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The map label for this gene is thrC [H]

Identifier: 113969484

GI number: 113969484

Start: 1341051

End: 1342334

Strand: Direct

Name: thrC [H]

Synonym: Shewmr4_1140

Alternate gene names: 113969484

Gene position: 1341051-1342334 (Clockwise)

Preceding gene: 113969483

Following gene: 113969485

Centisome position: 28.49

GC content: 50.23

Gene sequence:

>1284_bases
ATGGAACTATATAATTTAAAACACCCTTCGCAGAAAGTGAGCTTTAAGGAAGCGGTGCAATTAGGACTCGGTAAAGACAG
AGGGTTGTTTTTTCCTACTCAAATCCCAGTGTTGCACGATATTGAGGCGCTGCTGGCAATGCCTTTTGTCGAGCGCAGTA
AAAAAGTGCTCGGCGCTTGGCTCGCCTCAGAGCTTGGGCAAGGCGCGGTAGATAAGCTAGTCGAGCGTGCCTTTAATTTC
GATTTGCCCTTGGTGGCGGTCGATGAGCAGCGCTCGTGCCTCGAGCTTTTCCATGGGCCAACTTTAGCATTCAAGGATTT
TGGTGCGCGCTTTATGGCGCAATGCATCAATGCCTTTGCTCAAGACTCGCGCTTAACCATTCTAACCGCGACCTCGGGTG
ACACTGGGGCGGCGGTGGCCGATGCCTTTTACGGCCTAGATAAAGTCAATGTAGTCGTGCTCTATCCTAAGGGCAAAATC
AGTGAGCTACAGGAAAAGATGTTCACCACCTTAGGTAAGAACATCCACACTGTGGCAGTAGCGTCCGATTTCGATGCTTG
CCAGCACTTAGTCAAACAGGCTTTTGAAGATAGCGATGTGCGTGATGGCTTGCATTTAAACTCGGCCAACTCAATCAACA
TCAGTCGTTTACTGGCACAGATTTGTTATTACTTCGAAGCGGTCGCCCAATCGAAACAGCGCCATGAGGCCGATCCTGTG
ATTGCCGTGCCCAGTGGAAACTTTGGAAACTTGACCGCGGGATTATTTGCCAAAGCCATGGGCTTACCTGTTAAACGTTT
TATTGCCGCCACCAACGCCAATGACACTGTCCCACGTTATTTAGAGAGTGGTGATTGGCAACCCAATCCCACTCAAGCGA
CTATGTCCAATGCGATGGATGTGAGCGAGCCAAGTAACTGGCCGCGCGTCGAGGCTATTTGCGAGAAACTCGGTTGGCCA
CTTTCGGACTTAGTGGGTATTCGCCTGTCTGAGGCTCAAACCTCGGAGGCCTTGGCGGAATTACAAGCTAAGGGCTATGT
GTCTGAGCCCCATGCGGCGATTGCGGCTAAGGCGTTATCGCTCAACTTAGTGCCTGATGAAGTGGGGATATTTTTAGGCA
CGGCGCATCCCGCCAAGTTTAAGGATGTCGTAGATAGAGAGCTTAACCTCGATTTACCTTTGCCTGCAGAACTTAAGGCG
GTGGAGCATAAACCTATACTCTCGGCTGAATTAGCCGCCGATTTTGCCCAGCTAAAGTCACATTTATTTGCGGTGTTAAG
CTGA

Upstream 100 bases:

>100_bases
GCCTCGATGAGCAAGGCACGCGCCGAGTCGATTAATTTTCTTACTTTTAACAGCATTAAGCCCAAGCCTAAAGGCTTGGC
ACTGATAAGGTCGAGTGAGC

Downstream 100 bases:

>100_bases
GCTTGAAAATTACTGTTAAGCGAAATATCAAGGGAGTCAATTGACTCCCTTTTTTACAAGTGTAAATGAGGCTCAAGAGA
ATTAATTAAAACTTATCATC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAWLASELGQGAVDKLVERAFNF
DLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFAQDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LSDLVGIRLSEAQTSEALAELQAKGYVSEPHAAIAAKALSLNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKA
VEHKPILSAELAADFAQLKSHLFAVLS

Sequences:

>Translated_427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAWLASELGQGAVDKLVERAFNF
DLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFAQDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LSDLVGIRLSEAQTSEALAELQAKGYVSEPHAAIAAKALSLNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKA
VEHKPILSAELAADFAQLKSHLFAVLS
>Mature_427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAWLASELGQGAVDKLVERAFNF
DLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFAQDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LSDLVGIRLSEAQTSEALAELQAKGYVSEPHAAIAAKALSLNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKA
VEHKPILSAELAADFAQLKSHLFAVLS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=450, Percent_Identity=31.5555555555556, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI149193323, Length=439, Percent_Identity=30.5239179954442, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1786185, Length=421, Percent_Identity=58.9073634204276, Blast_Score=477, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=32.6754385964912, Blast_Score=207, Evalue=3e-54,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46455; Mature: 46455

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LASELGQGAVDKLVERAFNFDLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFA
HHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
ECCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHCCC
VSEPSNWPRVEAICEKLGWPLSDLVGIRLSEAQTSEALAELQAKGYVSEPHAAIAAKALS
CCCCCCCCHHHHHHHHHCCCHHHHHCCEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKAVEHKPILSAELAADFAQLKS
EECCCHHHCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
HLFAVLS
HHHHHCC
>Mature Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LASELGQGAVDKLVERAFNFDLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFA
HHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
ECCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHCCC
VSEPSNWPRVEAICEKLGWPLSDLVGIRLSEAQTSEALAELQAKGYVSEPHAAIAAKALS
CCCCCCCCHHHHHHHHHCCCHHHHHCCEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKAVEHKPILSAELAADFAQLKS
EECCCHHHCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
HLFAVLS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]