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The map label for this gene is murB

Identifier: 114330271

GI number: 114330271

Start: 256600

End: 257598

Strand: Reverse

Name: murB

Synonym: Neut_0244

Alternate gene names: 114330271

Gene position: 257598-256600 (Counterclockwise)

Preceding gene: 114330272

Following gene: 114330270

Centisome position: 9.68

GC content: 51.75

Gene sequence:

>999_bases
ATGCAGACAAAAGCCCGACTGCCAGTCGATATAAATGCTCCGAGCTTGCAGTCTCCTGCACTCGGTATCGACACACATCT
GCTACGCGGCGAATTACGTCAACATGAACCCATGAAGCAGCATGTTTCCTGGCGCGCCGGTGGACACGCTGCCTATTTTT
ACCAACCGGCAGATCTGGAAGATCTGGCTGTATTTTTACACTTCTGGCCGAAAGATGAACCCGTCATGATGATTGGCCTT
GGTAGTAATTTTCTGGTTCGGGATGGTGGACTACCGGGAGTAATGATTGCATTGCATGCAAAACTTAATGACCTGCTGCT
GGTTGAACAAGAGGAGGATGGTGGCCTGATTTATGCCGGAGCGGGGGTACCCTGCGCCAAGCTGGCCAGGTTTGCTTCAT
TACATAACCTGGCCGGTGCGGAATTTCTGGCCGGCATTCCCGGTACGGTCGGCGGCGCACTGGCGATGAACGCAGGGTGT
TACGGCTCTGAAACATGGGAACGGGTAGAGCGGGTCAAAACCATTGATCGCGACGGTACATTGCATGAGCGAACACCTGA
GGATTACCGTATCGGCTACCGTCAGGTCGAATTGCATGAAGTCGTGCCGCCCGATACATCTTGCAGCTGGTTTGTCGGCG
GCTGGTTCAGACTTCGCCCTGGTCAGCAGGAATCTTCCCGTCAGGCGGTCAAAGCATTGCTTGGTACACGTATCAAAACG
CAACCCTTGGGATTTCCCAGCGCAGGATCGGTTTTTCGCAATCCGCCAGGAGATTATGCCGCCCGGTTAGTTGAGCAATG
TGGTCTGAAGGGATTTCGGATCGGTGATGCCATGATTTCTACGTTACATGCCAATTTTATTATTAACTGCGGACACGCTA
CTGCTACTGAAATCGAGACAGTGATTAATACTGTGCAAGATATCGTTTACAAGAAAACCGAGATCAGGCTGGTCACGGAA
GTACGCATTATCGGACAGCACAAAGGAAACGAGCTATGA

Upstream 100 bases:

>100_bases
CGTAGTTCTCATTATGGGGGCCGGATCCATTGGAAAAATCGCACCTGGCCTGGCAGAGCCAACGATGAAGCTGACACTGA
TAACAGGTTGATTGAAAAAC

Downstream 100 bases:

>100_bases
ACATTCGTGACCTTGGGAAAGTAGCTGTATTGCTGGGTGGACGTTCCGCTGAACGTGAAATCTCACTTAAAAGCGGCCAT
GCCGTACTGGCAGCATTACA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MQTKARLPVDINAPSLQSPALGIDTHLLRGELRQHEPMKQHVSWRAGGHAAYFYQPADLEDLAVFLHFWPKDEPVMMIGL
GSNFLVRDGGLPGVMIALHAKLNDLLLVEQEEDGGLIYAGAGVPCAKLARFASLHNLAGAEFLAGIPGTVGGALAMNAGC
YGSETWERVERVKTIDRDGTLHERTPEDYRIGYRQVELHEVVPPDTSCSWFVGGWFRLRPGQQESSRQAVKALLGTRIKT
QPLGFPSAGSVFRNPPGDYAARLVEQCGLKGFRIGDAMISTLHANFIINCGHATATEIETVINTVQDIVYKKTEIRLVTE
VRIIGQHKGNEL

Sequences:

>Translated_332_residues
MQTKARLPVDINAPSLQSPALGIDTHLLRGELRQHEPMKQHVSWRAGGHAAYFYQPADLEDLAVFLHFWPKDEPVMMIGL
GSNFLVRDGGLPGVMIALHAKLNDLLLVEQEEDGGLIYAGAGVPCAKLARFASLHNLAGAEFLAGIPGTVGGALAMNAGC
YGSETWERVERVKTIDRDGTLHERTPEDYRIGYRQVELHEVVPPDTSCSWFVGGWFRLRPGQQESSRQAVKALLGTRIKT
QPLGFPSAGSVFRNPPGDYAARLVEQCGLKGFRIGDAMISTLHANFIINCGHATATEIETVINTVQDIVYKKTEIRLVTE
VRIIGQHKGNEL
>Mature_332_residues
MQTKARLPVDINAPSLQSPALGIDTHLLRGELRQHEPMKQHVSWRAGGHAAYFYQPADLEDLAVFLHFWPKDEPVMMIGL
GSNFLVRDGGLPGVMIALHAKLNDLLLVEQEEDGGLIYAGAGVPCAKLARFASLHNLAGAEFLAGIPGTVGGALAMNAGC
YGSETWERVERVKTIDRDGTLHERTPEDYRIGYRQVELHEVVPPDTSCSWFVGGWFRLRPGQQESSRQAVKALLGTRIKT
QPLGFPSAGSVFRNPPGDYAARLVEQCGLKGFRIGDAMISTLHANFIINCGHATATEIETVINTVQDIVYKKTEIRLVTE
VRIIGQHKGNEL

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=312, Percent_Identity=25.9615384615385, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_NITEC (Q0AJE3)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746493.1
- ProteinModelPortal:   Q0AJE3
- SMR:   Q0AJE3
- STRING:   Q0AJE3
- GeneID:   4272260
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0244
- NMPDR:   fig|335283.3.peg.2117
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   NEUT335283:NEUT_0244-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 36426; Mature: 36426

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 194-194 ACT_SITE 250-250 ACT_SITE 320-320

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKARLPVDINAPSLQSPALGIDTHLLRGELRQHEPMKQHVSWRAGGHAAYFYQPADLE
CCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCHH
DLAVFLHFWPKDEPVMMIGLGSNFLVRDGGLPGVMIALHAKLNDLLLVEQEEDGGLIYAG
HHEEEEEECCCCCCEEEEEECCCEEEECCCCCEEEEEEEECCCCEEEEEECCCCCEEEEC
AGVPCAKLARFASLHNLAGAEFLAGIPGTVGGALAMNAGCYGSETWERVERVKTIDRDGT
CCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCC
LHERTPEDYRIGYRQVELHEVVPPDTSCSWFVGGWFRLRPGQQESSRQAVKALLGTRIKT
CCCCCCHHHHCCCEEEEEEECCCCCCCCCEEECCEEEECCCCCHHHHHHHHHHHCCCCCC
QPLGFPSAGSVFRNPPGDYAARLVEQCGLKGFRIGDAMISTLHANFIINCGHATATEIET
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCEEEECCCCCHHHHHH
VINTVQDIVYKKTEIRLVTEVRIIGQHKGNEL
HHHHHHHHHHHHHHEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MQTKARLPVDINAPSLQSPALGIDTHLLRGELRQHEPMKQHVSWRAGGHAAYFYQPADLE
CCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCHH
DLAVFLHFWPKDEPVMMIGLGSNFLVRDGGLPGVMIALHAKLNDLLLVEQEEDGGLIYAG
HHEEEEEECCCCCCEEEEEECCCEEEECCCCCEEEEEEEECCCCEEEEEECCCCCEEEEC
AGVPCAKLARFASLHNLAGAEFLAGIPGTVGGALAMNAGCYGSETWERVERVKTIDRDGT
CCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCC
LHERTPEDYRIGYRQVELHEVVPPDTSCSWFVGGWFRLRPGQQESSRQAVKALLGTRIKT
CCCCCCHHHHCCCEEEEEEECCCCCCCCCEEECCEEEECCCCCHHHHHHHHHHHCCCCCC
QPLGFPSAGSVFRNPPGDYAARLVEQCGLKGFRIGDAMISTLHANFIINCGHATATEIET
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCEEEECCCCCHHHHHH
VINTVQDIVYKKTEIRLVTEVRIIGQHKGNEL
HHHHHHHHHHHHHHEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA