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The map label for this gene is murC

Identifier: 114330272

GI number: 114330272

Start: 257608

End: 259029

Strand: Reverse

Name: murC

Synonym: Neut_0245

Alternate gene names: 114330272

Gene position: 259029-257608 (Counterclockwise)

Preceding gene: 114330273

Following gene: 114330271

Centisome position: 9.73

GC content: 49.44

Gene sequence:

>1422_bases
ATGAAACATAAAATCAAGCATATTCATTTTGTAGGGATTGGTGGTTCGGGAATGGGCGGGATTGCTGAGGTGCTGATCAA
TCAAGGCTTCCAGATCAGCGGCTCGGATCTGAATGGCAATTCGACCACCAAACGTCTGCAATGCCTGGGTGCTGTCATTC
ATCATACCCACGCGGCTGAAAACATCCAATCTGCAGATGCCGTCGTCATTTCAACAGCTATCCAGCCTGATAACCCGGAA
GTTATTGCAGCACGTGAACGCCGTATACCCGTGGTACCTCGGGCCATGATGCTAGCTGAGTTGTTACGTCTGCACCAGGG
TATTGCAATCGCAGGCACTCACGGTAAAACCACTACCACAAGCCTGGTTGCCAGTATTCTGGCGGAAGCAGGCCAAGATC
CAACGTTTGTAATAGGCGGCAGACTTAAAACAGTCGATAGCCACGCCAGGCTGGGCAAAGGAGAATTCATTGTAGTTGAG
GCGGATGAATCCGATGCTTCGTTCCTCTATCTGCAACCAGTGTTGACCGTGGTGACCAATATCGATGCAGATCACATGAG
CACGTACGAACATGATTTCAACCGGCTCAAACAGACTTTTGTCGAATTCATCGAACACCTGCCTTTTTATGGCATGGCAG
TACTTTGTGCAGATGATCCGCATGTAAGCGCCATCATACCAATGGTTTCCAAGCAAGTAACCACGTATGGGATTACATCT
GAAAATGCACAAATACGTGCCACCGATATTCGCCACGATCAATGCAAGATGCATTTCTGTGCCCATATTGGTGTCAATGG
CTCGGCACGAACACTAGACATCACATTAAATCTGCCAGGCAAACACAATGTACTCAATGCGCTGGCAGCCATTGCGGTTG
GCAATGAACTGAATATACCGGATGAAGCAATGGTAAAAGCGCTGGCTACCTTCGGCGGAGTCGATAGACGATTTCAGCAG
TATGGTGAAATCCGTTTGCCGGATCGAAGATCTTTTACCCTCATTGATGATTATGGCCATCATCCGGCTGAAATCGCTGC
CACGATGGCAGCTGCCCGCAATGCTTTTCCCGGTCGTCGCCTGGTTTTGGTGTTTCAACCACATCGCTACAGTCGTACAC
GGGATTTATTCGAGGATTTTGTCCGGGTGTTATCCAGTGCGGATGCACTGCTGCTGACAGAAATATATTCAGCCGGGGAA
GAACCAATCATTGCTGCCGACAGCAAATCTCTGGTCCGGGCGATCCGGGTGCAGGGAAAGATTGAGCCTATTTATATTGA
GCACATCAACGAGCTGAAATCCGCCGTTCATACCGTTGTACAGGAGGGTGACGTAGTTCTCATTATGGGGGCCGGATCCA
TTGGAAAAATCGCACCTGGCCTGGCAGAGCCAACGATGAAGCTGACACTGATAACAGGTTGA

Upstream 100 bases:

>100_bases
CACAACTGCAAACAATGGCAATCAATGCACGCATGCTGGCCATGCCTGAAGCTGCACAAAGCGTAGTCACAGTTTGTCAA
CAACTTATTGAGACAGGCCC

Downstream 100 bases:

>100_bases
TTGAAAAACATGCAGACAAAAGCCCGACTGCCAGTCGATATAAATGCTCCGAGCTTGCAGTCTCCTGCACTCGGTATCGA
CACACATCTGCTACGCGGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKHKIKHIHFVGIGGSGMGGIAEVLINQGFQISGSDLNGNSTTKRLQCLGAVIHHTHAAENIQSADAVVISTAIQPDNPE
VIAARERRIPVVPRAMMLAELLRLHQGIAIAGTHGKTTTTSLVASILAEAGQDPTFVIGGRLKTVDSHARLGKGEFIVVE
ADESDASFLYLQPVLTVVTNIDADHMSTYEHDFNRLKQTFVEFIEHLPFYGMAVLCADDPHVSAIIPMVSKQVTTYGITS
ENAQIRATDIRHDQCKMHFCAHIGVNGSARTLDITLNLPGKHNVLNALAAIAVGNELNIPDEAMVKALATFGGVDRRFQQ
YGEIRLPDRRSFTLIDDYGHHPAEIAATMAAARNAFPGRRLVLVFQPHRYSRTRDLFEDFVRVLSSADALLLTEIYSAGE
EPIIAADSKSLVRAIRVQGKIEPIYIEHINELKSAVHTVVQEGDVVLIMGAGSIGKIAPGLAEPTMKLTLITG

Sequences:

>Translated_473_residues
MKHKIKHIHFVGIGGSGMGGIAEVLINQGFQISGSDLNGNSTTKRLQCLGAVIHHTHAAENIQSADAVVISTAIQPDNPE
VIAARERRIPVVPRAMMLAELLRLHQGIAIAGTHGKTTTTSLVASILAEAGQDPTFVIGGRLKTVDSHARLGKGEFIVVE
ADESDASFLYLQPVLTVVTNIDADHMSTYEHDFNRLKQTFVEFIEHLPFYGMAVLCADDPHVSAIIPMVSKQVTTYGITS
ENAQIRATDIRHDQCKMHFCAHIGVNGSARTLDITLNLPGKHNVLNALAAIAVGNELNIPDEAMVKALATFGGVDRRFQQ
YGEIRLPDRRSFTLIDDYGHHPAEIAATMAAARNAFPGRRLVLVFQPHRYSRTRDLFEDFVRVLSSADALLLTEIYSAGE
EPIIAADSKSLVRAIRVQGKIEPIYIEHINELKSAVHTVVQEGDVVLIMGAGSIGKIAPGLAEPTMKLTLITG
>Mature_473_residues
MKHKIKHIHFVGIGGSGMGGIAEVLINQGFQISGSDLNGNSTTKRLQCLGAVIHHTHAAENIQSADAVVISTAIQPDNPE
VIAARERRIPVVPRAMMLAELLRLHQGIAIAGTHGKTTTTSLVASILAEAGQDPTFVIGGRLKTVDSHARLGKGEFIVVE
ADESDASFLYLQPVLTVVTNIDADHMSTYEHDFNRLKQTFVEFIEHLPFYGMAVLCADDPHVSAIIPMVSKQVTTYGITS
ENAQIRATDIRHDQCKMHFCAHIGVNGSARTLDITLNLPGKHNVLNALAAIAVGNELNIPDEAMVKALATFGGVDRRFQQ
YGEIRLPDRRSFTLIDDYGHHPAEIAATMAAARNAFPGRRLVLVFQPHRYSRTRDLFEDFVRVLSSADALLLTEIYSAGE
EPIIAADSKSLVRAIRVQGKIEPIYIEHINELKSAVHTVVQEGDVVLIMGAGSIGKIAPGLAEPTMKLTLITG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=468, Percent_Identity=54.0598290598291, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1790680, Length=473, Percent_Identity=27.4841437632135, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_NITEC (Q0AJE2)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746494.1
- ProteinModelPortal:   Q0AJE2
- SMR:   Q0AJE2
- STRING:   Q0AJE2
- GeneID:   4272261
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0245
- NMPDR:   fig|335283.3.peg.2118
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q0AJE2
- ProtClustDB:   PRK00421
- BioCyc:   NEUT335283:NEUT_0245-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51323; Mature: 51323

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHKIKHIHFVGIGGSGMGGIAEVLINQGFQISGSDLNGNSTTKRLQCLGAVIHHTHAAE
CCCCEEEEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
NIQSADAVVISTAIQPDNPEVIAARERRIPVVPRAMMLAELLRLHQGIAIAGTHGKTTTT
CCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SLVASILAEAGQDPTFVIGGRLKTVDSHARLGKGEFIVVEADESDASFLYLQPVLTVVTN
HHHHHHHHHCCCCCEEEECCEEEEECHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
IDADHMSTYEHDFNRLKQTFVEFIEHLPFYGMAVLCADDPHVSAIIPMVSKQVTTYGITS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEC
ENAQIRATDIRHDQCKMHFCAHIGVNGSARTLDITLNLPGKHNVLNALAAIAVGNELNIP
CCCEEEEECCCCHHHHEEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCC
DEAMVKALATFGGVDRRFQQYGEIRLPDRRSFTLIDDYGHHPAEIAATMAAARNAFPGRR
HHHHHHHHHHHCCHHHHHHHCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCE
LVLVFQPHRYSRTRDLFEDFVRVLSSADALLLTEIYSAGEEPIIAADSKSLVRAIRVQGK
EEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCC
IEPIYIEHINELKSAVHTVVQEGDVVLIMGAGSIGKIAPGLAEPTMKLTLITG
CCEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MKHKIKHIHFVGIGGSGMGGIAEVLINQGFQISGSDLNGNSTTKRLQCLGAVIHHTHAAE
CCCCEEEEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
NIQSADAVVISTAIQPDNPEVIAARERRIPVVPRAMMLAELLRLHQGIAIAGTHGKTTTT
CCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SLVASILAEAGQDPTFVIGGRLKTVDSHARLGKGEFIVVEADESDASFLYLQPVLTVVTN
HHHHHHHHHCCCCCEEEECCEEEEECHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
IDADHMSTYEHDFNRLKQTFVEFIEHLPFYGMAVLCADDPHVSAIIPMVSKQVTTYGITS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEEC
ENAQIRATDIRHDQCKMHFCAHIGVNGSARTLDITLNLPGKHNVLNALAAIAVGNELNIP
CCCEEEEECCCCHHHHEEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCC
DEAMVKALATFGGVDRRFQQYGEIRLPDRRSFTLIDDYGHHPAEIAATMAAARNAFPGRR
HHHHHHHHHHHCCHHHHHHHCCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCE
LVLVFQPHRYSRTRDLFEDFVRVLSSADALLLTEIYSAGEEPIIAADSKSLVRAIRVQGK
EEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCC
IEPIYIEHINELKSAVHTVVQEGDVVLIMGAGSIGKIAPGLAEPTMKLTLITG
CCEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA