHEEECHHHHCCHHHHHHHHHHCCCCCC
CGLGGIGVKYPAADHTKDTTTTSAAPSVQPLDSKDLNFDRQLVVFESENCEFCVQFKQDI
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
LDHWQADVPMIVTMNANPPTDWVLDKPLFASPTMVLFSKGKEVARYTGYNGEKEKFWQWL
HHHHCCCCCEEEEECCCCCCCCEECCCCCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHH
GFQLLTPEQQKIAFEQGTERAFTGSNLDEKRPGRFVDPITGVTLFRSQTKFNSGTGWPSF
CEEEECCHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
FEPAEGSVTYHKDNSGYMQRIEVRSASSGIHLGHVFNDGPPPSHKRYCINGNVLKFVPD
CCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCEEEECCCEEEECCC
>Mature Secondary Structure 
TPSSVNSNQTTDSKSNYIVLGMGCFWGAEKRMGELPGVVDVESGYAGGDHAGVGYEDIL
CCCCCCCCCCCCCCCCEEEEECCHHCCCHHHHHCCCCEEEECCCCCCCCCCCCCHHHHH
NFERALRIGRAAGRNHAEVVKVTFAPEQVSLESVLAKFWESHNPTQGDRQGNDIGSNYRS
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
AIYYHDEDQKTLALATRDTYQQALTAAGYGQITTEILPLKNYITAEEYHQNYLKKNPDGY
EEEEECCCCCEEEEEEHHHHHHHHHHCCCCCHHHEEECHHHHCCHHHHHHHHHHCCCCCC
CGLGGIGVKYPAADHTKDTTTTSAAPSVQPLDSKDLNFDRQLVVFESENCEFCVQFKQDI
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
LDHWQADVPMIVTMNANPPTDWVLDKPLFASPTMVLFSKGKEVARYTGYNGEKEKFWQWL
HHHHCCCCCEEEEECCCCCCCCEECCCCCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHH
GFQLLTPEQQKIAFEQGTERAFTGSNLDEKRPGRFVDPITGVTLFRSQTKFNSGTGWPSF
CEEEECCHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
FEPAEGSVTYHKDNSGYMQRIEVRSASSGIHLGHVFNDGPPPSHKRYCINGNVLKFVPD
CCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA