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The map label for this gene is yeeO [C]

Identifier: 113969963

GI number: 113969963

Start: 1919763

End: 1921325

Strand: Direct

Name: yeeO [C]

Synonym: Shewmr4_1623

Alternate gene names: 113969963

Gene position: 1919763-1921325 (Clockwise)

Preceding gene: 113969962

Following gene: 113969965

Centisome position: 40.79

GC content: 52.34

Gene sequence:

>1563_bases
ATGACCCAAGCCAAATTCGTTGAAGGTTCGATTCTTCGTCATATCCTGGTGATGAGTTCGACCGCCGCGGTGGGGATTTC
TGCCTTATTTGTGGTCGATTTACTCGATATTTTCTTCTTAAGTTTACTCGGCGAACATGAACTGGCCGCGGCGGTGGGCT
ATGCGGGCAGTATTTCGTTTTTTACGACTTCTATTGGTATCGGCCTCTCGATTGCGCTCGGCGCGTTAGTATCCCGCTCG
ATTGGTGCAAAGGATGTCGAGTTAGCTAAACGCCTCTTGCTCAATAGTGCGGCGGTGACCACCCTAATCAGCCTTTTTGT
GAGTGTGGTGGTGACCTGTTTTATCCCCGAATTAGTGACTTTGGTAGGGGCGAGCGGCCATACCGCGGAACTTGCCGAGA
GTTATCTGTACATTTTGGTGCCTTCTTTACCCTTTATTTGCCTTGCGATGGCCCTTGGCGGTGCGCTGCGTGCCGTTGGG
GATGCCAAGCTGTCGATGATGTCGACCTTAGCGGGCGGCGGCGTTAATGCTGTGCTGGATCCGATTTTTATTTTCCTGTT
TGCCATGGGGATTGAAGGCGCGGCACTGGCGTCGGTCCTTGCCCGTATAGCGGTCTTTATCATTGCCGGGCGCGGTGTTG
TGGTAAAACATCAACTGCTAGGCAAATTTAACTTCAGCTATTTTGTTGCCGATCTCAAACCGATTTTCGCTATTGCCGGG
CCTGCCATGCTGACGAATATCGCGACGCCCATTGGTAACGCCTTTGTGACCCGCGCGATTGCGGATTTTGGTGATGCCTA
TGTGGCCGGTTGGGCGGTGCTTGGCAGGTTAGTCCCGGTCACCTTTGGGATGATTTTTGCGTTATCCGGCGCCATTGGGC
CGATTGTTGGGCAAAACTTTGGGGCGGGTCGATTCGACCGGGTGCGCGAGAGTTTAACCAAGGCGATTCAATTTTGTACC
TTGTATGTGGTGGTGATGTCGCTGCTGCTGTTCTTGCTCAAATCGCAGGTGGTGAGCCTGTTCGATATGAAAGGCGATAG
CGCGGCGCTTATCGAGTTTTTCTGTAGCTATATCGCGGTGTTTTTTACCTTCTCTGGCATTTTATTTGTGGCCAATGCTT
CGTTTAATAATCTGGGCAAAGCGAAATACTCCACCTTGTTCAACGTCGGTAAAGCCACGTTAGGGACTGTGCCATTTGTG
TATTTTGGCGCCCAGTGGGGCGGGGTATACGGTGTGTTAATCGGCCAAGTATTGGGCTCGATTCTGTTTGGGATTATGGG
TGTGTGGGTGGCCTACCGATTAGTCGATAAAGTCGCACTGGCAAGCCGCGCGAGCGTGGCACAGCCCTTGGGGAACGAAA
CCGAAGAGGCGCAGGCTAAGTGCCAGCAACTGCTGGCGGGGGATGAGGAAGAAATTGCCAATTGTGTTGGCCAAAATCTG
CCCTCATCTACGAGTCCGTTTTCATCCTCCCATGTGCAAATGGGCCAATTGACCGAAGAGCAGGAATGCGAGGCGGCCAC
GGCAGCGGTGGATTTTGATAAAGCAAAACCGAATACGCCGTAA

Upstream 100 bases:

>100_bases
GCCTCATGGTAGGCTAGCGTATTCAAGATAATGCTTAAGTGGCGTTGACCATTGACCTCGTTTTAATGTCCGCCTTTCCA
ATAGATCAAGGTAATTCCCC

Downstream 100 bases:

>100_bases
ACCCTGTGAAAGCTATGCTTTGTCATCATAAAAACTCATAAAATATAAAGGCCACTGAAAAGTGGCCTTTATATTTAAAA
CTAACATTTTTCAAATCAGC

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTQAKFVEGSILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISFFTTSIGIGLSIALGALVSRS
IGAKDVELAKRLLLNSAAVTTLISLFVSVVVTCFIPELVTLVGASGHTAELAESYLYILVPSLPFICLAMALGGALRAVG
DAKLSMMSTLAGGGVNAVLDPIFIFLFAMGIEGAALASVLARIAVFIIAGRGVVVKHQLLGKFNFSYFVADLKPIFAIAG
PAMLTNIATPIGNAFVTRAIADFGDAYVAGWAVLGRLVPVTFGMIFALSGAIGPIVGQNFGAGRFDRVRESLTKAIQFCT
LYVVVMSLLLFLLKSQVVSLFDMKGDSAALIEFFCSYIAVFFTFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFV
YFGAQWGGVYGVLIGQVLGSILFGIMGVWVAYRLVDKVALASRASVAQPLGNETEEAQAKCQQLLAGDEEEIANCVGQNL
PSSTSPFSSSHVQMGQLTEEQECEAATAAVDFDKAKPNTP

Sequences:

>Translated_520_residues
MTQAKFVEGSILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISFFTTSIGIGLSIALGALVSRS
IGAKDVELAKRLLLNSAAVTTLISLFVSVVVTCFIPELVTLVGASGHTAELAESYLYILVPSLPFICLAMALGGALRAVG
DAKLSMMSTLAGGGVNAVLDPIFIFLFAMGIEGAALASVLARIAVFIIAGRGVVVKHQLLGKFNFSYFVADLKPIFAIAG
PAMLTNIATPIGNAFVTRAIADFGDAYVAGWAVLGRLVPVTFGMIFALSGAIGPIVGQNFGAGRFDRVRESLTKAIQFCT
LYVVVMSLLLFLLKSQVVSLFDMKGDSAALIEFFCSYIAVFFTFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFV
YFGAQWGGVYGVLIGQVLGSILFGIMGVWVAYRLVDKVALASRASVAQPLGNETEEAQAKCQQLLAGDEEEIANCVGQNL
PSSTSPFSSSHVQMGQLTEEQECEAATAAVDFDKAKPNTP
>Mature_519_residues
TQAKFVEGSILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISFFTTSIGIGLSIALGALVSRSI
GAKDVELAKRLLLNSAAVTTLISLFVSVVVTCFIPELVTLVGASGHTAELAESYLYILVPSLPFICLAMALGGALRAVGD
AKLSMMSTLAGGGVNAVLDPIFIFLFAMGIEGAALASVLARIAVFIIAGRGVVVKHQLLGKFNFSYFVADLKPIFAIAGP
AMLTNIATPIGNAFVTRAIADFGDAYVAGWAVLGRLVPVTFGMIFALSGAIGPIVGQNFGAGRFDRVRESLTKAIQFCTL
YVVVMSLLLFLLKSQVVSLFDMKGDSAALIEFFCSYIAVFFTFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFVY
FGAQWGGVYGVLIGQVLGSILFGIMGVWVAYRLVDKVALASRASVAQPLGNETEEAQAKCQQLLAGDEEEIANCVGQNLP
SSTSPFSSSHVQMGQLTEEQECEAATAAVDFDKAKPNTP

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=429, Percent_Identity=23.3100233100233, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI153792564, Length=504, Percent_Identity=22.0238095238095, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 54629; Mature: 54497

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAKFVEGSILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHH
FTTSIGIGLSIALGALVSRSIGAKDVELAKRLLLNSAAVTTLISLFVSVVVTCFIPELVT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGASGHTAELAESYLYILVPSLPFICLAMALGGALRAVGDAKLSMMSTLAGGGVNAVLD
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
PIFIFLFAMGIEGAALASVLARIAVFIIAGRGVVVKHQLLGKFNFSYFVADLKPIFAIAG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHCCHHHHHHHHHHHHHHHH
PAMLTNIATPIGNAFVTRAIADFGDAYVAGWAVLGRLVPVTFGMIFALSGAIGPIVGQNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAGRFDRVRESLTKAIQFCTLYVVVMSLLLFLLKSQVVSLFDMKGDSAALIEFFCSYIAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FFTFSGILFVANASFNNLGKAKYSTLFNVGKATLGTVPFVYFGAQWGGVYGVLIGQVLGS
HHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHEECCHHHHHHHHHHHHHHHH
ILFGIMGVWVAYRLVDKVALASRASVAQPLGNETEEAQAKCQQLLAGDEEEIANCVGQNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCC
PSSTSPFSSSHVQMGQLTEEQECEAATAAVDFDKAKPNTP
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TQAKFVEGSILRHILVMSSTAAVGISALFVVDLLDIFFLSLLGEHELAAAVGYAGSISF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHH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CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]