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The map label for this gene is merR [H]

Identifier: 114330067

GI number: 114330067

Start: 35591

End: 36067

Strand: Direct

Name: merR [H]

Synonym: Neut_0034

Alternate gene names: 114330067

Gene position: 35591-36067 (Clockwise)

Preceding gene: 114330059

Following gene: 114330068

Centisome position: 1.34

GC content: 57.44

Gene sequence:

>477_bases
ATGCGAACTAATTTTAAGAATGTGACTATTGGCGTTTTTGCCAAGGCGGCCGGAGTCAATGTGGAGACCATCCGGTTCTA
CCAGCGCAAGGGCCTGCTGTCGGAGCCAGACAAGCCCTATGGCAGCATTCGCCGCTATGGCGAGGCGGATGTAACACGGG
TGCGCTTTGTGAAATCGGCCCAGCGGCTGGGCTTTAGCCTGGATGAAATCGCCGAGCTCCTACGGCTAGATGACGGAACA
CATTGCGAGGAAGCCAGCGGCCTAGCCGAGCACAAGCTCAAGGATGTGCGCGAAAAGATGGCCGATTTGGCGCGCATGGA
GGCCGTGCTGTCTGAACTGGTGTGCGCCTGCCACTCACGGAAGGGAAACGTTACCTGCCCGCTGATTGCGTCACTGCAAG
ACGGAGCGAACCTCGCGGTGTCGGTGCAGAGTGGTCATGGGTTGACTACGCAGCCTGCTTTATTTTCCGAATTCTGA

Upstream 100 bases:

>100_bases
ACGCCGCGCCCGCTTTGTGGTGGAAACATGCGCTTGTCCTTTCAAATTTGTATTCGATAGCTTAAGCTTACTTCCGTAGT
TATGTACGGAGTCAAGAGAT

Downstream 100 bases:

>100_bases
GACACCCCAAATAGAAACTGCAATTGAACGACCATCTCCATGTCGAAGGCCGTCGGCATCAGTTAACGCCATGACACTTG
CTGGGAAGTACCGTACCGCC

Product: putative transcriptional regulator MerR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MRTNFKNVTIGVFAKAAGVNVETIRFYQRKGLLSEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLDDGT
HCEEASGLAEHKLKDVREKMADLARMEAVLSELVCACHSRKGNVTCPLIASLQDGANLAVSVQSGHGLTTQPALFSEF

Sequences:

>Translated_158_residues
MRTNFKNVTIGVFAKAAGVNVETIRFYQRKGLLSEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLDDGT
HCEEASGLAEHKLKDVREKMADLARMEAVLSELVCACHSRKGNVTCPLIASLQDGANLAVSVQSGHGLTTQPALFSEF
>Mature_158_residues
MRTNFKNVTIGVFAKAAGVNVETIRFYQRKGLLSEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLDDGT
HCEEASGLAEHKLKDVREKMADLARMEAVLSELVCACHSRKGNVTCPLIASLQDGANLAVSVQSGHGLTTQPALFSEF

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=143, Percent_Identity=36.3636363636364, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 17357; Mature: 17357

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTNFKNVTIGVFAKAAGVNVETIRFYQRKGLLSEPDKPYGSIRRYGEADVTRVRFVKSA
CCCCCCCEEEEEEHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEIAELLRLDDGTHCEEASGLAEHKLKDVREKMADLARMEAVLSELVCACHSR
HHHCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGNVTCPLIASLQDGANLAVSVQSGHGLTTQPALFSEF
CCCEECHHHEECCCCCCEEEEEECCCCCCCCCHHHCCC
>Mature Secondary Structure
MRTNFKNVTIGVFAKAAGVNVETIRFYQRKGLLSEPDKPYGSIRRYGEADVTRVRFVKSA
CCCCCCCEEEEEEHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEIAELLRLDDGTHCEEASGLAEHKLKDVREKMADLARMEAVLSELVCACHSR
HHHCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGNVTCPLIASLQDGANLAVSVQSGHGLTTQPALFSEF
CCCEECHHHEECCCCCCEEEEEECCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6091128; 2551364 [H]