Click here to switch to the map view.

The map label for this gene is hemE [H]

Identifier: 113968783

GI number: 113968783

Start: 497447

End: 498511

Strand: Direct

Name: hemE [H]

Synonym: Shewmr4_0439

Alternate gene names: 113968783

Gene position: 497447-498511 (Clockwise)

Preceding gene: 113968781

Following gene: 113968784

Centisome position: 10.57

GC content: 49.11

Gene sequence:

>1065_bases
ATGGCAGAATTAAAGAATGATCGTTATTTACGCGCCCTACTAAAACAGCCTGTTGATATGACCCCAGTGTGGATGATGCG
TCAAGCTGGCCGTTATCTTCCTGAATATAAAGCGACTCGCGCTCAAGCGGGTGACTTCATGTCTTTATGTAAAAACCATG
AATTGGCTTGTGAAGTAACGCTACAACCGCTGCGTCGTTATGAGTTGGATGCAGCAATTCTGTTTTCCGATATTCTGACT
GTTCCCGATGCGATGGGTTTAGGTCTGTATTTTGAGGCGGGCGAAGGCCCACGTTTTGAGCGCCCAACAGACACTATCGA
TGCCATCAAAAAATTAGCCGTTCCCGATCCAGAAGATGATCTGGGTTATGTGATGAAAGCGGTTAGCACTATTCGCCGTG
AACTGAATGGTCAAGTGCCATTGATCGGTTTCTCTGGTTCTCCTTGGACACTCGCGACTTACATGGTTGAAGGTGGCTCG
AGCAAAACCTTCGAAAAAATTAAGAAGATGGCCTACGCAGAGCCAGCGGCGCTGCATATGTTACTCGACAAGTTAGCCGA
TTCTGTGACTCTGTACCTGAATGCACAGGTTGCTAACGGTGCTCAATCGCTGATGATCTTCGACTCATGGGGCGGCGCCT
TATCGCACACGGCTTACCGTGAATTCTCACTGCGTTATATGCAGAAGATTGTCGATGGCCTGACTCGTTTTGCCGATGGC
CGCCAAGTACCAGTGACCTTATTCACTAAGGGCGGTGGCTTATGGTTAGAAGCCATGGCAGAAACTGGCTGTGATGCTTT
AGGTTTAGACTGGACTGTCGATATTGCCGATGCCCGTCGCCGTGTCGGCCACAAAGTGGCGCTTCAGGGCAACATGGATC
CTTCTATGCTGTACGCGCCAATTCCACGTATCGAAGAAGAAGTGGCTCAAATTCTGGCGGGCTATGGTGAAGGTACAGGC
CATGTGTTTAACTTAGGCCATGGTATTCACCAGCACGTTGACCCAGAGCATGCGGGTGCCTTTATCAAGGCGGTTCATGC
TCAATCTAAGCAGTATCATAAGTAA

Upstream 100 bases:

>100_bases
GGGAATAGCTCACATAAATTTGCACATAAAGGTTACATTATCCGCGTAAATGCTAAACTACCGACCCAGCGGATCTCAAT
AAGTCTAGGAATCAAGCCAA

Downstream 100 bases:

>100_bases
GCGATACTGAAGAAAAAACGGACCTTAAGGTCCGTTTTTTTATGCTGTGACTCTGTGCTAAACAATGTGTGCTTAACGTC
AACTCGGCTCGGATTATGCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAELKNDRYLRALLKQPVDMTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYELDAAILFSDILT
VPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLAVPDPEDDLGYVMKAVSTIRRELNGQVPLIGFSGSPWTLATYMVEGGS
SKTFEKIKKMAYAEPAALHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHTAYREFSLRYMQKIVDGLTRFADG
RQVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVAQILAGYGEGTG
HVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK

Sequences:

>Translated_354_residues
MAELKNDRYLRALLKQPVDMTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYELDAAILFSDILT
VPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLAVPDPEDDLGYVMKAVSTIRRELNGQVPLIGFSGSPWTLATYMVEGGS
SKTFEKIKKMAYAEPAALHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHTAYREFSLRYMQKIVDGLTRFADG
RQVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVAQILAGYGEGTG
HVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
>Mature_353_residues
AELKNDRYLRALLKQPVDMTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVTLQPLRRYELDAAILFSDILTV
PDAMGLGLYFEAGEGPRFERPTDTIDAIKKLAVPDPEDDLGYVMKAVSTIRRELNGQVPLIGFSGSPWTLATYMVEGGSS
KTFEKIKKMAYAEPAALHMLLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHTAYREFSLRYMQKIVDGLTRFADGR
QVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAPIPRIEEEVAQILAGYGEGTGH
VFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=47.7401129943503, Blast_Score=317, Evalue=1e-86,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=81.0734463276836, Blast_Score=596, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=39.031339031339, Blast_Score=263, Evalue=3e-71,
Organism=Drosophila melanogaster, GI19921920, Length=346, Percent_Identity=42.1965317919075, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI221330099, Length=346, Percent_Identity=42.1965317919075, Blast_Score=278, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39207; Mature: 39075

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKNDRYLRALLKQPVDMTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYELDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLAVPDPEDD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHH
LGYVMKAVSTIRRELNGQVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPAALHM
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHTAYREFSLRYMQKIVDGLTRFADG
HHHHHHCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAP
CCCCEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCHHEECC
IPRIEEEVAQILAGYGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
CCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AELKNDRYLRALLKQPVDMTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNHELACEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
LQPLRRYELDAAILFSDILTVPDAMGLGLYFEAGEGPRFERPTDTIDAIKKLAVPDPEDD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHH
LGYVMKAVSTIRRELNGQVPLIGFSGSPWTLATYMVEGGSSKTFEKIKKMAYAEPAALHM
HHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADSVTLYLNAQVANGAQSLMIFDSWGGALSHTAYREFSLRYMQKIVDGLTRFADG
HHHHHHCCEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQVPVTLFTKGGGLWLEAMAETGCDALGLDWTVDIADARRRVGHKVALQGNMDPSMLYAP
CCCCEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCHHEECC
IPRIEEEVAQILAGYGEGTGHVFNLGHGIHQHVDPEHAGAFIKAVHAQSKQYHK
CCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA