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The map label for this gene is pyrD [H]

Identifier: 113970021

GI number: 113970021

Start: 1991279

End: 1992298

Strand: Direct

Name: pyrD [H]

Synonym: Shewmr4_1681

Alternate gene names: 113970021

Gene position: 1991279-1992298 (Clockwise)

Preceding gene: 113970020

Following gene: 113970022

Centisome position: 42.31

GC content: 41.76

Gene sequence:

>1020_bases
ATGTTTTATAAAATCGCACAGAAAGTCATGTTTCAGATGGATCCTGAGCGAGCGCATAATTTAGCCATTGGCAGCCTGAA
AATGACAGGTAATAGTCCATTGAATGCGTTTTATGCCCAGAATATTGCGCCAGCGCCCGTCAGCTTTATGGGACTGACTT
TTCCAAACCCTGTCGGCCTTGCCGCAGGTATGGATAAAGATGGCGAATCGATCGATGCCTTTCATGCGATGGGATTTGGT
CATGTGGAAGTGGGGACTGTGACCCCAAGACCACAACCCGGTAATGATTTACCCCGTTTGTTTAGATTAAAACCCGCAAA
GGCGATCATCAATCGCATGGGCTTTAATAACAAAGGTGTCGATAATCTGGTCAAAAATTTGATCGCAAAGAAAACCGATA
TCATGGTTGGGGTCAATATTGGTAAAAATAAAGACACGCCAGTAGAGCAGGGCAAAGACGATTATTTGATCTGCATGGAC
AAAGTCTATCCCTATGCAGCCTATATTGCGGTGAATATTTCATCACCGAATACACCAGGATTACGATCGCTGCAATATGG
CGATCTATTAGACGAATTATTAAGCGCATTAAAAACTAAGCAACTTGAGTTGGCCGAGAAACATAAAAAATATGTGCCAA
TTGCCCTTAAAATTGCGCCTGATTTAACCACGGAAGAAATCGAAAATATTGCTCAATCCTTGATTAAAAACAAGTTTGAT
GGCGCGATTGCGACTAACACTACCTTAACCCGTGACGGTGTGAGTGGCCTTGCGAATGCCAATGAAAGCGGTGGGTTAAG
TGGTAAACCATTGACTGAGCTTTCAACTAAAGTGATCAAACAATTAGCTACTTGTTTAAATGGTCAGATCCCGATTATTG
GAGTAGGTGGTATTAATAGCGCCGAAGATGCCTTAGCAAAATTTGATGCGGGCGCGACTATGGTGCAAATTTACTCAGGT
TTTATTTACCAAGGTCCAAAGTTAATTAAAGAAATTGTTGAAGCTTACCGTTTAAAATAA

Upstream 100 bases:

>100_bases
TTAACCTTCTGATCCTTCATTGCGAAGGCCAAAAGTAAACTTTTATAACAATCAGAAGCCCTGGCGATCGCCGGGGCTTT
TTTTAGGTCGAGGAAAATAC

Downstream 100 bases:

>100_bases
TGATCTTTAGATCTCAATAGGGATCTAAATTACGATCATTTATCTTAGCTGCGATCTAAAACGATCAATAGATCGCAGTT
AAGATCCTTAAATAGATCTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATCLNGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK

Sequences:

>Translated_339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATCLNGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK
>Mature_339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATCLNGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=43.030303030303, Blast_Score=248, Evalue=5e-66,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=61.8618618618619, Blast_Score=433, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17509475, Length=351, Percent_Identity=41.3105413105413, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI281361352, Length=326, Percent_Identity=42.0245398773006, Blast_Score=237, Evalue=8e-63,
Organism=Drosophila melanogaster, GI17137316, Length=326, Percent_Identity=42.0245398773006, Blast_Score=237, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36599; Mature: 36599

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHCEEEEEEEECCCCCCHHHHHCCCCCCCHHEEECCCCCCCCC
AAGMDKDGESIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCH
DNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATCLNGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVEAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHCEEEEEEEECCCCCCHHHHHCCCCCCCHHEEECCCCCCCCC
AAGMDKDGESIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCH
DNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATCLNGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVEAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA